ofloxacin has been researched along with Infections, Rickettsia in 4 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We found serological evidence of acute murine typhus in 21 of 125 (17%) patients, with 12 of 21 (57%) patients polymerase chain reaction (PCR)-positive for Rickettsia typhi." | 1.42 | Undifferentiated febrile illness in Kathmandu, Nepal. ( Arjyal, A; Baker, S; Basnyat, B; Blacksell, SD; Day, N; Dolecek, C; Dongol, S; Farrar, J; Giri, A; Karkey, A; Paris, DH; Thompson, CN; Thwaites, G, 2015) |
| "Levofloxacin was bacteriostatic against R." | 1.30 | Bacteriostatic and bactericidal activity of levofloxacin against Rickettsia rickettsii, Rickettsia conorii, 'Israeli spotted fever group rickettsia' and Coxiella burnetii. ( Maurin, M; Raoult, D, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thompson, CN | 1 |
| Blacksell, SD | 1 |
| Paris, DH | 1 |
| Arjyal, A | 1 |
| Karkey, A | 1 |
| Dongol, S | 1 |
| Giri, A | 1 |
| Dolecek, C | 1 |
| Day, N | 1 |
| Baker, S | 1 |
| Thwaites, G | 1 |
| Farrar, J | 1 |
| Basnyat, B | 1 |
| Kondo, M | 1 |
| Kurokawa, I | 1 |
| Yamanaka, K | 1 |
| Akachi, S | 1 |
| Nishii, M | 1 |
| Maurin, M | 1 |
| Raoult, D | 1 |
| Oka, N | 1 |
| Kato, Y | 1 |
| Dekio, S | 1 |
| Nishio, T | 1 |
| Itagaki, A | 1 |
| Uchiyama, T | 1 |
| Uchida, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Parallel Group, Double Blinded, 1:1, Randomized Controlled Phase III Trial of Co-trimoxazole Versus Azithromycin for the Treatment of Undifferentiated Fever In Nepal[NCT02773407] | Phase 3 | 330 participants (Actual) | Interventional | 2016-05-23 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for ofloxacin and Infections, Rickettsia
| Article | Year |
|---|---|
Undifferentiated febrile illness in Kathmandu, Nepal.
Topics: Anti-Bacterial Agents; Fever; Fluoroquinolones; Gatifloxacin; Humans; Nepal; Ofloxacin; Prospective | 2015 |
Topical treatment with incision and antiseptic may prevent the severity of Japan spotted fever.
Topics: Aged; Anti-Infective Agents, Local; Ceftriaxone; Erythema; Female; Fever; Humans; Minocycline; Oflox | 2010 |
Bacteriostatic and bactericidal activity of levofloxacin against Rickettsia rickettsii, Rickettsia conorii, 'Israeli spotted fever group rickettsia' and Coxiella burnetii.
Topics: Anti-Infective Agents; Colony Count, Microbial; Coxiella burnetii; Levofloxacin; Ofloxacin; Ricketts | 1997 |
[A case report of spotted fever group rickettsiosis first encountered in Shimane Prefecture, Japan].
Topics: Antibodies, Bacterial; Drug Therapy, Combination; Humans; Japan; Male; Middle Aged; Minocycline; Ofl | 1990 |