ofloxacin has been researched along with Stevens-Johnson Syndrome in 13 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Generalized tonic-clonic seizures are a rare complication of levofloxacin therapy." | 3.73 | Generalized seizure and toxic epidermal necrolysis following levofloxacin exposure. ( Christie, MJ; Sikaneta, TG; Tam, PY; Ting, RH; Wong, K, 2005) |
| "To report a fatal case of toxic epidermal necrolysis in a man who was treated with oral ofloxacin for epididymitis." | 3.71 | Ofloxacin: a probable cause of toxic epidermal necrolysis. ( Melde, SL, 2001) |
| "The series is part of an ongoing randomised controlled trial assessing rechallenge dosing following TB-associated cutaneous ADR." | 2.77 | Multiple drug hypersensitivity reactions to anti-tuberculosis drugs: five cases in HIV-infected patients. ( Dheda, K; Lehloenya, RJ; Todd, G; Wallace, J, 2012) |
| "Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), also known as Lyell's syndrome, are rare and life-threatening conditions, for which etiopathogenesis, as well as pharmacotherapy, is yet unclear." | 1.48 | A Rare Case Report of Toxic Epidermal Necrolysis Due to Ofloxacin. ( Chavda, BC; Mehta, HH; Nimbark, VN; Purohit, BM; Vaghela, JJ, 2018) |
| "Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN) are mild-to-life-threatening adverse reactions that have been described after exposure to fluoroquinolones." | 1.31 | Levofloxacin-induced toxic epidermal necrolysis in an elderly patient. ( Ackerman, BH; Cawley, MJ; Digwood-Lettieri, S; Guilday, RJ; Haith, LR; Patton, ML; Reilly, KJ, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Shaw, B | 1 |
| Madden, M | 1 |
| Crespo, A | 1 |
| Madruga, M | 1 |
| Carlan, SJ | 1 |
| Vaghela, JJ | 1 |
| Nimbark, VN | 1 |
| Chavda, BC | 1 |
| Mehta, HH | 1 |
| Purohit, BM | 1 |
| Parmar, NV | 1 |
| Kuruvila, S | 1 |
| Ganguly, S | 1 |
| Krishna, CV | 1 |
| Davila, G | 1 |
| Ruiz-Hornillos, J | 1 |
| Rojas, P | 1 |
| De Castro, F | 1 |
| Zubeldia, JM | 1 |
| Hafiji, J | 1 |
| Orpin, S | 1 |
| Roberts, C | 1 |
| Heagerty, A | 1 |
| Lewis, H | 1 |
| Yoon, SY | 1 |
| Bae, YJ | 1 |
| Cho, YS | 1 |
| Moon, HB | 1 |
| Kim, TB | 1 |
| Teo, WL | 1 |
| Pang, SM | 1 |
| Lehloenya, RJ | 1 |
| Wallace, J | 1 |
| Todd, G | 1 |
| Dheda, K | 1 |
| Christie, MJ | 1 |
| Wong, K | 1 |
| Ting, RH | 1 |
| Tam, PY | 1 |
| Sikaneta, TG | 1 |
| Islam, AF | 1 |
| Rahman, MS | 1 |
| Melde, SL | 1 |
| Digwood-Lettieri, S | 1 |
| Reilly, KJ | 1 |
| Haith, LR | 1 |
| Patton, ML | 1 |
| Guilday, RJ | 1 |
| Cawley, MJ | 1 |
| Ackerman, BH | 1 |
1 review available for ofloxacin and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Levofloxacin revisited.
Topics: Animals; Anti-Infective Agents; Bacterial Infections; Gastrointestinal Diseases; Humans; Levofloxaci | 2011 |
1 trial available for ofloxacin and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Multiple drug hypersensitivity reactions to anti-tuberculosis drugs: five cases in HIV-infected patients.
Topics: Adult; Antitubercular Agents; Coinfection; Drug Eruptions; Drug Hypersensitivity; Edema; Eosinophili | 2012 |
11 other studies available for ofloxacin and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
A Rare Case of Severe Stevens-Johnson Syndrome Triggered by Topical Ofloxacin.
Topics: Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Exanthema; Female; Humans; Ofloxacin; Stevens | 2023 |
A Rare Case Report of Toxic Epidermal Necrolysis Due to Ofloxacin.
Topics: Anti-Bacterial Agents; Fatal Outcome; Humans; Male; Middle Aged; Ofloxacin; Stevens-Johnson Syndrome | 2018 |
Ofloxacin eyedrops-induced toxic epidermal necrolysis treated with intravenous immunoglobulin.
Topics: Administration, Topical; Anti-Bacterial Agents; Hordeolum; Humans; Immunoglobulins, Intravenous; Imm | 2014 |
Toxic epidermal necrolysis induced by levofloxacin.
Topics: Fatal Outcome; Female; Humans; Levofloxacin; Middle Aged; Ofloxacin; Pyelonephritis; Stevens-Johnson | 2009 |
Radiotherapy: a protective role for toxic epidermal necrolysis?
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Humans; Lung Neoplasms; Male; | 2010 |
Toxic epidermal necrolysis induced by ofloxacin.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Bandages; Combined Moda | 2010 |
Levofloxacin-induced toxic epidermal necrolysis treated with intravenous immunoglobulin.
Topics: Anti-Bacterial Agents; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Levofloxacin; Oflo | 2010 |
Generalized seizure and toxic epidermal necrolysis following levofloxacin exposure.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Female; Humans; Levofloxacin; Ofloxacin; Se | 2005 |
Levofloxacin-induced fatal toxic epidermal necrolysis.
Topics: Administration, Oral; Adolescent; Anti-Bacterial Agents; Fatal Outcome; Humans; Levofloxacin; Male; | 2005 |
Ofloxacin: a probable cause of toxic epidermal necrolysis.
Topics: Aged; Anti-Infective Agents; Epididymitis; Fatal Outcome; Humans; Male; Ofloxacin; Stevens-Johnson S | 2001 |
Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.
Topics: Aged; Anti-Infective Agents; Community-Acquired Infections; Female; Fluid Therapy; Humans; Levofloxa | 2002 |