ofloxacin has been researched along with Seizures in 22 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures." | 8.85 | Seizures associated with levofloxacin: case presentation and literature review. ( Bellon, A; Chacko, RC; Coverdale, JH; Perez-Garcia, G, 2009) |
| "We describe four patients who had seizures while receiving ofloxacin; no other causes were evident." | 8.79 | Seizures associated with ofloxacin therapy. ( Bonfiglio, MF; Martin, BR; Nackes, NA; Traeger, SM; Wilson, JA, 1995) |
| "Seizures have been reported in patients receiving fluoroquinolones, including levofloxacin (LVFX)." | 7.74 | Effects of acute renal failure and ganciclovir on the pharmacodynamics of levofloxacin-induced seizures in rats. ( Ishiwata, Y; Itoga, Y; Son, K; Yasuhara, M, 2007) |
| "We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures." | 4.85 | Seizures associated with levofloxacin: case presentation and literature review. ( Bellon, A; Chacko, RC; Coverdale, JH; Perez-Garcia, G, 2009) |
| "To report two cases of seizures following administration of levofoxacin and ciprofloxacin." | 4.81 | Seizures associated with fluoroquinolones. ( Kushner, JM; Peckman, HJ; Snyder, CR, 2001) |
| "We describe four patients who had seizures while receiving ofloxacin; no other causes were evident." | 4.79 | Seizures associated with ofloxacin therapy. ( Bonfiglio, MF; Martin, BR; Nackes, NA; Traeger, SM; Wilson, JA, 1995) |
| "Seizures have been reported in patients receiving fluoroquinolones, including levofloxacin (LVFX)." | 3.74 | Effects of acute renal failure and ganciclovir on the pharmacodynamics of levofloxacin-induced seizures in rats. ( Ishiwata, Y; Itoga, Y; Son, K; Yasuhara, M, 2007) |
| "Generalized tonic-clonic seizures are a rare complication of levofloxacin therapy." | 3.73 | Generalized seizure and toxic epidermal necrolysis following levofloxacin exposure. ( Christie, MJ; Sikaneta, TG; Tam, PY; Ting, RH; Wong, K, 2005) |
| "Levofloxacin was found to be very safe with a low rate of hepatic abnormalities (1/650,000)." | 2.41 | Comparison of side effects of levofloxacin versus other fluoroquinolones. ( Carbon, C, 2001) |
| "Only 61 cases of convulsions have been reported with levofloxacin, with 33 of those affected having received NSAIDs." | 2.41 | Latest industry information on the safety profile of levofloxacin in Japan. ( Yagawa, K, 2001) |
| "The clinical risk of convulsion for each combination was estimated using a pharmacodynamic model based on receptor occupancy using the in vitro data set obtained and pharmacokinetic parameters in humans collected from the literature." | 1.35 | Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents. ( Kim, J; Ohtani, H; Sawada, Y; Tsujimoto, M, 2009) |
| " The incidence of adverse reactions was 1." | 1.34 | Post-marketing surveillance of the safety of levofloxacin in Japan. ( Kawai, H; Komiya, M; Matsumoto, T; Nakayasu, T; Shimada, J; Yamaguchi, H; Yokoyama, H, 2007) |
| "1." | 1.30 | Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coadministered with 4-biphenyl acetic acid. ( Fujimura, H; Kohno, K; Niwa, M; Nozaki, M; Uematsu, T, 1997) |
| "The ofloxacin was discontinued and aztreonam therapy was started." | 1.30 | Ofloxacin-induced seizure. ( Hon, JK; Mulpur, TG; Walton, GD, 1997) |
| "Levofloxacin-induced-neurological adverse events such as convulsion, involuntary movement (tremor, myoclonus and chorea-like) and visual hallucination in two elderly patients are reported." | 1.30 | [Levofloxacin-induced neurological adverse effects such as convulsion, involuntary movement (tremor, myoclonus and chorea like), visual hallucination in two elderly patients]. ( Fukayama, M; Inamatsu, T; Kita, Y; Masuda, Y; Yasuda, H; Yoshida, A, 1999) |
| "The incidence of these convulsions was enhanced by the combination with BPAA (50 micrograms)." | 1.29 | Levofloxacin, an optical isomer of ofloxacin, has attenuated epileptogenic activity in mice and inhibitory potency in GABA receptor binding. ( Akahane, K; Kimura, Y; Kitano, Y; Tsutomi, Y, 1994) |
| "The animals were observed for clonic convulsion and death, and latency times to the appearance of convulsion were determined." | 1.29 | Involvement of inhibitory and excitatory neurotransmitters in levofloxacin- and ciprofloxacin-induced convulsions in mice. ( Akahane, K; Kato, M; Takayama, S, 1993) |
| "This order reflects that for the convulsion-inducing doses." | 1.29 | Effect of bile duct ligation and unilateral nephrectomy on brain concentration and convulsant potential of the quinolone antibacterial agent levofloxacin in rats. ( Akahane, K; Kato, M; Nomura, M; Ohkawara, S, 1996) |
| " Although treatment with each quinolone or fenbufen alone at a dosage level tested in mice showed no changes, coadministration of a large dose of all quinolones and fenbufen caused convulsant death." | 1.28 | Interaction of the new quinolone antibacterial agent levofloxacin with fenbufen in mice. ( Akahane, K; Furuhama, K; Takayama, S; Tawara, K, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (50.00) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gervasoni, C | 1 |
| Cattaneo, D | 1 |
| Falvella, FS | 1 |
| Vitiello, P | 1 |
| Cheli, S | 1 |
| Milazzo, L | 1 |
| Clementi, E | 1 |
| Riva, A | 1 |
| Kim, J | 1 |
| Ohtani, H | 1 |
| Tsujimoto, M | 1 |
| Sawada, Y | 1 |
| Hori, S | 1 |
| Bellon, A | 1 |
| Perez-Garcia, G | 1 |
| Coverdale, JH | 1 |
| Chacko, RC | 1 |
| Christie, MJ | 1 |
| Wong, K | 1 |
| Ting, RH | 1 |
| Tam, PY | 1 |
| Sikaneta, TG | 1 |
| Bird, SB | 1 |
| Orr, PG | 1 |
| Mazzola, JL | 1 |
| Brush, DE | 1 |
| Boyer, EW | 1 |
| Yamaguchi, H | 1 |
| Kawai, H | 1 |
| Matsumoto, T | 1 |
| Yokoyama, H | 1 |
| Nakayasu, T | 1 |
| Komiya, M | 1 |
| Shimada, J | 1 |
| Ishiwata, Y | 1 |
| Son, K | 1 |
| Itoga, Y | 1 |
| Yasuhara, M | 1 |
| Akahane, K | 4 |
| Tsutomi, Y | 1 |
| Kimura, Y | 1 |
| Kitano, Y | 1 |
| Kato, M | 2 |
| Takayama, S | 2 |
| Bercault, N | 1 |
| Demasure, M | 1 |
| Benhamou, CL | 1 |
| Gueveler, C | 1 |
| Yew, WW | 1 |
| Wong, CF | 1 |
| Wong, PC | 1 |
| Lee, J | 1 |
| Chau, CH | 1 |
| Ohkawara, S | 1 |
| Nomura, M | 1 |
| Traeger, SM | 1 |
| Bonfiglio, MF | 1 |
| Wilson, JA | 1 |
| Martin, BR | 1 |
| Nackes, NA | 1 |
| Sire, S | 1 |
| Staub-Schmidt, T | 1 |
| Ragnaud, JM | 1 |
| Christmann, D | 1 |
| Aubertin, J | 1 |
| Kohno, K | 1 |
| Niwa, M | 1 |
| Nozaki, M | 1 |
| Uematsu, T | 1 |
| Fujimura, H | 1 |
| Walton, GD | 1 |
| Hon, JK | 1 |
| Mulpur, TG | 1 |
| Yasuda, H | 1 |
| Yoshida, A | 1 |
| Masuda, Y | 1 |
| Fukayama, M | 1 |
| Kita, Y | 1 |
| Inamatsu, T | 1 |
| Carbon, C | 1 |
| Yagawa, K | 1 |
| Kushner, JM | 1 |
| Peckman, HJ | 1 |
| Snyder, CR | 1 |
| Furuhama, K | 1 |
| Tawara, K | 1 |
5 reviews available for ofloxacin and Seizures
| Article | Year |
|---|---|
Seizures associated with levofloxacin: case presentation and literature review.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Cytochrome | 2009 |
Seizures associated with ofloxacin therapy.
Topics: Aged; Aged, 80 and over; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Klebsiella | 1995 |
Comparison of side effects of levofloxacin versus other fluoroquinolones.
Topics: Anti-Infective Agents; Cardiovascular System; Dermatitis, Phototoxic; Digestive System; Hepatocytes; | 2001 |
Latest industry information on the safety profile of levofloxacin in Japan.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Infective Agents; Central Nervous System; Chemical and | 2001 |
Seizures associated with fluoroquinolones.
Topics: Aged; Anti-Infective Agents; Ciprofloxacin; Female; Humans; Levofloxacin; Magnesium; Ofloxacin; Seiz | 2001 |
17 other studies available for ofloxacin and Seizures
| Article | Year |
|---|---|
Levofloxacin-induced seizures in a patient without predisposing risk factors: the impact of pharmacogenetics.
Topics: Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transport | 2013 |
Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Cipr | 2009 |
Convulsant activity of sitafloxacin and its interactions with anti-inflammatory drugs in mice.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Int | 2009 |
Generalized seizure and toxic epidermal necrolysis following levofloxacin exposure.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Female; Humans; Levofloxacin; Ofloxacin; Se | 2005 |
Levofloxacin-related seizure activity in a patient with Alzheimer's disease: assessment of potential risk factors.
Topics: Aged; Alzheimer Disease; Humans; Levofloxacin; Male; Ofloxacin; Risk Factors; Seizures; Urologic Dis | 2005 |
Post-marketing surveillance of the safety of levofloxacin in Japan.
Topics: Achilles Tendon; Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Chemical and | 2007 |
Effects of acute renal failure and ganciclovir on the pharmacodynamics of levofloxacin-induced seizures in rats.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Antiviral Agents; Dose-Response Relationship, D | 2007 |
Levofloxacin, an optical isomer of ofloxacin, has attenuated epileptogenic activity in mice and inhibitory potency in GABA receptor binding.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cisterna Magna; GABA Antagonists; In Vitro Techniq | 1994 |
Involvement of inhibitory and excitatory neurotransmitters in levofloxacin- and ciprofloxacin-induced convulsions in mice.
Topics: Acetamides; Alcohol Oxidoreductases; Animals; Ciprofloxacin; Excitatory Amino Acid Antagonists; Inje | 1993 |
[Convulsions during prolonged treatment with ofloxacin].
Topics: Female; Humans; Middle Aged; Ofloxacin; Seizures; Time Factors | 1993 |
Adverse neurological reactions in patients with multidrug-resistant pulmonary tuberculosis after coadministration of cycloserine and ofloxacin.
Topics: Adult; Cycloserine; Depression; Drug Therapy, Combination; Humans; Male; Middle Aged; Ofloxacin; Sei | 1993 |
Effect of bile duct ligation and unilateral nephrectomy on brain concentration and convulsant potential of the quinolone antibacterial agent levofloxacin in rats.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Bile | 1996 |
[Convulsion caused by ofloxacin].
Topics: Adult; Anti-Infective Agents; Female; Humans; Ofloxacin; Seizures | 1996 |
Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coadministered with 4-biphenyl acetic acid.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Ciprofloxacin; Convulsants; | 1997 |
Ofloxacin-induced seizure.
Topics: Aged; Anti-Infective Agents; Female; Humans; Ofloxacin; Risk Factors; Seizures | 1997 |
[Levofloxacin-induced neurological adverse effects such as convulsion, involuntary movement (tremor, myoclonus and chorea like), visual hallucination in two elderly patients].
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Bronchitis; Dyskinesia, Drug-Induced; Hallucinations | 1999 |
Interaction of the new quinolone antibacterial agent levofloxacin with fenbufen in mice.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Levoflox | 1992 |