ofloxacin has been researched along with Renal Insufficiency in 10 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levofloxacin is a third-generation fluorinated quinolone antibiotic, is the active levo stereoisomer of ofloxacin, and has one of the most favorable adverse reaction profiles." | 5.38 | Levofloxacin-induced delirium: is it a dangerous drug in patients with renal dysfunction? ( Dortdudak, S; Eroglu, E; Kocyigit, I; Oymak, O; Sipahioglu, M; Tokgoz, B; Unal, A; Utas, C; Yucel, HE, 2012) |
| "Levofloxacin is a third-generation fluorinated quinolone antibiotic, is the active levo stereoisomer of ofloxacin, and has one of the most favorable adverse reaction profiles." | 1.38 | Levofloxacin-induced delirium: is it a dangerous drug in patients with renal dysfunction? ( Dortdudak, S; Eroglu, E; Kocyigit, I; Oymak, O; Sipahioglu, M; Tokgoz, B; Unal, A; Utas, C; Yucel, HE, 2012) |
| "Cryoglobulinemia has been described in infectious diseases, but in only three patients with brucellosis." | 1.33 | Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis. ( Hermida Lazcano, I; Sáez Méndez, L; Solera Santos, J, 2005) |
| "Levofloxacin clearance was substantially increased during both CVVH and CVVHDF, while ciprofloxacin clearance was affected less." | 1.31 | Pharmacokinetics of levofloxacin and ciprofloxacin during continuous renal replacement therapy in critically ill patients. ( Abraham, E; Fish, DN; Malone, RS; Teitelbaum, I, 2001) |
| "To clarify effects of renal failure on salivary distribution of ofloxacin (OFLX), a quinolone antibiotics, blood, parotid and mandibular saliva were collected from the single-step 5/6th-nephrectomized and sham-operated (control) rats after bolus i." | 1.30 | Excretion of ofloxacin into saliva in rats with renal failure. ( Ding, G; Hirano, H; Iwamoto, K; Nagasako, S; Naora, K, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 7 (70.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Monescillo Francia, A | 1 |
| Kocyigit, I | 1 |
| Dortdudak, S | 1 |
| Sipahioglu, M | 1 |
| Unal, A | 1 |
| Yucel, HE | 1 |
| Tokgoz, B | 1 |
| Eroglu, E | 1 |
| Oymak, O | 1 |
| Utas, C | 1 |
| Hermida Lazcano, I | 1 |
| Sáez Méndez, L | 1 |
| Solera Santos, J | 1 |
| Tian, Q | 1 |
| Gomersall, CD | 1 |
| Wong, A | 1 |
| Leung, P | 1 |
| Choi, G | 1 |
| Joynt, GM | 1 |
| Tan, P | 1 |
| Lipman, J | 1 |
| Topkaya, AE | 1 |
| Ozakkaş, F | 1 |
| Aksungar, FB | 1 |
| Tülbek, Y | 1 |
| Iakovlev, SV | 1 |
| Iakovlev, VP | 1 |
| Izotova, GN | 1 |
| Ding, G | 1 |
| Naora, K | 1 |
| Nagasako, S | 1 |
| Hirano, H | 1 |
| Iwamoto, K | 1 |
| Malone, RS | 1 |
| Fish, DN | 1 |
| Abraham, E | 1 |
| Teitelbaum, I | 1 |
| Mizuta, K | 1 |
| Hishikawa, S | 1 |
| Hirota, M | 1 |
| Miyamoto, G | 1 |
| Fujimura, A | 1 |
| Hakamata, Y | 1 |
| Kobayashi, E | 1 |
| Bellmann, R | 1 |
| Egger, P | 1 |
| Gritsch, W | 1 |
| Bellmann-Weiler, R | 1 |
| Joannidis, M | 1 |
| Dunzendorfer, S | 1 |
| Wiedermann, CJ | 1 |
1 review available for ofloxacin and Renal Insufficiency
| Article | Year |
|---|---|
[Pharmacokinetics of fluoroquinolones in patients with renal insufficiency].
Topics: Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Humans; Ofloxacin; Pefloxacin; Quinolones; R | 1995 |
9 other studies available for ofloxacin and Renal Insufficiency
| Article | Year |
|---|---|
[Spontaneous bacterial peritonitis].
Topics: Anti-Bacterial Agents; Cefotaxime; Ciprofloxacin; Humans; Ofloxacin; Peritonitis; Primary Prevention | 2009 |
Levofloxacin-induced delirium: is it a dangerous drug in patients with renal dysfunction?
Topics: Anti-Bacterial Agents; Delirium; Follow-Up Studies; Humans; Levofloxacin; Magnetic Resonance Imaging | 2012 |
Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis.
Topics: Anti-Bacterial Agents; Ascitic Fluid; Brucella melitensis; Brucellosis; Cryoglobulinemia; Doxycyclin | 2005 |
Effect of drug concentration on adsorption of levofloxacin by polyacrylonitrile haemofilters.
Topics: Acrylic Resins; Adsorption; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Hemofiltration; | 2006 |
[A case of urinary tract infection caused by Flavimonas oryzihabitans].
Topics: Anti-Infective Agents, Urinary; Bacteriuria; Carbapenems; Drug Resistance, Multiple, Bacterial; Fema | 2007 |
Excretion of ofloxacin into saliva in rats with renal failure.
Topics: Animals; Anti-Infective Agents; Hydrogen-Ion Concentration; Male; Nephrectomy; Ofloxacin; Rats; Rats | 1998 |
Pharmacokinetics of levofloxacin and ciprofloxacin during continuous renal replacement therapy in critically ill patients.
Topics: Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Critical Illness; Female; Hemofiltration; Humans; | 2001 |
Fluoroquinolone concentrations in plasma, urine, and bile after oral administration in rats with renal failure: useful technique for long-term bile collection.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Bile; Blood Urea Nitrogen; Fluoroquinolones; L | 2001 |
Elimination of levofloxacin in critically ill patients with renal failure: influence of continuous veno-venous hemofiltration.
Topics: Adult; Aged; Anti-Infective Agents, Urinary; Critical Illness; Female; Hemofiltration; Humans; Infus | 2002 |