Page last updated: 2024-11-01

ofloxacin and Recrudescence

ofloxacin has been researched along with Recrudescence in 79 studies

Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

Research Excerpts

ExcerptRelevanceReference
"The objective of this open-label, single-arm, multicenter study was to assess the efficacy and safety of levofloxacin in the treatment of complicated urinary tract infections."9.10[Multicentric study for evaluation of levofloxacin in the treatment of complicated urinary tract infections]. ( Marchetti, F; Trinchieri, A, 2003)
"In a prospective randomized study ofloxacin (400 mg orally once daily) versus co-trimoxazole (320/1,600 mg orally once daily) were given for 3 weeks in 30 and 22 elderly semimobile patients respectively, suffering from asymptomatic bacteriuria."9.07Kinetics and comparative efficacy of ofloxacin versus co-trimoxazole in the asymptomatic bacteriuria of elderly subjects. ( Dontas, A; Giamarellou, H; Iakovou, M; Petrikkos, G; Pistoni, M; Sfikakis, P, 1991)
"In order to reduce the dosage of aminoglycoside in the treatment of patients with complicated urinary tract infections (UTI) in outpatient clinics and to improve cost benefits, we tried both ofloxacin (OFX) treatment and a combination treatment with OFX and a single dose of aminoglycoside (isepamicin)."9.07Treatment of complicated urinary tract infections with ofloxacin following an aminoglycoside. ( Eto, K; Ishii, T; Kumazawa, J; Matsumoto, T; Saito, Y; Sawae, Y; Ueda, S; Yushita, Y, 1991)
" The objective is to determine the effect of application of topical ofloxacin on nasal and sinus mucosa in patients with proven existence of bacterial biofilms and persistent chronic sinusitis after FESS."7.81Effect of topical ofloxacin on bacterial biofilms in refractory post-sinus surgery rhino-sinusitis. ( Ezzat, WF; Fawaz, SA; Hamdy, TA; Rabie, H; Shokry, YA, 2015)
"It has been shown previously that fluoroquinolone resistance (defined by resistance to at least 2 mg/liter ofloxacin) has a different impact on moxifloxacin monotherapy depending on the mutation in the sole fluoroquinolone target in Mycobacterium tuberculosis, i."7.79Impact of fluoroquinolone resistance on bactericidal and sterilizing activity of a moxifloxacin-containing regimen in murine tuberculosis. ( Aubry, A; Brossier, F; Chauffour, A; Fillion, A; Jarlier, V; Veziris, N, 2013)
"The aim of this prospective observational study was to present relevant data on the efficacy and safety of levofloxacin in the treatment of chronic bacterial prostatitis (NIH-II) in the daily clinical routine of urologists in their practices."7.77[Practice management of chronic bacterial prostatitis with levofloxacin]. ( Naber, KG; Roscher, K; Wagenlehner, F, 2011)
" Hypoglycemia because of use of levofloxacin is a rarely reported complication."7.74Fatal hypoglycemia with levofloxacin use in an elderly patient in the post-operative period. ( Abraham, J; Jacob, JJ; Kapoor, R; Singh, M, 2008)
"Molecular detection of rifampin resistance (rpoB analysis) in Mycobacterium leprae was determined for 49 patients who experienced relapse of multibacillary leprosy and for 34 untreated patients."7.71Molecular detection of rifampin and ofloxacin resistance for patients who experience relapse of multibacillary leprosy. ( Bonnafous, P; Cambau, E; Jarlier, V; Ji, B; Perani, E; Sougakoff, W, 2002)
"The objective of this open-label, single-arm, multicenter study was to assess the efficacy and safety of levofloxacin in the treatment of complicated urinary tract infections."5.10[Multicentric study for evaluation of levofloxacin in the treatment of complicated urinary tract infections]. ( Marchetti, F; Trinchieri, A, 2003)
"The efficacy and safety of ofloxacin in the treatment of upper and lower urinary tract infections were studied with the drug use according to 4 regimens by comparison with nitrofurantoin in the treatment of lower urinary tract infections and trimethoprim/sulfamethoxazole in the treatment of upper urinary tract infections."5.08[Clinical experience with the use of ofloxacin in infections of the upper and lower urinary tracts: demonstrations of the results of clinical trials]. ( Liudvig, G, 1996)
"The efficacy and safety of a 3-day regimen of sparfloxacin were compared with those of a 3-day regimen of ofloxacin for the treatment of community-acquired acute uncomplicated urinary tract infections."5.08Treatment of community-acquired acute uncomplicated urinary tract infection with sparfloxacin versus ofloxacin. The Sparfloxacin Multi Center UUTI Study Group. ( Dorr, MB; Ellison, W; Henry, D; Magner, DJ; Mansfield, DL; Sullivan, J; Talbot, GH, 1998)
"In a prospective randomized study ofloxacin (400 mg orally once daily) versus co-trimoxazole (320/1,600 mg orally once daily) were given for 3 weeks in 30 and 22 elderly semimobile patients respectively, suffering from asymptomatic bacteriuria."5.07Kinetics and comparative efficacy of ofloxacin versus co-trimoxazole in the asymptomatic bacteriuria of elderly subjects. ( Dontas, A; Giamarellou, H; Iakovou, M; Petrikkos, G; Pistoni, M; Sfikakis, P, 1991)
"In order to reduce the dosage of aminoglycoside in the treatment of patients with complicated urinary tract infections (UTI) in outpatient clinics and to improve cost benefits, we tried both ofloxacin (OFX) treatment and a combination treatment with OFX and a single dose of aminoglycoside (isepamicin)."5.07Treatment of complicated urinary tract infections with ofloxacin following an aminoglycoside. ( Eto, K; Ishii, T; Kumazawa, J; Matsumoto, T; Saito, Y; Sawae, Y; Ueda, S; Yushita, Y, 1991)
"From 2009 to 2015, multi-bacillary leprosy cases at sentinel sites of 19 countries were studied for resistance to rifampicin, dapsone and ofloxacin by PCR sequencing of the drug-resistance-determining regions of the genes rpoB, folP1 and gyrA."3.88Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009-15. ( Cambau, E; Cardona-Castro, N; Cauchoix, B; Cole, ST; Cooreman, EAWD; Gillini, L; Gupta, UD; Hagge, D; Hongseng, W; Indropo, A; Johnson, RC; Kai, M; Lavania, M; Matsuoka, M; Miyamoto, Y; Pannikar, VK; Pemmaraju, VRR; Rosa, PS; Saunderson, P; Srikantam, A; Suffys, P; Vissa, V; Williams, D, 2018)
" The objective is to determine the effect of application of topical ofloxacin on nasal and sinus mucosa in patients with proven existence of bacterial biofilms and persistent chronic sinusitis after FESS."3.81Effect of topical ofloxacin on bacterial biofilms in refractory post-sinus surgery rhino-sinusitis. ( Ezzat, WF; Fawaz, SA; Hamdy, TA; Rabie, H; Shokry, YA, 2015)
"It has been shown previously that fluoroquinolone resistance (defined by resistance to at least 2 mg/liter ofloxacin) has a different impact on moxifloxacin monotherapy depending on the mutation in the sole fluoroquinolone target in Mycobacterium tuberculosis, i."3.79Impact of fluoroquinolone resistance on bactericidal and sterilizing activity of a moxifloxacin-containing regimen in murine tuberculosis. ( Aubry, A; Brossier, F; Chauffour, A; Fillion, A; Jarlier, V; Veziris, N, 2013)
"The aim of this prospective observational study was to present relevant data on the efficacy and safety of levofloxacin in the treatment of chronic bacterial prostatitis (NIH-II) in the daily clinical routine of urologists in their practices."3.77[Practice management of chronic bacterial prostatitis with levofloxacin]. ( Naber, KG; Roscher, K; Wagenlehner, F, 2011)
" Hypoglycemia because of use of levofloxacin is a rarely reported complication."3.74Fatal hypoglycemia with levofloxacin use in an elderly patient in the post-operative period. ( Abraham, J; Jacob, JJ; Kapoor, R; Singh, M, 2008)
" We report the first case of tendinitis after treatment with moxifloxacin, and of recurrent tendinitis after treatment with 2 different fluoroquinolones."3.72Recurrent tendinitis after treatment with two different fluoroquinolones. ( Burkhardt, O; Köhnlein, T; Pap, T; Welte, T, 2004)
"A systemic antibiotic, 1 g levofloxacin daily, had been started at the initial abscess operation."3.71[Osteomyelitis of the tibial head caused by Mycobacterium haemophilium in a patient with AIDS]. ( Brade, V; Enzensberger, R; Gruschke, A, 2002)
"Between 1989 and 1993, 136 multibacillary leprosy patients received a 6-week treatment regimen consisting of daily rifampicin 600 mg, ofloxacin 400 mg, clofazimine 100 mg and a weekly dose of 100 mg minocycline."3.71Relapse rates and a 10-year follow-up of a 6-week quadruple drug regimen for multibacillary leprosy. ( Grillone, S; Pattyn, S, 2002)
"In this study, 72 men with nongonococcal urethritis were treated with levofloxacin."3.71Association of Mycoplasma genitalium persistence in the urethra with recurrence of nongonococcal urethritis. ( Deguchi, T; Ishiko, H; Kojima, K; Maeda, SI; Tamaki, M; Yasuda, M; Yoshida, T, 2001)
"Molecular detection of rifampin resistance (rpoB analysis) in Mycobacterium leprae was determined for 49 patients who experienced relapse of multibacillary leprosy and for 34 untreated patients."3.71Molecular detection of rifampin and ofloxacin resistance for patients who experience relapse of multibacillary leprosy. ( Bonnafous, P; Cambau, E; Jarlier, V; Ji, B; Perani, E; Sougakoff, W, 2002)
"The effect of a single day treatment with 600 mg norfloxacin 600 mg ofloxacin or 1,920 mg trimethoprim-sulfamethoxazol was determined on 114 patients with acute cystitis."3.67[Single day treatment in acute cystitis]. ( Kawaguchi, K; Yamaguchi, K, 1988)
"Typhoid and paratyphoid (enteric fever) are febrile bacterial illnesses common in many low- and middle-income countries."2.82Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins. ( Basnyat, B; Darton, TC; Eyre, D; Kuehn, R; Parry, CM; Stoesser, N, 2022)
"This study aimed to explore the pharmacokinetic features of levofloxacin (LVFX) in Chinese patients with infections and to confirm oral LVFX 500 mg once daily as an optimal treatment regimen based on pharmacokinetic-pharmacodynamic (PK-PD) analysis."2.74Population pharmacokinetics of oral levofloxacin 500 mg once-daily dosage in community-acquired lower respiratory tract infections: results of a prospective multicenter study in China. ( Cao, GY; Huang, JA; Liu, YB; Shi, YG; Si, B; Sun, SH; Wu, XJ; Xia, QM; Xiao, ZK; Xu, JF; Zhang, J; Zhang, YY, 2009)
"No further relapse has been diagnosed since the beginning of retreatment."2.68High relapse rate among lepromatous leprosy patients treated with rifampin plus ofloxacin daily for 4 weeks. ( Grosset, JH; Jamet, P; Ji, B; Perani, EG; Sow, S; Traore, I, 1997)
"The case experienced pyothorax due to pulmonary tuberculosis three years before and Mycobacterium avium pleuritis one year before this episode."1.35[Case of pneumothorax associated with pulmonary Mycobacterium fortuitum infection]. ( Baba, T; Endo, T; Hagiwara, E; Komatsu, S; Matsumoto, Y; Nishihira, R; Ogura, T; Sato, T; Sekine, A; Shinohara, T; Sogo, Y; Takahashi, H, 2008)

Research

Studies (79)

TimeframeStudies, this research(%)All Research%
pre-19903 (3.80)18.7374
1990's23 (29.11)18.2507
2000's34 (43.04)29.6817
2010's17 (21.52)24.3611
2020's2 (2.53)2.80

Authors

AuthorsStudies
Blango, MG1
Mulvey, MA1
Kuehn, R3
Stoesser, N3
Eyre, D3
Darton, TC3
Basnyat, B3
Parry, CM3
Lazo-Porras, M1
Prutsky, GJ1
Barrionuevo, P1
Tapia, JC1
Ugarte-Gil, C1
Ponce, OJ1
Acuña-Villaorduña, A1
Domecq, JP1
De la Cruz-Luque, C1
Prokop, LJ1
Málaga, G1
Cambau, E2
Saunderson, P1
Matsuoka, M1
Cole, ST1
Kai, M1
Suffys, P1
Rosa, PS1
Williams, D1
Gupta, UD1
Lavania, M1
Cardona-Castro, N2
Miyamoto, Y1
Hagge, D1
Srikantam, A1
Hongseng, W1
Indropo, A1
Vissa, V1
Johnson, RC1
Cauchoix, B1
Pannikar, VK1
Cooreman, EAWD1
Pemmaraju, VRR1
Gillini, L1
Khasawneh, FA1
Jou-Tindo, AJ1
Woods, JL1
Scurlock, AM1
Hensel, DJ1
Fillion, A1
Aubry, A1
Brossier, F1
Chauffour, A1
Jarlier, V2
Veziris, N1
Ezzat, WF1
Fawaz, SA1
Rabie, H1
Hamdy, TA1
Shokry, YA1
Beltrán-Alzate, C1
López Díaz, F1
Romero-Montoya, M1
Sakamuri, R1
Li, W1
Kimura, M1
Brennan, P1
Béraud, G1
Iba Ba, J1
Legout, L1
Senneville, E1
Yazdanpanah, Y1
Mouton, Y1
Cox, HS1
Sibilia, K1
Feuerriegel, S1
Kalon, S1
Polonsky, J1
Khamraev, AK1
Rüsch-Gerdes, S1
Mills, C1
Niemann, S1
Zhang, J1
Xu, JF1
Liu, YB1
Xiao, ZK1
Huang, JA1
Si, B1
Sun, SH1
Xia, QM1
Wu, XJ1
Cao, GY1
Shi, YG1
Zhang, YY1
Blasi, F1
Balagon, MF1
Cellona, RV1
Abalos, RM1
Gelber, RH1
Saunderson, PR1
Han, JH1
Nguyen, JC1
Harada, S1
Baddour, LM1
Edelstein, PH1
Li, Y1
Huang, X1
Yao, L1
Shi, R1
Zhang, G1
Gaborieau, V1
Weill, FX1
Marchou, B1
Wagenlehner, F1
Roscher, K1
Naber, KG1
Girdhar, A1
Kumar, A1
Girdhar, BK1
Lee, J2
Lee, CH1
Kim, DK1
Yoon, HI1
Kim, JY1
Lee, SM1
Yang, SC1
Lee, JH1
Yoo, CG1
Lee, CT1
Chung, HS1
Kim, YW1
Han, SK1
Yim, JJ1
Basu, PP1
Rayapudi, K1
Pacana, T1
Shah, NJ1
Krishnaswamy, N1
Flynn, M1
Shetty, VP2
Wakade, AV2
Ghate, SD1
Pai, VV4
Kumari, JO1
Revankar, CR2
Bulchand, HO3
Ganapati, R3
Zuck, P1
Gruschke, A1
Enzensberger, R1
Brade, V1
Pattyn, S1
Grillone, S1
Bello, S1
Torres, A1
Trinchieri, A1
Marchetti, F1
Schindler, C1
Pittrow, D1
Kirch, W1
Kam, KM1
Yip, CW1
Burkhardt, O1
Köhnlein, T1
Pap, T1
Welte, T1
Soley, C1
Arguedas, A1
Porras, W1
Guevara, S1
Loaiza, C1
Pérez, A1
Rincón, G1
Schultz, M1
Arguedas, J1
Brilla, R1
Marone, P1
Concia, E1
Quarta, V1
Minoli, L1
Carnevale, G1
Vogt, P1
Schorn, T1
Repp, H1
Frei, U1
Pichlmayr, R1
Serra, AL1
Klein, M1
Nitsch, D1
Dürr, D1
Wermuth, B1
Frey, FJ1
Gabriels, P1
Joosen, H1
Put, E1
Verhaegen, J1
Magerman, K1
Cartuyvels, R1
De Benedetto, M1
Salerni, L1
De Benedetto, L1
Passali, GC1
Passali, D1
Chiang, CY1
Enarson, DA1
Yu, MC1
Bai, KJ1
Huang, RM1
Hsu, CJ1
Suo, J1
Lin, TP1
Wormser, GP1
Filozov, A1
Telford, SR1
Utpat, S1
Kamer, RS1
Liveris, D1
Wang, G1
Zentmaier, L1
Schwartz, I1
Aguero-Rosenfeld, ME1
Ruiz-González, A1
Giménez, A1
Gómez-Arbonés, X1
Soler-González, J1
Sánchez, V1
Falguera, M1
Porcel, JM1
Rivero, M1
Otermin, I1
Pereda, A1
Cía, M1
Martínez, M1
Szklo, A1
Mello, FC1
Guerra, RL1
Dorman, SE1
Muzy-de-Souza, GR1
Conde, MB1
Singh, M1
Jacob, JJ1
Kapoor, R1
Abraham, J1
Hagiwara, E1
Sekine, A1
Sato, T1
Baba, T1
Shinohara, T1
Endo, T1
Sogo, Y1
Nishihira, R1
Komatsu, S1
Matsumoto, Y1
Ogura, T1
Takahashi, H1
Marlier, S1
Carsuzaa, F1
De Jaureguiberry, JP1
Galzin, M1
Carloz, E1
Carli, P1
Chagnon, A1
Mühlberger, F1
Nturanye, F1
Nasbimana, J1
Portaels, F1
Pfau, A1
Sacks, TG1
Liudvig, G1
Bruguera, M1
Ji, B3
Jamet, P1
Sow, S1
Perani, EG1
Traore, I1
Grosset, JH1
Sehgal, VN1
Kumar, S1
Jain, S1
Bhattacharya, SN1
el-Sadr, WM1
Perlman, DC1
Matts, JP1
Nelson, ET1
Cohn, DL1
Salomon, N1
Olibrice, M1
Medard, F1
Chirgwin, KD1
Mildvan, D1
Jones, BE1
Telzak, EE1
Klein, O1
Heifets, L1
Hafner, R1
Kingsley, S1
Henry, D1
Ellison, W1
Sullivan, J1
Mansfield, DL1
Magner, DJ1
Dorr, MB1
Talbot, GH1
Vila, J1
Ruiz, J1
Sanchez, F1
Navarro, F1
Mirelis, B1
de Anta, MT1
Prats, G1
Ishida, Y1
Ozaki, M1
Picorini, L1
Guglielmelli, E1
Supiyaphun, P1
Kerekhanjanarong, V1
Koranasophonepun, J1
Sastarasadhit, V1
Yew, WW1
Chan, CK1
Chau, CH1
Tam, CM1
Leung, CC1
Wong, PC1
Tauro, S1
Dobie, D1
Richardson, G1
Hastings, M1
Mahendra, P1
Del Pozo, JL1
Lecároz, C1
Hernáez, S1
Leiva, J1
Ballester, B1
Antia, NH1
Revenker, CR1
Gupta, K1
Hooton, TM1
Roberts, PL1
Stamm, WE1
Maeda, SI1
Tamaki, M1
Kojima, K1
Yoshida, T1
Ishiko, H1
Yasuda, M1
Deguchi, T1
Bonnafous, P1
Perani, E1
Sougakoff, W1
Liassine, N1
Chelfi, A1
Rahal, K1
Kumamoto, Y1
Kulessa, W1
Becker, EW1
Berg, PA1
Gentry, LO1
Rodriguez-Gomez, G1
Giamarellou, H1
Iakovou, M1
Pistoni, M1
Petrikkos, G1
Dontas, A1
Sfikakis, P1
Matsumoto, T1
Kumazawa, J1
Ueda, S1
Eto, K1
Yushita, Y1
Saito, Y1
Ishii, T1
Sawae, Y1
Khuri-Bulos, N1
Shaker, K1
Oksa, A1
Dzúriková, V1
Gajdos, M1
Krechnáková, A1
Krivosíková, G1
Ploczeková, C1
Spustová, V1
Kiriushchenkov, AP1
Yamaguchi, K1
Kawaguchi, K1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis[NCT03827811]625 participants (Anticipated)Observational2020-01-30Recruiting
Comparison Between Hybrid, Reverse Hybrid, and Non-Bismuth Levofloxacin Quadruple Regimens for Helicobacter Pylori Infection in Egypt: A Randomized Controlled Trial[NCT04039412]Phase 4330 participants (Actual)Interventional2018-06-01Completed
STREAM: The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB[NCT02409290]Phase 3588 participants (Actual)Interventional2016-03-31Completed
The Treatment of Pulmonary Mycobacterium Tuberculosis in HIV Infection[NCT00001033]Phase 3650 participants InterventionalCompleted
Randomized Clinical Trial to Assess the Efficacy of Short Course Intermittent Regimens for the Treatment of HIV-Associated Tuberculosis[NCT00376012]Phase 3300 participants (Actual)Interventional2001-02-28Active, not recruiting
Does Prophylaxis With Macrobid Reduce the Incidence of Urinary Tract Infection in Patients Who Receive a Sub-Urethral Sling for the Treatment of Stress Urinary Incontinence: Randomized, Double Blinded Placebo Controlled Clinical Trial[NCT00734968]Phase 4161 participants (Actual)Interventional2008-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Incidence of Treatment-Emergent Adverse Events

Questionnaire to measure the number of Participants with Treatment-Emergent Adverse Events (NCT04039412)
Timeframe: 10-14 days

InterventionParticipants (Count of Participants)
(1) Reverse Hybrid Regimen49
(2) Hybrid Regimen58
(3) Levofloxacin Quadruple Regimen44

Percentage of Helicobacter Pylori Infection Cure

Measuring the curative rate of each regimen by a fecal antigen test (NCT04039412)
Timeframe: 40-44 days

InterventionParticipants (Count of Participants)
(1) Reverse Hybrid Regimen102
(2) Hybrid Regimen101
(3) Levofloxacin Quadruple Regimen91

Rate of Helicobacter Pylori Treatment Completion

Questionnaire to evaluate the compliance with each treatment regimen (NCT04039412)
Timeframe: 10-14 days

InterventionParticipants (Count of Participants)
(1) Reverse Hybrid Regimen109
(2) Hybrid Regimen107
(3) Levofloxacin Quadruple Regimen108

Failure or Recurrence (FoR)

probable or definite failure or recurrence (FoR) (NCT02409290)
Timeframe: final efficacy week (between 96 and 132 weeks)

InterventionParticipants (Count of Participants)
Regimen A (Long Regimen)0
Regimen B (Control Regimen)17
Regimen C (Oral Regimen)4
Regimen D (6-month Regimen)0

Failure or Recurrence (FoR)

The proportion of patients with failure or recurrence (FoR) (NCT02409290)
Timeframe: 132 weeks, control regimen (arm B) using concurrent controls only

InterventionParticipants (Count of Participants)
Regimen B (Control Regimen)14
Regimen D (6-month Regimen)2

Favourable Outcome After Long-term Follow-up (132 Weeks)

The proportion of patients with a favourable outcome at their last efficacy visit (NCT02409290)
Timeframe: Last efficacy visit, between 96 and 132 weeks

InterventionParticipants (Count of Participants)
Regimen A (Long Regimen)17
Regimen B (Control Regimen)126
Regimen C (Oral Regimen)152
Regimen D (6-month Regimen)115

Proportion of Patients With Acquired Drug Resistance

The proportion of patients with acquired drug resistance (any drug) (NCT02409290)
Timeframe: 132 weeks

InterventionParticipants (Count of Participants)
Regimen A (Long Regimen)0
Regimen B (Control Regimen)5
Regimen C (Oral Regimen)5
Regimen D (6-month Regimen)3

STREAM Stage 2 Primary Outcome Measure (the Proportion of Patients With a Favourable Outcome at Week 76)

The primary efficacy outcome of the STREAM Stage 2 comparison is status at Week 76 i.e. the proportion of patients with a favourable outcome at Week 76 (NCT02409290)
Timeframe: 76 weeks

InterventionParticipants (Count of Participants)
Regimen A (Long Regimen)0
Regimen B (Control Regimen)133
Regimen C (Oral Regimen)162
Regimen D (6-month Regimen)122

Incidence of Post-operative UTI Following the Placement of Sub-urethral Sling for the Treatment of Stress Urinary Incontinence

The overall rate of UTI following the placement of sub-urethral sling for the treatment of stress urinary incontinence in our study was 24.8% (n = 37) (NCT00734968)
Timeframe: 6 weeks

Interventionparticipants (Number)
Treatment13
Placebo24

Incidence of Post-operative UTI in Placebo Group

The incidence of UTI in the placebo group was 32%. (NCT00734968)
Timeframe: 6 weeks

Interventionparticipants (Number)
Treatment13
Placebo24

Incidence of Post-operative UTI in Treatment Group

The incidence of UTI in the nitrofurantoin group was 17.6%. (NCT00734968)
Timeframe: 6 weeks

Interventionparticipants (Number)
Treatment13
Placebo24

Reviews

8 reviews available for ofloxacin and Recrudescence

ArticleYear
Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.
    The Cochrane database of systematic reviews, 2022, 11-24, Volume: 11

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Cefixime; Ceftriaxone

2022
Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.
    The Cochrane database of systematic reviews, 2022, 11-24, Volume: 11

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Cefixime; Ceftriaxone

2022
Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.
    The Cochrane database of systematic reviews, 2022, 11-24, Volume: 11

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Cefixime; Ceftriaxone

2022
Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.
    The Cochrane database of systematic reviews, 2022, 11-24, Volume: 11

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Cefixime; Ceftriaxone

2022
Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.
    The Cochrane database of systematic reviews, 2022, 11-24, Volume: 11

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Cefixime; Ceftriaxone

2022
Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.
    The Cochrane database of systematic reviews, 2022, 11-24, Volume: 11

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Cefixime; Ceftriaxone

2022
Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.
    The Cochrane database of systematic reviews, 2022, 11-24, Volume: 11

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Cefixime; Ceftriaxone

2022
Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.
    The Cochrane database of systematic reviews, 2022, 11-24, Volume: 11

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Cefixime; Ceftriaxone

2022
Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.
    The Cochrane database of systematic reviews, 2022, 11-24, Volume: 11

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Cefixime; Ceftriaxone

2022
World Health Organization (WHO) antibiotic regimen against other regimens for the treatment of leprosy: a systematic review and meta-analysis.
    BMC infectious diseases, 2020, Jan-20, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Clinical Protocols; Drug Therapy, Combination; Female; Humans; Lepro

2020
[Therapeutic experience with levofloxacin in pneumonia and COPD].
    Le infezioni in medicina, 2009, Volume: 17 Suppl 5

    Topics: Algorithms; Anti-Bacterial Agents; Clinical Trials as Topic; Community-Acquired Infections; Cross In

2009
Relapsing Legionella pneumophila cellulitis: a case report and review of the literature.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2010, Volume: 16, Issue:6

    Topics: Aged; Anti-Bacterial Agents; Azithromycin; Cellulitis; Fatal Outcome; Female; Humans; Immunocompromi

2010
Advantages of Moxifloxacin and Levofloxacin-based triple therapy for second-line treatments of persistent Helicobacter pylori infection: a meta analysis.
    Wiener klinische Wochenschrift, 2010, Volume: 122, Issue:13-14

    Topics: Anti-Infective Agents; Aza Compounds; Bismuth; Clarithromycin; Drug Administration Schedule; Drug Re

2010
Coexistence of rhinoscleroma with Rosai-Dorfman disease: is rhinoscleroma a cause of this disease?
    The Journal of laryngology and otology, 2012, Volume: 126, Issue:6

    Topics: Adult; Anti-Bacterial Agents; Biopsy; Emperipolesis; Female; Histiocytosis, Sinus; Humans; Klebsiell

2012
[Rhinosinusitis: etiopathogenesis and antimicrobial therapy, an update].
    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 2006, Volume: 26, Issue:1 Suppl 82

    Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Aza Compounds; Bacteria

2006
[Treatment of chronic hepatitis C: still many problems pending].
    Gastroenterologia y hepatologia, 1997, Volume: 20, Issue:1

    Topics: Adrenal Cortex Hormones; Aged; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antiv

1997

Trials

18 trials available for ofloxacin and Recrudescence

ArticleYear
Population pharmacokinetics of oral levofloxacin 500 mg once-daily dosage in community-acquired lower respiratory tract infections: results of a prospective multicenter study in China.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2009, Volume: 15, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Bacterial Agents; Bronchitis, Chronic; China; Co

2009
The efficacy of a four-week, ofloxacin-containing regimen compared with standard WHO-MDT in PB leprosy.
    Leprosy review, 2010, Volume: 81, Issue:1

    Topics: Adult; Dapsone; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; L

2010
A randomised controlled trial assessing the effect of adding clarithromycin to rifampicin, ofloxacin and minocycline in the treatment of single lesion paucibacillary leprosy in Agra District, India.
    Leprosy review, 2011, Volume: 82, Issue:1

    Topics: Adolescent; Adult; Child; Child, Preschool; Clarithromycin; Female; Humans; India; Leprosy, Paucibac

2011
A randomized study comparing levofloxacin, omeprazole, nitazoxanide, and doxycycline versus triple therapy for the eradication of Helicobacter pylori.
    The American journal of gastroenterology, 2011, Volume: 106, Issue:11

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agent

2011
[Multicentric study for evaluation of levofloxacin in the treatment of complicated urinary tract infections].
    Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 2003, Volume: 75, Issue:1

    Topics: Anti-Infective Agents; Drug Administration Schedule; Drug Resistance, Bacterial; Enterobacteriaceae

2003
In vitro activities of levofloxacin and comparable agents against middle ear fluid, nasopharyngeal, and oropharyngeal pathogens obtained from Costa Rican children with recurrent otitis media or failing other antibiotic therapy.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:7

    Topics: Anti-Bacterial Agents; Child, Preschool; Costa Rica; Haemophilus influenzae; Humans; Infant; Levoflo

2005
Open-label, randomized comparison trial of long-term outcomes of levofloxacin versus standard antibiotic therapy in acute exacerbations of chronic obstructive pulmonary disease.
    Respirology (Carlton, Vic.), 2007, Volume: 12, Issue:1

    Topics: Amoxicillin; Anti-Infective Agents; Cefuroxime; Clarithromycin; Female; Follow-Up Studies; Forced Ex

2007
Effective postcoital quinolone prophylaxis of recurrent urinary tract infections in women.
    The Journal of urology, 1994, Volume: 152, Issue:1

    Topics: Adult; Ciprofloxacin; Coitus; Female; Humans; Norfloxacin; Ofloxacin; Prospective Studies; Recurrenc

1994
[Clinical experience with the use of ofloxacin in infections of the upper and lower urinary tracts: demonstrations of the results of clinical trials].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1996, Volume: 41, Issue:9

    Topics: Anti-Infective Agents, Urinary; Dose-Response Relationship, Drug; Drug Administration Schedule; Fema

1996
High relapse rate among lepromatous leprosy patients treated with rifampin plus ofloxacin daily for 4 weeks.
    Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:9

    Topics: Adult; Anti-Infective Agents; Dapsone; Drug Administration Schedule; Drug Therapy, Combination; Fema

1997
Evaluation of an intensive intermittent-induction regimen and duration of short-course treatment for human immunodeficiency virus-related pulmonary tuberculosis. Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) and the AIDS Clinical Tr
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1998, Volume: 26, Issue:5

    Topics: Adult; AIDS-Related Opportunistic Infections; Antitubercular Agents; Drug Administration Schedule; D

1998
Evaluation of an intensive intermittent-induction regimen and duration of short-course treatment for human immunodeficiency virus-related pulmonary tuberculosis. Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) and the AIDS Clinical Tr
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1998, Volume: 26, Issue:5

    Topics: Adult; AIDS-Related Opportunistic Infections; Antitubercular Agents; Drug Administration Schedule; D

1998
Evaluation of an intensive intermittent-induction regimen and duration of short-course treatment for human immunodeficiency virus-related pulmonary tuberculosis. Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) and the AIDS Clinical Tr
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1998, Volume: 26, Issue:5

    Topics: Adult; AIDS-Related Opportunistic Infections; Antitubercular Agents; Drug Administration Schedule; D

1998
Evaluation of an intensive intermittent-induction regimen and duration of short-course treatment for human immunodeficiency virus-related pulmonary tuberculosis. Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) and the AIDS Clinical Tr
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1998, Volume: 26, Issue:5

    Topics: Adult; AIDS-Related Opportunistic Infections; Antitubercular Agents; Drug Administration Schedule; D

1998
Treatment of community-acquired acute uncomplicated urinary tract infection with sparfloxacin versus ofloxacin. The Sparfloxacin Multi Center UUTI Study Group.
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:9

    Topics: Acute Disease; Adolescent; Adult; Anti-Infective Agents; Community-Acquired Infections; Female; Fluo

1998
Comparison of ofloxacin otic solution with oral amoxycillin plus chloramphenicol ear drop in treatment of chronic suppurative otitis media with acute exacerbation.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2000, Volume: 83, Issue:1

    Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Amoxicillin; Anti-Infective

2000
Patient-initiated treatment of uncomplicated recurrent urinary tract infections in young women.
    Annals of internal medicine, 2001, Jul-03, Volume: 135, Issue:1

    Topics: Adult; Algorithms; Anti-Infective Agents, Urinary; Feasibility Studies; Female; Follow-Up Studies; H

2001
Single-dose treatment of female acute uncomplicated cystitis.
    Infection, 1992, Volume: 20 Suppl 3

    Topics: Acute Disease; Administration, Oral; Anti-Infective Agents; Cefixime; Cefotaxime; Clinical Protocols

1992
Ofloxacin versus parenteral therapy for chronic osteomyelitis.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:3

    Topics: Administration, Oral; Adult; Aged; Cefazolin; Ceftazidime; Chronic Disease; Female; Gram-Negative Ba

1991
Kinetics and comparative efficacy of ofloxacin versus co-trimoxazole in the asymptomatic bacteriuria of elderly subjects.
    Chemotherapy, 1991, Volume: 37 Suppl 1

    Topics: Aged; Aged, 80 and over; Ambulatory Care; Bacteriuria; Female; Humans; Male; Ofloxacin; Prospective

1991
Treatment of complicated urinary tract infections with ofloxacin following an aminoglycoside.
    Chemotherapy, 1991, Volume: 37 Suppl 1

    Topics: Administration, Oral; Adolescent; Aged; Bacteriuria; Drug Therapy, Combination; Gentamicins; Humans;

1991

Other Studies

53 other studies available for ofloxacin and Recrudescence

ArticleYear
Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Biofilms; Cell Membrane Permeability; Cells, Cultured; Drug Resistan

2010
Antimicrobial resistance in leprosy: results of the first prospective open survey conducted by a WHO surveillance network for the period 2009-15.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2018, Volume: 24, Issue:12

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Biopsy, Needle; Brazil; Colombia; Dapsone; DNA Gyrase; Dr

2018
A 30-year-old woman with recurrent lower respiratory tract infections.
    Chest, 2013, Volume: 143, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Comorbidity; Diverticulum; Female; Humans; Ofloxacin; Radiography, Tho

2013
Pelvic inflammatory disease in the adolescent: understanding diagnosis and treatment as a health care provider.
    Pediatric emergency care, 2013, Volume: 29, Issue:6

    Topics: Adolescent; Anti-Bacterial Agents; Arkansas; Ceftriaxone; Centers for Disease Control and Prevention

2013
Impact of fluoroquinolone resistance on bactericidal and sterilizing activity of a moxifloxacin-containing regimen in murine tuberculosis.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:9

    Topics: Amikacin; Animals; Antitubercular Agents; Aza Compounds; DNA Gyrase; Drug Administration Schedule; D

2013
Effect of topical ofloxacin on bacterial biofilms in refractory post-sinus surgery rhino-sinusitis.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2015, Volume: 272, Issue:9

    Topics: Administration, Intranasal; Administration, Topical; Adult; Anti-Bacterial Agents; Biofilms; Case-Co

2015
Leprosy Drug Resistance Surveillance in Colombia: The Experience of a Sentinel Country.
    PLoS neglected tropical diseases, 2016, Volume: 10, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bacterial Proteins; Child; Colombia; Dapsone; DNA, Bacte

2016
[Primary Salmonella vascular graft infection and conservative treatment].
    Medecine et maladies infectieuses, 2008, Volume: 38, Issue:12

    Topics: Aged; Amikacin; Anti-Bacterial Agents; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Blood Vessel Pr

2008
Emergence of extensive drug resistance during treatment for multidrug-resistant tuberculosis.
    The New England journal of medicine, 2008, Nov-27, Volume: 359, Issue:22

    Topics: Analysis of Variance; Antitubercular Agents; Cross Infection; Extensively Drug-Resistant Tuberculosi

2008
[A case of Salmonella enterica serovar typhi with decreased susceptibility to ciprofloxacin].
    Medecine et maladies infectieuses, 2010, Volume: 40, Issue:12

    Topics: Anti-Bacterial Agents; Bacteremia; Ceftriaxone; Ciprofloxacin; Drug Resistance, Multiple, Bacterial;

2010
[Practice management of chronic bacterial prostatitis with levofloxacin].
    Aktuelle Urologie, 2011, Volume: 42, Issue:3

    Topics: Adult; Aged; Anti-Infective Agents, Urinary; Bacterial Infections; Chronic Disease; Escherichia coli

2011
Retrospective comparison of levofloxacin and moxifloxacin on multidrug-resistant tuberculosis treatment outcomes.
    The Korean journal of internal medicine, 2011, Volume: 26, Issue:2

    Topics: Adult; Antitubercular Agents; Aza Compounds; Case-Control Studies; Chi-Square Distribution; Drug Res

2011
Clinical, bacteriological and histopathological study of 62 referral relapse cases between Jan 2004 and Dec 2009 at the Foundation for Medical Research, Mumbai.
    Leprosy review, 2011, Volume: 82, Issue:3

    Topics: Academies and Institutes; Adult; Aged; Biomedical Research; Drug Therapy, Combination; Female; Follo

2011
Single-dose ROM treatment for multilesion paucibacillary leprosy--further observations.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 2002, Volume: 70, Issue:1

    Topics: Clinical Trials as Topic; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Minocyclin

2002
[Update on the use of levofloxacin in the management of acute exacerbations of chronic bronchitis with risk factors].
    Presse medicale (Paris, France : 1983), 2002, Jun-15, Volume: 31, Issue:21 Pt 2

    Topics: Acute Disease; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Infective Agents; Bronchitis; Chron

2002
[Osteomyelitis of the tibial head caused by Mycobacterium haemophilium in a patient with AIDS].
    Deutsche medizinische Wochenschrift (1946), 2002, Sep-20, Volume: 127, Issue:38

    Topics: Abscess; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antitubercular Agents; Clarit

2002
Relapse rates and a 10-year follow-up of a 6-week quadruple drug regimen for multibacillary leprosy.
    Leprosy review, 2002, Volume: 73, Issue:3

    Topics: Belgium; Clofazimine; Drug Administration Schedule; Drug Therapy, Combination; Follow-Up Studies; Hu

2002
[Pneumococcus and quinolone resistance].
    Archivos de bronconeumologia, 2003, Volume: 39, Issue:3

    Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Child, Preschool; Ciproflo

2003
[Fluoroquinolone superior to macrolide. Longer infection free period after acute bronchitis].
    MMW Fortschritte der Medizin, 2003, Feb-13, Volume: 145, Issue:7

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Bronchitis; Clarithromycin; Doub

2003
Reoccurrence of levofloxacin-induced tendinitis by phenoxymethylpenicillin therapy after 6 months: a rare complication of fluoroquinolone therapy?
    Chemotherapy, 2003, Volume: 49, Issue:1-2

    Topics: Achilles Tendon; Adverse Drug Reaction Reporting Systems; Aged; Anti-Bacterial Agents; Arthritis; Dr

2003
Surveillance of Mycobacterium tuberculosis susceptibility to second-line drugs in Hong Kong, 1995-2002, after the implementation of DOTS-plus.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2004, Volume: 8, Issue:6

    Topics: Amikacin; Anti-Bacterial Agents; Antitubercular Agents; Communicable Disease Control; Cycloserine; D

2004
Recurrent tendinitis after treatment with two different fluoroquinolones.
    Scandinavian journal of infectious diseases, 2004, Volume: 36, Issue:4

    Topics: Achilles Tendon; Aged; Anti-Infective Agents; Asthma; Aza Compounds; Female; Fluoroquinolones; Human

2004
Ofloxacin in the treatment of genito-urinary tract infections.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Female Urogenital Disea

1989
Experience with ofloxacin for short and long-term treatment of urinary tract infections in renal transplant recipients.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl

    Topics: Follow-Up Studies; Humans; Kidney Transplantation; Ofloxacin; Postoperative Complications; Recurrenc

1989
A puzzling case of high serum creatinine in a healthy woman.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2006, Volume: 21, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Creatinine; Drug Administration Schedule; False Positive Reactions; Fe

2006
Recurrent Rhodococcus equi infection with fatal outcome in an immunocompetent patient.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2006, Volume: 25, Issue:1

    Topics: Actinomycetales Infections; Aged; Brain Abscess; Fatal Outcome; Female; Humans; Immunocompetence; Mi

2006
Outcome of pulmonary multidrug-resistant tuberculosis: a 6-yr follow-up study.
    The European respiratory journal, 2006, Volume: 28, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antitubercular Agents; Drug Resis

2006
Dissociation between inhibition and killing by levofloxacin in human granulocytic anaplasmosis.
    Vector borne and zoonotic diseases (Larchmont, N.Y.), 2006,Winter, Volume: 6, Issue:4

    Topics: Aged; Anaplasma phagocytophilum; Anaplasmosis; Animals; Anti-Bacterial Agents; Disease Models, Anima

2006
[Musculoskeletal adverse effects of levofloxacin].
    Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2006, Volume: 19, Issue:4

    Topics: Anti-Bacterial Agents; Arthralgia; Arthritis; Arthritis, Infectious; Arthroplasty, Replacement, Knee

2006
Alternative anti-tuberculosis regimen including ofloxacin for the treatment of patients with hepatic injury.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2007, Volume: 11, Issue:7

    Topics: Antitubercular Agents; Brazil; Cohort Studies; Comorbidity; Confidence Intervals; Dose-Response Rela

2007
Fatal hypoglycemia with levofloxacin use in an elderly patient in the post-operative period.
    Langenbeck's archives of surgery, 2008, Volume: 393, Issue:2

    Topics: Acute Kidney Injury; Aged; Anti-Bacterial Agents; Drug Therapy, Combination; Duodenal Ulcer; Fatal O

2008
[Case of pneumothorax associated with pulmonary Mycobacterium fortuitum infection].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 2008, Volume: 82, Issue:2

    Topics: Adult; Anti-Bacterial Agents; Clarithromycin; Combined Modality Therapy; Drainage; Drug Resistance,

2008
[Recurrent lepromatous leprosy in conventional triple therapy: value of the rifampicin-ofloxacin combination].
    Medecine tropicale : revue du Corps de sante colonial, 1995, Volume: 55, Issue:2

    Topics: Aged; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy, Lepromatous; Male; Ofloxacin;

1995
[Ofloxacin-cycloserine-protionamide-INH combination against treatment refractory lung tuberculosis].
    Pneumologie (Stuttgart, Germany), 1995, Volume: 49, Issue:2

    Topics: Adult; AIDS-Related Opportunistic Infections; Cycloserine; Dose-Response Relationship, Drug; Drug Ad

1995
Relapse (reactivation) in borderline tuberculoid (BT) leprosy.
    The Journal of dermatology, 1998, Volume: 25, Issue:1

    Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Dapsone; Drug Monitoring; Granuloma; Histiocyte

1998
Relapse of multibacillary leprosy after rifampin and ofloxacin treatment for 28 days; a case report.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1998, Volume: 66, Issue:1

    Topics: Adult; Drug Therapy, Combination; Humans; Leprosy; Male; Ofloxacin; Recurrence; Rifampin

1998
Increase in quinolone resistance in a Haemophilus influenzae strain isolated from a patient with recurrent respiratory infections treated with ofloxacin.
    Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:1

    Topics: Amino Acid Substitution; Anti-Infective Agents; DNA Topoisomerase IV; DNA Topoisomerases, Type II; F

1999
Relapse of multibacillary leprosy after treatment with daily rifampin plus ofloxacin for four weeks.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1998, Volume: 66, Issue:3

    Topics: Anti-Infective Agents; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy; Ofloxacin; Re

1998
National guideline for the management of non-gonococcal urethritis. Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases)
    Sexually transmitted infections, 1999, Volume: 75 Suppl 1

    Topics: Anti-Bacterial Agents; Azithromycin; Chlamydia Infections; Chlamydia trachomatis; Chlortetracycline;

1999
A recurrent case of BT leprosy with widely spread skin lesions showing a histopathology of indeterminate group after 4.5-years irregular treatment, Bangladesh.
    Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association, 1999, Volume: 68, Issue:3

    Topics: Adult; Bangladesh; Drug Therapy, Combination; Humans; Leprostatic Agents; Leprosy, Borderline; Lepro

1999
Outcomes of patients with multidrug-resistant pulmonary tuberculosis treated with ofloxacin/levofloxacin-containing regimens.
    Chest, 2000, Volume: 117, Issue:3

    Topics: Adult; Aged; Antitubercular Agents; Drug Therapy, Combination; Female; Hong Kong; Humans; Levofloxac

2000
Recurrent penicillin-resistant pneumococcal sepsis after matched unrelated donor (MUD) transplantation for refractory T cell lymphoma.
    Bone marrow transplantation, 2000, Volume: 26, Issue:9

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bacteremia; Bone Marrow Transplantation; Carm

2000
[Recurrent abscesses in a renal transplant recipient].
    Enfermedades infecciosas y microbiologia clinica, 2001, Volume: 19, Issue:2

    Topics: Abscess; Drug Therapy, Combination; Humans; Immunocompromised Host; Immunosuppressive Agents; Kidney

2001
Clinical, histopathological and bacteriological investigations in two cases of relapse following ROM treatment.
    Leprosy review, 2001, Volume: 72, Issue:1

    Topics: Adult; Animals; Drug Therapy, Combination; Female; Humans; Leprostatic Agents; Leprosy; Male; Mice;

2001
Patient-initiated treatment of recurrent urinary tract infection in women.
    Annals of internal medicine, 2001, Jul-03, Volume: 135, Issue:1

    Topics: Adult; Anti-Infective Agents, Urinary; Female; Follow-Up Studies; Humans; Middle Aged; Ofloxacin; Pa

2001
Association of Mycoplasma genitalium persistence in the urethra with recurrence of nongonococcal urethritis.
    Sexually transmitted diseases, 2001, Volume: 28, Issue:8

    Topics: Adolescent; Adult; Anti-Infective Agents, Urinary; DNA Primers; DNA, Bacterial; Humans; Levofloxacin

2001
Molecular detection of rifampin and ofloxacin resistance for patients who experience relapse of multibacillary leprosy.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002, Jan-01, Volume: 34, Issue:1

    Topics: Adult; Aged; Antibiotics, Antitubercular; Disease Models, Animal; DNA Gyrase; DNA-Directed RNA Polym

2002
[Resistance to new quinolones among the enterobacteria].
    Archives de l'Institut Pasteur d'Algerie. Institut Pasteur d'Algerie, 1992, Volume: 58

    Topics: Drug Resistance, Microbial; Enterobacteriaceae; Enterobacteriaceae Infections; Humans; Nalidixic Aci

1992
[Recurrent agranulocytosis after taking calcium dobesilate].
    Deutsche medizinische Wochenschrift (1946), 1992, Mar-06, Volume: 117, Issue:10

    Topics: Agranulocytosis; Calcium Dobesilate; Cefotaxime; Drug Hypersensitivity; Female; Humans; Lymphocyte A

1992
Relapse of brucellosis following ofloxacin therapy.
    The Journal of infection, 1991, Volume: 22, Issue:3

    Topics: Adolescent; Adult; Brucellosis; Female; Humans; Male; Ofloxacin; Prospective Studies; Recurrence

1991
[Pefloxacin in the treatment of recurrent urinary tract infections].
    Casopis lekaru ceskych, 1990, Jul-27, Volume: 129, Issue:30

    Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Ofloxacin; Pefloxacin; Recurrence; Urinary Tract Inf

1990
[Urogenital chlamydiosis].
    Fel'dsher i akusherka, 1990, Volume: 55, Issue:9

    Topics: Adult; Chlamydia Infections; Chronic Disease; Diagnosis, Differential; Female; Female Urogenital Dis

1990
[Single day treatment in acute cystitis].
    Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Cystitis;

1988