ofloxacin has been researched along with Middle Ear Effusion in 15 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After ascertaining the bacterial spectrum in 105 patients with Otitis media acutissima, Otitis media chronica mesotympanalis and Otitis media chronica epitympanalis, the efficacy of oral therapy with ofloxacin in five patients from each of these groups was assessed." | 7.67 | [Ofloxacin in the conservative therapy of acute and chronic otitis media--a preliminary clinical report of experiences]. ( Lenarz, T, 1986) |
| "After ascertaining the bacterial spectrum in 105 patients with Otitis media acutissima, Otitis media chronica mesotympanalis and Otitis media chronica epitympanalis, the efficacy of oral therapy with ofloxacin in five patients from each of these groups was assessed." | 3.67 | [Ofloxacin in the conservative therapy of acute and chronic otitis media--a preliminary clinical report of experiences]. ( Lenarz, T, 1986) |
| "Ciprofloxacin/dexamethasone treatment is also superior to improvement in clinical response by visit, absence of otorrhea by visit, and reduction of otorrhea volume by visit." | 2.71 | Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of children with acute otitis media with otorrhea through tympanostomy tubes. ( Anon, JB; Conroy, PJ; Dupre, SJ; Hogg, G; Kreisler, LS; Lanier, B; McLean, C; Potts, S; Reese, B; Roland, PS; Stroman, DW; Wall, GM, 2004) |
| "Ofloxacin otic solution was instilled into the chamber to cover the plugged TT, and the time to clearance of each plug was recorded." | 1.33 | Opening plugged tympanostomy tubes: effect of inner diameter and shaft length. ( Antonelli, PJ; Mehta, AJ; Stevens, GR, 2005) |
| " The authors thus recommend a dosage of 400 mg of ofloxacin three to five hours prior to surgery for middle ear infection." | 1.27 | Tissue concentrations of ofloxacin in the middle ear. ( Thorn, V, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gohil, RD | 1 |
| Syed, MI | 1 |
| Watson, NA | 1 |
| Gomez Serrano, M | 1 |
| Selvadurai, D | 1 |
| Gan, CW | 1 |
| Chooi, WH | 1 |
| Ng, HC | 1 |
| Wong, YS | 1 |
| Venkatraman, SS | 1 |
| Lim, LH | 1 |
| Filsoof, DM | 1 |
| Park, SY | 1 |
| Dohar, J | 1 |
| Roland, PS | 2 |
| Kreisler, LS | 1 |
| Reese, B | 1 |
| Anon, JB | 1 |
| Lanier, B | 1 |
| Conroy, PJ | 2 |
| Wall, GM | 2 |
| Dupre, SJ | 2 |
| Potts, S | 1 |
| Hogg, G | 1 |
| Stroman, DW | 1 |
| McLean, C | 1 |
| Dohar, JE | 2 |
| Lanier, BJ | 1 |
| Hekkenburg, R | 1 |
| Lane, EM | 1 |
| Potts, SL | 1 |
| Mehta, AJ | 1 |
| Stevens, GR | 1 |
| Antonelli, PJ | 1 |
| Soley, C | 1 |
| Arguedas, A | 1 |
| Porras, W | 1 |
| Guevara, S | 1 |
| Loaiza, C | 1 |
| Pérez, A | 1 |
| Rincón, G | 1 |
| Schultz, M | 1 |
| Arguedas, J | 1 |
| Brilla, R | 1 |
| Davies, TA | 1 |
| Leibovitz, E | 1 |
| Noel, GJ | 1 |
| McNeeley, DF | 1 |
| Bush, K | 1 |
| Dagan, R | 1 |
| Kaga, K | 1 |
| Ichimura, K | 1 |
| Garner, ET | 1 |
| Nielsen, RW | 1 |
| Biel, MA | 1 |
| Seidlin, M | 1 |
| François, M | 1 |
| Mariani-Kurkdjian, P | 1 |
| Doit, C | 1 |
| Benzekri, P | 1 |
| Bingen, E | 1 |
| Macé, JG | 1 |
| Lenarz, T | 1 |
| Thorn, V | 1 |
5 trials available for ofloxacin and Middle Ear Effusion
| Article | Year |
|---|---|
Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of children with acute otitis media with otorrhea through tympanostomy tubes.
Topics: Acute Disease; Administration, Topical; Anti-Infective Agents; Anti-Inflammatory Agents; Child; Chil | 2004 |
Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes.
Topics: Administration, Topical; Adolescent; Anti-Infective Agents; Anti-Inflammatory Agents; Cerebrospinal | 2004 |
In vitro activities of levofloxacin and comparable agents against middle ear fluid, nasopharyngeal, and oropharyngeal pathogens obtained from Costa Rican children with recurrent otitis media or failing other antibiotic therapy.
Topics: Anti-Bacterial Agents; Child, Preschool; Costa Rica; Haemophilus influenzae; Humans; Infant; Levoflo | 2005 |
A preliminary report: clinical effects of otic solution of ofloxacin in infantile myringitis and chronic otitis media.
Topics: Anti-Infective Agents; Child; Chronic Disease; Female; Humans; Male; Ofloxacin; Otitis Media with Ef | 1998 |
Topical ofloxacin treatment of otorrhea in children with tympanostomy tubes.
Topics: Administration, Topical; Adolescent; Anti-Infective Agents; Child; Child, Preschool; Female; Humans; | 1999 |
10 other studies available for ofloxacin and Middle Ear Effusion
| Article | Year |
|---|---|
The SIGN 104 guideline (2014) for topical antibiotic prophylaxis during grommet insertion: Misguided?
Topics: Administration, Topical; Anti-Bacterial Agents; Antibiotic Prophylaxis; Ciprofloxacin; Clinical Prot | 2018 |
Topical ofloxacin use in glucose-6-phosphate dehydrogenase deficiency-safe or unsafe?
Topics: Administration, Topical; Anemia, Hemolytic; Anti-Bacterial Agents; Child, Preschool; Glucosephosphat | 2018 |
Development of a novel biodegradable drug-eluting ventilation tube for chronic otitis media with effusion.
Topics: Animals; Coated Materials, Biocompatible; Guinea Pigs; Lactic Acid; Middle Ear Ventilation; Ofloxaci | 2013 |
Eustachian tube foreign body undetected for 30 years: case report.
Topics: Anti-Bacterial Agents; Audiometry, Pure-Tone; Eustachian Tube; Foreign Bodies; Hearing Loss, Conduct | 2009 |
Microbiology of otorrhea in children with tympanostomy tubes: implications for therapy.
Topics: Anti-Infective Agents; Child; Child, Preschool; Female; Haemophilus influenzae; Humans; Infant; Logi | 2003 |
Opening plugged tympanostomy tubes: effect of inner diameter and shaft length.
Topics: Anti-Bacterial Agents; Humans; Instillation, Drug; Middle Ear Ventilation; Models, Biological; Oflox | 2005 |
Characterization and dynamics of middle ear fluid and nasopharyngeal isolates of Streptococcus pneumoniae from 12 children treated with levofloxacin.
Topics: Acute Disease; Anti-Bacterial Agents; Child, Preschool; Drug Resistance, Bacterial; Electrophoresis, | 2008 |
[Tympanostomy tube otorrhea: microbiological epidemiology, pathogen susceptibility to local antibiotics and bactericidal power of the rifamycin-olfloxacin combination].
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Child, Preschool; Drug Therapy, Combination; Female; H | 2001 |
[Ofloxacin in the conservative therapy of acute and chronic otitis media--a preliminary clinical report of experiences].
Topics: Acute Disease; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Chronic Disease; Humans; Oflox | 1986 |
Tissue concentrations of ofloxacin in the middle ear.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Infective Agents; Bacterial Infections; Ear, Mid | 1987 |