Page last updated: 2024-11-01

ofloxacin and Keratitis

ofloxacin has been researched along with Keratitis in 56 studies

Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

Keratitis: Inflammation of the cornea.

Research Excerpts

ExcerptRelevanceReference
"3% levofloxacin eyedrops on the treatment of acute bacterial conjunctivitis and bacterial keratitis."9.09[Clinical investigation of 0.3% levofloxacin eyedrops on the treatment of cases with acute bacterial conjunctivitis and bacterial keratitis]. ( Chen, F; Hu, Y; Zhang, M, 2000)
"The objective of the present study was to evaluate the effectiveness of topically applied gemifloxacin for the treatment of experimental Staphylococcus aureus keratitis in a rabbit model."7.78Efficacy of gemifloxacin for the treatment of experimental Staphylococcus aureus keratitis. ( Chen, H; Jiang, H; Liu, T; Song, Z; Wu, X; Xu, Y; Yang, L; Yue, W, 2012)
"5% levofloxacin in rabbits, and to determine its improved efficacy against experimental keratitis."7.76Novel mucoadhesive polysaccharide isolated from Bletilla striata improves the intraocular penetration and efficacy of levofloxacin in the topical treatment of experimental bacterial keratitis. ( Chen, H; Jiang, HR; Wu, XG; Xin, M; Yang, LN, 2010)
"In the rabbit keratitis model, the ocular inflammation was significantly reduced by gatifloxacin as compared to levofloxacin but there was no significant difference between the groups in the number of viable bacteria."7.74Immunomodulatory effect of gatifloxacin on mouse peritoneal macrophages in vitro and in models of endotoxin-induced rat conjunctivitis and rabbit bacterial keratitis. ( Inoue, T; Kida, T; Naka, H; Sakaki, H; Tokushige, H; Wada, T, 2008)
"Six cases of microbial keratitis treated with multiple topical medications, including topical ofloxacin, resulted in corneal precipitates and poor wound healing."7.74Corneal deposits and topical ofloxacin--the effect of polypharmacy in the management of microbial keratitis. ( McElvanney, A; Mitra, A; Tsesmetzoglou, E, 2007)
"3% ofloxacin solution) on methicillin-resistant Staphylococcus aureus (MRSA) keratitis were compared in a rabbit model."7.73Antibiotic effects of WP-0405, a thermo-setting ofloxacin gel, on methicillin-resistant Staphylococcus aureus keratitis in rabbits. ( Fukaya, Y; Hirata, H; Kamata, Y; Kambara, Y; Kurasawa, N; Kurita, A; Naito, A; Nakaya, S; Ohashi, Y; Sato, M; Shirasawa, E; Toyoda, Y; Tsuruga, H; Wada, T, 2006)
"Taurolidine is a broad-spectrum, non antibiotic antimicrobial agent, not previously tested against the common causes of bacterial keratitis."7.73Effectiveness of topical taurolidine versus ciprofloxacin, ofloxacin, and fortified cefazolin in a rabbit Staphylococcus aureus keratitis model. ( Gurkan, T; Oguz, E; Oguz, H; Ozbilge, H, 2005)
"The purpose of this study was to quantitatively compare, in a rabbit keratitis model, the levels of effectiveness of moxifloxacin, levofloxacin, and ciprofloxacin for the treatment of Staphylococcus aureus isolates of diverse antibiotic susceptibilities."7.72Effectiveness of ciprofloxacin, levofloxacin, or moxifloxacin for treatment of experimental Staphylococcus aureus keratitis. ( Dajcs, JJ; Girgis, DO; Marquart, ME; O'Callaghan, RJ; Thibodeaux, BA; Traidej, M, 2004)
" In this study we investigate the emergence of fluoroquinolone (ciprofloxacin, levofloxacin) resistance among methicillin-sensitive Staphylococcus aureus isolates from keratitis and conjunctivitis."7.72Ciprofloxacin and levofloxacin resistance among methicillin-sensitive Staphylococcus aureus isolates from keratitis and conjunctivitis. ( Alfonso, EC; Marangon, FB; Miller, D; Muallem, MS; Romano, AC, 2004)
"Taken together, our susceptibility and time kill data failed to demonstrate convincing differences in the susceptibility of SA and PA keratitis isolates to levofloxacin, ciprofloxacin, and ofloxacin."7.71An in vitro resistance study of levofloxacin, ciprofloxacin, and ofloxacin using keratitis isolates of Staphylococcus aureus and Pseudomonas aeruginosa. ( Gordon, YJ; Husted, RC; Karenchak, LM; Kowalski, RP; Pandya, AN; Ritterband, DC; Romanowski, EG; Shah, MK, 2001)
"Topical treatment of experimental Staphylococcus keratitis with ciprofloxacin-PSS, ciprofloxacin, or ofloxacin was effective."7.70Effectiveness of ciprofloxacin-polystyrene sulfonate (PSS), ciprofloxacin and ofloxacin in a Staphylococcus keratitis model. ( Engel, LS; Green, LC; Hill, JM; Moreau, JM; O'Callaghan, RJ, 1998)
"To compare the antibacterial effect of povidone-iodine (PI) with that of ofloxacin in an experimental model of bacterial keratitis."7.70Effect of topical povidone-iodine versus topical ofloxacin on experimental Staphylococcus keratitis. ( Goldberg, MA; Lustbader, J; MacDowell, AL; Melki, SA; Safar, A; Scharper, M; Scharper, P; Yaghouti, F; Zeligs, B, 2000)
"Bacterial keratitis is a serious infectious ocular disease requiring prompt treatment to prevent frequent and severe visual disabilities."5.32A mucoadhesive polymer extracted from tamarind seed improves the intraocular penetration and efficacy of rufloxacin in topical treatment of experimental bacterial keratitis. ( Boldrini, E; Campa, M; Celandroni, F; Davini, P; Ghelardi, E; Parisio, E; Salvetti, S; Senesi, S; Tavanti, A, 2004)
"Bacterial keratitis (BK) presentations are often treated using the commercially available second-generation fluoroquinolones ciprofloxacin 0."5.22The clinical treatment of bacterial keratitis: A review of drop instillation regimes. ( Essex, RW; Maddess, T; Pearce, JG, 2022)
"3% levofloxacin eyedrops on the treatment of acute bacterial conjunctivitis and bacterial keratitis."5.09[Clinical investigation of 0.3% levofloxacin eyedrops on the treatment of cases with acute bacterial conjunctivitis and bacterial keratitis]. ( Chen, F; Hu, Y; Zhang, M, 2000)
" A MEDLINE search was conducted using the following search terms: moxifloxacin or gatifloxacin; levofloxacin; minimum inhibitory concentration or prevention or prophylaxis; keratitis or endophthalmitis."4.84Review of third-and fourth-generation fluoroquinolones in ophthalmology: in-vitro and in-vivo efficacy. ( Scoper, SV, 2008)
" This study aims to investigate the effectiveness of ofloxacin-loaded contact lenses as prolonged release devices for the treatment of bacterial keratitis."3.91Evaluating the potential of drug eluting contact lenses for treatment of bacterial keratitis using an ex vivo corneal model. ( Chauhan, A; Gibson, D; Schultz, G; Silva, BO; Ubani-Ukoma, U, 2019)
"The aim of the present study was to develop novel ofloxacin (OFX)-loaded nanostructured lipid carrier (NLC)-based inserts for ocular application for treatment of bacterial keratitis."3.81Novel nanostructured lipid carrier-based inserts for controlled ocular drug delivery: evaluation of corneal bioavailability and treatment efficacy in bacterial keratitis. ( Bozbıyık, Dİ; Eğrilmez, S; Ertan, G; Gökçe, EH; Özer, Ö; Üstündağ-Okur, N, 2015)
"Corneal cross-linking (CXL) with riboflavin is being used more frequently for the treatment of therapy-resistant microbial keratitis, since increasing drug resistance and specific pathogens, e."3.80[Corneal cross-linking in microbial keratitis to prevent à chaud keratoplasty: a retrospective case series]. ( Ammermann, C; Cursiefen, C; Hermann, M, 2014)
"The objective of the present study was to evaluate the effectiveness of topically applied gemifloxacin for the treatment of experimental Staphylococcus aureus keratitis in a rabbit model."3.78Efficacy of gemifloxacin for the treatment of experimental Staphylococcus aureus keratitis. ( Chen, H; Jiang, H; Liu, T; Song, Z; Wu, X; Xu, Y; Yang, L; Yue, W, 2012)
"5% levofloxacin in rabbits, and to determine its improved efficacy against experimental keratitis."3.76Novel mucoadhesive polysaccharide isolated from Bletilla striata improves the intraocular penetration and efficacy of levofloxacin in the topical treatment of experimental bacterial keratitis. ( Chen, H; Jiang, HR; Wu, XG; Xin, M; Yang, LN, 2010)
"Six cases of microbial keratitis treated with multiple topical medications, including topical ofloxacin, resulted in corneal precipitates and poor wound healing."3.74Corneal deposits and topical ofloxacin--the effect of polypharmacy in the management of microbial keratitis. ( McElvanney, A; Mitra, A; Tsesmetzoglou, E, 2007)
"In the rabbit keratitis model, the ocular inflammation was significantly reduced by gatifloxacin as compared to levofloxacin but there was no significant difference between the groups in the number of viable bacteria."3.74Immunomodulatory effect of gatifloxacin on mouse peritoneal macrophages in vitro and in models of endotoxin-induced rat conjunctivitis and rabbit bacterial keratitis. ( Inoue, T; Kida, T; Naka, H; Sakaki, H; Tokushige, H; Wada, T, 2008)
"Taurolidine is a broad-spectrum, non antibiotic antimicrobial agent, not previously tested against the common causes of bacterial keratitis."3.73Effectiveness of topical taurolidine versus ciprofloxacin, ofloxacin, and fortified cefazolin in a rabbit Staphylococcus aureus keratitis model. ( Gurkan, T; Oguz, E; Oguz, H; Ozbilge, H, 2005)
"3% ofloxacin solution) on methicillin-resistant Staphylococcus aureus (MRSA) keratitis were compared in a rabbit model."3.73Antibiotic effects of WP-0405, a thermo-setting ofloxacin gel, on methicillin-resistant Staphylococcus aureus keratitis in rabbits. ( Fukaya, Y; Hirata, H; Kamata, Y; Kambara, Y; Kurasawa, N; Kurita, A; Naito, A; Nakaya, S; Ohashi, Y; Sato, M; Shirasawa, E; Toyoda, Y; Tsuruga, H; Wada, T, 2006)
"The purpose of this study was to quantitatively compare, in a rabbit keratitis model, the levels of effectiveness of moxifloxacin, levofloxacin, and ciprofloxacin for the treatment of Staphylococcus aureus isolates of diverse antibiotic susceptibilities."3.72Effectiveness of ciprofloxacin, levofloxacin, or moxifloxacin for treatment of experimental Staphylococcus aureus keratitis. ( Dajcs, JJ; Girgis, DO; Marquart, ME; O'Callaghan, RJ; Thibodeaux, BA; Traidej, M, 2004)
" In this study we investigate the emergence of fluoroquinolone (ciprofloxacin, levofloxacin) resistance among methicillin-sensitive Staphylococcus aureus isolates from keratitis and conjunctivitis."3.72Ciprofloxacin and levofloxacin resistance among methicillin-sensitive Staphylococcus aureus isolates from keratitis and conjunctivitis. ( Alfonso, EC; Marangon, FB; Miller, D; Muallem, MS; Romano, AC, 2004)
"The fourth-generation fluoroquinolone, gatifloxacin, is an effective prophylaxis against the development of keratitis after lamellar keratectomy in rabbits with an organism resistant to methicillin, levofloxacin, and ciprofloxacin."3.72Fluoroquinolone therapy in multiple-drug resistant staphylococcal keratitis after lamellar keratectomy in a rabbit model. ( Carpenter, TR; Kaufman, MB; McDonnell, PJ; Sarayba, MA; Sweet, PM; Taban, M; Tungsiripat, T, 2003)
"Overall, moxifloxacin was the most effective of the four fluoroquinolones in reducing CFU/cornea in the rabbit model of gram-negative keratitis."3.72Quantitative comparison of fluoroquinolone therapies of experimental gram-negative bacterial keratitis. ( Caballero, AR; Dajcs, JJ; Girgis, DO; Marquart, ME; O'Callaghan, RJ; Thibodeaux, BA, 2004)
"To determine the in vitro efficacy of levofloxacin, ofloxacin, and ciprofloxacin against Streptococcus pneumoniae and Streptococcus viridans isolates recovered from clinical cases of keratitis and endophthalmitis."3.72Comparative in vitro activity of levofloxacin, ofloxacin, and ciprofloxacin against ocular streptococcal isolates. ( Alfonso, EC; Miller, D, 2004)
"Taken together, our susceptibility and time kill data failed to demonstrate convincing differences in the susceptibility of SA and PA keratitis isolates to levofloxacin, ciprofloxacin, and ofloxacin."3.71An in vitro resistance study of levofloxacin, ciprofloxacin, and ofloxacin using keratitis isolates of Staphylococcus aureus and Pseudomonas aeruginosa. ( Gordon, YJ; Husted, RC; Karenchak, LM; Kowalski, RP; Pandya, AN; Ritterband, DC; Romanowski, EG; Shah, MK, 2001)
"Topical treatment of experimental Staphylococcus keratitis with ciprofloxacin-PSS, ciprofloxacin, or ofloxacin was effective."3.70Effectiveness of ciprofloxacin-polystyrene sulfonate (PSS), ciprofloxacin and ofloxacin in a Staphylococcus keratitis model. ( Engel, LS; Green, LC; Hill, JM; Moreau, JM; O'Callaghan, RJ, 1998)
"To compare the antibacterial effect of povidone-iodine (PI) with that of ofloxacin in an experimental model of bacterial keratitis."3.70Effect of topical povidone-iodine versus topical ofloxacin on experimental Staphylococcus keratitis. ( Goldberg, MA; Lustbader, J; MacDowell, AL; Melki, SA; Safar, A; Scharper, M; Scharper, P; Yaghouti, F; Zeligs, B, 2000)
" The combined effects of ovoM and the new quinolone, ofloxacin (OFLX) on experimental Pseudomonas aeruginosa keratitis were investigated."3.69Therapeutic intervention with chicken egg white ovomacroglobulin and a new quinolone on experimental Pseudomonas keratitis. ( Kamata, R; Maeda, H; Matsumoto, K; Miyagawa, S; Okamura, R, 1994)
"Cefazolin resistance was seen in 13."1.72Corynebacterium Keratitis: Pure Versus Mixed Infection and Antibiotic Susceptibility Patterns From Different Tertiary Eye Care Centers. ( Das, S; Gunasekaran, R; Mitra, S; Mohamed, A; Prajna, L; Prajna, NV; Sharma, S; Soni, T, 2022)
"Gatifloxacin showed lower resistance levels than moxifloxacin."1.38[In vitro antibiotic susceptibility to fluoroquinolones]. ( Galvis, V; Rey, JJ; Tello, A; Villareal, D; Wong, CA, 2012)
"Bacterial keratitis is a serious infectious ocular disease requiring prompt treatment to prevent frequent and severe visual disabilities."1.32A mucoadhesive polymer extracted from tamarind seed improves the intraocular penetration and efficacy of rufloxacin in topical treatment of experimental bacterial keratitis. ( Boldrini, E; Campa, M; Celandroni, F; Davini, P; Ghelardi, E; Parisio, E; Salvetti, S; Senesi, S; Tavanti, A, 2004)
"Marginal keratitis is postulated, but not proven, to be caused by an enhanced immune response to Staphylococcus aureus antigens."1.31Dissecting folliculitis of the scalp with marginal keratitis. ( Burrows, NP; Meyer, P; Sivakumaran, S, 2001)

Research

Studies (56)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (14.29)18.2507
2000's29 (51.79)29.6817
2010's15 (26.79)24.3611
2020's4 (7.14)2.80

Authors

AuthorsStudies
Duan, F1
Li, X1
Cai, S1
Xin, G1
Wang, Y1
Du, D1
He, S1
Huang, B1
Guo, X1
Zhao, H1
Zhang, R1
Ma, L1
Liu, Y1
Du, Q1
Wei, Z1
Xing, Z1
Liang, Y1
Wu, X2
Fan, C1
Ji, C1
Zeng, D1
Chen, Q1
He, Y1
Liu, X1
Huang, W1
Soni, T1
Gunasekaran, R1
Das, S1
Mitra, S1
Prajna, NV1
Prajna, L1
Sharma, S1
Mohamed, A1
Pearce, JG1
Essex, RW1
Maddess, T1
Sanap, SN1
Bisen, AC1
Kedar, A1
Yadav, KS1
Krishna, A1
Akhir, A1
Chopra, S1
Mugale, MN1
Bhatta, RS1
Priyadarshini, SR1
Behera, HS1
Sahu, S1
Dutta, A1
Gandhi, P1
Radhakrishnan, N1
Khaitan, I1
Srinivasan, M1
Prajna, VN1
Ubani-Ukoma, U1
Gibson, D1
Schultz, G1
Silva, BO1
Chauhan, A1
Ammermann, C1
Cursiefen, C1
Hermann, M1
Ustündağ-Okur, N2
Gökçe, EH2
Bozbıyık, Dİ2
Eğrilmez, S2
Ozer, O2
Ertan, G2
Chaudhry, NL1
Przybek, J1
Hamilton, A1
Carley, F1
Ranjan, A1
Murthy, SI1
Rathi, VM1
Sangwan, VS1
Scoper, SV1
Elias, JA1
Pandit, RT1
Jhanji, V1
Sharma, N1
Vajpayee, RB1
Jun, EJ1
Chung, SK1
Panagiotopoulos, M1
Sönne, H1
Kamiya, K1
Ikeda, T1
Aizawa, D1
Shimizu, K1
Wu, XG1
Xin, M1
Chen, H2
Yang, LN1
Jiang, HR1
Jiang, H1
Xu, Y1
Yue, W1
Yang, L1
Song, Z1
Liu, T1
Wong, CA1
Galvis, V1
Tello, A1
Villareal, D1
Rey, JJ1
Sotozono, C1
Inagaki, K1
Fujita, A1
Koizumi, N1
Sano, Y1
Inatomi, T1
Kinoshita, S1
Zhang, M1
Hu, Y1
Chen, F1
Holzer, MP1
Sandoval, HP1
Vargas, LG1
Kasper, TJ1
Vroman, DT1
Apple, DJ1
Solomon, KD1
Tungsiripat, T1
Sarayba, MA2
Kaufman, MB1
Sweet, PM2
Taban, M2
Carpenter, TR1
McDonnell, PJ4
Wallin, TR1
Weikert, MP1
Moshirfar, M1
Marangon, FB1
Miller, D2
Muallem, MS1
Romano, AC1
Alfonso, EC2
Dajcs, JJ4
Thibodeaux, BA4
Marquart, ME3
Girgis, DO3
Traidej, M2
O'Callaghan, RJ5
Gris, O1
Güell, JL1
Wolley-Dod, C1
Adán, A1
Solomon, R1
Biser, SA1
Donnenfeld, ED1
Perry, HD1
Doshi, SJ1
Lee, CC1
Caballero, AR2
Ghelardi, E1
Tavanti, A1
Davini, P1
Celandroni, F1
Salvetti, S1
Parisio, E1
Boldrini, E1
Senesi, S1
Campa, M1
Oguz, H2
Ozbilge, H1
Oguz, E1
Gurkan, T1
Shamie, N1
Reiser, BJ1
Graff, JM1
Kesler-Diaz, A1
Osann, KE1
Mitra, A1
Tsesmetzoglou, E1
McElvanney, A1
Mah, FS1
Romanowski, EG2
Dhaliwal, DK1
Yates, KA1
Gordon, YJ3
Fukaya, Y1
Kurita, A1
Tsuruga, H1
Naito, A1
Nakaya, S1
Sato, M1
Kamata, Y1
Hirata, H1
Kambara, Y1
Kurasawa, N1
Wada, T2
Toyoda, Y1
Shirasawa, E1
Ohashi, Y1
Altaie, R1
Fahy, GT1
Cormican, M1
Kida, T1
Inoue, T2
Tokushige, H1
Naka, H1
Sakaki, H1
Hori, Y1
Maeda, N1
Kosaki, R1
Tano, Y1
Diamond, JP1
White, L1
Leeming, JP1
Bing Hoh, H1
Easty, DL1
Miyagawa, S1
Kamata, R1
Matsumoto, K1
Okamura, R1
Maeda, H1
Behrens-Baumann, W1
Kowalski, RP2
Karenchak, LM2
Moreau, JM3
Green, LC1
Engel, LS1
Hill, JM1
Morlet, N1
Minassian, D1
Butcher, J1
Melki, SA1
Safar, A1
Yaghouti, F1
Scharper, P1
Scharper, M1
Zeligs, B1
MacDowell, AL1
Goldberg, MA1
Lustbader, J1
Chang-Godinich, A1
Steinert, RF1
Wu, HK1
Pandya, AN1
Husted, RC1
Ritterband, DC1
Shah, MK1
Sivakumaran, S1
Meyer, P1
Burrows, NP1
Austin, MS1
Stroman, DW2
Schlech, BA1
Ke, TL1
Ohadi, C1
Litwin, KL1
Moreira, H1
Kwitko, S1
Gauderman, WJ1
Gritz, DC2
Gwon, A2
Jones, R1
Lee, TY1
Tang-Liu, D1
Hubbard, BB1

Reviews

2 reviews available for ofloxacin and Keratitis

ArticleYear
The clinical treatment of bacterial keratitis: A review of drop instillation regimes.
    Contact lens & anterior eye : the journal of the British Contact Lens Association, 2022, Volume: 45, Issue:6

    Topics: Ciprofloxacin; Eye Infections, Bacterial; Fluoroquinolones; Humans; Keratitis; Ofloxacin

2022
Review of third-and fourth-generation fluoroquinolones in ophthalmology: in-vitro and in-vivo efficacy.
    Advances in therapy, 2008, Volume: 25, Issue:10

    Topics: Administration, Topical; Anti-Bacterial Agents; Aza Compounds; Endophthalmitis; Fluoroquinolones; Ga

2008

Trials

2 trials available for ofloxacin and Keratitis

ArticleYear
[Clinical investigation of 0.3% levofloxacin eyedrops on the treatment of cases with acute bacterial conjunctivitis and bacterial keratitis].
    Yan ke xue bao = Eye science, 2000, Volume: 16, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Conjunctivitis, Bacterial; Eye Infections, Bacterial

2000
Risk factors for treatment outcome of suspected microbial keratitis. Ofloxacin Study Group.
    The British journal of ophthalmology, 1999, Volume: 83, Issue:9

    Topics: Adolescent; Aged; Aged, 80 and over; Anti-Infective Agents; Cefuroxime; Cephalosporins; Eye Infectio

1999

Other Studies

52 other studies available for ofloxacin and Keratitis

ArticleYear
Haloemodin as novel antibacterial agent inhibiting DNA gyrase and bacterial topoisomerase I.
    Journal of medicinal chemistry, 2014, May-08, Volume: 57, Issue:9

    Topics: Animals; Anti-Bacterial Agents; Emodin; Enterococcus faecium; Keratitis; Methicillin-Resistant Staph

2014
Corynebacterium Keratitis: Pure Versus Mixed Infection and Antibiotic Susceptibility Patterns From Different Tertiary Eye Care Centers.
    Cornea, 2022, Nov-01, Volume: 41, Issue:11

    Topics: Anti-Bacterial Agents; Cefazolin; Ciprofloxacin; Coinfection; Corynebacterium; Eye Infections, Bacte

2022
Chitosan/HPMC-based mucoadhesive film co-loaded with fluconazole and ofloxacin for management of polymicrobial keratitis.
    International journal of biological macromolecules, 2022, Dec-01, Volume: 222, Issue:Pt B

    Topics: Chitosan; Drug Compounding; Drug Delivery Systems; Fluconazole; Humans; Keratitis; Ofloxacin

2022
    BMJ case reports, 2021, Jul-01, Volume: 14, Issue:7

    Topics: Anti-Bacterial Agents; Child; Corynebacterium; Eye Infections, Bacterial; Humans; Keratitis; Male; M

2021
Toxic Keratitis After Application of Custard Apple Seed for Head Lice Infestation.
    Cornea, 2019, Volume: 38, Issue:8

    Topics: Administration, Ophthalmic; Adolescent; Adult; Animals; Annona; Anti-Bacterial Agents; Child; Eye Pa

2019
Evaluating the potential of drug eluting contact lenses for treatment of bacterial keratitis using an ex vivo corneal model.
    International journal of pharmaceutics, 2019, Jun-30, Volume: 565

    Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Contact Lenses, Hydrophilic; Cornea; Drug Delivery S

2019
[Corneal cross-linking in microbial keratitis to prevent à chaud keratoplasty: a retrospective case series].
    Klinische Monatsblatter fur Augenheilkunde, 2014, Volume: 231, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Bacterial Infections; Biological Dressings; C

2014
Preparation and in vitro-in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Oct-15, Volume: 63

    Topics: Animals; Anti-Bacterial Agents; Chitosan; Drug Carriers; Escherichia coli; Hydrogen-Ion Concentratio

2014
Novel nanostructured lipid carrier-based inserts for controlled ocular drug delivery: evaluation of corneal bioavailability and treatment efficacy in bacterial keratitis.
    Expert opinion on drug delivery, 2015, Volume: 12, Issue:11

    Topics: Animals; Biological Availability; Cornea; Drug Delivery Systems; Excipients; Eye Infections, Bacteri

2015
Unique case of palytoxin-related keratitis.
    Clinical & experimental ophthalmology, 2016, Volume: 44, Issue:9

    Topics: Acrylamides; Animals; Anthozoa; Anti-Bacterial Agents; Aquaculture; Cnidarian Venoms; Drug Therapy,

2016
Acute Bilateral Toxic Endotheliitis Following Alcohol Consumption.
    Ocular immunology and inflammation, 2018, Volume: 26, Issue:2

    Topics: Acute Disease; Adult; Alcohol Drinking; Anti-Bacterial Agents; Cataract; Cataract Extraction; Cornea

2018
Primary Neisseria meningitidis Keratitis.
    Cornea, 2009, Volume: 28, Issue:6

    Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents; Drug Administration Schedule; Drug Therapy,

2009
Intraoperative perforation of Descemet's membrane during "big bubble" deep anterior lamellar keratoplasty.
    International ophthalmology, 2010, Volume: 30, Issue:3

    Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents; Child; Corneal Diseases; Corneal Transplanta

2010
Toxic anterior segment syndrome after cataract surgery.
    Journal of cataract and refractive surgery, 2010, Volume: 36, Issue:2

    Topics: Aged; Anterior Eye Segment; Corneal Edema; Drug Therapy, Combination; Endotoxins; Female; Humans; Ke

2010
Chronic granulomatous disease and serious unilateral keratitis with bilateral conjunctivitis: a rare case of external ocular disease.
    Acta ophthalmologica, 2011, Volume: 89, Issue:3

    Topics: Adult; Colitis, Ulcerative; Conjunctivitis; Dexamethasone; Drug Therapy, Combination; Functional Lat

2011
A case of late-onset diffuse lamellar keratitis 12 years after laser in situ keratomileusis.
    Japanese journal of ophthalmology, 2010, Volume: 54, Issue:2

    Topics: Betamethasone; Cornea; Drug Therapy, Combination; Humans; Keratitis; Keratomileusis, Laser In Situ;

2010
Novel mucoadhesive polysaccharide isolated from Bletilla striata improves the intraocular penetration and efficacy of levofloxacin in the topical treatment of experimental bacterial keratitis.
    The Journal of pharmacy and pharmacology, 2010, Volume: 62, Issue:9

    Topics: Absorption; Administration, Topical; Animals; Anti-Bacterial Agents; Aqueous Humor; Bacterial Load;

2010
Efficacy of gemifloxacin for the treatment of experimental Staphylococcus aureus keratitis.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2012, Volume: 28, Issue:4

    Topics: Animals; Anti-Infective Agents, Local; Colony Count, Microbial; Conjunctival Diseases; Cornea; Eye;

2012
[In vitro antibiotic susceptibility to fluoroquinolones].
    Archivos de la Sociedad Espanola de Oftalmologia, 2012, Volume: 87, Issue:3

    Topics: Acanthamoeba Keratitis; Anti-Bacterial Agents; Aza Compounds; Body Fluids; Ciprofloxacin; Colombia;

2012
Methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis infections in the cornea.
    Cornea, 2002, Volume: 21, Issue:7 Suppl

    Topics: Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Child; Dibekacin; Eye Infections, Bacterial; Fe

2002
Corneal flap complications in refractive surgery: Part 2: postoperative treatments of diffuse lamellar keratitis in an experimental animal model.
    Journal of cataract and refractive surgery, 2003, Volume: 29, Issue:4

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Corneal Stroma; Disease Mod

2003
Fluoroquinolone therapy in multiple-drug resistant staphylococcal keratitis after lamellar keratectomy in a rabbit model.
    American journal of ophthalmology, 2003, Volume: 136, Issue:1

    Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Colony Count, Microbial; Corneal Stroma; Disease Mode

2003
Effect of flap hinge placement on post-laser in situ keratomileusis wound healing in the presence of superior corneal vascularization.
    Journal of cataract and refractive surgery, 2003, Volume: 29, Issue:12

    Topics: Adult; Anti-Infective Agents; Corneal Edema; Corneal Neovascularization; Corneal Stroma; Corneal Top

2003
Ciprofloxacin and levofloxacin resistance among methicillin-sensitive Staphylococcus aureus isolates from keratitis and conjunctivitis.
    American journal of ophthalmology, 2004, Volume: 137, Issue:3

    Topics: Anti-Infective Agents; Ciprofloxacin; Conjunctivitis, Bacterial; Cross-Sectional Studies; Drug Resis

2004
Comparative in vitro activity of levofloxacin, ofloxacin, and ciprofloxacin against ocular streptococcal isolates.
    Cornea, 2004, Volume: 23, Issue:3

    Topics: Anti-Infective Agents; Ciprofloxacin; Endophthalmitis; Humans; Keratitis; Levofloxacin; Microbial Se

2004
Effectiveness of ciprofloxacin, levofloxacin, or moxifloxacin for treatment of experimental Staphylococcus aureus keratitis.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:6

    Topics: Animals; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Cornea; Drug Resistance, Bacterial; Fl

2004
Diffuse lamellar keratitis and corneal edema associated with viral keratoconjunctivitis 2 years after laser in situ keratomileusis.
    Journal of cataract and refractive surgery, 2004, Volume: 30, Issue:6

    Topics: Adenovirus Infections, Human; Anti-Infective Agents; Astigmatism; Conjunctivitis, Viral; Corneal Ede

2004
Candida parapsilosis keratitis following treatment of epithelial ingrowth after laser in situ keratomileusis.
    Eye & contact lens, 2004, Volume: 30, Issue:2

    Topics: Amphotericin B; Antifungal Agents; Candidiasis; Debridement; Drug Therapy, Combination; Epithelium,

2004
Quantitative comparison of fluoroquinolone therapies of experimental gram-negative bacterial keratitis.
    Current eye research, 2004, Volume: 28, Issue:5

    Topics: Animals; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Colony Count, Microbial; Cornea; Eye I

2004
A mucoadhesive polymer extracted from tamarind seed improves the intraocular penetration and efficacy of rufloxacin in topical treatment of experimental bacterial keratitis.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:9

    Topics: Adhesives; Administration, Topical; Animals; Anti-Bacterial Agents; Chemistry, Pharmaceutical; Colon

2004
Effectiveness of topical taurolidine versus ciprofloxacin, ofloxacin, and fortified cefazolin in a rabbit Staphylococcus aureus keratitis model.
    Current eye research, 2005, Volume: 30, Issue:3

    Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Cefazolin; Ciprofloxacin; Colony Cou

2005
Fluoroquinolone therapy in Mycobacterium chelonae keratitis after lamellar keratectomy.
    Journal of cataract and refractive surgery, 2005, Volume: 31, Issue:7

    Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Colony Count, Microbial; Cornea; Corneal Transplantat

2005
Corneal deposits and topical ofloxacin--the effect of polypharmacy in the management of microbial keratitis.
    Eye (London, England), 2007, Volume: 21, Issue:3

    Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Corne

2007
Role of topical fluoroquinolones on the pathogenesis of diffuse lamellar keratitis in experimental in vivo studies.
    Journal of cataract and refractive surgery, 2006, Volume: 32, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Corneal Stroma; Disease Models, Animal; Endotoxins; F

2006
Antibiotic effects of WP-0405, a thermo-setting ofloxacin gel, on methicillin-resistant Staphylococcus aureus keratitis in rabbits.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2006, Volume: 22, Issue:4

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Aqueous Humor; Biological Availability; Cil

2006
Failure of Listeria monocytogenes keratitis to respond to topical ofloxacin.
    Cornea, 2006, Volume: 25, Issue:7

    Topics: Adolescent; Anti-Bacterial Agents; Cornea; Drug Resistance, Bacterial; Eye Infections, Bacterial; Hu

2006
Cytotoxic effects of the fluoroquinolone ofloxacin on stromal keratocytes.
    Cornea, 2007, Volume: 26, Issue:2

    Topics: Animals; Anti-Infective Agents; Corneal Stroma; Disease Models, Animal; Eye Infections, Bacterial; H

2007
Immunomodulatory effect of gatifloxacin on mouse peritoneal macrophages in vitro and in models of endotoxin-induced rat conjunctivitis and rabbit bacterial keratitis.
    Ophthalmic research, 2008, Volume: 40, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Aza Compounds; Cells, Cultured; Conjunctivitis; Endotoxins; Fluor

2008
Three cases of idiopathic "multiple-parallel-line" endotheliitis.
    Cornea, 2008, Volume: 27, Issue:1

    Topics: Aged; Anti-Bacterial Agents; Betamethasone; Drug Therapy, Combination; Endothelium, Corneal; Glucoco

2008
Topical 0.3% ciprofloxacin, norfloxacin, and ofloxacin in treatment of bacterial keratitis: a new method for comparative evaluation of ocular drug penetration.
    The British journal of ophthalmology, 1995, Volume: 79, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Chromatography, High Pressure Liquid; Ciprofloxac

1995
Therapeutic intervention with chicken egg white ovomacroglobulin and a new quinolone on experimental Pseudomonas keratitis.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1994, Volume: 232, Issue:8

    Topics: alpha-Macroglobulins; Animals; Cathepsin G; Cathepsins; Egg Proteins, Dietary; Eye Infections, Bacte

1994
Absorption of topically administered ciprofloxacin, ofloxacin and gentamicin in the inflamed rabbit eye.
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1996, Volume: 210, Issue:2

    Topics: Absorption; Administration, Topical; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Aqueous

1996
Comparison of ciprofloxacin and ofloxacin using human corneal susceptibility levels.
    Cornea, 1998, Volume: 17, Issue:3

    Topics: Anti-Infective Agents; Biological Availability; Ciprofloxacin; Colony Count, Microbial; Cornea; Gram

1998
Effectiveness of ciprofloxacin-polystyrene sulfonate (PSS), ciprofloxacin and ofloxacin in a Staphylococcus keratitis model.
    Current eye research, 1998, Volume: 17, Issue:8

    Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Colony Count, Microbial; Cornea; Disease Models, Anim

1998
Effect of topical povidone-iodine versus topical ofloxacin on experimental Staphylococcus keratitis.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2000, Volume: 238, Issue:5

    Topics: Animals; Anti-Infective Agents; Colony Count, Microbial; Cornea; Disease Models, Animal; Eye Infecti

2000
Late occurrence of diffuse lamellar keratitis after laser in situ keratomileusis.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2001, Volume: 119, Issue:7

    Topics: Anti-Infective Agents; Cornea; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Keratitis

2001
An in vitro resistance study of levofloxacin, ciprofloxacin, and ofloxacin using keratitis isolates of Staphylococcus aureus and Pseudomonas aeruginosa.
    Ophthalmology, 2001, Volume: 108, Issue:10

    Topics: Anti-Infective Agents; Ciprofloxacin; Colony Count, Microbial; Drug Resistance, Microbial; Eye Infec

2001
Dissecting folliculitis of the scalp with marginal keratitis.
    Clinical and experimental dermatology, 2001, Volume: 26, Issue:6

    Topics: Administration, Topical; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agen

2001
Effectiveness of ciprofloxacin and ofloxacin in a prophylaxis model of Staphylococcus keratitis.
    Cornea, 2001, Volume: 20, Issue:8

    Topics: Animals; Anti-Infective Agents; Antibiotic Prophylaxis; Ciprofloxacin; Colony Count, Microbial; Corn

2001
The effectiveness of tobramycin and Ocuflox in a prophylaxis model of Staphylococcus keratitis.
    Current eye research, 2001, Volume: 23, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Colony Count, Microbi

2001
Anti-inflammatory therapy and outcome in a guinea pig model of Pseudomonas keratitis.
    Cornea, 1992, Volume: 11, Issue:5

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dicarboxylic Acids; Disease

1992
Topical ofloxacin in the treatment of Pseudomonas keratitis in a rabbit model.
    Cornea, 1992, Volume: 11, Issue:2

    Topics: Administration, Topical; Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Disease Model

1992