ofloxacin has been researched along with Otitis Media, Suppurative in 25 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Otitis Media, Suppurative: Inflammation of the middle ear with purulent discharge.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, the efficacy and safety of ofloxacin alone (OA) and the ofloxacin + dexamethasone combination (ODC) is compared by studying clinical cure rates and adverse drug reactions in patients with CSOM." | 2.80 | Efficacy and safety of ofloxacin and its combination with dexamethasone in chronic suppurative otitis media. A randomised, double blind, parallel group, comparative study. ( Jha, S; Mandavia, D; Panchasara, A; Singh, A; Tripathi, C, 2015) |
| "Ofloxacin has not been associated with ototoxicity in animal models or in children participating in the clinical trials." | 2.70 | Efficacy of ofloxacin and other otic preparations for acute otitis media in patients with tympanostomy tubes. ( Goldblatt, EL, 2001) |
| "Ofloxacin eardrops were effective in the initial treatment of active chronic suppurative otitis media." | 2.67 | Ofloxacin eardrop treatment for active chronic suppurative otitis media: prospective randomized study. ( Chau, PY; Hui, Y; Lau, SK; Wei, WI; Wong, S; Wong, SF; Yuen, PW, 1994) |
| "Chronic suppurative otitis media is still a significant health problem." | 1.33 | In vitro efficacy of the successive or staggered use of eardrops. ( Aktas, E; Durmaz, R; Kalcioglu, MT; Ozturan, O, 2006) |
| "Ofloxacin was susceptible on all isolates." | 1.32 | Bacteriology of chronic suppurative otitis media in congolese children. ( Muyunga, CK; Nyembue, DT; Sabue, MJ; Tshiswaka, JM, 2003) |
| "25 mL in children with chronic suppurative otitis media and perforated tympanic membrane, with serial sampling of otorrhea and serum up to 8 hours after dosing and middle ear mucosa up to 2 hours after dosing." | 1.30 | Ofloxacin otic solution in patients with otitis media: an analysis of drug concentrations. ( Furuta, S; Katsuda, K; Kiyota, R; Miyazaki, Y; Nobori, T; Ohyama, M; Ueno, K, 1999) |
| "Ofloxacin treatment gave good result in reduction of otorrhea, regardless of the earlier treatment of chronic otitis media." | 1.30 | [Clinical success of treatment of chronic otitis media using topical and peroral administration of ofloxacin]. ( Dzelalija, B; Kovacić, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (36.00) | 18.2507 |
| 2000's | 9 (36.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 5 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ai, L | 1 |
| Huang, H | 1 |
| Wu, Z | 1 |
| Liu, P | 1 |
| Huang, J | 1 |
| Chen, Y | 1 |
| Khomtchouk, KM | 2 |
| Kouhi, A | 2 |
| Xia, A | 3 |
| Bekale, LA | 2 |
| Massa, SM | 1 |
| Sweere, JM | 1 |
| Pletzer, D | 2 |
| Hancock, RE | 1 |
| Bollyky, PL | 2 |
| Santa Maria, PL | 3 |
| Chong, LY | 1 |
| Head, K | 1 |
| Webster, KE | 1 |
| Daw, J | 1 |
| Richmond, P | 1 |
| Snelling, T | 1 |
| Bhutta, MF | 1 |
| Schilder, AG | 1 |
| Burton, MJ | 1 |
| Brennan-Jones, CG | 1 |
| Joseph, LI | 1 |
| Khomtchouk, BB | 1 |
| Massa, S | 1 |
| Koliesnik, I | 1 |
| Kaufman, AC | 1 |
| Bacacao, B | 1 |
| Thai, A | 1 |
| Chen, X | 1 |
| Cao, Z | 1 |
| Fouad, A | 1 |
| Panchasara, A | 1 |
| Singh, A | 1 |
| Mandavia, D | 1 |
| Jha, S | 1 |
| Tripathi, C | 1 |
| Balasubramanian, A | 1 |
| Mohamad, I | 1 |
| Sidek, D | 1 |
| Nyembue, DT | 1 |
| Tshiswaka, JM | 1 |
| Sabue, MJ | 1 |
| Muyunga, CK | 1 |
| Kalcioglu, MT | 1 |
| Ozturan, O | 1 |
| Durmaz, R | 1 |
| Aktas, E | 1 |
| Sumitsawan, Y | 1 |
| Tharavichitkul, P | 1 |
| Prawatmuang, W | 1 |
| Ingsuwan, B | 1 |
| Sriburi, P | 1 |
| Supiyaphun, P | 2 |
| Tonsakulrungruang, K | 1 |
| Chochaipanichnon, L | 1 |
| Chongtateong, A | 1 |
| Samart, Y | 1 |
| Yuen, AP | 1 |
| Chau, PY | 2 |
| Wei, WI | 2 |
| Yuen, PW | 1 |
| Lau, SK | 1 |
| Hui, Y | 1 |
| Wong, SF | 1 |
| Wong, S | 1 |
| Tong, MC | 2 |
| Woo, JK | 1 |
| van Hasselt, CA | 2 |
| Goldblatt, EL | 2 |
| Dohar, J | 1 |
| Nozza, RJ | 1 |
| Nielsen, RW | 1 |
| Goldberg, T | 1 |
| Sidman, JD | 1 |
| Seidlin, M | 1 |
| Ohyama, M | 1 |
| Furuta, S | 1 |
| Ueno, K | 1 |
| Katsuda, K | 1 |
| Nobori, T | 1 |
| Kiyota, R | 1 |
| Miyazaki, Y | 1 |
| Enin, IP | 1 |
| Kovacić, M | 1 |
| Dzelalija, B | 1 |
| Kerekhanjanarong, V | 1 |
| Koranasophonepun, J | 1 |
| Sastarasadhit, V | 1 |
| Bluestone, CD | 1 |
| Klein, JO | 1 |
| McCracken, GH | 1 |
| Yue, V | 1 |
| Ku, PK | 1 |
| van Hasselt, P | 1 |
| van Kregten, E | 1 |
| Jung, HH | 1 |
| Cho, SD | 1 |
| Yoo, CK | 1 |
| Lim, HH | 1 |
| Chae, SW | 1 |
3 reviews available for ofloxacin and Otitis Media, Suppurative
| Article | Year |
|---|---|
Topical versus systemic antibiotics for chronic suppurative otitis media.
Topics: Administration, Topical; Adult; Aminoglycosides; Amoxicillin-Potassium Clavulanate Combination; Anti | 2021 |
Efficacy of ofloxacin and other ototopical preparations for chronic suppurative otitis media in children.
Topics: Anti-Infective Agents; Anti-Infective Agents, Local; Bacteria; Child; Chronic Disease; Humans; Middl | 2001 |
The use of topical ofloxacin for otic diseases in infants and children. Summary and conclusions.
Topics: Acute Disease; Anti-Infective Agents; Anti-Infective Agents, Local; Chronic Disease; Humans; Middle | 2001 |
8 trials available for ofloxacin and Otitis Media, Suppurative
| Article | Year |
|---|---|
Efficacy and safety of ofloxacin and its combination with dexamethasone in chronic suppurative otitis media. A randomised, double blind, parallel group, comparative study.
Topics: Adult; Anti-Bacterial Agents; Chronic Disease; Dexamethasone; Double-Blind Method; Drug Therapy, Com | 2015 |
The treatment of chronic suppurative otitis media and otitis externa with 0.3 per cent ofloxacin otic solution: a clinico-microbiological study.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Chronic Disease; Hum | 1995 |
Ofloxacin eardrop treatment for active chronic suppurative otitis media: prospective randomized study.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amoxicillin; Amoxicillin-Potassium Clavulanate Combin | 1994 |
A double-blind comparative study of ofloxacin otic drops versus neomycin-polymyxin B-hydrocortisone otic drops in the medical treatment of chronic suppurative otitis media.
Topics: Anti-Infective Agents; Chronic Disease; Double-Blind Method; Drug Combinations; Humans; Hydrocortiso | 1996 |
Topical ofloxacin versus systemic amoxicillin/clavulanate in purulent otorrhea in children with tympanostomy tubes.
Topics: Acute Disease; Administration, Oral; Administration, Topical; Amoxicillin-Potassium Clavulanate Comb | 1998 |
Comparison of ofloxacin otic solution with oral amoxycillin plus chloramphenicol ear drop in treatment of chronic suppurative otitis media with acute exacerbation.
Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Amoxicillin; Anti-Infective | 2000 |
Efficacy of ofloxacin and other otic preparations for acute otitis media in patients with tympanostomy tubes.
Topics: Acute Disease; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Child; Child, P | 2001 |
Preoperative topical ofloxacin solution for tympanoplasty: a randomized, controlled study.
Topics: Adult; Anti-Infective Agents; Chronic Disease; Female; Humans; Male; Myringoplasty; Ofloxacin; Otiti | 2002 |
14 other studies available for ofloxacin and Otitis Media, Suppurative
| Article | Year |
|---|---|
Chronic suppurative otitis media due to Streptomyces cacaoi, the second case report in human infection.
Topics: Anti-Bacterial Agents; China; Female; Gram-Positive Bacterial Infections; Humans; Middle Aged; Oflox | 2020 |
A novel mouse model of chronic suppurative otitis media and its use in preclinical antibiotic evaluation.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Humans; Mice; Ofloxacin; Otitis Media, Suppu | 2020 |
Treatment with a neutrophil elastase inhibitor and ofloxacin reduces P. aeruginosa burden in a mouse model of chronic suppurative otitis media.
Topics: Animals; Antigens, Ly; Disease Models, Animal; Drug Synergism; Female; Flow Cytometry; Humans; Machi | 2021 |
Topical Therapy Failure in Chronic Suppurative Otitis Media is Due to Persister Cells in Biofilms.
Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Biofilms; Chronic Disease; Humans; Ofloxacin; O | 2021 |
Extensive dural sinus thrombosis and bilateral lateral rectus palsy as an uncommon complication of chronic suppurative otitis media.
Topics: Abducens Nerve Diseases; Adolescent; Anti-Bacterial Agents; Ceftriaxone; Chronic Disease; Fibrinolyt | 2013 |
Bacteriology of chronic suppurative otitis media in congolese children.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Chronic Disease; Citrobacter; Congo; Fem | 2003 |
In vitro efficacy of the successive or staggered use of eardrops.
Topics: Acetic Acid; Adjuvants, Pharmaceutic; Administration, Topical; Anti-Bacterial Agents; Bacteria; Cipr | 2006 |
Ofloxacin otic solution as treatment of chronic suppurative otitis media and diffuse bacterial otitis externa.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Child; Child, Preschool; Chronic Disease; Humans; In | 1995 |
Bacteriology of chronic suppurative otitis media: ofloxacin susceptibility.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Bacterial Infections; Chronic Disease; Female; Human | 1995 |
Ofloxacin otic solution in patients with otitis media: an analysis of drug concentrations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Child; Child, Preschool; Chronic | 1999 |
[Rehabilitation of patients with chronic purulent otitis media].
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Chronic Disease; Humans; Ofloxacin; Otitis Media, Supp | 1999 |
[Clinical success of treatment of chronic otitis media using topical and peroral administration of ofloxacin].
Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Anti-Infective Agents; Chronic Dis | 1999 |
Treatment of chronic suppurative otitis media with ofloxacin in hydroxypropyl methylcellulose ear drops: a clinical/bacteriological study in a rural area of Malawi.
Topics: Adolescent; Adult; Anti-Infective Agents; Bacteriological Techniques; Child; Child, Preschool; Chron | 2002 |
Vinegar treatment in the management of granular myringitis.
Topics: Acetic Acid; Adolescent; Adult; Anti-Infective Agents; Chronic Disease; Female; Follow-Up Studies; G | 2002 |