ofloxacin has been researched along with Middle Ear Inflammation in 25 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levofloxacin has excellent activity against common respiratory pathogens and therefore is likely to be effective in treating children with persistent or recurrent otitis media." | 9.12 | An open-label, double tympanocentesis study of levofloxacin therapy in children with, or at high risk for, recurrent or persistent acute otitis media. ( Arguedas, A; Blumer, J; Dagan, R; Leibovitz, E; McNeeley, DF; Melkote, R; Noel, GJ; Pichichero, M, 2006) |
| "A multicentric study was conducted to evaluate the clinical efficacy and tolerance of ofloxacin in the treatment of chronic sinusitis and chronic otitis (CSOM) in outpatients." | 9.07 | Effectiveness and safety of ofloxacin in chronic otitis media and chronic sinusitis in adult outpatients. ( Cohen, B; Gehanno, P, 1993) |
| " An approach to combine ofloxacin with humanized Fab fragments that disrupt biofilms has tremendous potential to quickly resolve chronic otorrhea suffered by children with chronic suppurative otitis media or chronic post-tympanostomy tube otorrhea and thereby improve their quality of life." | 8.02 | Humanized Anti-DNABII Fab Fragments Plus Ofloxacin Eradicated Biofilms in Experimental Otitis Media. ( Bakaletz, LO; Chiang, T; Elmaraghy, CA; Goodman, SD; Novotny, LA, 2021) |
| "We examined the cases that prescribed levofloxacin (LVFX) 500mg for middle ear diseases in our hospital." | 7.78 | [Efficacy of levofloxacin 500 mg for middle ear diseases]. ( Kimitsuki, T; Komune, S; Yoshida, T, 2012) |
| "In order to evaluate the annual changes of susceptibility, minimum inhibitory concentrations (MICs) of ofloxacin (OFLX) and 4 control drugs were determined against clinical isolates that were obtained from patients with otitis media and otitis externa during the periods between January and December 1993, and the periods between October 1996 and March 1997." | 7.70 | [Antimicrobial activity of ofloxacin against recent clinical isolates from otitis media and otitis externa]. ( Deguchi, K; Ishihara, R; Ishii, Y; Matsumoto, Y; Nakane, Y; Nakazawa, A; Nishinari, C; Suzuki, Y, 1998) |
| "After ascertaining the bacterial spectrum in 105 patients with Otitis media acutissima, Otitis media chronica mesotympanalis and Otitis media chronica epitympanalis, the efficacy of oral therapy with ofloxacin in five patients from each of these groups was assessed." | 7.67 | [Ofloxacin in the conservative therapy of acute and chronic otitis media--a preliminary clinical report of experiences]. ( Lenarz, T, 1986) |
| "After ascertaining the bacterial spectrum in 210 patients with Otitis media acuta, Otitis media chronica mesotympanalis and Otitis media chronica epitympanalis, the clinical efficacy of oral therapy with ofloxacin in 40 patients from each of these groups was assessed." | 7.67 | Ofloxacin in oral chemotherapy of acute and chronic otitis media. ( Lenarz, T, 1986) |
| "This study evaluated the therapeutic role of ofloxacin in different forms of otitis media." | 7.67 | Chemotherapy of otitis media with ofloxacin. ( Lenarz, T, 1987) |
| "Levofloxacin was not inferior to amoxicillin/clavulanate for the treatment of recurrent and/or persistent AOM in infants and children." | 6.73 | A randomized comparative study of levofloxacin versus amoxicillin/clavulanate for treatment of infants and young children with recurrent or persistent acute otitis media. ( Arguedas, A; Bagchi, P; Balis, DA; Blumer, JL; Hedrick, JA; Melkote, R; Noel, GJ; Pichichero, ME; Schwartz, RH, 2008) |
| "Levofloxacin has excellent activity against common respiratory pathogens and therefore is likely to be effective in treating children with persistent or recurrent otitis media." | 5.12 | An open-label, double tympanocentesis study of levofloxacin therapy in children with, or at high risk for, recurrent or persistent acute otitis media. ( Arguedas, A; Blumer, J; Dagan, R; Leibovitz, E; McNeeley, DF; Melkote, R; Noel, GJ; Pichichero, M, 2006) |
| "A multicentric study was conducted to evaluate the clinical efficacy and tolerance of ofloxacin in the treatment of chronic sinusitis and chronic otitis (CSOM) in outpatients." | 5.07 | Effectiveness and safety of ofloxacin in chronic otitis media and chronic sinusitis in adult outpatients. ( Cohen, B; Gehanno, P, 1993) |
| " An approach to combine ofloxacin with humanized Fab fragments that disrupt biofilms has tremendous potential to quickly resolve chronic otorrhea suffered by children with chronic suppurative otitis media or chronic post-tympanostomy tube otorrhea and thereby improve their quality of life." | 4.02 | Humanized Anti-DNABII Fab Fragments Plus Ofloxacin Eradicated Biofilms in Experimental Otitis Media. ( Bakaletz, LO; Chiang, T; Elmaraghy, CA; Goodman, SD; Novotny, LA, 2021) |
| "We examined the cases that prescribed levofloxacin (LVFX) 500mg for middle ear diseases in our hospital." | 3.78 | [Efficacy of levofloxacin 500 mg for middle ear diseases]. ( Kimitsuki, T; Komune, S; Yoshida, T, 2012) |
| "Levofloxacin (levogyre form of ofloxacin) has been approved for the treatment of acute and chronic sinusitis, pneumonia, and exacerbation of bronchopulmonary diseases, urinary, digestive and biliary infections in adults." | 3.76 | [Levofloxacin in children]. ( Cohen, R; Grimprel, E, 2010) |
| "In order to evaluate the annual changes of susceptibility, minimum inhibitory concentrations (MICs) of ofloxacin (OFLX) and 4 control drugs were determined against clinical isolates that were obtained from patients with otitis media and otitis externa during the periods between January and December 1993, and the periods between October 1996 and March 1997." | 3.70 | [Antimicrobial activity of ofloxacin against recent clinical isolates from otitis media and otitis externa]. ( Deguchi, K; Ishihara, R; Ishii, Y; Matsumoto, Y; Nakane, Y; Nakazawa, A; Nishinari, C; Suzuki, Y, 1998) |
| "After ascertaining the bacterial spectrum in 105 patients with Otitis media acutissima, Otitis media chronica mesotympanalis and Otitis media chronica epitympanalis, the efficacy of oral therapy with ofloxacin in five patients from each of these groups was assessed." | 3.67 | [Ofloxacin in the conservative therapy of acute and chronic otitis media--a preliminary clinical report of experiences]. ( Lenarz, T, 1986) |
| "After ascertaining the bacterial spectrum in 210 patients with Otitis media acuta, Otitis media chronica mesotympanalis and Otitis media chronica epitympanalis, the clinical efficacy of oral therapy with ofloxacin in 40 patients from each of these groups was assessed." | 3.67 | Ofloxacin in oral chemotherapy of acute and chronic otitis media. ( Lenarz, T, 1986) |
| "This study evaluated the therapeutic role of ofloxacin in different forms of otitis media." | 3.67 | Chemotherapy of otitis media with ofloxacin. ( Lenarz, T, 1987) |
| "Levofloxacin was not inferior to amoxicillin/clavulanate for the treatment of recurrent and/or persistent AOM in infants and children." | 2.73 | A randomized comparative study of levofloxacin versus amoxicillin/clavulanate for treatment of infants and young children with recurrent or persistent acute otitis media. ( Arguedas, A; Bagchi, P; Balis, DA; Blumer, JL; Hedrick, JA; Melkote, R; Noel, GJ; Pichichero, ME; Schwartz, RH, 2008) |
| "Ofloxacin was used at a dosage of 300 mg to 800 mg daily for three to 20 days in 206 cases of various infectious diseases in the otorhinolaryngological field such as otitis media, external otitis, paranasal sinusitis, tonsillitis and pharyngolaryngitis." | 2.66 | Clinical efficacy of ofloxacin in the treatment of otorhinolaryngological infections. ( Baba, S, 1986) |
| " Topical ofloxacin has no demonstrable adverse effects on middle ear or cochlear function." | 2.41 | Safety of ofloxacin otic and other ototopical treatments in animal models and in humans. ( Gates, GA, 2001) |
| "Gentamicin was found to be released more slowly from the fibrin-gelatin mixture than from the fibrin mixture in this experiment." | 1.30 | Sustained release of antibiotic from a fibrin-gelatin-antibiotic mixture. ( Kim, YB; Park, MS, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.00) | 18.7374 |
| 1990's | 7 (28.00) | 18.2507 |
| 2000's | 9 (36.00) | 29.6817 |
| 2010's | 3 (12.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Novotny, LA | 1 |
| Chiang, T | 1 |
| Goodman, SD | 1 |
| Elmaraghy, CA | 1 |
| Bakaletz, LO | 1 |
| Grimprel, E | 1 |
| Cohen, R | 1 |
| Boyd, NH | 1 |
| Gottschall, JA | 1 |
| Kimitsuki, T | 1 |
| Yoshida, T | 1 |
| Komune, S | 1 |
| Gao, Q | 1 |
| Liu, Z | 1 |
| Cui, Y | 1 |
| Cristobal, R | 1 |
| Edmiston, CE | 1 |
| Runge-Samuelson, CL | 1 |
| Owen, HA | 1 |
| Firszt, JB | 1 |
| Wackym, PA | 1 |
| Roland, PS | 1 |
| Pontius, A | 1 |
| Michael Wall, G | 1 |
| Waycaster, CR | 1 |
| Arguedas, A | 2 |
| Dagan, R | 1 |
| Pichichero, M | 1 |
| Leibovitz, E | 1 |
| Blumer, J | 1 |
| McNeeley, DF | 1 |
| Melkote, R | 2 |
| Noel, GJ | 2 |
| Poetker, DM | 1 |
| Lindstrom, DR | 1 |
| Patel, NJ | 1 |
| Conley, SF | 1 |
| Flanary, VA | 1 |
| Link, TR | 1 |
| Kerschner, JE | 1 |
| Ivanov, DV | 1 |
| Budanov, SV | 1 |
| Blumer, JL | 1 |
| Pichichero, ME | 1 |
| Hedrick, JA | 1 |
| Schwartz, RH | 1 |
| Balis, DA | 1 |
| Bagchi, P | 1 |
| Gehanno, P | 1 |
| Cohen, B | 1 |
| Heppt, W | 1 |
| Lutz, H | 1 |
| Gaillot, O | 1 |
| Berche, P | 1 |
| Park, MS | 1 |
| Kim, YB | 1 |
| Matsumoto, Y | 1 |
| Suzuki, Y | 2 |
| Ishii, Y | 1 |
| Ishihara, R | 2 |
| Nakazawa, A | 1 |
| Nakane, Y | 1 |
| Nishinari, C | 1 |
| Deguchi, K | 2 |
| Klein, JO | 1 |
| Gates, GA | 1 |
| Jung, HH | 1 |
| Cho, SD | 1 |
| Yoo, CK | 1 |
| Lim, HH | 1 |
| Chae, SW | 1 |
| Yokota, N | 1 |
| Koguchi, M | 1 |
| Suzuki, K | 1 |
| Fukayama, S | 1 |
| Oda, S | 1 |
| Oberascher, G | 1 |
| Karas, C | 1 |
| Lenarz, T | 3 |
| Baba, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-Label Study of Levofloxacin to Evaluate Bacteriologic Outcome in the Treatment of Children Who Are at Risk for Acute Otitis Media That is Difficult to Treat[NCT00044473] | Phase 3 | 206 participants (Actual) | Interventional | 2002-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for ofloxacin and Middle Ear Inflammation
| Article | Year |
|---|---|
[Levofloxacin and other antibacterial drugs].
Topics: Anti-Bacterial Agents; Bacterial Infections; Dermatitis; Dosage Forms; Humans; Levofloxacin; Ofloxac | 2006 |
In vitro and in vivo antimicrobial activity of topical ofloxacin and other ototopical agents.
Topics: Acute Disease; Anti-Infective Agents; Anti-Infective Agents, Local; Chronic Disease; Clinical Trials | 2001 |
Safety of ofloxacin otic and other ototopical treatments in animal models and in humans.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local | 2001 |
8 trials available for ofloxacin and Middle Ear Inflammation
| Article | Year |
|---|---|
Assessing the efficacy of tragal pumping: a randomized controlled trial.
Topics: Anti-Bacterial Agents; Child; Child, Preschool; Chronic Disease; Double-Blind Method; Ear Canal; Fem | 2011 |
An open-label, double tympanocentesis study of levofloxacin therapy in children with, or at high risk for, recurrent or persistent acute otitis media.
Topics: Acute Disease; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Child, Preschool; Exudates and | 2006 |
Ofloxacin otic drops vs neomycin-polymyxin B otic drops as prophylaxis against early postoperative tympanostomy tube otorrhea.
Topics: Administration, Topical; Anti-Bacterial Agents; Cerebrospinal Fluid Otorrhea; Child, Preschool; Fema | 2006 |
A randomized comparative study of levofloxacin versus amoxicillin/clavulanate for treatment of infants and young children with recurrent or persistent acute otitis media.
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Child, Preschool; Female; Huma | 2008 |
Effectiveness and safety of ofloxacin in chronic otitis media and chronic sinusitis in adult outpatients.
Topics: Administration, Oral; Adult; Ambulatory Care; Bacterial Infections; Chronic Disease; Humans; Ofloxac | 1993 |
Clinical experiences with ofloxacin sequential therapy in chronic ear infections.
Topics: Administration, Oral; Adult; Bacterial Infections; Chronic Disease; Drug Administration Schedule; Fe | 1993 |
[Bacteriological evaluation of ofloxacin otic solution].
Topics: Bacteria; Double-Blind Method; Drug Resistance, Microbial; Humans; Ofloxacin; Otitis Media; Solution | 1992 |
Clinical efficacy of ofloxacin in the treatment of otorhinolaryngological infections.
Topics: Anti-Infective Agents; Bacterial Infections; Clinical Trials as Topic; Humans; Laryngitis; Ofloxacin | 1986 |
14 other studies available for ofloxacin and Middle Ear Inflammation
| Article | Year |
|---|---|
Humanized Anti-DNABII Fab Fragments Plus Ofloxacin Eradicated Biofilms in Experimental Otitis Media.
Topics: Animals; Biofilms; Chinchilla; DNA-Binding Proteins; DNA, Bacterial; Haemophilus Infections; Haemoph | 2021 |
[Levofloxacin in children].
Topics: Adult; Anti-Bacterial Agents; Bacterial Infections; Child; Community-Acquired Infections; Humans; Le | 2010 |
[Efficacy of levofloxacin 500 mg for middle ear diseases].
Topics: Adult; Anti-Bacterial Agents; Ear Diseases; Ear, Middle; Female; Humans; Levofloxacin; Male; Middle | 2012 |
[Clinical and bacteriology observation on intraoperation usage of tarivid otic solution in treatment of chronic otitis media with cholesteatoma].
Topics: Adult; Aged; Anti-Infective Agents; Cholesteatoma, Middle Ear; Chronic Disease; Combined Modality Th | 1999 |
Fungal biofilm formation on cochlear implant hardware after antibiotic-induced fungal overgrowth within the middle ear.
Topics: Anti-Infective Agents; Antifungal Agents; Beckwith-Wiedemann Syndrome; Biofilms; Candida; Cefdinir; | 2004 |
A cost threshold analysis of ciprofloxacin-dexamethasone versus ofloxacin for acute otitis media in pediatric patients with tympanostomy tubes.
Topics: Anti-Bacterial Agents; Canada; Child; Ciprofloxacin; Cost-Benefit Analysis; Costs and Cost Analysis; | 2004 |
In vitro susceptibility to ciprofloxacin of bacterial strains isolated from chronic otitis media and chronic sinusitis.
Topics: Adult; Anti-Infective Agents; Bacteria; Chronic Disease; Ciprofloxacin; Drug Resistance, Microbial; | 1995 |
Sustained release of antibiotic from a fibrin-gelatin-antibiotic mixture.
Topics: Administration, Topical; Ampicillin; Anti-Bacterial Agents; Bacillus subtilis; Delayed-Action Prepar | 1997 |
[Antimicrobial activity of ofloxacin against recent clinical isolates from otitis media and otitis externa].
Topics: Anti-Infective Agents; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Haemophilus inf | 1998 |
Vinegar treatment in the management of granular myringitis.
Topics: Acetic Acid; Adolescent; Adult; Anti-Infective Agents; Chronic Disease; Female; Follow-Up Studies; G | 2002 |
[Ofloxacin in the treatment of Pseudomonas aeruginosa infections of the ear].
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Ofloxacin; Otitis; Otitis Externa; Otitis Media; Oxa | 1988 |
[Ofloxacin in the conservative therapy of acute and chronic otitis media--a preliminary clinical report of experiences].
Topics: Acute Disease; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Chronic Disease; Humans; Oflox | 1986 |
Ofloxacin in oral chemotherapy of acute and chronic otitis media.
Topics: Acute Disease; Anti-Bacterial Agents; Chronic Disease; Ear, Middle; Humans; Ofloxacin; Otitis Media; | 1986 |
Chemotherapy of otitis media with ofloxacin.
Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Humans; Ofloxacin; Otitis Media; Oxazin | 1987 |