ofloxacin has been researched along with Magnesium Deficiency in 6 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Magnesium Deficiency: A nutritional condition produced by a deficiency of magnesium in the diet, characterized by anorexia, nausea, vomiting, lethargy, and weakness. Symptoms are paresthesias, muscle cramps, irritability, decreased attention span, and mental confusion, possibly requiring months to appear. Deficiency of body magnesium can exist even when serum values are normal. In addition, magnesium deficiency may be organ-selective, since certain tissues become deficient before others. (Harrison's Principles of Internal Medicine, 12th ed, p1936)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recently, we showed that magnesium deficiency induces lesions in knee joint cartilage from 5-week-old rats that are very similar to ofloxacin-induced cartilage defects." | 7.69 | Integrins on joint cartilage chondrocytes and alterations by ofloxacin or magnesium deficiency in immature rats. ( Förster, C; Günther, T; Kociok, K; Merker, HJ; Shakibaei, M; Stahlmann, R; Vormann, J, 1996) |
| "Ofloxacin treatment did not change the total magnesium concentrations in tissues, as determined with ashed samples." | 5.31 | Synergistic effect of ofloxacin and magnesium deficiency on joint cartilage in immature rats. ( Lozo, E; Riecke, K; Schwabe, R; Stahlmann, R; Vormann, J, 2002) |
| " To test the hypothesis that quinolone-induced arthropathy is caused (or aggravated) by magnesium deficiency in cartilage, we induced magnesium deficiency by feeding juvenile rats a magnesium-deficient diet for 9 days and treated the rats with single oral doses of ofloxacin (0, 100, 300, 600, or 1,200 mg/kg of body weight) during this period." | 3.69 | Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone-induced arthropathy. ( Förster, C; Günther, T; Merker, HJ; Shakibaei, M; Stahlmann, R; Vormann, J, 1995) |
| "Recently, we showed that magnesium deficiency induces lesions in knee joint cartilage from 5-week-old rats that are very similar to ofloxacin-induced cartilage defects." | 3.69 | Integrins on joint cartilage chondrocytes and alterations by ofloxacin or magnesium deficiency in immature rats. ( Förster, C; Günther, T; Kociok, K; Merker, HJ; Shakibaei, M; Stahlmann, R; Vormann, J, 1996) |
| "Ofloxacin treatment did not change the total magnesium concentrations in tissues, as determined with ashed samples." | 1.31 | Synergistic effect of ofloxacin and magnesium deficiency on joint cartilage in immature rats. ( Lozo, E; Riecke, K; Schwabe, R; Stahlmann, R; Vormann, J, 2002) |
| "5 and 6 h after dosing and the drug was still detectable in plasma 48 h after dosing (0." | 1.30 | Quinolone-induced arthropathy: exposure of magnesium-deficient aged rats or immature rats, mineral concentrations in target tissues and pharmacokinetics. ( Förster, C; Günther, T; Lozo, E; Merker, HJ; Schwabe, R; Stahlmann, R; Vormann, J; Zippel, U, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stahlmann, R | 6 |
| Förster, C | 4 |
| Shakibaei, M | 4 |
| Vormann, J | 6 |
| Günther, T | 3 |
| Merker, HJ | 3 |
| Kociok, K | 1 |
| Schwabe, R | 3 |
| Lozo, E | 2 |
| Zippel, U | 1 |
| Rücker, M | 1 |
| Baumann-Wilschke, I | 1 |
| Pfister, K | 1 |
| Riecke, K | 1 |
6 other studies available for ofloxacin and Magnesium Deficiency
| Article | Year |
|---|---|
Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone-induced arthropathy.
Topics: Animals; Anti-Infective Agents; Bone and Bones; Cartilage Diseases; Cartilage, Articular; Diet; Fema | 1995 |
Integrins on joint cartilage chondrocytes and alterations by ofloxacin or magnesium deficiency in immature rats.
Topics: Animals; Anti-Infective Agents; Calcium; Cartilage, Articular; Immunohistochemistry; Integrins; Magn | 1996 |
Quinolone-induced arthropathy: exposure of magnesium-deficient aged rats or immature rats, mineral concentrations in target tissues and pharmacokinetics.
Topics: Age Factors; Animals; Anti-Infective Agents; Calcium; Cartilage; Ciprofloxacin; Contraindications; F | 1997 |
Effects of fluoroquinolones and magnesium deficiency in murine limb bud cultures.
Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Dose-Response Relationship, Drug; Embryo, Mammalian; | 1998 |
Ultrastructure of Achilles tendons of rats treated with ofloxacin and fed a normal or magnesium-deficient diet.
Topics: Achilles Tendon; Aging; Animals; Anti-Infective Agents; Diet; Magnesium Deficiency; Ofloxacin; Rats; | 2000 |
Synergistic effect of ofloxacin and magnesium deficiency on joint cartilage in immature rats.
Topics: Animals; Anti-Infective Agents; Cartilage; Cartilage Diseases; Joints; Magnesium; Magnesium Deficien | 2002 |