ofloxacin and Infections, Staphylococcal studies

Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

Research Excerpts

Excerpt	Relevance	Reference
"Levofloxacin is a synthetic fluoroquinolone that is usually used to treat chronic bacterial prostatitis."	9.16	Safety and efficacy of levofloxacin versus ciprofloxacin for the treatment of chronic bacterial prostatitis in Chinese patients. ( Guo, YL; Jin, FS; Liu, DM; Shen, ZJ; Sun, YH; Zhang, ZC, 2012)
"The authors had for aim to evaluate the efficacy and tolerance of oral levofloxacin (500 mg once a day during ten days), as a treatment for acute bacterial sinusitis at risk for complications in adult patients."	9.11	[Levofloxacin in the treatment of acute and bacteriologically documented sinusitis with high risk of complications]. ( Gehanno, P; Pessey, JJ; Serrano, E, 2005)
"The objective of this open-label, single-arm, multicenter study was to assess the efficacy and safety of levofloxacin in the treatment of complicated urinary tract infections."	9.10	[Multicentric study for evaluation of levofloxacin in the treatment of complicated urinary tract infections]. ( Marchetti, F; Trinchieri, A, 2003)
"Comparison of efficacy and safety of sparfloxacin vs ofloxacin for treatment of acute bacterial exacerbations of chronic bronchitis (ABECB)."	9.08	Sparfloxacin vs ofloxacin in the treatment of acute bacterial exacerbations of chronic bronchitis: a multicenter, double-blind, randomized, comparative study. Sparfloxacin Multicenter ABECB Study Group. ( Bensch, G; Chodosh, S; DeAbate, CA; Harper, L; Henry, D; Jubran, A; Talbot, GH; Tipping, D, 1998)
"The experience with lomefloxacin and ofloxacin respectively in the complex therapy of 26 and 40 patients with burns is described."	9.08	[Efficacy of lomefloxacin and ofloxacin in complex therapy of infections in patients with burns]. ( Alekseev, AA; Bobrovnikov, AE; Elagina, LV; Grishina, IA; Iakovlev, VP; Izotova, GN; Krutikov, MG, 1998)
" To this day, no other case of prostatic abscess due to this strain but susceptible to methicillin has been described."	7.80	Prostatic abscesses and severe sepsis due to methicillin-susceptible Staphylococcus aureus producing Panton-Valentine leukocidin. ( Barraud, O; Brakbi, Y; Cypierre, A; Dubos, M; Fedou, AL; François, B; Fredon, F; Laurent, F, 2014)
"We investigated whether the foldable capsular vitreous body (FCVB) could release levofloxacin sustainably in vitro and inhibit endophthalmitis in rabbit models."	7.79	A preliminary study to treat severe endophthalmitis via a foldable capsular vitreous body with sustained levofloxacin release in rabbits. ( Feng, L; Gao, Q; Huang, X; Jiang, Z; Li, Y; Lin, J; Lin, X; Liu, Y; Wang, T; Xie, Z, 2013)
"The objective of the present study was to evaluate the effectiveness of topically applied gemifloxacin for the treatment of experimental Staphylococcus aureus keratitis in a rabbit model."	7.78	Efficacy of gemifloxacin for the treatment of experimental Staphylococcus aureus keratitis. ( Chen, H; Jiang, H; Liu, T; Song, Z; Wu, X; Xu, Y; Yang, L; Yue, W, 2012)
"The aim of this prospective observational study was to present relevant data on the efficacy and safety of levofloxacin in the treatment of chronic bacterial prostatitis (NIH-II) in the daily clinical routine of urologists in their practices."	7.77	[Practice management of chronic bacterial prostatitis with levofloxacin]. ( Naber, KG; Roscher, K; Wagenlehner, F, 2011)
"5% levofloxacin in rabbits, and to determine its improved efficacy against experimental keratitis."	7.76	Novel mucoadhesive polysaccharide isolated from Bletilla striata improves the intraocular penetration and efficacy of levofloxacin in the topical treatment of experimental bacterial keratitis. ( Chen, H; Jiang, HR; Wu, XG; Xin, M; Yang, LN, 2010)
"In the rabbit keratitis model, the ocular inflammation was significantly reduced by gatifloxacin as compared to levofloxacin but there was no significant difference between the groups in the number of viable bacteria."	7.74	Immunomodulatory effect of gatifloxacin on mouse peritoneal macrophages in vitro and in models of endotoxin-induced rat conjunctivitis and rabbit bacterial keratitis. ( Inoue, T; Kida, T; Naka, H; Sakaki, H; Tokushige, H; Wada, T, 2008)
"5% levofloxacin versus combined treatment with vancomycin and ceftazidime in an experimental model of bacterial endophthalmitis."	7.74	Bactericidal effect of intravitreal levofloxacin in an experimental model of endophthalmitis. ( Abad, JL; Alió, JL; Fernandez, J; Ferrer, C; Rodríguez, A, 2008)
"Taurolidine is a broad-spectrum, non antibiotic antimicrobial agent, not previously tested against the common causes of bacterial keratitis."	7.73	Effectiveness of topical taurolidine versus ciprofloxacin, ofloxacin, and fortified cefazolin in a rabbit Staphylococcus aureus keratitis model. ( Gurkan, T; Oguz, E; Oguz, H; Ozbilge, H, 2005)
"3% ofloxacin solution) on methicillin-resistant Staphylococcus aureus (MRSA) keratitis were compared in a rabbit model."	7.73	Antibiotic effects of WP-0405, a thermo-setting ofloxacin gel, on methicillin-resistant Staphylococcus aureus keratitis in rabbits. ( Fukaya, Y; Hirata, H; Kamata, Y; Kambara, Y; Kurasawa, N; Kurita, A; Naito, A; Nakaya, S; Ohashi, Y; Sato, M; Shirasawa, E; Toyoda, Y; Tsuruga, H; Wada, T, 2006)
" In this study we investigate the emergence of fluoroquinolone (ciprofloxacin, levofloxacin) resistance among methicillin-sensitive Staphylococcus aureus isolates from keratitis and conjunctivitis."	7.72	Ciprofloxacin and levofloxacin resistance among methicillin-sensitive Staphylococcus aureus isolates from keratitis and conjunctivitis. ( Alfonso, EC; Marangon, FB; Miller, D; Muallem, MS; Romano, AC, 2004)
"The purpose of this study was to quantitatively compare, in a rabbit keratitis model, the levels of effectiveness of moxifloxacin, levofloxacin, and ciprofloxacin for the treatment of Staphylococcus aureus isolates of diverse antibiotic susceptibilities."	7.72	Effectiveness of ciprofloxacin, levofloxacin, or moxifloxacin for treatment of experimental Staphylococcus aureus keratitis. ( Dajcs, JJ; Girgis, DO; Marquart, ME; O'Callaghan, RJ; Thibodeaux, BA; Traidej, M, 2004)
"Methicillin-susceptible Staphylococcus aureus (MSSA) is the most common pathogen recovered from osteomyelitis patients."	7.71	Comparative evaluation of oral levofloxacin and parenteral nafcillin in the treatment of experimental methicillin-susceptible Staphylococcus aureus osteomyelitis in rabbits. ( Calhoun, JH; Mader, JT; Shirtliff, ME, 2001)
"To compare the antibacterial effect of povidone-iodine (PI) with that of ofloxacin in an experimental model of bacterial keratitis."	7.70	Effect of topical povidone-iodine versus topical ofloxacin on experimental Staphylococcus keratitis. ( Goldberg, MA; Lustbader, J; MacDowell, AL; Melki, SA; Safar, A; Scharper, M; Scharper, P; Yaghouti, F; Zeligs, B, 2000)
" This study, employing an experimental rabbit model of Staphylococcus keratitis, compared the effectiveness of two commonly prescribed formulations of fluoroquinolones to an experimental formulation, ciprofloxacin with polystyrene sulfonate (ciprofloxacin-PSS)."	7.70	Effectiveness of ciprofloxacin-polystyrene sulfonate (PSS), ciprofloxacin and ofloxacin in a Staphylococcus keratitis model. ( Engel, LS; Green, LC; Hill, JM; Moreau, JM; O'Callaghan, RJ, 1998)
"We investigated the use of an ofloxacin-impregnated bioabsorbable composite for the prevention of acute Staphylococcus aureus osteomyelitis."	7.70	Prophylaxis of acute osteomyelitis with absorbable ofloxacin-impregnated beads. ( Kourea, HP; Nicolau, DP; Nie, L; Nightingale, CH; Tessier, PR, 1998)
"The therapeutic effects of nimodipine (CAS 66085-59-4) and ofloxacin (CAS 82419-36-1) were investigated against experimental brain abscess formation in rats."	7.69	Effects of nimodipine and ofloxacin on staphylococcal brain abscesses in rats. ( Ceviz, A; Ciçek, R; Gül, K; Inalöz, SS; Sanli, A; Sari, I, 1997)
"We studied the efficacies of ofloxacin, rifampin, and clindamycin in a Staphylococcus aureus abscess model and seven antimicrobial regimens in an intracellular killing assay."	7.69	Efficacies of ofloxacin, rifampin, and clindamycin in treatment of Staphylococcus aureus abscesses and correlation with results of an in vitro assay of intracellular bacterial killing. ( Bamberger, DM; Chern, RP; Dew, M; Herndon, BL; Kim, SC; Marcus, RF; Mitchell, H; Summers, LE; Suvarna, PR, 1997)
" In a murine model of hematogenous pyelonephritis, the in vivo efficacies of levofloxacin and ciprofloxacin were evaluated against two methicillin-susceptible and two methicillin-resistant S."	7.69	In vivo efficacies of levofloxacin and ciprofloxacin in acute murine hematogenous pyelonephritis induced by methicillin-susceptible and-resistant Staphylococcus aureus strains. ( Barrett, JF; Frosco, MB; Kulwich, BA; Licata, L; Melton, JL; Stewart, FP, 1996)
"Eighteen episodes of peritonitis in 16 CAPD patients were treated with oral ofloxacin 400 mg initially, followed by 300 mg daily for a total of 10 days."	7.67	Oral treatment of peritonitis in CAPD patients with ofloxacin. ( Chan, MK; Chan, WW; Chau, PY, 1988)
"The study shows that it is possible to treat complicated urinary tract infections just as successfully with 200 mg i."	6.67	Comparison of i.v. ofloxacin and piperacillin in the treatment of complicated urinary tract infections. ( Schalkhäuser, K, 1990)
"Bacterial keratitis is a serious infectious ocular disease requiring prompt treatment to prevent frequent and severe visual disabilities."	5.32	A mucoadhesive polymer extracted from tamarind seed improves the intraocular penetration and efficacy of rufloxacin in topical treatment of experimental bacterial keratitis. ( Boldrini, E; Campa, M; Celandroni, F; Davini, P; Ghelardi, E; Parisio, E; Salvetti, S; Senesi, S; Tavanti, A, 2004)
"Levofloxacin is a synthetic fluoroquinolone that is usually used to treat chronic bacterial prostatitis."	5.16	Safety and efficacy of levofloxacin versus ciprofloxacin for the treatment of chronic bacterial prostatitis in Chinese patients. ( Guo, YL; Jin, FS; Liu, DM; Shen, ZJ; Sun, YH; Zhang, ZC, 2012)
"The authors had for aim to evaluate the efficacy and tolerance of oral levofloxacin (500 mg once a day during ten days), as a treatment for acute bacterial sinusitis at risk for complications in adult patients."	5.11	[Levofloxacin in the treatment of acute and bacteriologically documented sinusitis with high risk of complications]. ( Gehanno, P; Pessey, JJ; Serrano, E, 2005)
"The objective of this open-label, single-arm, multicenter study was to assess the efficacy and safety of levofloxacin in the treatment of complicated urinary tract infections."	5.10	[Multicentric study for evaluation of levofloxacin in the treatment of complicated urinary tract infections]. ( Marchetti, F; Trinchieri, A, 2003)
"Levofloxacin is a useful quinolone for patients infected with osteomyelitis or tuberculosis."	5.09	[Tolerability and safety of levofloxacinin long-term treatment]. ( Almela, M; Alvárez, JL; García, S; Mensa, J; Ortega, M; Soriano, A; Soriano, E; Tomás, X, 2000)
"Ofloxacin and combined fortified tobramycin and cefazolin topical drops were comparable for treating cases of bacterial corneal ulcer."	5.09	Comparison of topical 0.3% ofloxacin with fortified tobramycin plus cefazolin in the treatment of bacterial keratitis. ( Ahuja, R; Panda, A; Sastry, SS, 1999)
"The experience with lomefloxacin and ofloxacin respectively in the complex therapy of 26 and 40 patients with burns is described."	5.08	[Efficacy of lomefloxacin and ofloxacin in complex therapy of infections in patients with burns]. ( Alekseev, AA; Bobrovnikov, AE; Elagina, LV; Grishina, IA; Iakovlev, VP; Izotova, GN; Krutikov, MG, 1998)
"Comparison of efficacy and safety of sparfloxacin vs ofloxacin for treatment of acute bacterial exacerbations of chronic bronchitis (ABECB)."	5.08	Sparfloxacin vs ofloxacin in the treatment of acute bacterial exacerbations of chronic bronchitis: a multicenter, double-blind, randomized, comparative study. Sparfloxacin Multicenter ABECB Study Group. ( Bensch, G; Chodosh, S; DeAbate, CA; Harper, L; Henry, D; Jubran, A; Talbot, GH; Tipping, D, 1998)
" To this day, no other case of prostatic abscess due to this strain but susceptible to methicillin has been described."	3.80	Prostatic abscesses and severe sepsis due to methicillin-susceptible Staphylococcus aureus producing Panton-Valentine leukocidin. ( Barraud, O; Brakbi, Y; Cypierre, A; Dubos, M; Fedou, AL; François, B; Fredon, F; Laurent, F, 2014)
"We investigated whether the foldable capsular vitreous body (FCVB) could release levofloxacin sustainably in vitro and inhibit endophthalmitis in rabbit models."	3.79	A preliminary study to treat severe endophthalmitis via a foldable capsular vitreous body with sustained levofloxacin release in rabbits. ( Feng, L; Gao, Q; Huang, X; Jiang, Z; Li, Y; Lin, J; Lin, X; Liu, Y; Wang, T; Xie, Z, 2013)
"The objective of the present study was to evaluate the effectiveness of topically applied gemifloxacin for the treatment of experimental Staphylococcus aureus keratitis in a rabbit model."	3.78	Efficacy of gemifloxacin for the treatment of experimental Staphylococcus aureus keratitis. ( Chen, H; Jiang, H; Liu, T; Song, Z; Wu, X; Xu, Y; Yang, L; Yue, W, 2012)
"The aim of this prospective observational study was to present relevant data on the efficacy and safety of levofloxacin in the treatment of chronic bacterial prostatitis (NIH-II) in the daily clinical routine of urologists in their practices."	3.77	[Practice management of chronic bacterial prostatitis with levofloxacin]. ( Naber, KG; Roscher, K; Wagenlehner, F, 2011)
"5% levofloxacin in rabbits, and to determine its improved efficacy against experimental keratitis."	3.76	Novel mucoadhesive polysaccharide isolated from Bletilla striata improves the intraocular penetration and efficacy of levofloxacin in the topical treatment of experimental bacterial keratitis. ( Chen, H; Jiang, HR; Wu, XG; Xin, M; Yang, LN, 2010)
"5% levofloxacin versus combined treatment with vancomycin and ceftazidime in an experimental model of bacterial endophthalmitis."	3.74	Bactericidal effect of intravitreal levofloxacin in an experimental model of endophthalmitis. ( Abad, JL; Alió, JL; Fernandez, J; Ferrer, C; Rodríguez, A, 2008)
"In the rabbit keratitis model, the ocular inflammation was significantly reduced by gatifloxacin as compared to levofloxacin but there was no significant difference between the groups in the number of viable bacteria."	3.74	Immunomodulatory effect of gatifloxacin on mouse peritoneal macrophages in vitro and in models of endotoxin-induced rat conjunctivitis and rabbit bacterial keratitis. ( Inoue, T; Kida, T; Naka, H; Sakaki, H; Tokushige, H; Wada, T, 2008)
"In vitro evidence of synergy between glycopeptides, fluoroquinolones (levofloxacin) and beta-lactams and of reduction of mutational frequencies by combinations are suggestive for a potential role in empirical therapy of severe pneumonia with suspected MRSA etiology."	3.74	In vitro evaluation of antibiotics' combinations for empirical therapy of suspected methicillin resistant Staphylococcus aureus severe respiratory infections. ( De Vecchi, E; Drago, L; Gismondo, MR; Nicola, L, 2007)
" Recently, the use of high doses of levofloxacin with rifampin has been recommended for staphylococcal infections."	3.73	Efficacy of high doses of levofloxacin in experimental foreign-body infection by methicillin-susceptible Staphylococcus aureus. ( Ariza, J; Cabellos, C; Doménech, A; Garcia, A; Gudiol, F; Murillo, O; Tubau, F, 2006)
"3% ofloxacin solution) on methicillin-resistant Staphylococcus aureus (MRSA) keratitis were compared in a rabbit model."	3.73	Antibiotic effects of WP-0405, a thermo-setting ofloxacin gel, on methicillin-resistant Staphylococcus aureus keratitis in rabbits. ( Fukaya, Y; Hirata, H; Kamata, Y; Kambara, Y; Kurasawa, N; Kurita, A; Naito, A; Nakaya, S; Ohashi, Y; Sato, M; Shirasawa, E; Toyoda, Y; Tsuruga, H; Wada, T, 2006)
"Taurolidine is a broad-spectrum, non antibiotic antimicrobial agent, not previously tested against the common causes of bacterial keratitis."	3.73	Effectiveness of topical taurolidine versus ciprofloxacin, ofloxacin, and fortified cefazolin in a rabbit Staphylococcus aureus keratitis model. ( Gurkan, T; Oguz, E; Oguz, H; Ozbilge, H, 2005)
"The purpose of this study was to quantitatively compare, in a rabbit keratitis model, the levels of effectiveness of moxifloxacin, levofloxacin, and ciprofloxacin for the treatment of Staphylococcus aureus isolates of diverse antibiotic susceptibilities."	3.72	Effectiveness of ciprofloxacin, levofloxacin, or moxifloxacin for treatment of experimental Staphylococcus aureus keratitis. ( Dajcs, JJ; Girgis, DO; Marquart, ME; O'Callaghan, RJ; Thibodeaux, BA; Traidej, M, 2004)
" In this study we investigate the emergence of fluoroquinolone (ciprofloxacin, levofloxacin) resistance among methicillin-sensitive Staphylococcus aureus isolates from keratitis and conjunctivitis."	3.72	Ciprofloxacin and levofloxacin resistance among methicillin-sensitive Staphylococcus aureus isolates from keratitis and conjunctivitis. ( Alfonso, EC; Marangon, FB; Miller, D; Muallem, MS; Romano, AC, 2004)
"The fourth-generation fluoroquinolone, gatifloxacin, is an effective prophylaxis against the development of keratitis after lamellar keratectomy in rabbits with an organism resistant to methicillin, levofloxacin, and ciprofloxacin."	3.72	Fluoroquinolone therapy in multiple-drug resistant staphylococcal keratitis after lamellar keratectomy in a rabbit model. ( Carpenter, TR; Kaufman, MB; McDonnell, PJ; Sarayba, MA; Sweet, PM; Taban, M; Tungsiripat, T, 2003)
"Methicillin-susceptible Staphylococcus aureus (MSSA) is the most common pathogen recovered from osteomyelitis patients."	3.71	Comparative evaluation of oral levofloxacin and parenteral nafcillin in the treatment of experimental methicillin-susceptible Staphylococcus aureus osteomyelitis in rabbits. ( Calhoun, JH; Mader, JT; Shirtliff, ME, 2001)
" This study, employing an experimental rabbit model of Staphylococcus keratitis, compared the effectiveness of two commonly prescribed formulations of fluoroquinolones to an experimental formulation, ciprofloxacin with polystyrene sulfonate (ciprofloxacin-PSS)."	3.70	Effectiveness of ciprofloxacin-polystyrene sulfonate (PSS), ciprofloxacin and ofloxacin in a Staphylococcus keratitis model. ( Engel, LS; Green, LC; Hill, JM; Moreau, JM; O'Callaghan, RJ, 1998)
"Vitreous levels of ofloxacin were above the MIC(90) at 2 and 8 h in all groups for most of the common microorganisms causing endophthalmitis and also at 24 h in traumatized-infected eyes."	3.70	Ofloxacin levels after intravitreal injection. Effects of trauma and inflammation. ( Basci, NE; Bozkurt, A; Kortunay, S; Kurt, E; Oguz Kayaalp, S; Oztürk, F; Sami Ilker, S; Ubeyt Inan, U, 1999)
"To compare the antibacterial effect of povidone-iodine (PI) with that of ofloxacin in an experimental model of bacterial keratitis."	3.70	Effect of topical povidone-iodine versus topical ofloxacin on experimental Staphylococcus keratitis. ( Goldberg, MA; Lustbader, J; MacDowell, AL; Melki, SA; Safar, A; Scharper, M; Scharper, P; Yaghouti, F; Zeligs, B, 2000)
"We investigated the use of an ofloxacin-impregnated bioabsorbable composite for the prevention of acute Staphylococcus aureus osteomyelitis."	3.70	Prophylaxis of acute osteomyelitis with absorbable ofloxacin-impregnated beads. ( Kourea, HP; Nicolau, DP; Nie, L; Nightingale, CH; Tessier, PR, 1998)
" In a murine model of hematogenous pyelonephritis, the in vivo efficacies of levofloxacin and ciprofloxacin were evaluated against two methicillin-susceptible and two methicillin-resistant S."	3.69	In vivo efficacies of levofloxacin and ciprofloxacin in acute murine hematogenous pyelonephritis induced by methicillin-susceptible and-resistant Staphylococcus aureus strains. ( Barrett, JF; Frosco, MB; Kulwich, BA; Licata, L; Melton, JL; Stewart, FP, 1996)
"We studied the efficacies of ofloxacin, rifampin, and clindamycin in a Staphylococcus aureus abscess model and seven antimicrobial regimens in an intracellular killing assay."	3.69	Efficacies of ofloxacin, rifampin, and clindamycin in treatment of Staphylococcus aureus abscesses and correlation with results of an in vitro assay of intracellular bacterial killing. ( Bamberger, DM; Chern, RP; Dew, M; Herndon, BL; Kim, SC; Marcus, RF; Mitchell, H; Summers, LE; Suvarna, PR, 1997)
"The therapeutic effects of nimodipine (CAS 66085-59-4) and ofloxacin (CAS 82419-36-1) were investigated against experimental brain abscess formation in rats."	3.69	Effects of nimodipine and ofloxacin on staphylococcal brain abscesses in rats. ( Ceviz, A; Ciçek, R; Gül, K; Inalöz, SS; Sanli, A; Sari, I, 1997)
"Ofloxacine (Tarivid-Hoechst) was used in 30 patients with infections of the respiratory system, including 12 with pneumonias, 18 with chronic bronchitis."	3.68	[Evaluation of the effectiveness of ofloxacin in the treatment of respiratory tract]. ( Chyrek-Borowska, S; Jakubicz, P; Siergiejko, Z, 1991)
"Ofloxacin, a new pyridone-carboxylic acid derivative, was evaluated in descending nephritis and subcutaneous abscess models with Staphylococcus aureus in mice in comparison with norfloxacin."	3.67	Chemotherapeutic efficacy of ofloxacin on renal and subcutaneous infection models with Staphylococcus aureus in mice. ( Fujimoto, T; Katami, K; Osada, Y; Sato, M; Tachizawa, H; Tsumura, M; Une, T, 1986)
" It was used alone 26 times and on 6 occasions it was associated with rifampin on 6 staphylococcal infections."	3.67	[Ofloxacin (RU 43280). Clinical study]. ( Bertrand, A; Despaux, E; Janbon, F; Jonquet, O; Reynes, J, 1987)
"Eighteen episodes of peritonitis in 16 CAPD patients were treated with oral ofloxacin 400 mg initially, followed by 300 mg daily for a total of 10 days."	3.67	Oral treatment of peritonitis in CAPD patients with ofloxacin. ( Chan, MK; Chan, WW; Chau, PY, 1988)
"The effect of a single day treatment with 600 mg norfloxacin 600 mg ofloxacin or 1,920 mg trimethoprim-sulfamethoxazol was determined on 114 patients with acute cystitis."	3.67	[Single day treatment in acute cystitis]. ( Kawaguchi, K; Yamaguchi, K, 1988)
" Drug-related adverse events were reported by 8."	2.69	A multicentre, double-blind, randomised study comparing the efficacy and safety of oral levofloxacin versus ciprofloxacin in the treatment of uncomplicated skin and skin structure infections. ( Jasovich, A; Neto, W; Nicodemo, AC; Robledo, JA, 1998)
"The study shows that it is possible to treat complicated urinary tract infections just as successfully with 200 mg i."	2.67	Comparison of i.v. ofloxacin and piperacillin in the treatment of complicated urinary tract infections. ( Schalkhäuser, K, 1990)
"Ofloxacin therapy was administered an average of 45 days per patient, and was well tolerated."	2.67	Oral ofloxacin for infections caused by bacteria resistant to oral antimicrobial agents. ( Eron, LJ; Gentry, LO, 1992)
" The choice of the initial dosage regimen actually takes into account toxicological, bacteriological and pharmacokinetic parameters."	2.67	A new approach to optimal antibiotic dosage regimen by coupling pharmacokinetics and killing curve parameters. ( Dellamonica, P; Drugeon, HB; Etesse, H; Garraffo, R; Lapalus, P, 1990)
"Ofloxacin was administered at a dose of 200 mg every 12 hours for a mean duration of ten days."	2.66	[Efficacy of injectable ofloxacin in treating septicemia. Multicenter study]. ( Doco-Lecompte, T; Modaï, J, 1989)
"Ofloxacin was radiolabeled with (99m) Tc using carbonyl core."	1.39	(99m) Tc-tricabonyl labeling of ofloxacin and its biological evaluation in Staphylococcus aureus as an infection imaging agent. ( Andishmand, A; Doroudi, A; Erfani, M; Hadisi, L; Mirshojaei, SF; Shafiei, M, 2013)
"We studied the pharmacokinetic and pharmacodynamic parameters of levofloxacin and rifampicin in bone and joint infections."	1.38	Pharmacokinetic and dynamic study of levofloxacin and rifampicin in bone and joint infections. ( Bensalem, M; Bland, S; Bru, JP; Gaillat, J; Garraffo, R; Guillaume, M; Janssen, C, 2012)
"Levofloxacin seems to be a good alternative treatment for patients with uncomplicated spontaneous ascites infections."	1.36	A recent evaluation of empirical cephalosporin treatment and antibiotic resistance of changing bacterial profiles in spontaneous bacterial peritonitis. ( Alişkan, H; Güçlü, M; Husamettin, E; Serin, E; Yakar, T, 2010)
"Levofloxacin 1."	1.36	Topical levofloxacin 1.5% overcomes in vitro resistance in rabbit keratitis models. ( Gordon, YJ; Kowalski, RP; Mah, FS; Romanowski, EG; Shanks, RM, 2010)
"Antofloxacin hydrochloride is a new fluoroquinolone antibiotic with broad-spectrum in vitro activity."	1.35	Pharmacokinetics/pharmacodynamics of antofloxacin hydrochloride in a neutropenic murine thigh model of Staphylococcus aureus infection. ( Xiao, XM; Xiao, YH, 2008)
"Levofloxacin was more efficient than cloxacillin (P < 0."	1.35	Intracellular antimicrobial activity appearing as a relevant factor in antibiotic efficacy against an experimental foreign-body infection caused by Staphylococcus aureus. ( Ariza, J; Cabellos, C; Cabo, J; Carreras, M; Euba, G; Gudiol, F; Murillo, O; Pachón, ME; Verdaguer, R, 2009)
" The efficacy of the rifampin-levofloxacin combination is not significantly improved by the dosage of levofloxacin."	1.35	Antagonistic effect of rifampin on the efficacy of high-dose levofloxacin in staphylococcal experimental foreign-body infection. ( Ariza, J; Cabellos, C; Cabo, J; Euba, G; Gudiol, F; Murillo, O; Pachón, ME; Tubau, F; Verdaguer, R, 2008)
"Levofloxacin treatment had no effect on IL-6 activities and concentrations in uninfected broilers."	1.34	Role of interleukin-6 in the pathogenesis of an avian model of Staphylococcus aureus arthritis. ( Cheng, GF; Gu, CQ; Hu, XY; Li, XM; Wang, DH; Zhou, Q; Zhou, SQ, 2007)
"A correlation was seen between both the area under the serum concentration curve and MIC (AUC/MIC) and the peak concentration/MIC (Cmax/MIC) versus area under the bactericidal killing curve (AUBKC) or Deltalog0-24 cfu/mL."	1.33	Pharmacodynamics of moxifloxacin and levofloxacin against Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae and Escherichia coli: simulation of human plasma concentrations after intravenous dosage in an in vitro kinetic model. ( Cars, O; Odenholt, I, 2006)
" Efforts should be directed at modifying hospital policies for dosing of levofloxacin and DTCCs to prevent coadministration."	1.33	Coadministration of oral levofloxacin with agents that impair its absorption: potential impact on emergence of resistance. ( Barton, TD; Fishman, NO; Lautenbach, E; Quain, RD; Weiner, MG, 2005)
"The objective of this paper was to investigate the in vitro effects of linezolid combined with five antistaphylococcal antibiotics--doxycycline, fosfomycin, levofloxacin, rifampicin and vancomycin--upon methicillin-susceptible Staphylococcus aureus (MSSA)."	1.33	In vitro activity of linezolid in combination with doxycycline, fosfomycin, levofloxacin, rifampicin and vancomycin against methicillin-susceptible Staphylococcus aureus. ( Cantón, E; Colombo Gainza, E; Gil Brusola, A; Gobernado, M; Ortiz Estévez, R; Sahuquillo Arce, JM, 2006)
"The mutant selection window hypothesis, originally based on agar plate assays, may lead to new antimicrobial dosing strategies that severely restrict the acquisition of resistance."	1.33	The mutant selection window in rabbits infected with Staphylococcus aureus. ( Cui, J; Drlica, K; Liu, Y; Tong, W; Wang, R; Zhao, X, 2006)
"A rat model was used to investigate the efficacy of linezolid, alone or in combination with levofloxacin and vancomycin, in the prevention of vascular prosthetic graft infection resulting from methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides."	1.32	Prophylactic efficacy of linezolid alone or combined with levofloxacin and vancomycin in a rat subcutaneous pouch model of graft infection caused by Staphylococcus epidermidis with intermediate resistance to glycopeptides. ( Cirioni, O; D'Amato, G; Del Prete, MS; Ghiselli, R; Giacometti, A; Mocchegiani, F; Orlando, F; Saba, V; Scalise, G; Silvestri, C, 2003)
"Bacterial keratitis is a serious infectious ocular disease requiring prompt treatment to prevent frequent and severe visual disabilities."	1.32	A mucoadhesive polymer extracted from tamarind seed improves the intraocular penetration and efficacy of rufloxacin in topical treatment of experimental bacterial keratitis. ( Boldrini, E; Campa, M; Celandroni, F; Davini, P; Ghelardi, E; Parisio, E; Salvetti, S; Senesi, S; Tavanti, A, 2004)
"We report a case of lumbar discitis caused by Staphylococcus lugdunensis in a 67-year-old man receiving chemotherapy for stage III IgA lambda multiple myeloma."	1.31	Three-year outcome in a patient with Staphylococcus lugdunensis discitis. ( Camacho, M; Costello, R; Guis, S; Mattei, JP; Roudier, J, 2002)
" Only the group treated with quinupristin/dalfopristin combined with levofloxacin or doxycycline showed no evidence of staphylococcal infection."	1.31	Quinupristin/dalfopristin bonding in combination with intraperitoneal antibiotics prevent infection of knitted polyester graft material in a subcutaneous rat pouch model infected with resistant Staphylococcus epidermidis. ( Cirioni, O; D'Amato, G; Del Prete, M; Ghiselli, R; Giacometti, A; Mocchegiani, F; Orlando, F; Saba, V; Scalise, G, 2002)
"Oral therapy of staphylococcal infection of orthopaedic implants with 900 mg/day rifampicin combined with either 1."	1.30	Oral treatment of Staphylococcus spp. infected orthopaedic implants with fusidic acid or ofloxacin in combination with rifampicin. ( Argenson, JN; Drancourt, M; Groulier, P; Raoult, D; Roiron, R; Stein, A, 1997)
"Levofloxacin was the most potent fluoroquinolone against both strains and its activity was not significantly affected by combination with omeprazole."	1.30	The effects of NorA inhibition on the activities of levofloxacin, ciprofloxacin and norfloxacin against two genetically related strains of Staphylococcus aureus in an in-vitro infection model. ( Aeschlimann, JR; Kaatz, GW; Rybak, MJ, 1999)
"Levofloxacin was no more effective than penicillin against the penicillin-resistant strain."	1.30	Efficacy of levofloxacin for experimental aortic-valve endocarditis in rabbits infected with viridans group streptococcus or Staphylococcus aureus. ( Chambers, HF; Chow, LL; Hackbarth, C; Xiang, Q, 1999)
"Vancomycin was the most effective prophylactic agent, exhibiting in vivo activity against all strains which was superior or equivalent to those of all other agents tested."	1.29	Comparative prophylactic efficacies of ciprofloxacin, ofloxacin, cefazolin, and vancomycin in experimental model of staphylococcal wound infection. ( Kaiser, AB; Kernodle, DS, 1994)
" The largest reductions of viable counts in the kidneys at each dosage as compared to the bacterial counts of untreated animals were achieved with coumermycin (3."	1.27	Efficacy of coumermycin, ofloxacin and vancomycin against methicillin-resistant Staphylococcus aureus in vitro and in experimental infections of mice. ( Breyer, S; Georgopoulos, A; Hirschl, AM; Rotter, ML; Stanek, G, 1988)
"Ofloxacin was active against all but one (Pseudomonas aeruginosa) blood culture isolates."	1.27	Comparative activity of ofloxacin with reference to bacterial strains isolated in in-patients and out-patients. ( Alkan, M; Berger, S; Bogokowski, B; Keren, G; Mark, Z; Rubinstein, E, 1986)

Research

Studies (158)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Average Number of Antibiotics to Which Isolated Organisms Were Resistant

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (6.96)	18.7374
1990's	48 (30.38)	18.2507
2000's	69 (43.67)	29.6817
2010's	28 (17.72)	24.3611
2020's	2 (1.27)	2.80

Authors	Studies
Jinbo, Y	2
Kondo, H	2
Taguchi, M	2
Inoue, Y	3
Sakamoto, F	2
Tsukamoto, G	2
Higashide, M	1
Kuroda, M	1
Omura, CT	1
Kumano, M	1
Ohkawa, S	1
Ichimura, S	1
Ohta, T	1
Cormier, R	1
Burda, WN	1
Harrington, L	1
Edlinger, J	1
Kodigepalli, KM	1
Thomas, J	1
Kapolka, R	1
Roma, G	1
Anderson, BE	1
Turos, E	1
Shaw, LN	1
Bhawsar, S	1
Joshi, S	1
Deshpande, P	1
Yeole, R	1
Bhagwat, S	1
Patel, M	1
Sivaraman, GK	1
Gupta, SS	1
Visnuvinayagam, S	1
Muthulakshmi, T	1
Elangovan, R	1
Perumal, V	1
Balasubramanium, G	1
Lodha, T	1
Yadav, A	1
Dey, S	2
Bishayi, B	2
Maderuelo Riesco, I	1
Tarrazo Tarrazo, C	1
Martínez García, P	1
Rasamiravaka, T	1
Rasoanandrasana, S	1
Zafindraibe, NJ	1
Rakoto Alson, AO	1
Rasamindrakotroka, A	1
Erfani, M	1
Doroudi, A	1
Hadisi, L	1
Andishmand, A	1
Mirshojaei, SF	1
Shafiei, M	1
Berlutti, F	1
Frioni, A	1
Natalizi, T	1
Pantanella, F	1
Valenti, P	1
Dubos, M	1
Barraud, O	1
Fedou, AL	1
Fredon, F	1
Laurent, F	1
Brakbi, Y	1
Cypierre, A	1
François, B	1
Rasool, MH	1
Siddique, AB	1
Saqalein, M	1
Asghar, MJ	1
Zahoor, MA	1
Aslam, B	1
Shafiq, HB	1
Nisar, MA	1
Mikhail, M	1
Koenekoop, RK	1
Khan, A	2
Ullah, O	1
Ambreen, A	1
Ahmad, I	1
Akhtar, T	1
Gandapor, AJ	1
Khan, AM	1
Barberán, J	2
Aguilar, L	2
Giménez, MJ	2
Carroquino, G	2
Granizo, JJ	1
Prieto, J	2
Videler, WJ	1
van Drunen, CM	1
Reitsma, JB	1
Fokkens, WJ	1
Murillo, O	4
Pachón, ME	3
Euba, G	3
Verdaguer, R	3
Tubau, F	3
Cabellos, C	4
Cabo, J	3
Gudiol, F	4
Ariza, J	4
El Samad, Y	1
Havet, E	1
Bentayeb, H	1
Olory, B	1
Canarelli, B	1
Lardanchet, JF	1
Douadi, Y	1
Rousseau, F	1
Lescure, FX	1
Mertl, P	1
Eb, F	1
Schmit, JL	1
Xiao, XM	1
Xiao, YH	1
Brousse, C	1
Montigny, JP	1
Marroun, I	1
Garreau de Loubresse, C	1
Kahn, JE	1
Muller-Serieys, C	1
Saleh Mghir, A	1
Massias, L	1
Fantin, B	1
Tattevin, P	1
Basuino, L	1
Chambers, HF	2
Yakar, T	1
Güçlü, M	1
Serin, E	1
Alişkan, H	1
Husamettin, E	1
Vignaroli, C	1
Carreras, M	1
Chee, E	1
Looi, A	1
Hart, E	1
Azzopardi, K	1
Taing, H	1
Graichen, F	1
Jeffery, J	1
Mayadunne, R	1
Wickramaratna, M	1
O'Shea, M	1
Nijagal, B	1
Watkinson, R	1
O'Leary, S	1
Finnin, B	1
Tait, R	1
Robins-Browne, R	1
Kowalski, RP	1
Romanowski, EG	1
Mah, FS	1
Shanks, RM	1
Gordon, YJ	1
Wu, XG	1
Xin, M	1
Chen, H	2
Yang, LN	1
Jiang, HR	1
Fernández-Ruiz, M	1
Cervera, C	1
Pitart, C	1
Pérez, G	1
del Río, A	1
Miró, JM	1
Marco, F	1
Moreno, A	1
Kim, SJ	1
Toma, HS	1
Wagenlehner, F	1
Roscher, K	1
Naber, KG	1
Shi, G	1
Chen, X	1
Wang, H	1
Wang, S	1
Guo, X	1
Zhang, X	1
Wu, X	1
Jiang, H	1
Xu, Y	1
Yue, W	1
Yang, L	1
Song, Z	1
Liu, T	1
Gomes, F	1
Teixeira, P	1
Ceri, H	1
Oliveira, R	1
Jamal, T	1
Rahman, MA	1
Mirza, MA	1
Panda, AK	1
Talegaonkar, S	1
Iqbal, Z	1
Hafezi, F	1
Zhang, ZC	1
Jin, FS	1
Liu, DM	1
Shen, ZJ	1
Sun, YH	1
Guo, YL	1
Guillaume, M	1
Garraffo, R	3
Bensalem, M	1
Janssen, C	1
Bland, S	1
Gaillat, J	1
Bru, JP	1
Paleiron, N	1
Nguyen, BV	1
Commandeur, D	1
Danguy des Déserts, M	1
Rioualen, S	1
Ralec, B	1
André, M	1
Ould-Ahmed, M	1
Rousset, J	1
Wang, T	1
Huang, X	1
Gao, Q	1
Feng, L	1
Xie, Z	1
Jiang, Z	1
Liu, Y	2
Li, Y	1
Lin, X	1
Lin, J	1
Taha, AB	1
Ghiselli, R	4
Giacometti, A	4
Cirioni, O	4
Mocchegiani, F	4
Orlando, F	2
Del Prete, M	1
D'Amato, G	2
Scalise, G	4
Saba, V	4
Sotozono, C	1
Inagaki, K	1
Fujita, A	1
Koizumi, N	1
Sano, Y	1
Inatomi, T	1
Kinoshita, S	1
Trinchieri, A	1
Marchetti, F	1
Tungsiripat, T	1
Sarayba, MA	1
Kaufman, MB	1
Sweet, PM	1
Taban, M	1
Carpenter, TR	1
McDonnell, PJ	2
Solomon, R	2
Donnenfeld, ED	2
Perry, HD	2
Biser, S	1
Del Prete, MS	1
Silvestri, C	1
Matoba, AY	1
Zeitlinger, MA	1
Dehghanyar, P	1
Mayer, BX	1
Schenk, BS	1
Neckel, U	1
Heinz, G	1
Georgopoulos, A	2
Müller, M	1
Joukhadar, C	1
Entenza, JM	2
Vouillamoz, J	2
Glauser, MP	2
Moreillon, P	2
Tenover, FC	1
Weigel, LM	1
Appelbaum, PC	1
McDougal, LK	1
Chaitram, J	1
McAllister, S	1
Clark, N	1
Killgore, G	1
O'Hara, CM	1
Jevitt, L	1
Patel, JB	1
Bozdogan, B	1
Barequet, IS	1
Denton, P	1
Osterhout, GJ	1
Tuli, S	1
O'Brien, TP	1
Marangon, FB	1
Miller, D	1
Muallem, MS	1
Romano, AC	1
Alfonso, EC	1
Dajcs, JJ	3
Thibodeaux, BA	3
Marquart, ME	2
Girgis, DO	2
Traidej, M	2
O'Callaghan, RJ	4
Ghelardi, E	1
Tavanti, A	1
Davini, P	1
Celandroni, F	1
Salvetti, S	1
Parisio, E	1
Boldrini, E	1
Senesi, S	1
Campa, M	1
Oguz, H	2
Ozbilge, H	1
Oguz, E	1
Gurkan, T	1
Arnold, FW	1
Wojda, B	1
Gehanno, P	1
Pessey, JJ	1
Serrano, E	1
Quain, RD	1
Barton, TD	1
Fishman, NO	1
Weiner, MG	1
Lautenbach, E	1
Turgut, H	1
Sacar, S	1
Kaleli, I	1
Sacar, M	1
Goksin, I	1
Toprak, S	1
Asan, A	1
Cevahir, N	1
Tekin, K	1
Baltalarli, A	1
Ruotsalainen, E	2
Järvinen, A	2
Koivula, I	1
Kauma, H	1
Rintala, E	1
Lumio, J	1
Kotilainen, P	1
Vaara, M	1
Nikoskelainen, J	1
Valtonen, V	2
Ramdani-Bouguessa, N	1
Bes, M	1
Meugnier, H	1
Forey, F	1
Reverdy, ME	1
Lina, G	1
Vandenesch, F	1
Tazir, M	1
Etienne, J	1
Yağci, R	1
Oflu, Y	1
Dinçel, A	1
Kaya, E	1
Yağci, S	1
Bayar, B	1
Duman, S	1
Bozkurt, A	3
Mecikoglu, M	1
Saygi, B	1
Yildirim, Y	1
Karadag-Saygi, E	1
Ramadan, SS	1
Esemenli, T	1
Fukaya, Y	1
Kurita, A	1
Tsuruga, H	1
Naito, A	1
Nakaya, S	1
Sato, M	2
Kamata, Y	1
Hirata, H	1
Kambara, Y	1
Kurasawa, N	1
Wada, T	2
Toyoda, Y	1
Shirasawa, E	1
Ohashi, Y	1
Odenholt, I	1
Cars, O	1
Doménech, A	1
Garcia, A	1
Sánchez, B	1
Martínez, D	1
Cui, J	1
Wang, R	1
Tong, W	1
Drlica, K	2
Zhao, X	2
Sahuquillo Arce, JM	1
Colombo Gainza, E	1
Gil Brusola, A	1
Ortiz Estévez, R	1
Cantón, E	1
Gobernado, M	1
Rubinfeld, RS	1
Ehrenhaus, M	1
Wittpenn, JR	1
Solomon, KD	1
Manche, EE	1
Moshirfar, M	1
Matzkin, DC	1
Mozayeni, RM	1
Maloney, RK	1
Nguyen, HA	1
Grellet, J	1
Dubois, V	1
Saux, MC	1
Quentin, C	1
Zhou, Q	1
Gu, CQ	1
Hu, XY	1
Wang, DH	1
Li, XM	1
Zhou, SQ	1
Cheng, GF	1
Trampuz, A	2
Murphy, CK	1
Rothstein, DM	1
Widmer, AF	1
Landmann, R	1
Zimmerli, W	2
Foo, SS	1
Lye, DC	1
Drago, L	1
De Vecchi, E	1
Nicola, L	1
Gismondo, MR	1
Liskova, A	1
Benca, J	1
Kalavsky, E	1
Kovac, M	1
Rudinsky, B	1
Ondrusova, A	1
Kiwou, M	1
Ferrer, C	1
Rodríguez, A	1
Abad, JL	1
Fernandez, J	1
Alió, JL	1
Kida, T	1
Inoue, T	1
Tokushige, H	1
Naka, H	1
Sakaki, H	1
Kardén-Lilja, M	1
Kuusela, P	1
Vuopio-Varkila, J	1
Virolainen-Julkunen, A	1
Sarna, S	1
Lin, B	1
Su, X	1
Hori, S	1
Ohshita, Y	1
Utsui, Y	1
Hiramatsu, K	1
Sesso, R	1
Parisio, K	1
Dalboni, A	1
Rabelo, T	1
Barbosa, D	1
Cendoroglo, M	1
Pignatari, A	1
Draibe, S	1
Ajzen, H	1
Kernodle, DS	1
Kaiser, AB	1
Drancourt, M	2
Stein, A	2
Argenson, JN	2
Zannier, A	1
Curvale, G	1
Raoult, D	2
Gentry, LO	2
Rodriguez-Gomez, G	1
Khardori, N	1
Yassien, M	1
Wilson, K	1
Bow, EJ	1
Mandell, LA	1
Louie, TJ	1
Feld, R	1
Palmer, M	1
Zee, B	1
Pater, J	1
Tong, MC	1
Woo, JK	1
van Hasselt, CA	1
Frosco, MB	1
Melton, JL	1
Stewart, FP	1
Kulwich, BA	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Conjunctival Floral Resistance in a Single Practice Site Comparing Povidone- Iodine Prep With or Without Post-Intravitreal Injection Second Generation Fluoroquinolones.[NCT02223338]		120 participants (Actual)	Interventional	2014-10-31	Completed
[NCT00548002]		430 participants (Actual)	Observational	1999-01-31	Completed
Concentration of Ofloxacin Into the Aqueous Humour of Patients After Topical Instillation According to the Severity of Dry Eye Disease[NCT05213156]	Phase 4	91 participants (Actual)	Interventional	2019-09-24	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Average number of antibiotics to which isolated organisms were resistant, isolated organisms include only coagulase negative Staphylococcus species and Staphylococcus aureus. Antibiotics are those described in the methods section. (NCT02223338)
Timeframe: Through study completion, average of 4 weeks

Number of Participants With Resistance of Ocular Flora to Commonly Used Post-injection Prophylactic Antibiotics

Intervention	antibiotics (Mean)
Ciprofloxacin	5.44
Standard Aseptic Technique	3.23

"Resistance of all coagulase negative staph and staph aureus species to a panel of commonly used antibiotics will be determined and compared between groups. Resistance will be measured using minimum inhibitory concentrations which will be tested on the Siemens MicroScan instrument by doubling broth dilutions. Antibiotic susceptibility interpretations using the categories S for susceptible, I for Intermediate and R for Resistance based on the Clinical and Laboratory Standards Institute (CLSI) guidelines.~Ciprofloxacin will be tested using the Biomerieux E test strip. The test directly quantifies antimicrobial susceptibility in terms of discrete MIC values on a continuous gradient strip. The MIC values are also based on the CLSI guidelines giving interpretations of S, I or R.~For information on other antibiotics to be tested, please contact the investigator or provide more characters for input." (NCT02223338)
Timeframe: Cultured organisms will be subjected to resistance panels once they have grown and been identified. Cultures will be followed for 7 days total, and if no growth is recorded at that time they will be considered sterile.

Article	Year
Fluoroquinolones as pneumococcal therapy: closing the barn door before the horse escapes. The Lancet. Infectious diseases, 2001, Volume: 1, Issue:3 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Bacterial; Drug Resistance, Multiple; Humans;	2001
Ofloxacin, a bactericidal antibacterial. Chemotherapy, 1991, Volume: 37 Suppl 1 Topics: Anti-Infective Agents; Bacteria; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Human	1991
[Refractory respiratory tract infections. 6. New problems in refractory respiratory tract infections. c. Chemotherapy of methicillin-resistant Staphylococci infection]. Nihon rinsho. Japanese journal of clinical medicine, 1987, Volume: 45, Issue:3 Topics: Anti-Bacterial Agents; Cefmetazole; Cephamycins; Drug Therapy, Combination; Fosfomycin; Humans; Meth	1987

Article	Year
Nebulized bacitracin/colimycin: a treatment option in recalcitrant chronic rhinosinusitis with Staphylococcus aureus? A double-blind, randomized, placebo-controlled, cross-over pilot study. Rhinology, 2008, Volume: 46, Issue:2 Topics: Administration, Inhalation; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacitracin; Chron	2008
Ophthalmic antibiotics and antimicrobial resistance a randomized, controlled study of patients undergoing intravitreal injections. Ophthalmology, 2011, Volume: 118, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Aza Compounds; Azithromycin; Conjunctiva; Dru	2011
Safety and efficacy of levofloxacin versus ciprofloxacin for the treatment of chronic bacterial prostatitis in Chinese patients. Asian journal of andrology, 2012, Volume: 14, Issue:6 Topics: Adult; Anti-Bacterial Agents; Asian People; Ciprofloxacin; Escherichia coli Infections; Humans; Levo	2012
[Multicentric study for evaluation of levofloxacin in the treatment of complicated urinary tract infections]. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 2003, Volume: 75, Issue:1 Topics: Anti-Infective Agents; Drug Administration Schedule; Drug Resistance, Bacterial; Enterobacteriaceae	2003
[Levofloxacin in the treatment of acute and bacteriologically documented sinusitis with high risk of complications]. Medecine et maladies infectieuses, 2005, Volume: 35, Issue:6 Topics: Acute Disease; Adolescent; Adult; Africa, Southern; Aged; Bacterial Infections; Female; France; Haem	2005
Levofloxacin does not decrease mortality in Staphylococcus aureus bacteraemia when added to the standard treatment: a prospective and randomized clinical trial of 381 patients. Journal of internal medicine, 2006, Volume: 259, Issue:2 Topics: Adult; Aged; Anti-Bacterial Agents; Bacteremia; Chi-Square Distribution; Drug Therapy, Combination;	2006
Methicillin-sensitive Staphylococcus aureus bacteraemia and endocarditis among injection drug users and nonaddicts: host factors, microbiological and serological characteristics. The Journal of infection, 2008, Volume: 56, Issue:4 Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Bacteremia; Case-Control Studies; Electro	2008
[The clinical observation of China-made ofloxacin eye drops in the treatment of bacterial infection of the external eye]. Yan ke xue bao = Eye science, 1994, Volume: 10, Issue:4 Topics: Adult; Aged; Conjunctivitis, Bacterial; Hordeolum; Humans; Middle Aged; Ofloxacin; Ophthalmic Soluti	1994
Effect of sodium fusidate and ofloxacin on Staphylococcus aureus colonization and infection in patients on continuous ambulatory peritoneal dialysis. Clinical nephrology, 1994, Volume: 41, Issue:6 Topics: Administration, Oral; Administration, Topical; Adult; Catheters, Indwelling; Female; Fusidic Acid; H	1994
Oral rifampin plus ofloxacin for treatment of Staphylococcus-infected orthopedic implants. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:6 Topics: Administration, Oral; Cohort Studies; Drug Therapy, Combination; Hip Prosthesis; Humans; Knee Prosth	1993
Ofloxacin treatment of difficult infections of the skin and skin structure. Cutis, 1993, Volume: 51, Issue:1 Topics: Abscess; Administration, Oral; Adult; Aged; Aged, 80 and over; Cellulitis; Drug Administration Sched	1993
Quinolone-based antibacterial chemoprophylaxis in neutropenic patients: effect of augmented gram-positive activity on infectious morbidity. National Cancer Institute of Canada Clinical Trials Group. Annals of internal medicine, 1996, Aug-01, Volume: 125, Issue:3 Topics: Adult; Aged; Anti-Infective Agents; Antineoplastic Agents; Bacteremia; Colony Count, Microbial; Fema	1996
A double-blind comparative study of ofloxacin otic drops versus neomycin-polymyxin B-hydrocortisone otic drops in the medical treatment of chronic suppurative otitis media. The Journal of laryngology and otology, 1996, Volume: 110, Issue:4 Topics: Anti-Infective Agents; Chronic Disease; Double-Blind Method; Drug Combinations; Humans; Hydrocortiso	1996
A multicentre, double-blind, randomised study comparing the efficacy and safety of oral levofloxacin versus ciprofloxacin in the treatment of uncomplicated skin and skin structure infections. International journal of clinical practice, 1998, Volume: 52, Issue:2 Topics: Administration, Oral; Adult; Anti-Infective Agents; Ciprofloxacin; Double-Blind Method; Female; Huma	1998
Sparfloxacin vs ofloxacin in the treatment of acute bacterial exacerbations of chronic bronchitis: a multicenter, double-blind, randomized, comparative study. Sparfloxacin Multicenter ABECB Study Group. Chest, 1998, Volume: 114, Issue:1 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Bronchitis; Chlamy	1998
[Efficacy of lomefloxacin and ofloxacin in complex therapy of infections in patients with burns]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1998, Volume: 43, Issue:10 Topics: Adolescent; Adult; Anti-Infective Agents; Burns; Drug Resistance, Microbial; Drug Resistance, Multip	1998
Comparison of topical 0.3% ofloxacin with fortified tobramycin plus cefazolin in the treatment of bacterial keratitis. Eye (London, England), 1999, Volume: 13 ( Pt 6) Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Cefazolin; Cephalosporins; Co	1999
Effect of topical ciprofloxacin 0.3% and ofloxacin 0.3% on the reduction of bacterial flora on the human conjunctiva. Journal of cataract and refractive surgery, 2000, Volume: 26, Issue:11 Topics: Alcaligenes; Anti-Infective Agents; Ciprofloxacin; Colony Count, Microbial; Conjunctiva; Conjunctivi	2000
[Tolerability and safety of levofloxacinin long-term treatment]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2000, Volume: 13, Issue:3 Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Bacterial Infections; Female; Humans; Levofloxacin;	2000
Oral fluoroquinolone therapy results in drug adsorption on ureteral stents and prevention of biofilm formation. International journal of antimicrobial agents, 2001, Volume: 17, Issue:4 Topics: Administration, Oral; Adsorption; Anti-Infective Agents; Anti-Infective Agents, Urinary; Biofilms; C	2001
Oral ofloxacin for infections caused by bacteria resistant to oral antimicrobial agents. Diagnostic microbiology and infectious disease, 1992, Volume: 15, Issue:5 Topics: Administration, Oral; Adult; Aged; Bacterial Infections; Diabetes Complications; Drug Resistance, Mi	1992
A new approach to optimal antibiotic dosage regimen by coupling pharmacokinetics and killing curve parameters. Methods and findings in experimental and clinical pharmacology, 1990, Volume: 12, Issue:5 Topics: Amikacin; Anti-Bacterial Agents; Cell Survival; Dose-Response Relationship, Drug; Drug Administratio	1990
A silicone gel sheet dressing containing an antimicrobial agent for split thickness donor site wounds. British journal of plastic surgery, 1990, Volume: 43, Issue:1 Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Collagen; Female; Gels; Humans	1990
Comparison of i.v. ofloxacin and piperacillin in the treatment of complicated urinary tract infections. The Journal of antimicrobial chemotherapy, 1990, Volume: 26 Suppl D Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Gram-Negative Bacteria; Humans; Injections, Intr	1990
[Efficacy of injectable ofloxacin in treating septicemia. Multicenter study]. Pathologie-biologie, 1989, Volume: 37, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Gram-Negative Bacteria; Humans; Injections, Intr	1989

Article	Year
Synthesis and antibacterial activity of thiazolopyrazine-incorporated tetracyclic quinolone antibacterial agents. 2. Journal of medicinal chemistry, 1994, Aug-19, Volume: 37, Issue:17 Topics: 4-Quinolones; Animals; Anti-Infective Agents; Gram-Negative Bacteria; Gram-Positive Bacteria; Indica	1994
Synthesis and antibacterial activity of thiazolopyrazine-incorporated tetracyclic quinolone antibacterials. Journal of medicinal chemistry, 1994, Mar-04, Volume: 37, Issue:5 Topics: Animals; Drug Resistance, Microbial; Gram-Negative Bacteria; Gram-Positive Bacteria; Male; Methicill	1994
Methicillin-resistant Staphylococcus saprophyticus isolates carrying staphylococcal cassette chromosome mec have emerged in urogenital tract infections. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:6 Topics: Bacterial Proteins; Chromosomes, Bacterial; Electrophoresis, Gel, Pulsed-Field; Methicillin Resistan	2008
Studies on the antimicrobial properties of N-acylated ciprofloxacins. Bioorganic & medicinal chemistry letters, 2012, Oct-15, Volume: 22, Issue:20 Topics: Acylation; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Bartonella; Bartonella Infections;	2012
WCK 1152, WCK 1153: Discovery and structure activity relationship for the treatment of resistant pneumococcal and staphylococcal respiratory infections. Bioorganic & medicinal chemistry letters, 2022, 05-01, Volume: 63 Topics: Anti-Bacterial Agents; DNA Gyrase; DNA Topoisomerase IV; Fluoroquinolones; Humans; Microbial Sensiti	2022
Prevalence of S. aureus and/or MRSA from seafood products from Indian seafood products. BMC microbiology, 2022, 10-01, Volume: 22, Issue:1 Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Cefoxitin; Gentamicins; Linezolid	2022
Killing of S. aureus in murine peritoneal macrophages by Ascorbic acid along with antibiotics Chloramphenicol or Ofloxacin: Correlation with inflammation. Microbial pathogenesis, 2018, Volume: 115 Topics: Animals; Anti-Bacterial Agents; Antioxidants; Ascorbic Acid; Chloramphenicol; Cyclooxygenase 2; Cyto	2018
[Herpes zoster ophthalmicus in an immunosuppressed patient]. Atencion primaria, 2019, Volume: 51, Issue:3 Topics: Acyclovir; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Antiviral Agents; H	2019
Evaluation of methicillin-resistant Staphylococcus aureus nasal carriage in Malagasy patients. Journal of infection in developing countries, 2013, Apr-17, Volume: 7, Issue:4 Topics: Adolescent; Adult; Carrier State; Confidence Intervals; Drug Resistance, Multiple, Bacterial; Erythr	2013
(99m) Tc-tricabonyl labeling of ofloxacin and its biological evaluation in Staphylococcus aureus as an infection imaging agent. Journal of labelled compounds & radiopharmaceuticals, 2013, Volume: 56, Issue:12 Topics: Animals; Anti-Bacterial Agents; Isotope Labeling; Male; Mice; Mice, Inbred BALB C; Muscle, Skeletal;	2013
Influence of sub-inhibitory antibiotics and flow condition on Staphylococcus aureus ATCC 6538 biofilm development and biofilm growth rate: BioTimer assay as a study model. The Journal of antibiotics, 2014, Volume: 67, Issue:11 Topics: Anti-Bacterial Agents; Azithromycin; Biofilms; Gentamicins; Microbial Sensitivity Tests; Models, The	2014
Prostatic abscesses and severe sepsis due to methicillin-susceptible Staphylococcus aureus producing Panton-Valentine leukocidin. BMC infectious diseases, 2014, Aug-27, Volume: 14 Topics: Abscess; Bacterial Toxins; Exotoxins; Humans; Leukocidins; Magnetic Resonance Imaging; Male; Methici	2014
Occurrence and antibacterial susceptibility pattern of bacterial pathogens isolated from diarrheal patients in Pakistan. Saudi medical journal, 2016, Volume: 37, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Bacillus cereus; Cef	2016
Orbital cellulitis and multiple abscess formation after strabismus surgery. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2016, Volume: 51, Issue:2 Topics: Abscess; Administration, Topical; Anti-Bacterial Agents; Ceftriaxone; Child, Preschool; Drug Therapy	2016
Antibiotic Sensitivity pattern of Bacterial Isolates of Neonatal Septicemia in Peshawar, Pakistan. Archives of Iranian medicine, 2016, Volume: 19, Issue:12 Topics: Anti-Bacterial Agents; Ciprofloxacin; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacteri	2016
Effect of iNOS inhibitor LNMMA along with antibiotics Chloramphenicol or Ofloxacin in murine peritoneal macrophages regulates S.aureus infection as well as inflammation: An in vitro study. Microbial pathogenesis, 2017, Volume: 105 Topics: Animals; Anti-Bacterial Agents; Antioxidants; Chloramphenicol; Cyclooxygenase 2; Cytokines; Disease	2017
Levofloxacin plus rifampicin conservative treatment of 25 early staphylococcal infections of osteosynthetic devices for rigid internal fixation. International journal of antimicrobial agents, 2008, Volume: 32, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Coagulase; Drug Therapy, Combination; Female;	2008
Antagonistic effect of rifampin on the efficacy of high-dose levofloxacin in staphylococcal experimental foreign-body infection. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10 Topics: Animals; Anti-Bacterial Agents; Biofilms; Dose-Response Relationship, Drug; Drug Interactions; Forei	2008
[Treatment of osteoarticular infections with clindamycin in adults]. Medecine et maladies infectieuses, 2008, Volume: 38, Issue:9 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bone Diseases; Clindamy	2008
Pharmacokinetics/pharmacodynamics of antofloxacin hydrochloride in a neutropenic murine thigh model of Staphylococcus aureus infection. Acta pharmacologica Sinica, 2008, Volume: 29, Issue:10 Topics: Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred ICR; Mi	2008
[Charcot's disease of the lumbosacral joint in spinal cord injury: a case report]. Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique, 2008, Volume: 51, Issue:9 Topics: Accidents, Traffic; Adult; Arthropathy, Neurogenic; Bacteremia; Diagnostic Errors; Discitis; Epidura	2008
High doses of levofloxacin vs moxifloxacin against staphylococcal experimental foreign-body infection: the effect of higher MIC-related pharmacokinetic parameters on efficacy. The Journal of infection, 2009, Volume: 58, Issue:3 Topics: Animals; Anti-Bacterial Agents; Aza Compounds; Fluoroquinolones; Foreign Bodies; Levofloxacin; Male;	2009
Bactericidal activity of the combination of levofloxacin with rifampin in experimental prosthetic knee infection in rabbits due to methicillin-susceptible Staphylococcus aureus. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:5 Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Therapy, Combination; Humans; Knee Pros	2009
Subinhibitory fluoroquinolone exposure selects for reduced beta-lactam susceptibility in methicillin-resistant Staphylococcus aureus and alterations in the SOS-mediated response. Research in microbiology, 2009, Volume: 160, Issue:3 Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactams; Ciprofloxacin; Comm	2009
A recent evaluation of empirical cephalosporin treatment and antibiotic resistance of changing bacterial profiles in spontaneous bacterial peritonitis. Digestive diseases and sciences, 2010, Volume: 55, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Ascitic Fluid; Bacterial Infections; Cefepime	2010
Methicillin-resistant Staphylococcus aureus USA400 Clone, Italy. Emerging infectious diseases, 2009, Volume: 15, Issue:6 Topics: Adult; Anti-Bacterial Agents; California; Female; Humans; Italy; Methicillin Resistance; Methicillin	2009
Intracellular antimicrobial activity appearing as a relevant factor in antibiotic efficacy against an experimental foreign-body infection caused by Staphylococcus aureus. The Journal of antimicrobial chemotherapy, 2009, Volume: 64, Issue:5 Topics: Animals; Anti-Bacterial Agents; Cloxacillin; Colony Count, Microbial; Cytoplasm; Disease Models, Ani	2009
Onodi sinusitis presenting with orbital apex syndrome. Orbit (Amsterdam, Netherlands), 2009, Volume: 28, Issue:6 Topics: Abscess; Anti-Bacterial Agents; Combined Modality Therapy; Drainage; Drug Therapy, Combination; Ethm	2009
Efficacy of antimicrobial polymer coatings in an animal model of bacterial infection associated with foreign body implants. The Journal of antimicrobial chemotherapy, 2010, Volume: 65, Issue:5 Topics: Animals; Anti-Bacterial Agents; Colony Count, Microbial; Disease Models, Animal; Female; Foreign Bod	2010
Topical levofloxacin 1.5% overcomes in vitro resistance in rabbit keratitis models. Acta ophthalmologica, 2010, Volume: 88, Issue:4 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Cefazolin; Ciprofloxacin; Colony Count, Mic	2010
Novel mucoadhesive polysaccharide isolated from Bletilla striata improves the intraocular penetration and efficacy of levofloxacin in the topical treatment of experimental bacterial keratitis. The Journal of pharmacy and pharmacology, 2010, Volume: 62, Issue:9 Topics: Absorption; Administration, Topical; Animals; Anti-Bacterial Agents; Aqueous Humor; Bacterial Load;	2010
Community-acquired methicillin-resistant Staphylococcus aureus meningitis complicated by cerebral infarction. Role of antibiotic combination of linezolid plus levofloxacin. Internal medicine (Tokyo, Japan), 2010, Volume: 49, Issue:18 Topics: Acetamides; Adult; Anti-Bacterial Agents; Cerebral Infarction; Community-Acquired Infections; Drug T	2010
[Practice management of chronic bacterial prostatitis with levofloxacin]. Aktuelle Urologie, 2011, Volume: 42, Issue:3 Topics: Adult; Aged; Anti-Infective Agents, Urinary; Bacterial Infections; Chronic Disease; Escherichia coli	2011
Activity of sitafloxacin against extracellular and intracellular Staphylococcus aureus in vitro and in vivo: comparison with levofloxacin and moxifloxacin. The Journal of antibiotics, 2012, Volume: 65, Issue:5 Topics: Animals; Anti-Bacterial Agents; Aza Compounds; Cell Line; Chromatography, High Pressure Liquid; Dise	2012
Efficacy of gemifloxacin for the treatment of experimental Staphylococcus aureus keratitis. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2012, Volume: 28, Issue:4 Topics: Animals; Anti-Infective Agents, Local; Colony Count, Microbial; Conjunctival Diseases; Cornea; Eye;	2012
Evaluation of antimicrobial activity of certain combinations of antibiotics against in vitro Staphylococcus epidermidis biofilms. The Indian journal of medical research, 2012, Volume: 135, Issue:4 Topics: Biofilms; Clindamycin; Drug Combinations; Gentamicins; Humans; Levofloxacin; Microbial Sensitivity T	2012
Formulation, antimicrobial and toxicity evaluation of bioceramic based ofloxacin loaded biodegradable microspheres for periodontal infection. Current drug delivery, 2012, Volume: 9, Issue:5 Topics: Animals; Anti-Bacterial Agents; Cell Survival; Chemistry, Pharmaceutical; Escherichia coli; Escheric	2012
Significant visual increase following infectious keratitis after collagen cross-linking. Journal of refractive surgery (Thorofare, N.J. : 1995), 2012, Volume: 28, Issue:8 Topics: Anti-Bacterial Agents; Collagen; Corneal Stroma; Corneal Topography; Corneal Ulcer; Cross-Linking Re	2012
Pharmacokinetic and dynamic study of levofloxacin and rifampicin in bone and joint infections. Medecine et maladies infectieuses, 2012, Volume: 42, Issue:9 Topics: Adult; Aged; Anti-Bacterial Agents; Area Under Curve; Arthritis, Infectious; Body Mass Index; Discit	2012
[Miliary X-ray pattern is not always related to tuberculosis]. Medecine et maladies infectieuses, 2013, Volume: 43, Issue:1 Topics: Aged; Anti-Bacterial Agents; Arthroplasty, Replacement, Hip; Combined Modality Therapy; Device Remov	2013
A preliminary study to treat severe endophthalmitis via a foldable capsular vitreous body with sustained levofloxacin release in rabbits. Investigative ophthalmology & visual science, 2013, Jan-28, Volume: 54, Issue:1 Topics: Animals; Anti-Bacterial Agents; Ciliary Body; Colony Count, Microbial; Cytokines; Drug Delivery Syst	2013
Relationship and susceptibility profile of Staphylococcus aureus infection diabetic foot ulcers with Staphylococcus aureus nasal carriage. Foot (Edinburgh, Scotland), 2013, Volume: 23, Issue:1 Topics: Adult; Aged; Anti-Bacterial Agents; Carrier State; Diabetic Foot; Female; Humans; Levofloxacin; Male	2013
Quinupristin/dalfopristin bonding in combination with intraperitoneal antibiotics prevent infection of knitted polyester graft material in a subcutaneous rat pouch model infected with resistant Staphylococcus epidermidis. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2002, Volume: 24, Issue:3 Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Disease Models, Anima	2002
Methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis infections in the cornea. Cornea, 2002, Volume: 21, Issue:7 Suppl Topics: Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Child; Dibekacin; Eye Infections, Bacterial; Fe	2002
Fluoroquinolone therapy in multiple-drug resistant staphylococcal keratitis after lamellar keratectomy in a rabbit model. American journal of ophthalmology, 2003, Volume: 136, Issue:1 Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Colony Count, Microbial; Corneal Stroma; Disease Mode	2003
Bilateral methicillin-resistant staphylococcus aureus keratitis in a medical resident following an uneventful bilateral photorefractive keratectomy. Eye & contact lens, 2003, Volume: 29, Issue:3 Topics: Adult; Cornea; Corneal Ulcer; Drug Therapy, Combination; Eye Infections, Bacterial; Eyelids; Female;	2003
Prophylactic efficacy of linezolid alone or combined with levofloxacin and vancomycin in a rat subcutaneous pouch model of graft infection caused by Staphylococcus epidermidis with intermediate resistance to glycopeptides. The Journal of antimicrobial chemotherapy, 2003, Volume: 52, Issue:4 Topics: Acetamides; Animals; Antibiotic Prophylaxis; Drug Resistance, Bacterial; Drug Therapy, Combination;	2003
Polymicrobial keratitis secondary to Burkholderia ambifaria, enterococcus, and staphylococcus aureus in a patient with herpetic stromal keratitis. American journal of ophthalmology, 2003, Volume: 136, Issue:4 Topics: Amikacin; Burkholderia; Burkholderia Infections; Corneal Stroma; Drug Therapy, Combination; Enteroco	2003
Relevance of soft-tissue penetration by levofloxacin for target site bacterial killing in patients with sepsis. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:11 Topics: Aged; Anti-Infective Agents; Area Under Curve; Blood Proteins; Drug Delivery Systems; Female; Humans	2003
Efficacy of garenoxacin in treatment of experimental endocarditis due to Staphylococcus aureus or viridans group streptococci. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:1 Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Bacterial; En	2004
Vancomycin-resistant Staphylococcus aureus isolate from a patient in Pennsylvania. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:1 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Proteins; Blotting, Southern; Carbon-Oxygen	2004
Treatment of experimental bacterial keratitis with topical trovafloxacin. Archives of ophthalmology (Chicago, Ill. : 1960), 2004, Volume: 122, Issue:1 Topics: Administration, Topical; Animals; Anti-Infective Agents; Biological Availability; Ciprofloxacin; Col	2004
Ciprofloxacin and levofloxacin resistance among methicillin-sensitive Staphylococcus aureus isolates from keratitis and conjunctivitis. American journal of ophthalmology, 2004, Volume: 137, Issue:3 Topics: Anti-Infective Agents; Ciprofloxacin; Conjunctivitis, Bacterial; Cross-Sectional Studies; Drug Resis	2004
Effectiveness of ciprofloxacin, levofloxacin, or moxifloxacin for treatment of experimental Staphylococcus aureus keratitis. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:6 Topics: Animals; Anti-Infective Agents; Aza Compounds; Ciprofloxacin; Cornea; Drug Resistance, Bacterial; Fl	2004
A mucoadhesive polymer extracted from tamarind seed improves the intraocular penetration and efficacy of rufloxacin in topical treatment of experimental bacterial keratitis. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:9 Topics: Adhesives; Administration, Topical; Animals; Anti-Bacterial Agents; Chemistry, Pharmaceutical; Colon	2004
Effectiveness of topical taurolidine versus ciprofloxacin, ofloxacin, and fortified cefazolin in a rabbit Staphylococcus aureus keratitis model. Current eye research, 2005, Volume: 30, Issue:3 Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Cefazolin; Ciprofloxacin; Colony Cou	2005
An analysis of a community-acquired pathogen in a Kentucky community: methicillin-resistant Staphylococcus aureus. The Journal of the Kentucky Medical Association, 2005, Volume: 103, Issue:5 Topics: Adult; Anti-Bacterial Agents; Cefazolin; Clindamycin; Community-Acquired Infections; Erythromycin; F	2005
Coadministration of oral levofloxacin with agents that impair its absorption: potential impact on emergence of resistance. International journal of antimicrobial agents, 2005, Volume: 26, Issue:4 Topics: Administration, Oral; Adsorption; Aged; Anti-Bacterial Agents; Case-Control Studies; Cations, Divale	2005
Systemic and local antibiotic prophylaxis in the prevention of Staphylococcus epidermidis graft infection. BMC infectious diseases, 2005, Oct-21, Volume: 5 Topics: Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Blood Vessel Prosthesis; Blood Vessel Prosth	2005
Detection of methicillin-resistant Staphylococcus aureus strains resistant to multiple antibiotics and carrying the Panton-Valentine leukocidin genes in an Algiers hospital. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:3 Topics: Algeria; Alleles; Anti-Bacterial Agents; Bacterial Toxins; Community-Acquired Infections; Drug Resis	2006
Penetration of second-, third-, and fourth-generation topical fluoroquinolone into aqueous and vitreous humour in a rabbit endophthalmitis model. Eye (London, England), 2007, Volume: 21, Issue:7 Topics: Animals; Anti-Bacterial Agents; Aqueous Humor; Aza Compounds; Ciprofloxacin; Disease Models, Animal;	2007
The effect of proteolytic enzyme serratiopeptidase in the treatment of experimental implant-related infection. The Journal of bone and joint surgery. American volume, 2006, Volume: 88, Issue:6 Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dru	2006
Antibiotic effects of WP-0405, a thermo-setting ofloxacin gel, on methicillin-resistant Staphylococcus aureus keratitis in rabbits. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2006, Volume: 22, Issue:4 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Aqueous Humor; Biological Availability; Cil	2006
Pharmacodynamics of moxifloxacin and levofloxacin against Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae and Escherichia coli: simulation of human plasma concentrations after intravenous dosage in an in vitro kinetic model. The Journal of antimicrobial chemotherapy, 2006, Volume: 58, Issue:5 Topics: Animals; Anti-Infective Agents; Area Under Curve; Aza Compounds; Escherichia coli; Escherichia coli	2006
Efficacy of high doses of levofloxacin in experimental foreign-body infection by methicillin-susceptible Staphylococcus aureus. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:12 Topics: Acetamides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Cloxacillin; Disease Models, Anim	2006
Conservative treatment of staphylococcal prosthetic joint infections in elderly patients. The American journal of medicine, 2006, Volume: 119, Issue:11 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Arthroplasty, Replacement, Hip; Arthroplasty, Replac	2006
The mutant selection window in rabbits infected with Staphylococcus aureus. The Journal of infectious diseases, 2006, Dec-01, Volume: 194, Issue:11 Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Area Under Curve; Colony Count, Microbial; Dif	2006
In vitro activity of linezolid in combination with doxycycline, fosfomycin, levofloxacin, rifampicin and vancomycin against methicillin-susceptible Staphylococcus aureus. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2006, Volume: 19, Issue:3 Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Doxycycline; Drug Therapy, Combination; En	2006
Cytotoxic effects of the fluoroquinolone ofloxacin on stromal keratocytes. Cornea, 2007, Volume: 26, Issue:2 Topics: Animals; Anti-Infective Agents; Corneal Stroma; Disease Models, Animal; Eye Infections, Bacterial; H	2007
Methicillin-resistant Staphylococcus aureus infectious keratitis following refractive surgery. American journal of ophthalmology, 2007, Volume: 143, Issue:4 Topics: Adult; Corneal Ulcer; Drug Therapy, Combination; Eye Infections, Bacterial; Female; Health Personnel	2007
Factors compromising the activity of moxifloxacin against intracellular Staphylococcus aureus. The Journal of antimicrobial chemotherapy, 2007, Volume: 59, Issue:4 Topics: Anti-Bacterial Agents; Aza Compounds; Cell Line; Extracellular Space; Fluoroquinolones; Humans; Hydr	2007
Role of interleukin-6 in the pathogenesis of an avian model of Staphylococcus aureus arthritis. Poultry science, 2007, Volume: 86, Issue:6 Topics: Animals; Anti-Bacterial Agents; Arthritis, Infectious; Chickens; Disease Models, Animal; Interleukin	2007
Efficacy of a novel rifamycin derivative, ABI-0043, against Staphylococcus aureus in an experimental model of foreign-body infection. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7 Topics: Animals; Anti-Bacterial Agents; Colony Count, Microbial; Disease Models, Animal; Drug Therapy, Combi	2007
Methicillin-sensitive Staphylococcus aureus tricuspid valve endocarditis with annular abscess cured with oral levofloxacin and rifampicin. International journal of antimicrobial agents, 2007, Volume: 30, Issue:3 Topics: Abscess; Adult; Anti-Bacterial Agents; Cloxacillin; Endocarditis, Bacterial; Fever; Humans; Levoflox	2007
In vitro evaluation of antibiotics' combinations for empirical therapy of suspected methicillin resistant Staphylococcus aureus severe respiratory infections. BMC infectious diseases, 2007, Sep-21, Volume: 7 Topics: Amikacin; Anti-Bacterial Agents; beta-Lactams; Drug Therapy, Combination; Humans; Levofloxacin; Meth	2007
Antimicrobial susceptibility of cerebrospinal isolates from patients with meningitis. Neuro endocrinology letters, 2007, Volume: 28 Suppl 3 Topics: Anti-Bacterial Agents; Cefotaxime; Chloramphenicol; Drug Resistance, Microbial; Haemophilus Infectio	2007
Bactericidal effect of intravitreal levofloxacin in an experimental model of endophthalmitis. The British journal of ophthalmology, 2008, Volume: 92, Issue:5 Topics: Animals; Anti-Bacterial Agents; Ceftazidime; Endophthalmitis; Female; Levofloxacin; Male; Microbial	2008
Immunomodulatory effect of gatifloxacin on mouse peritoneal macrophages in vitro and in models of endotoxin-induced rat conjunctivitis and rabbit bacterial keratitis. Ophthalmic research, 2008, Volume: 40, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Aza Compounds; Cells, Cultured; Conjunctivitis; Endotoxins; Fluor	2008
Sequential acquisition of norfloxacin and ofloxacin resistance by methicillin-resistant and -susceptible Staphylococcus aureus. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:11 Topics: Base Sequence; Humans; Japan; Methicillin Resistance; Microbial Sensitivity Tests; Molecular Sequenc	1993
Comparative prophylactic efficacies of ciprofloxacin, ofloxacin, cefazolin, and vancomycin in experimental model of staphylococcal wound infection. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:6 Topics: Animals; Cefazolin; Ciprofloxacin; Drug Resistance, Microbial; Female; Guinea Pigs; Male; Ofloxacin;	1994
Tolerance of Staphylococcus epidermidis grown from indwelling vascular catheters to antimicrobial agents. Journal of industrial microbiology, 1995, Volume: 15, Issue:3 Topics: Anti-Bacterial Agents; Biofilms; Catheters, Indwelling; Drug Resistance, Microbial; Humans; In Vitro	1995
In vivo efficacies of levofloxacin and ciprofloxacin in acute murine hematogenous pyelonephritis induced by methicillin-susceptible and-resistant Staphylococcus aureus strains. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:11 Topics: Acute Disease; Animals; Anti-Infective Agents; Ciprofloxacin; Colony Count, Microbial; Female; Kidne	1996
Oral treatment of Staphylococcus spp. infected orthopaedic implants with fusidic acid or ofloxacin in combination with rifampicin. The Journal of antimicrobial chemotherapy, 1997, Volume: 39, Issue:2 Topics: Administration, Oral; Adult; Aged; Drug Therapy, Combination; Female; Fusidic Acid; Humans; Male; Mi	1997
Efficacies of ofloxacin, rifampin, and clindamycin in treatment of Staphylococcus aureus abscesses and correlation with results of an in vitro assay of intracellular bacterial killing. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:5 Topics: Abscess; Animals; Anti-Infective Agents; Antibiotics, Antitubercular; Clindamycin; Microbial Sensiti	1997
Levofloxacin versus ciprofloxacin, flucloxacillin, or vancomycin for treatment of experimental endocarditis due to methicillin-susceptible or -resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:8 Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Endocarditis, Bacterial; Floxa	1997
Bilateral corneal infection as a complication of laser in situ keratomileusis. Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:12 Topics: Adolescent; Cilastatin; Cornea; Corneal Diseases; Corneal Transplantation; Drug Therapy, Combination	1997
Effects of nimodipine and ofloxacin on staphylococcal brain abscesses in rats. Arzneimittel-Forschung, 1997, Volume: 47, Issue:12 Topics: Animals; Anti-Infective Agents; Brain Abscess; Calcium Channel Blockers; Male; Nimodipine; Ofloxacin	1997
Prophylaxis of acute osteomyelitis with absorbable ofloxacin-impregnated beads. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:4 Topics: Absorption; Acute Disease; Animals; Anti-Infective Agents; Bone and Bones; Female; Microspheres; Ofl	1998
Analysis of antibiotic susceptibilities of skin wound flora in hospitalized dermatology patients. The crisis of antibiotic resistance has come to the surface. Archives of dermatology, 1998, Volume: 134, Issue:8 Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Dermatitis; Drug Resistance, Microbial;	1998
Effectiveness of ciprofloxacin-polystyrene sulfonate (PSS), ciprofloxacin and ofloxacin in a Staphylococcus keratitis model. Current eye research, 1998, Volume: 17, Issue:8 Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Colony Count, Microbial; Cornea; Disease Models, Anim	1998
[Endogenous infectious endophthalmitis]. La Revue de medecine interne, 1998, Volume: 19, Issue:9 Topics: Aged; Amphotericin B; Antifungal Agents; Candidiasis; Drug Therapy, Combination; Endophthalmitis; Fl	1998
In-vitro activity of three fluoroquinolones, cefotaxime and clindamycin against staphylococci. Zentralblatt fur Bakteriologie : international journal of medical microbiology, 1995, Volume: 282, Issue:4 Topics: Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents; Cefotaxime; Cephalosporins; Ciproflox	1995
Effects of sucrose and silver on Staphylococcus aureus biofilms. The Journal of antimicrobial chemotherapy, 1998, Volume: 42, Issue:5 Topics: Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Adhesion; Biofilms; Blood Coagulation	1998
Molecular characterization of epidemic multiresistant Staphylococcus haemolyticus isolates. Diagnostic microbiology and infectious disease, 1998, Volume: 32, Issue:3 Topics: Ampicillin; Anti-Bacterial Agents; Cefazolin; Cefmetazole; Cross Infection; DNA Restriction Enzymes;	1998
Antistaphylococcal and antistreptococcal killing kinetics of ciprofloxacin, ofloxacin, sparfloxacin, and trovafloxacin. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1998, Volume: 17, Issue:11 Topics: Anti-Infective Agents; Ciprofloxacin; Drug Resistance, Microbial; Fluoroquinolones; Humans; Microbia	1998
Effects of NorA inhibitors on in vitro antibacterial activities and postantibiotic effects of levofloxacin, ciprofloxacin, and norfloxacin in genetically related strains of Staphylococcus aureus. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:2 Topics: Anti-Infective Agents; Bacterial Proteins; Biological Transport; Ciprofloxacin; Drug Synergism; Huma	1999
Prophylaxis of local vascular graft infection with levofloxacin incorporated into albumin-sealed dacron graft (LVFX-ALB Graft). Microbiology and immunology, 1999, Volume: 43, Issue:4 Topics: Albumins; Animals; Anti-Infective Agents; Bacterial Adhesion; Blood Vessel Prosthesis Implantation;	1999
[An animal model of corneal bacterial infection induced by intra-corneal injection of Staphylococcus epidermidis]. Nippon Ganka Gakkai zasshi, 1999, Volume: 103, Issue:7 Topics: Animals; Anti-Infective Agents; Corneal Diseases; Disease Models, Animal; Injections; Ofloxacin; Rab	1999
Ofloxacin levels after intravitreal injection. Effects of trauma and inflammation. Ophthalmic research, 1999, Volume: 31, Issue:6 Topics: Animals; Anti-Infective Agents; Endophthalmitis; Eye Injuries; Half-Life; Injections; Ofloxacin; Osm	1999
The effects of NorA inhibition on the activities of levofloxacin, ciprofloxacin and norfloxacin against two genetically related strains of Staphylococcus aureus in an in-vitro infection model. The Journal of antimicrobial chemotherapy, 1999, Volume: 44, Issue:3 Topics: Anti-Infective Agents; Bacterial Proteins; Ciprofloxacin; Drug Interactions; Drug Resistance, Microb	1999
Efficacy of levofloxacin for experimental aortic-valve endocarditis in rabbits infected with viridans group streptococcus or Staphylococcus aureus. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:11 Topics: Animals; Aortic Valve; Drug Resistance, Microbial; Endocarditis, Bacterial; Heart Valve Diseases; Le	1999
The effect of long-term use and inflammation on the ocular penetration of topical ofloxacin. Current eye research, 1999, Volume: 19, Issue:6 Topics: Administration, Topical; Animals; Anti-Infective Agents; Aqueous Humor; Endophthalmitis; Eye; Eye In	1999
Pharmacokinetics and pharmacodynamics of levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in human skin blister fluid. Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:5 Topics: Anti-Infective Agents; Blister; Body Fluids; Granulocytes; Humans; Levofloxacin; Microbial Sensitivi	2000
Effect of topical povidone-iodine versus topical ofloxacin on experimental Staphylococcus keratitis. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2000, Volume: 238, Issue:5 Topics: Animals; Anti-Infective Agents; Colony Count, Microbial; Cornea; Disease Models, Animal; Eye Infecti	2000
The effectiveness of a topical antibiotic irrigating solution in a model of staphylococcal keratitis after lamellar keratectomy. American journal of ophthalmology, 2000, Volume: 130, Issue:1 Topics: Administration, Topical; Animals; Anti-Infective Agents; Colony Count, Microbial; Corneal Stroma; Co	2000
Efficacy of rifampin-levofloxacin as a prophylactic agent in preventing Staphylococcus epidermidis graft infection. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2000, Volume: 20, Issue:6 Topics: Animals; Blood Vessel Prosthesis; Humans; Levofloxacin; Male; Methicillin Resistance; Microbial Sens	2000
Evaluation of oral antimicrobial agent levels in tooth extraction sites. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2001, Volume: 91, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Alveolar Process; Anti-Bacterial A	2001
Comparative evaluation of oral levofloxacin and parenteral nafcillin in the treatment of experimental methicillin-susceptible Staphylococcus aureus osteomyelitis in rabbits. The Journal of antimicrobial chemotherapy, 2001, Volume: 48, Issue:2 Topics: Administration, Oral; Animals; Anti-Infective Agents; Humans; Infusions, Parenteral; Levofloxacin; M	2001
Effectiveness of ciprofloxacin and ofloxacin in a prophylaxis model of Staphylococcus keratitis. Cornea, 2001, Volume: 20, Issue:8 Topics: Animals; Anti-Infective Agents; Antibiotic Prophylaxis; Ciprofloxacin; Colony Count, Microbial; Corn	2001
The effectiveness of tobramycin and Ocuflox in a prophylaxis model of Staphylococcus keratitis. Current eye research, 2001, Volume: 23, Issue:1 Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Colony Count, Microbi	2001
Three-year outcome in a patient with Staphylococcus lugdunensis discitis. Joint bone spine, 2002, Volume: 69, Issue:1 Topics: Aged; Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols;	2002
Comparison of levofloxacin, alatrofloxacin, and vancomycin for prophylaxis and treatment of experimental foreign-body-associated infection by methicillin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:5 Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Disease Models, Anima	2002
Risk factors associated with nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection including previous use of antimicrobials. The Journal of antimicrobial chemotherapy, 2002, Volume: 49, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Chi-Square Distribution; Confiden	2002
[Vascular graft infection by Staphylococcus epidermidis: efficacy of various perioperative prophylaxis protocols in an animal model]. Le infezioni in medicina, 2001, Volume: 9, Issue:1 Topics: Animals; Blood Vessel Prosthesis Implantation; Cefazolin; Drug Evaluation, Preclinical; Drug Implant	2001
Occurrence of bacteremia in hematologic patients. European journal of epidemiology, 1992, Volume: 8, Issue:5 Topics: Adolescent; Adult; Aged; Bacteremia; Bone Marrow Transplantation; Catheterization; Ciprofloxacin; Fe	1992
[In vitro kinetics of the activity of fusidic acid and fluoroquinolones combinations against staphylococci according to methicillin-resistance phenotype. Implications for the treatment of osteoarticular infections]. Pathologie-biologie, 1992, Volume: 40, Issue:5 Topics: Bone Diseases; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fusidic Acid; Humans; In	1992
[Levofloxacin in the field of dermatology]. The Japanese journal of antibiotics, 1992, Volume: 45, Issue:5 Topics: Adolescent; Adult; Animals; Drug Evaluation; Drug Resistance, Microbial; Female; Humans; Levofloxaci	1992
[Three cases of postpartum infection with methicillin-resistant Staphylococcus aureus (MRSA)]. Nihon Sanka Fujinka Gakkai zasshi, 1992, Volume: 44, Issue:3 Topics: Adult; Cefmetazole; Drug Therapy, Combination; Female; Humans; Imipenem; Methicillin Resistance; Min	1992
Anti-staphylococcal activity of temafloxacin, ciprofloxacin, ofloxacin and enoxacin. The Journal of antimicrobial chemotherapy, 1991, Volume: 28, Issue:5 Topics: Anti-Infective Agents; Ciprofloxacin; Enoxacin; Fluoroquinolones; Humans; Microbial Sensitivity Test	1991
[Evaluation of the effectiveness of ofloxacin in the treatment of respiratory tract]. Pneumonologia i alergologia polska, 1991, Volume: 59, Issue:1-2 Topics: Administration, Oral; Adult; Aged; Bronchitis; Chronic Disease; Drug Resistance, Microbial; Enteroco	1991
Efficacy of ofloxacin in experimental Staphylococcus aureus endocarditis. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:2 Topics: Animals; Drug Resistance, Microbial; Endocarditis, Bacterial; Female; Methicillin; Microbial Sensiti	1990
[In vivo bactericidal effect of ciprofloxacin, ofloxacin and pefloxacin against Staphylococcus aureus]. Pathologie-biologie, 1989, Volume: 37, Issue:5 Pt 2 Topics: Animals; Ciprofloxacin; Microbial Sensitivity Tests; Ofloxacin; Pefloxacin; Rabbits; Staphylococcal	1989
The role of quinolones in staphylococcal infection. Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Topics: Anti-Infective Agents; Ciprofloxacin; Enoxacin; Humans; Norfloxacin; Ofloxacin; Pefloxacin; Staphylo	1989
[Single day treatment in acute cystitis]. Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:5 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Cystitis;	1988
Oral treatment of peritonitis in CAPD patients with ofloxacin. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1988, Volume: 3, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Aged; Drug Administration Schedule; Female; Humans; Male; M	1988
Efficacy of coumermycin, ofloxacin and vancomycin against methicillin-resistant Staphylococcus aureus in vitro and in experimental infections of mice. Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology, 1988, Volume: 267, Issue:4 Topics: Aminocoumarins; Animals; Anti-Bacterial Agents; Coumarins; Drug Resistance, Microbial; Male; Methici	1988
[Ofloxacin (RU 43280). Clinical study]. Pathologie-biologie, 1987, Volume: 35, Issue:5 Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Drug Therapy, Combination; Enterobacteriaceae Infect	1987
[Bone infections: treatment by ofloxacin. Apropos of 10 cases]. Pathologie-biologie, 1987, Volume: 35, Issue:5 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Enterobacteriaceae Infections;	1987
Chemotherapeutic efficacy of ofloxacin on renal and subcutaneous infection models with Staphylococcus aureus in mice. Chemotherapy, 1986, Volume: 32, Issue:3 Topics: Abscess; Animals; Anti-Bacterial Agents; Autoradiography; Disease Models, Animal; Kinetics; Male; Mi	1986
Comparative activity of ofloxacin with reference to bacterial strains isolated in in-patients and out-patients. Infection, 1986, Volume: 14 Suppl 1 Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Cross Infection; Dose-Response Relationship,	1986

ofloxacin and Infections, Staphylococcal