ofloxacin has been researched along with Maxillary Sinusitis in 11 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Maxillary Sinusitis: Inflammation of the NASAL MUCOSA in the MAXILLARY SINUS. In many cases, it is caused by an infection of the bacteria HAEMOPHILUS INFLUENZAE; STREPTOCOCCUS PNEUMONIAE; or STAPHYLOCOCCUS AUREUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study assessed daily aspirate samples from an indwelling sinus catheter during high-dose, short-course levofloxacin (750 mg daily x 5 days) treatment of acute maxillary sinusitis." | 9.12 | Serial sinus aspirate samples during high-dose, short-course levofloxacin treatment of acute maxillary sinusitis. ( Ambrose, PG; Anon, JB; Jones, RN; Kahn, JB; Paglia, M; Xiang, J, 2007) |
| "This case report highlights a rare adverse drug reaction caused by levofloxacin, resulting in optic neuritis progressing into unilateral loss of vision." | 7.78 | Oral levofloxacin-induced optic neuritis progressing in loss of vision. ( Das, S; Mondal, S, 2012) |
| "This study assessed daily aspirate samples from an indwelling sinus catheter during high-dose, short-course levofloxacin (750 mg daily x 5 days) treatment of acute maxillary sinusitis." | 5.12 | Serial sinus aspirate samples during high-dose, short-course levofloxacin treatment of acute maxillary sinusitis. ( Ambrose, PG; Anon, JB; Jones, RN; Kahn, JB; Paglia, M; Xiang, J, 2007) |
| "The objective of the study was to compare the clinical efficacy and bacteriological response of levofloxacin and amoxicillin/clavulanic acid (co-amoxiclav) in the treatment of purulent maxillary sinusitis." | 5.11 | An open label, randomized comparative study of levofloxacin and amoxicillin/clavulanic acid in the treatment of purulent sinusitis in adult Thai patients. ( Bunnag, C; Dhiraputra, C; Fooanant, S; Jareoncharsri, P; Srifuengfung, S; Tunsuriyawong, P; Voraprayoon, S, 2004) |
| "0-g dose of a novel azithromycin microsphere formulation with that of 10 days of levofloxacin, 500 mg/d, when used to treat adults with uncomplicated acute bacterial maxillary sinusitis (ABS)." | 5.11 | Efficacy and safety of a novel, single-dose azithromycin microsphere formulation versus 10 days of levofloxacin for the treatment of acute bacterial sinusitis in adults. ( Breen, JD; Emparanza, P; Lesinskas, E; Murray, JJ; Tawadrous, M, 2005) |
| "This case report highlights a rare adverse drug reaction caused by levofloxacin, resulting in optic neuritis progressing into unilateral loss of vision." | 3.78 | Oral levofloxacin-induced optic neuritis progressing in loss of vision. ( Das, S; Mondal, S, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (90.91) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, S | 1 |
| Mondal, S | 1 |
| Wellinghausen, N | 1 |
| Sing, A | 1 |
| Kern, WV | 1 |
| Perner, S | 1 |
| Marre, R | 1 |
| Rentschler, J | 1 |
| Greene, BL | 1 |
| Kriukov, AI | 1 |
| Sedinkin, AA | 1 |
| Gerasimov, KV | 1 |
| Jareoncharsri, P | 1 |
| Bunnag, C | 1 |
| Fooanant, S | 1 |
| Tunsuriyawong, P | 1 |
| Voraprayoon, S | 1 |
| Srifuengfung, S | 1 |
| Dhiraputra, C | 1 |
| Murray, JJ | 1 |
| Emparanza, P | 1 |
| Lesinskas, E | 1 |
| Tawadrous, M | 1 |
| Breen, JD | 1 |
| Marple, BF | 1 |
| Anon, JB | 2 |
| Paglia, M | 1 |
| Xiang, J | 1 |
| Ambrose, PG | 2 |
| Jones, RN | 2 |
| Kahn, JB | 1 |
| Bhavnani, SM | 1 |
| Okusanya, OO | 1 |
| Paglia, MR | 1 |
| Kahn, J | 1 |
| Drusano, GL | 1 |
| Gwaltney, JM | 1 |
| Budanov, SV | 1 |
| Vasil'ev, AN | 1 |
| Smirnova, LB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label, Multi-center, Non-comparative Sinus Puncture Study of 750 mg, Short-course Levofloxacin in the Treatment of Acute Maxillary Sinusitis[NCT00236652] | Phase 3 | 18 participants (Actual) | Interventional | 2003-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ofloxacin and Maxillary Sinusitis
| Article | Year |
|---|---|
[The first 'respiration' fluoroquinolone--levofloxacin (Tavanic) in therapy of bacterial infections. Pharmacodynamics principles in optimization of administration regimens].
Topics: Acute Disease; Animals; Anti-Infective Agents; Bronchitis; Chronic Disease; Community-Acquired Infec | 2001 |
5 trials available for ofloxacin and Maxillary Sinusitis
| Article | Year |
|---|---|
[Efficacy of the drug tavanik (levofloxacin) in acute and maxillary sinusitis].
Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Infective Agents; Drug Administration Schedule; Female; | 2003 |
An open label, randomized comparative study of levofloxacin and amoxicillin/clavulanic acid in the treatment of purulent sinusitis in adult Thai patients.
Topics: Acute Disease; Adolescent; Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Infectiv | 2004 |
Efficacy and safety of a novel, single-dose azithromycin microsphere formulation versus 10 days of levofloxacin for the treatment of acute bacterial sinusitis in adults.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Azithromycin; Bacte | 2005 |
Serial sinus aspirate samples during high-dose, short-course levofloxacin treatment of acute maxillary sinusitis.
Topics: Acute Disease; Adult; Anti-Bacterial Agents; Catheters, Indwelling; Dose-Response Relationship, Drug | 2007 |
Use of pharmacodynamic endpoints for the evaluation of levofloxacin for the treatment of acute maxillary sinusitis.
Topics: Adult; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Female; Humans; Levofloxacin; Male; Ma | 2008 |
5 other studies available for ofloxacin and Maxillary Sinusitis
| Article | Year |
|---|---|
Oral levofloxacin-induced optic neuritis progressing in loss of vision.
Topics: Administration, Oral; Anti-Bacterial Agents; Ethmoid Sinusitis; Humans; Levofloxacin; Male; Maxillar | 2012 |
A fatal case of necrotizing sinusitis due to toxigenic Corynebacterium ulcerans.
Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; C | 2002 |
Physical therapist management of fluoroquinolone-induced Achilles tendinopathy.
Topics: Achilles Tendon; Adult; Anti-Infective Agents; Humans; Levofloxacin; Male; Maxillary Sinusitis; Oflo | 2002 |
Editorial commentary: dilemma in trial design: do current study designs adequately evaluate effectiveness antibiotic in ABRS?
Topics: Acute Disease; Azithromycin; Bacterial Infections; Chemistry, Pharmaceutical; Dose-Response Relation | 2005 |
Commentary on "Use of pharmacodynamic endpoints for the evaluation of levofloxacin for the treatment of acute maxillary sinusitis" by Ambrose et al.
Topics: Anti-Bacterial Agents; Bacterial Infections; Humans; Levofloxacin; Maxillary Sinusitis; Ofloxacin | 2008 |