ofloxacin has been researched along with Osteomyelitis in 35 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Osteomyelitis: INFLAMMATION of the bone as a result of infection. It may be caused by a variety of infectious agents, especially pyogenic (PUS - producing) BACTERIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment of chronic osteomyelitis were analyzed." | 9.09 | Ciprofloxacin, lomefloxacin, or levofloxacin as treatment for chronic osteomyelitis. ( Greenberg, RN; Newman, MT; Pectol, RW; Shariaty, S, 2000) |
| "We conducted a prospective, randomized, open-label trial, comparing oral ofloxacin with intravenous imipenem-cilastatin for the treatment of chronic osteomyelitis in order to evaluate the efficacy and tolerance." | 9.09 | Oral ofloxacin versus parenteral imipenem-cilastatin in the treatment of osteomyelitis. ( Barberán, J; Borja, J; García-Barbal, J; Gomis, M; Khorrami, S; Sánchez, B, 1999) |
| "In two open prospective studies, the efficacy and tolerance of ofloxacin in the prevention of infection in patients with open fractures (n = 58) and in the treatment of chronic post-traumatic osteomyelitis (n = 115) were examined." | 9.06 | Use of ofloxacin in open fractures and in the treatment of post-traumatic osteomyelitis. ( Beckurts, T; Claudi, B; Ketterl, R; Stübinger, B, 1988) |
| "The present study deals with preparation, optimization and in-vitro drug release study of hydroxyapatite (HAp)- ofloxacin for bone-implantable delivery in osteomyelitis treatment." | 7.79 | Development and optimization of hydroxyapatite-ofloxacin implants for possible bone delivery in osteomyelitis treatment. ( Hasnain, MS; Malakar, J; Nayak, AK, 2013) |
| "Methicillin-susceptible Staphylococcus aureus (MSSA) is the most common pathogen recovered from osteomyelitis patients." | 7.71 | Comparative evaluation of oral levofloxacin and parenteral nafcillin in the treatment of experimental methicillin-susceptible Staphylococcus aureus osteomyelitis in rabbits. ( Calhoun, JH; Mader, JT; Shirtliff, ME, 2001) |
| "We investigated the use of an ofloxacin-impregnated bioabsorbable composite for the prevention of acute Staphylococcus aureus osteomyelitis." | 7.70 | Prophylaxis of acute osteomyelitis with absorbable ofloxacin-impregnated beads. ( Kourea, HP; Nicolau, DP; Nie, L; Nightingale, CH; Tessier, PR, 1998) |
| "This study was performed to investigate the potential utility of ofloxacin-impregnated bioabsorbable polymers for osteomyelitis therapy." | 7.70 | Use of a bioabsorbable polymer for the delivery of ofloxacin during experimental osteomyelitis treatment. ( Browner, BD; Kourea, HP; Nicolau, DP; Nie, L; Nightingale, CH; Tessier, PR, 1998) |
| "From October 1983 to October 1986, 39 patients with chronic osteomyelitis (of at least two month's duration) were treated with either pefloxacin (n = 15), ofloxacin (n = 17), or ciprofloxacin (n = 7)." | 7.67 | Evaluation of pefloxacin, ofloxacin and ciprofloxacin in the treatment of thirty-nine cases of chronic osteomyelitis. ( Bernard, E; Dellamonica, P; Drugeon, HB; Etesse, H; Garraffo, R, 1989) |
| "The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment of chronic osteomyelitis were analyzed." | 5.09 | Ciprofloxacin, lomefloxacin, or levofloxacin as treatment for chronic osteomyelitis. ( Greenberg, RN; Newman, MT; Pectol, RW; Shariaty, S, 2000) |
| "We conducted a prospective, randomized, open-label trial, comparing oral ofloxacin with intravenous imipenem-cilastatin for the treatment of chronic osteomyelitis in order to evaluate the efficacy and tolerance." | 5.09 | Oral ofloxacin versus parenteral imipenem-cilastatin in the treatment of osteomyelitis. ( Barberán, J; Borja, J; García-Barbal, J; Gomis, M; Khorrami, S; Sánchez, B, 1999) |
| "Levofloxacin is a useful quinolone for patients infected with osteomyelitis or tuberculosis." | 5.09 | [Tolerability and safety of levofloxacinin long-term treatment]. ( Almela, M; Alvárez, JL; García, S; Mensa, J; Ortega, M; Soriano, A; Soriano, E; Tomás, X, 2000) |
| "In two open prospective studies, the efficacy and tolerance of ofloxacin in the prevention of infection in patients with open fractures (n = 58) and in the treatment of chronic post-traumatic osteomyelitis (n = 115) were examined." | 5.06 | Use of ofloxacin in open fractures and in the treatment of post-traumatic osteomyelitis. ( Beckurts, T; Claudi, B; Ketterl, R; Stübinger, B, 1988) |
| "The present study deals with preparation, optimization and in-vitro drug release study of hydroxyapatite (HAp)- ofloxacin for bone-implantable delivery in osteomyelitis treatment." | 3.79 | Development and optimization of hydroxyapatite-ofloxacin implants for possible bone delivery in osteomyelitis treatment. ( Hasnain, MS; Malakar, J; Nayak, AK, 2013) |
| "A systemic antibiotic, 1 g levofloxacin daily, had been started at the initial abscess operation." | 3.71 | [Osteomyelitis of the tibial head caused by Mycobacterium haemophilium in a patient with AIDS]. ( Brade, V; Enzensberger, R; Gruschke, A, 2002) |
| "Methicillin-susceptible Staphylococcus aureus (MSSA) is the most common pathogen recovered from osteomyelitis patients." | 3.71 | Comparative evaluation of oral levofloxacin and parenteral nafcillin in the treatment of experimental methicillin-susceptible Staphylococcus aureus osteomyelitis in rabbits. ( Calhoun, JH; Mader, JT; Shirtliff, ME, 2001) |
| "We investigated the use of an ofloxacin-impregnated bioabsorbable composite for the prevention of acute Staphylococcus aureus osteomyelitis." | 3.70 | Prophylaxis of acute osteomyelitis with absorbable ofloxacin-impregnated beads. ( Kourea, HP; Nicolau, DP; Nie, L; Nightingale, CH; Tessier, PR, 1998) |
| "From October 1983 to October 1986, 39 patients with chronic osteomyelitis (of at least two month's duration) were treated with either pefloxacin (n = 15), ofloxacin (n = 17), or ciprofloxacin (n = 7)." | 3.67 | Evaluation of pefloxacin, ofloxacin and ciprofloxacin in the treatment of thirty-nine cases of chronic osteomyelitis. ( Bernard, E; Dellamonica, P; Drugeon, HB; Etesse, H; Garraffo, R, 1989) |
| "Ofloxacin therapy was administered an average of 45 days per patient, and was well tolerated." | 2.67 | Oral ofloxacin for infections caused by bacteria resistant to oral antimicrobial agents. ( Eron, LJ; Gentry, LO, 1992) |
| "Pelvis osteomyelitis is rare in childhood." | 1.37 | Salmonella pelvic osteomyelitis in an immunocompetent child. ( Campanacci, D; Canessa, C; Chiappini, E; Maglione, M; Resti, M; Trapani, S, 2011) |
| "Tubercular sternal osteomyelitis is a rare manifestation of tuberculosis." | 1.35 | Sternal tuberculosis. ( Howell, JM; Mohammadi, A, 2009) |
| "Ofloxacin was loaded with an 8:1 weight ratio of the blend to the drug." | 1.34 | Ofloxacin-delivery system of a polyanhydride and polylactide blend used in the treatment of bone infection. ( Chen, L; Chen, M; Shang, L; Wang, H; Wang, J, 2007) |
| " A dosage of 750 mg q." | 1.34 | Safety of prolonged high-dose levofloxacin therapy for bone infections. ( Beltrand, E; Caillaux, M; Dehecq, C; Legout, L; Loïez, C; Migaud, H; Mouton, Y; Poissy, J; Senneville, E; Valette, M; Yazdanpanah, Y, 2007) |
| "Cervical osteomyelitis is uncommon." | 1.31 | Zenker's diverticulum associated with multilevel cervical osteomyelitis. ( Bernard, L; Carlier, RY; Faye, A; Frot-Martin, B; Morand-Blot, V; Vallée, C, 2001) |
| "The principal treatment of brucellosis of the spine is conservative, namely, immobilization and antimicrobial therapy." | 1.29 | Brucellosis of the spine. ( Akalin, E; Berker, M; Ozcan, OE; Ozgen, T; Tekkök, IH, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (17.14) | 18.7374 |
| 1990's | 8 (22.86) | 18.2507 |
| 2000's | 17 (48.57) | 29.6817 |
| 2010's | 4 (11.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Salman, S | 1 |
| Young, M | 1 |
| Van Sickels, JE | 1 |
| Lebeaux, D | 1 |
| Zarrouk, V | 1 |
| Petrover, D | 1 |
| Nicolas-Chanoine, MH | 1 |
| Fantin, B | 1 |
| Canessa, C | 1 |
| Trapani, S | 1 |
| Campanacci, D | 1 |
| Chiappini, E | 1 |
| Maglione, M | 1 |
| Resti, M | 1 |
| Nayak, AK | 1 |
| Hasnain, MS | 1 |
| Malakar, J | 1 |
| Gruschke, A | 1 |
| Enzensberger, R | 1 |
| Brade, V | 1 |
| Ma, J | 1 |
| Chan, JK | 1 |
| Bar-Natan, M | 1 |
| Salai, M | 1 |
| Sidi, Y | 1 |
| Gur, H | 1 |
| Arora, A | 1 |
| Singh, S | 1 |
| Aggarwal, A | 1 |
| Aggarwal, PK | 1 |
| Amankwa, K | 1 |
| Krishnan, SC | 1 |
| Tisdale, JE | 1 |
| Bloom, C | 1 |
| Thomson, EC | 1 |
| Main, J | 1 |
| Chen, L | 1 |
| Wang, H | 1 |
| Wang, J | 1 |
| Chen, M | 1 |
| Shang, L | 1 |
| Bindal, M | 1 |
| Krabak, B | 1 |
| Mohammadi, A | 1 |
| Howell, JM | 1 |
| Metallidis, S | 1 |
| Topsis, D | 1 |
| Nikolaidis, J | 1 |
| Alexiadou, E | 1 |
| Lazaraki, G | 1 |
| Grovaris, L | 1 |
| Theodoridou, A | 1 |
| Nikolaidis, P | 1 |
| Senneville, E | 2 |
| Poissy, J | 1 |
| Legout, L | 1 |
| Dehecq, C | 1 |
| Loïez, C | 1 |
| Valette, M | 2 |
| Beltrand, E | 2 |
| Caillaux, M | 2 |
| Mouton, Y | 2 |
| Migaud, H | 1 |
| Yazdanpanah, Y | 2 |
| Tekaya, R | 1 |
| Saidane, O | 1 |
| Abdelmoula, L | 1 |
| Ben Hadj Yahia, C | 1 |
| Manamani, L | 1 |
| Chaabouni, L | 1 |
| Zouari, R | 1 |
| Declercq, J | 1 |
| Verhaegen, J | 1 |
| Verbist, L | 1 |
| Lammens, J | 1 |
| Stuyck, J | 1 |
| Fabry, G | 1 |
| Tekkök, IH | 1 |
| Berker, M | 1 |
| Ozcan, OE | 1 |
| Ozgen, T | 1 |
| Akalin, E | 1 |
| Nicolau, DP | 2 |
| Nie, L | 2 |
| Tessier, PR | 2 |
| Kourea, HP | 2 |
| Nightingale, CH | 2 |
| Browner, BD | 1 |
| Greenberg, RN | 1 |
| Newman, MT | 1 |
| Shariaty, S | 1 |
| Pectol, RW | 1 |
| Gomis, M | 1 |
| Barberán, J | 1 |
| Sánchez, B | 1 |
| Khorrami, S | 1 |
| Borja, J | 1 |
| García-Barbal, J | 1 |
| Ortega, M | 1 |
| Soriano, A | 1 |
| García, S | 1 |
| Almela, M | 1 |
| Alvárez, JL | 1 |
| Tomás, X | 1 |
| Mensa, J | 1 |
| Soriano, E | 1 |
| Frot-Martin, B | 1 |
| Carlier, RY | 1 |
| Morand-Blot, V | 1 |
| Faye, A | 1 |
| Bernard, L | 1 |
| Vallée, C | 1 |
| Shirtliff, ME | 1 |
| Calhoun, JH | 1 |
| Mader, JT | 1 |
| Cazaubiel, M | 1 |
| Cordonnier, M | 1 |
| Khazarjian, A | 1 |
| Maulin, L | 1 |
| Alfandari, S | 1 |
| Dubreuil, L | 1 |
| Hasegawa, T | 1 |
| Watanabe, R | 1 |
| Hayashi, K | 1 |
| Inufusa, A | 1 |
| Nakagawa, H | 1 |
| Eron, LJ | 1 |
| Gentry, LO | 2 |
| Rodriguez-Gomez, G | 1 |
| Dellamonica, P | 1 |
| Bernard, E | 1 |
| Etesse, H | 1 |
| Garraffo, R | 1 |
| Drugeon, HB | 1 |
| Fong, IW | 1 |
| Neu, HC | 1 |
| Ketterl, R | 1 |
| Beckurts, T | 1 |
| Stübinger, B | 1 |
| Claudi, B | 1 |
| Norden, CW | 1 |
| Niederriter, K | 1 |
| Szabó, G | 1 |
| Fülöp, E | 1 |
| Jancsó, J | 1 |
1 review available for ofloxacin and Osteomyelitis
| Article | Year |
|---|---|
Sternoclavicular infectious arthritis in previously healthy adults.
Topics: Anti-Infective Agents; Arthritis, Infectious; Escherichia coli; Humans; Israel; Male; Middle Aged; O | 2002 |
7 trials available for ofloxacin and Osteomyelitis
| Article | Year |
|---|---|
Ciprofloxacin, lomefloxacin, or levofloxacin as treatment for chronic osteomyelitis.
Topics: Adult; Anti-Infective Agents; Chronic Disease; Ciprofloxacin; Female; Fluoroquinolones; Follow-Up St | 2000 |
Oral ofloxacin versus parenteral imipenem-cilastatin in the treatment of osteomyelitis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Chronic Disease; Cilast | 1999 |
[Tolerability and safety of levofloxacinin long-term treatment].
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Bacterial Infections; Female; Humans; Levofloxacin; | 2000 |
Oral ofloxacin for infections caused by bacteria resistant to oral antimicrobial agents.
Topics: Administration, Oral; Adult; Aged; Bacterial Infections; Diabetes Complications; Drug Resistance, Mi | 1992 |
Ofloxacin versus parenteral therapy for chronic osteomyelitis.
Topics: Administration, Oral; Adult; Aged; Cefazolin; Ceftazidime; Chronic Disease; Female; Gram-Negative Ba | 1991 |
The role of fluoroquinolones in the management of skin, soft tissue, and bone infections.
Topics: Anti-Infective Agents; Bacterial Infections; Ciprofloxacin; Clinical Trials as Topic; Dermatitis; En | 1989 |
Use of ofloxacin in open fractures and in the treatment of post-traumatic osteomyelitis.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Fractures, Open; Gram-Negative Bacteria; Gram-Positiv | 1988 |
27 other studies available for ofloxacin and Osteomyelitis
| Article | Year |
|---|---|
Osteomyelitis after bilateral sagittal split osteotomy: case report and a review of the management.
Topics: Adult; Anti-Bacterial Agents; beta-Lactams; Bone Plates; Bone Screws; Clindamycin; Drainage; Enterob | 2011 |
Salmonella Colindale osteomyelitis in an immunocompetent female patient.
Topics: Abscess; Adolescent; Anti-Bacterial Agents; Bacterial Typing Techniques; Ceftriaxone; Combined Modal | 2012 |
Salmonella pelvic osteomyelitis in an immunocompetent child.
Topics: Anti-Bacterial Agents; Child; Humans; Immunocompetence; Magnetic Resonance Imaging; Male; Ofloxacin; | 2011 |
Development and optimization of hydroxyapatite-ofloxacin implants for possible bone delivery in osteomyelitis treatment.
Topics: Anti-Bacterial Agents; Bone and Bones; Drug Implants; Durapatite; Humans; Ofloxacin; Osteomyelitis | 2013 |
[Osteomyelitis of the tibial head caused by Mycobacterium haemophilium in a patient with AIDS].
Topics: Abscess; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antitubercular Agents; Clarit | 2002 |
Granulomatous osteomyelitis caused by bacteria other than mycobacteria: a report of two cases.
Topics: Adult; Ampicillin; Anti-Infective Agents; Ciprofloxacin; Female; Granuloma; Humans; Male; Middle Age | 2002 |
Salmonella osteomyelitis in an otherwise healthy adult male-successful management with conservative treatment: a case report.
Topics: Adult; Anti-Infective Agents; Ceftazidime; Femur; Humans; Magnetic Resonance Imaging; Male; Ofloxaci | 2003 |
Torsades de pointes associated with fluoroquinolones: importance of concomitant risk factors.
Topics: Aged; Cardiovascular Diseases; Female; Fluoroquinolones; Humans; Levofloxacin; Lupus Erythematosus, | 2004 |
An elderly lady with sudden blindness and a sore foot.
Topics: Administration, Topical; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Blindness; Ceftriaxon | 2006 |
Ofloxacin-delivery system of a polyanhydride and polylactide blend used in the treatment of bone infection.
Topics: Animals; Anti-Bacterial Agents; Delayed-Action Preparations; Escherichia coli; Ofloxacin; Osteomyeli | 2007 |
Acute bacterial sacroiliitis in an adult: a case report and review of the literature.
Topics: Adult; Anti-Bacterial Agents; Bacterial Infections; Clindamycin; Female; Humans; Joint Diseases; Low | 2007 |
Sternal tuberculosis.
Topics: Abscess; Adult; Anti-Bacterial Agents; Antitubercular Agents; Drug Therapy, Combination; Humans; Mal | 2009 |
Penetration of moxifloxacin and levofloxacin into cancellous and cortical bone in patients undergoing total hip arthroplasty.
Topics: Anti-Bacterial Agents; Arthroplasty, Replacement, Hip; Aza Compounds; Bone and Bones; Chromatography | 2007 |
Safety of prolonged high-dose levofloxacin therapy for bone infections.
Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluati | 2007 |
[Clostridium clostridiiforme vertebral osteomyelitis].
Topics: Adult; Anti-Bacterial Agents; Ciprofloxacin; Clostridium; Clostridium Infections; Drug Therapy, Comb | 2008 |
Salmonella typhi osteomyelitis.
Topics: Adult; Cefotaxime; Forearm; Humans; Male; Ofloxacin; Osteomyelitis; Trimethoprim, Sulfamethoxazole D | 1994 |
Brucellosis of the spine.
Topics: Adolescent; Adult; Aged; Brucella melitensis; Brucellosis; Combined Modality Therapy; Diagnosis, Dif | 1993 |
Prophylaxis of acute osteomyelitis with absorbable ofloxacin-impregnated beads.
Topics: Absorption; Acute Disease; Animals; Anti-Infective Agents; Bone and Bones; Female; Microspheres; Ofl | 1998 |
Use of a bioabsorbable polymer for the delivery of ofloxacin during experimental osteomyelitis treatment.
Topics: Animals; Anti-Infective Agents; Female; Ofloxacin; Osteomyelitis; Pharmaceutical Vehicles; Polymers; | 1998 |
Zenker's diverticulum associated with multilevel cervical osteomyelitis.
Topics: Anti-Infective Agents; Antibiotics, Antitubercular; Cervical Vertebrae; Fistula; Humans; Magnetic Re | 2001 |
Comparative evaluation of oral levofloxacin and parenteral nafcillin in the treatment of experimental methicillin-susceptible Staphylococcus aureus osteomyelitis in rabbits.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Humans; Infusions, Parenteral; Levofloxacin; M | 2001 |
Rifampicin-ofloxacin oral regimen for the treatment of mild to moderate diabetic foot osteomyelitis.
Topics: Administration, Oral; Aged; Anti-Infective Agents; Antibiotics, Antitubercular; Bacterial Infections | 2001 |
Postoperative osteomyelitis due to Mycobacterium fortuitum. A case report.
Topics: Adolescent; Antitubercular Agents; Combined Modality Therapy; Drug Therapy, Combination; Fracture Fi | 1992 |
Evaluation of pefloxacin, ofloxacin and ciprofloxacin in the treatment of thirty-nine cases of chronic osteomyelitis.
Topics: Administration, Oral; Adult; Bacterial Infections; Ciprofloxacin; Drug Evaluation; Escherichia coli; | 1989 |
Clinical use of the quinolones.
Topics: Anti-Infective Agents; Ciprofloxacin; Diarrhea; Enoxacin; Gastrointestinal Diseases; Humans; Naphthy | 1987 |
Ofloxacin therapy for experimental osteomyelitis caused by Pseudomonas aeruginosa.
Topics: Animals; Anti-Bacterial Agents; Bone and Bones; Ofloxacin; Osteomyelitis; Oxazines; Pseudomonas aeru | 1987 |
[Experience with Tarivid (Ofloxacin) in maxillofacial surgery].
Topics: Female; Humans; Male; Mandibular Diseases; Ofloxacin; Osteomyelitis; Osteotomy; Parotitis | 1988 |