Page last updated: 2024-11-01

ofloxacin and Myeloproliferative Disorders

ofloxacin has been researched along with Myeloproliferative Disorders in 1 studies

Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

Myeloproliferative Disorders: Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.

Research Excerpts

ExcerptRelevanceReference
"To report a patient with lung cancer and idiopathic myelofibrosis with myeloid metaplasia who developed purpura and acute renal failure while receiving levofloxacin, and review the existing literature on quinolone nephrotoxicity."7.71Nephrotoxicity and purpura associated with levofloxacin. ( De Simone, C; Famularo, G, 2002)
"To report a patient with lung cancer and idiopathic myelofibrosis with myeloid metaplasia who developed purpura and acute renal failure while receiving levofloxacin, and review the existing literature on quinolone nephrotoxicity."3.71Nephrotoxicity and purpura associated with levofloxacin. ( De Simone, C; Famularo, G, 2002)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Famularo, G1
De Simone, C1

Other Studies

1 other study available for ofloxacin and Myeloproliferative Disorders

ArticleYear
Nephrotoxicity and purpura associated with levofloxacin.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:9

    Topics: Acute Kidney Injury; Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Diuretics; Drug Eruption

2002