ofloxacin has been researched along with Meningitis, Pneumococcal in 9 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Meningitis, Pneumococcal: An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ofloxacin diffusion into cerebrospinal fluid (CSF) was evaluated in nine patients with bacterial meningitis." | 7.67 | Diffusion of ofloxacin into the cerebrospinal fluid in patients with bacterial meningitis. ( Bru, JP; Croize, J; Fourtillan, JB; Guyot, A; Leduc, D; Lefèbvre, MA; Micoud, M; Stahl, JP, 1986) |
| "Ofloxacin diffusion into cerebrospinal fluid (CSF) was evaluated in nine patients with bacterial meningitis." | 3.67 | Diffusion of ofloxacin into the cerebrospinal fluid in patients with bacterial meningitis. ( Bru, JP; Croize, J; Fourtillan, JB; Guyot, A; Leduc, D; Lefèbvre, MA; Micoud, M; Stahl, JP, 1986) |
| " The elimination half-life in plasma and CSF was calculated using non-linear regression analysis." | 1.31 | Cerebrospinal fluid penetration and pharmacokinetics of levofloxacin in an experimental rabbit meningitis model. ( Dash, AK; Destache, CJ; Larsen, C; Owens, H; Pakiz, CB, 2001) |
| "We have assessed levofloxacin penetration in cerebrospinal fluid (CSF) and the liquor-to-plasma ratio (C(L)/C(P)) at 2 hours after dosing in 5 patients with spontaneous acute bacterial meningitis." | 1.31 | Cerebrospinal fluid penetration of levofloxacin in patients with spontaneous acute bacterial meningitis. ( Baraldo, M; Furlanut, M; Giobbia, M; Pea, F; Scotton, PG; Vaglia, A, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ciccotelli, W | 1 |
| Poutanen, S | 1 |
| Morris, S | 1 |
| Alqahtani, M | 1 |
| Cox, P | 1 |
| Low, D | 1 |
| Pillai, D | 1 |
| Opavsky, M | 1 |
| Kühn, F | 3 |
| Cottagnoud, M | 3 |
| Acosta, F | 2 |
| Flatz, L | 3 |
| Entenza, J | 3 |
| Cottagnoud, P | 3 |
| Stucki, A | 2 |
| Wortmann, GW | 1 |
| Bennett, SP | 1 |
| Klugman, KP | 1 |
| Destache, CJ | 1 |
| Pakiz, CB | 1 |
| Larsen, C | 1 |
| Owens, H | 1 |
| Dash, AK | 1 |
| Scotton, PG | 1 |
| Pea, F | 1 |
| Giobbia, M | 1 |
| Baraldo, M | 1 |
| Vaglia, A | 1 |
| Furlanut, M | 1 |
| Stahl, JP | 1 |
| Croize, J | 1 |
| Lefèbvre, MA | 1 |
| Bru, JP | 1 |
| Guyot, A | 1 |
| Leduc, D | 1 |
| Fourtillan, JB | 1 |
| Micoud, M | 1 |
9 other studies available for ofloxacin and Meningitis, Pneumococcal
| Article | Year |
|---|---|
A new twist on an old problem: a case of pediatric meningitis caused by multidrug-resistant Streptococcus pneumoniae serotype 19A.
Topics: Anti-Bacterial Agents; Cefuroxime; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; | 2008 |
Cefotaxime acts synergistically with levofloxacin in experimental meningitis due to penicillin-resistant pneumococci and prevents selection of levofloxacin-resistant mutants in vitro.
Topics: Animals; Anti-Infective Agents; Cefotaxime; Cephalosporins; DNA, Bacterial; Drug Resistance, Bacteri | 2003 |
Meropenem prevents levofloxacin-induced resistance in penicillin-resistant pneumococci and acts synergistically with levofloxacin in experimental meningitis.
Topics: Animals; Disease Models, Animal; DNA, Bacterial; Dose-Response Relationship, Drug; Drug Resistance, | 2003 |
Ceftriaxone acts synergistically with levofloxacin in experimental meningitis and reduces levofloxacin-induced resistance in penicillin-resistant pneumococci.
Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Cephalosporins; DNA Topoisomerase IV; DNA, Bacterial; D | 2004 |
Fatal meningitis due to levofloxacin-resistant Streptococcus pneumoniae.
Topics: Anti-Infective Agents; Drug Resistance, Microbial; Fatal Outcome; Humans; Levofloxacin; Male; Mening | 1999 |
Levofloxacin-resistant pneumococcus.
Topics: Anti-Infective Agents; Drug Resistance, Microbial; Humans; Levofloxacin; Meningitis, Pneumococcal; M | 2000 |
Cerebrospinal fluid penetration and pharmacokinetics of levofloxacin in an experimental rabbit meningitis model.
Topics: Animals; Anti-Infective Agents; Area Under Curve; Disease Models, Animal; Levofloxacin; Meningitis, | 2001 |
Cerebrospinal fluid penetration of levofloxacin in patients with spontaneous acute bacterial meningitis.
Topics: Acute Disease; Adult; Aged; Anti-Infective Agents; Female; Humans; Levofloxacin; Male; Meningitis, E | 2001 |
Diffusion of ofloxacin into the cerebrospinal fluid in patients with bacterial meningitis.
Topics: Adult; Anti-Infective Agents; Bacterial Infections; Female; Humans; Male; Meningitis; Meningitis, Me | 1986 |