ofloxacin has been researched along with Otitis Externa in 23 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Otitis Externa: Inflammation of the OUTER EAR including the external EAR CANAL, cartilages of the auricle (EAR CARTILAGE), and the TYMPANIC MEMBRANE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared the efficacy, safety, and ear-pain resolution of once-daily ofloxacin otic solution (0." | 9.12 | Once-daily ofloxacin otic solution versus neomycin sulfate/polymyxin B sulfate/hydrocortisone otic suspension four times a day: a multicenter, randomized, evaluator-blinded trial to compare the efficacy, safety, and pain relief in pediatric patients with ( Schwartz, RH, 2006) |
| "To compare the safety and efficacy of ofloxacin otic solution with those of Cortisporin otic solutions (neomycin sulfate, polymyxin B sulfate, and hydrocortisone) in otitis externa in adults and children." | 9.08 | Ofloxacin otic solution for treatment of otitis externa in children and adults. ( Jones, RN; Milazzo, J; Seidlin, M, 1997) |
| "Ofloxacin otic is as effective in curing otitis externa in children (<12 years of age) as is the preparation combining polymyxin/neomycin plus hydrocortisone and as ciprofloxacin otic." | 8.81 | Efficacy of ofloxacin and other otic preparations for otitis externa. ( Ruben, RJ, 2001) |
| "In order to evaluate the annual changes of susceptibility, minimum inhibitory concentrations (MICs) of ofloxacin (OFLX) and 4 control drugs were determined against clinical isolates that were obtained from patients with otitis media and otitis externa during the periods between January and December 1993, and the periods between October 1996 and March 1997." | 7.70 | [Antimicrobial activity of ofloxacin against recent clinical isolates from otitis media and otitis externa]. ( Deguchi, K; Ishihara, R; Ishii, Y; Matsumoto, Y; Nakane, Y; Nakazawa, A; Nishinari, C; Suzuki, Y, 1998) |
| "Ofloxacin otic solution was instilled once daily for 7 days (5 drops for children aged 6 months to <13 years, 10 drops for adolescents/adults aged > or = 13 years)." | 6.71 | Efficacy of ofloxacin otic solution once daily for 7 days in the treatment of otitis externa: a multicenter, open-label, phase III trial. ( Avila, H; Block, SL; Cantrell, HF; Duncanson, F; Katz, E; Lombardy, E; Montiel, F; Oliva, A; Quintanilla, W; Riefler, J; Torum, B, 2004) |
| "This study compared the efficacy, safety, and ear-pain resolution of once-daily ofloxacin otic solution (0." | 5.12 | Once-daily ofloxacin otic solution versus neomycin sulfate/polymyxin B sulfate/hydrocortisone otic suspension four times a day: a multicenter, randomized, evaluator-blinded trial to compare the efficacy, safety, and pain relief in pediatric patients with ( Schwartz, RH, 2006) |
| "Two multicenter clinical trials (one in adults and adolescents, and one in children), conducted between 1995 and 1996, compared neomycin/polymyxin B/hydrocortisone with ofloxacin for the treatment of otitis externa; two similar trials were conducted between 1999 and 2000." | 5.11 | Declining susceptibility to neomycin and polymyxin B of pathogens recovered in otitis externa clinical trials. ( Barone, JS; Cantrell, HF; Duncanson, FP; Katz, E; Lombardy, EE, 2004) |
| "To compare the safety and efficacy of ofloxacin otic solution with those of Cortisporin otic solutions (neomycin sulfate, polymyxin B sulfate, and hydrocortisone) in otitis externa in adults and children." | 5.08 | Ofloxacin otic solution for treatment of otitis externa in children and adults. ( Jones, RN; Milazzo, J; Seidlin, M, 1997) |
| "Ofloxacin otic is as effective in curing otitis externa in children (<12 years of age) as is the preparation combining polymyxin/neomycin plus hydrocortisone and as ciprofloxacin otic." | 4.81 | Efficacy of ofloxacin and other otic preparations for otitis externa. ( Ruben, RJ, 2001) |
| "In order to evaluate the annual changes of susceptibility, minimum inhibitory concentrations (MICs) of ofloxacin (OFLX) and 4 control drugs were determined against clinical isolates that were obtained from patients with otitis media and otitis externa during the periods between January and December 1993, and the periods between October 1996 and March 1997." | 3.70 | [Antimicrobial activity of ofloxacin against recent clinical isolates from otitis media and otitis externa]. ( Deguchi, K; Ishihara, R; Ishii, Y; Matsumoto, Y; Nakane, Y; Nakazawa, A; Nishinari, C; Suzuki, Y, 1998) |
| "Ofloxacin otic solution was instilled once daily for 7 days (5 drops for children aged 6 months to <13 years, 10 drops for adolescents/adults aged > or = 13 years)." | 2.71 | Efficacy of ofloxacin otic solution once daily for 7 days in the treatment of otitis externa: a multicenter, open-label, phase III trial. ( Avila, H; Block, SL; Cantrell, HF; Duncanson, F; Katz, E; Lombardy, E; Montiel, F; Oliva, A; Quintanilla, W; Riefler, J; Torum, B, 2004) |
| "Ofloxacin was used at a dosage of 300 mg to 800 mg daily for three to 20 days in 206 cases of various infectious diseases in the otorhinolaryngological field such as otitis media, external otitis, paranasal sinusitis, tonsillitis and pharyngolaryngitis." | 2.66 | Clinical efficacy of ofloxacin in the treatment of otorhinolaryngological infections. ( Baba, S, 1986) |
| "Facial paralysis was present in 19." | 1.34 | Necrotizing external otitis: a report of 46 cases. ( Bebear, C; Blanchet, H; Darrouzet, V; Dutronc, H; Franco-Vidal, V, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.04) | 18.7374 |
| 1990's | 8 (34.78) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Alshahni, MM | 1 |
| Alshahni, RZ | 1 |
| Fujisaki, R | 1 |
| Tamura, T | 1 |
| Shimizu, Y | 1 |
| Yamanishi, C | 1 |
| Makimura, K | 1 |
| Wang, X | 1 |
| Winterstein, AG | 1 |
| Alrwisan, A | 1 |
| Antonelli, PJ | 1 |
| Crowson, MG | 1 |
| Schulz, K | 1 |
| Tucci, DL | 1 |
| Isaacson, G | 1 |
| Cantrell, HF | 2 |
| Lombardy, EE | 1 |
| Duncanson, FP | 1 |
| Katz, E | 2 |
| Barone, JS | 1 |
| Torum, B | 1 |
| Block, SL | 1 |
| Avila, H | 1 |
| Montiel, F | 1 |
| Oliva, A | 1 |
| Quintanilla, W | 1 |
| Duncanson, F | 1 |
| Riefler, J | 1 |
| Lombardy, E | 1 |
| Schwartz, RH | 1 |
| Franco-Vidal, V | 1 |
| Blanchet, H | 1 |
| Bebear, C | 1 |
| Dutronc, H | 1 |
| Darrouzet, V | 1 |
| Sumitsawan, Y | 1 |
| Tharavichitkul, P | 1 |
| Prawatmuang, W | 1 |
| Ingsuwan, B | 1 |
| Sriburi, P | 1 |
| Supiyaphun, P | 1 |
| Tonsakulrungruang, K | 1 |
| Chochaipanichnon, L | 1 |
| Chongtateong, A | 1 |
| Samart, Y | 1 |
| Himmelfarb, MZ | 2 |
| Zikk, D | 2 |
| Rapoport, Y | 2 |
| Redianu, C | 2 |
| Shalit, I | 2 |
| Heppt, W | 1 |
| Lutz, H | 1 |
| Jones, RN | 1 |
| Milazzo, J | 1 |
| Seidlin, M | 1 |
| Matsumoto, Y | 1 |
| Suzuki, Y | 1 |
| Ishii, Y | 1 |
| Ishihara, R | 1 |
| Nakazawa, A | 1 |
| Nakane, Y | 1 |
| Nishinari, C | 1 |
| Deguchi, K | 1 |
| Ruben, RJ | 1 |
| Klein, JO | 1 |
| McCracken, GH | 1 |
| Levy, R | 1 |
| Shpitzer, T | 1 |
| Shvero, J | 1 |
| Pitlik, SD | 1 |
| Hoffmann, M | 1 |
| Oberascher, G | 1 |
| Karas, C | 1 |
| Baba, S | 1 |
3 reviews available for ofloxacin and Otitis Externa
| Article | Year |
|---|---|
A Case of Topical Ofloxacin-Induced Otomycosis and Literature Review.
Topics: Fungi; Humans; Malassezia; Ofloxacin; Otitis Externa; Otomycosis | 2021 |
Efficacy of ofloxacin and other otic preparations for otitis externa.
Topics: Anti-Infective Agents; Anti-Infective Agents, Local; Bacteria; Child; Child, Preschool; Humans; Infa | 2001 |
The use of topical ofloxacin for otic diseases in infants and children. Summary and conclusions.
Topics: Acute Disease; Anti-Infective Agents; Anti-Infective Agents, Local; Chronic Disease; Humans; Middle | 2001 |
7 trials available for ofloxacin and Otitis Externa
| Article | Year |
|---|---|
Declining susceptibility to neomycin and polymyxin B of pathogens recovered in otitis externa clinical trials.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents; C | 2004 |
Efficacy of ofloxacin otic solution once daily for 7 days in the treatment of otitis externa: a multicenter, open-label, phase III trial.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Child; Child, Preschool; Drug Administration Schedul | 2004 |
Once-daily ofloxacin otic solution versus neomycin sulfate/polymyxin B sulfate/hydrocortisone otic suspension four times a day: a multicenter, randomized, evaluator-blinded trial to compare the efficacy, safety, and pain relief in pediatric patients with
Topics: Administration, Topical; Anti-Bacterial Agents; Child; Child, Preschool; Double-Blind Method; Drug A | 2006 |
The treatment of chronic suppurative otitis media and otitis externa with 0.3 per cent ofloxacin otic solution: a clinico-microbiological study.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Chronic Disease; Hum | 1995 |
Clinical experiences with ofloxacin sequential therapy in chronic ear infections.
Topics: Administration, Oral; Adult; Bacterial Infections; Chronic Disease; Drug Administration Schedule; Fe | 1993 |
Ofloxacin otic solution for treatment of otitis externa in children and adults.
Topics: Adult; Anti-Infective Agents; Child; Child, Preschool; Drug Administration Schedule; Drug Combinatio | 1997 |
Clinical efficacy of ofloxacin in the treatment of otorhinolaryngological infections.
Topics: Anti-Infective Agents; Bacterial Infections; Clinical Trials as Topic; Humans; Laryngitis; Ofloxacin | 1986 |
13 other studies available for ofloxacin and Otitis Externa
| Article | Year |
|---|---|
Risk for Tympanic Membrane Perforation After Quinolone Ear Drops for Acute Otitis Externa.
Topics: Adult; Anti-Bacterial Agents; Child; Humans; Ofloxacin; Otitis Externa; Quinolones; Retrospective St | 2020 |
Tendon disorders with ofloxacin ear drops.
Topics: Achilles Tendon; Anti-Bacterial Agents; Humans; Ofloxacin; Otitis Externa | 2016 |
National Utilization and Forecasting of Ototopical Antibiotics: Medicaid Data Versus "Dr. Google".
Topics: Anti-Bacterial Agents; Ciprofloxacin; Databases, Factual; Dexamethasone; Drug Combinations; Forecast | 2016 |
Treatment of otitis externa.
Topics: Amoxicillin; Candida; Child, Preschool; Ciprofloxacin; Female; Gram-Negative Bacteria; Gram-Positive | 2003 |
[Otitis externa: which antibiotics are first choice?].
Topics: Anti-Bacterial Agents; Cephalosporins; Ciprofloxacin; Clindamycin; Drug Therapy, Combination; Humans | 2006 |
Necrotizing external otitis: a report of 46 cases.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Diabetes Complications; Facial Paralysis; Fem | 2007 |
Ofloxacin otic solution as treatment of chronic suppurative otitis media and diffuse bacterial otitis externa.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Child; Child, Preschool; Chronic Disease; Humans; In | 1995 |
Granulation tissue concentrations of ofloxacin after oral administration in invasive external otitis.
Topics: Administration, Oral; Aged; Female; Granulation Tissue; Humans; Male; Middle Aged; Ofloxacin; Otitis | 1993 |
[Antimicrobial activity of ofloxacin against recent clinical isolates from otitis media and otitis externa].
Topics: Anti-Infective Agents; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Haemophilus inf | 1998 |
Oral ofloxacin therapy for invasive external otitis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Diabetes Complications; Drug Administration Sc | 1991 |
Oral ofloxacin as treatment of malignant external otitis: a study of 17 cases.
Topics: Aged; Aged, 80 and over; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Ofloxacin; | 1990 |
[Local treatment of Pseudomonas aeruginosa infection of the external ear canal with the gyrase inhibitor Tarivid].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Ofloxacin; Otitis Ext | 1989 |
[Ofloxacin in the treatment of Pseudomonas aeruginosa infections of the ear].
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Ofloxacin; Otitis; Otitis Externa; Otitis Media; Oxa | 1988 |