ofloxacin has been researched along with Pink Eye in 9 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5% levofloxacin, with and without eyelid scrub, in patients with chronic blepharoconjunctivitis (CBC)." | 9.14 | A prospective study determining the efficacy of topical 0.5% levofloxacin on bacterial flora of patients with chronic blepharoconjunctivitis. ( He, L; Kampik, A; Kreutzer, TC; Mino de Kaspar, H; Nentwich, MM; Ta, CN; Yactayo-Miranda, Y, 2009) |
| "Currently, conjunctivitis is treated using ofloxacin eye drop solution, which shows low bioavailability and patient non-compliance." | 7.96 | Ofloxacin laden microemulsion contact lens to treat conjunctivitis. ( Huang, C; Li, Y; Yang, X; Zhang, X, 2020) |
| "In the rabbit keratitis model, the ocular inflammation was significantly reduced by gatifloxacin as compared to levofloxacin but there was no significant difference between the groups in the number of viable bacteria." | 7.74 | Immunomodulatory effect of gatifloxacin on mouse peritoneal macrophages in vitro and in models of endotoxin-induced rat conjunctivitis and rabbit bacterial keratitis. ( Inoue, T; Kida, T; Naka, H; Sakaki, H; Tokushige, H; Wada, T, 2008) |
| "5% levofloxacin, with and without eyelid scrub, in patients with chronic blepharoconjunctivitis (CBC)." | 5.14 | A prospective study determining the efficacy of topical 0.5% levofloxacin on bacterial flora of patients with chronic blepharoconjunctivitis. ( He, L; Kampik, A; Kreutzer, TC; Mino de Kaspar, H; Nentwich, MM; Ta, CN; Yactayo-Miranda, Y, 2009) |
| "Currently, conjunctivitis is treated using ofloxacin eye drop solution, which shows low bioavailability and patient non-compliance." | 3.96 | Ofloxacin laden microemulsion contact lens to treat conjunctivitis. ( Huang, C; Li, Y; Yang, X; Zhang, X, 2020) |
| "In the rabbit keratitis model, the ocular inflammation was significantly reduced by gatifloxacin as compared to levofloxacin but there was no significant difference between the groups in the number of viable bacteria." | 3.74 | Immunomodulatory effect of gatifloxacin on mouse peritoneal macrophages in vitro and in models of endotoxin-induced rat conjunctivitis and rabbit bacterial keratitis. ( Inoue, T; Kida, T; Naka, H; Sakaki, H; Tokushige, H; Wada, T, 2008) |
| "Ofloxacin treatment eradicated or controlled 85% (86/101) of the Gram positive and 89% (17/19) of the Gram negative organisms cultured, compared with 83% (103/124) and 78% (29/37), respectively, after gentamicin treatment." | 2.67 | Topical ofloxacin compared with gentamicin in the treatment of external ocular infection. Ofloxacin Study Group. ( Gwon, A, 1992) |
| "Patients with suspected bacterial ocular infections were evaluated for clinical improvement and were included in drug safety and comfort analyses." | 2.67 | Ofloxacin compared with chloramphenicol in the management of external ocular infection. ( Baig, H; Bron, AJ; Elkington, AR; Harden, A; Kirkby, GR; Leber, G; Leong, T; Neoh, C; Rizk, SN, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Huang, C | 1 |
| Yang, X | 1 |
| Zhang, X | 1 |
| Kutlutürk, I | 1 |
| Tamer, GZ | 1 |
| Karabaş, L | 1 |
| Erbesler, AN | 1 |
| Yazar, S | 1 |
| Figueira-Coelho, J | 1 |
| Lourenço, S | 1 |
| Pires, AC | 1 |
| Mendonça, P | 1 |
| Malhado, JA | 1 |
| Yactayo-Miranda, Y | 1 |
| Ta, CN | 1 |
| He, L | 1 |
| Kreutzer, TC | 1 |
| Nentwich, MM | 1 |
| Kampik, A | 1 |
| Mino de Kaspar, H | 1 |
| Keating, GM | 1 |
| Panagiotopoulos, M | 1 |
| Sönne, H | 1 |
| Wada, T | 1 |
| Kida, T | 1 |
| Inoue, T | 1 |
| Tokushige, H | 1 |
| Naka, H | 1 |
| Sakaki, H | 1 |
| Gwon, A | 1 |
| Bron, AJ | 1 |
| Leber, G | 1 |
| Rizk, SN | 1 |
| Baig, H | 1 |
| Elkington, AR | 1 |
| Kirkby, GR | 1 |
| Neoh, C | 1 |
| Harden, A | 1 |
| Leong, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intracameral Levofloxacin (0.5%) Versus Intracameral Cefuroxime (1mg/0.1ml) Effect on Corneal Endothelial Cell Count and Morphology in Uneventful Phacoemulsification[NCT04212078] | Phase 1/Phase 2 | 138 participants (Anticipated) | Interventional | 2019-07-29 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ofloxacin and Pink Eye
| Article | Year |
|---|---|
Levofloxacin 0.5% ophthalmic solution: a review of its use in the treatment of external ocular infections and in intraocular surgery.
Topics: Anti-Bacterial Agents; Conjunctivitis; Drug Resistance, Bacterial; Eye Infections; Humans; Levofloxa | 2009 |
3 trials available for ofloxacin and Pink Eye
| Article | Year |
|---|---|
A prospective study determining the efficacy of topical 0.5% levofloxacin on bacterial flora of patients with chronic blepharoconjunctivitis.
Topics: Administration, Topical; Anti-Bacterial Agents; Blepharitis; Chronic Disease; Colony Count, Microbia | 2009 |
Topical ofloxacin compared with gentamicin in the treatment of external ocular infection. Ofloxacin Study Group.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Blepharitis; Conjunctivitis; Eye Infections | 1992 |
Ofloxacin compared with chloramphenicol in the management of external ocular infection.
Topics: Adult; Aged; Aged, 80 and over; Blepharitis; Chloramphenicol; Conjunctivitis; Double-Blind Method; E | 1991 |
5 other studies available for ofloxacin and Pink Eye
| Article | Year |
|---|---|
Ofloxacin laden microemulsion contact lens to treat conjunctivitis.
Topics: Animals; Conjunctivitis; Contact Lenses; Contact Lenses, Hydrophilic; Drug Delivery Systems; Drug Li | 2020 |
A rapidly emerging ocular zoonosis; Dirofilaria repens.
Topics: Adult; Animals; Anti-Bacterial Agents; Communicable Diseases, Emerging; Conjunctivitis; Dirofilaria | 2016 |
Mycoplasma pneumoniae-associated mucositis with minimal skin manifestations.
Topics: Adult; Anti-Bacterial Agents; Asthma; Conjunctivitis; Humans; Immunoglobulin G; Immunoglobulin M; Le | 2008 |
Chronic granulomatous disease and serious unilateral keratitis with bilateral conjunctivitis: a rare case of external ocular disease.
Topics: Adult; Colitis, Ulcerative; Conjunctivitis; Dexamethasone; Drug Therapy, Combination; Functional Lat | 2011 |
Immunomodulatory effect of gatifloxacin on mouse peritoneal macrophages in vitro and in models of endotoxin-induced rat conjunctivitis and rabbit bacterial keratitis.
Topics: Animals; Anti-Inflammatory Agents; Aza Compounds; Cells, Cultured; Conjunctivitis; Endotoxins; Fluor | 2008 |