ofloxacin has been researched along with Hypoglycemia in 24 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although hypoglycemia is known to be associated with levofloxacin, patients are continually being hospitalized because of this adverse event." | 7.78 | Severe hypoglycemia associated with levofloxacin in Type 2 diabetic patients receiving polytherapy: two case reports. ( Micheli, L; Nencini, C; Sbrilli, M, 2012) |
| "A malnourished 58-year-old man with diabetes developed hypoglycemia after receiving levofloxacin in conjunction with glipizide." | 7.75 | Hypoglycemia associated with the use of levofloxacin. ( Garber, SM; Miller, SM; Pound, MW, 2009) |
| "To compare rates of hypoglycemia and hyperglycemia among elderly hospitalized patients with normal blood glucose concentrations at baseline who were receiving either gatifloxacin or levofloxacin, and to determine if appropriateness of their doses, according to their package inserts, was associated with hypoglycemia or hyperglycemia." | 7.74 | Effects of gatifloxacin and levofloxacin on rates of hypoglycemia and hyperglycemia among elderly hospitalized patients. ( Graves, J; Lodise, T; Lomaestro, B; Miller, C; Mohr, JF; Smith, RP, 2007) |
| " Hypoglycemia because of use of levofloxacin is a rarely reported complication." | 7.74 | Fatal hypoglycemia with levofloxacin use in an elderly patient in the post-operative period. ( Abraham, J; Jacob, JJ; Kapoor, R; Singh, M, 2008) |
| " We describe an elderly, non-diabetic patient with steroid-induced hyperglycemia prescribed glyburide who later developed severe hypoglycemia resulting in anoxic brain injury soon after initiating therapy with levofloxacin." | 7.73 | Hypoglycemia-induced anoxic brain injury possibly associated with levofloxacin. ( Adra, M; Keir, C; Lawrence, KR, 2006) |
| "Although uncommon, hypoglycemia has been reported with all the fluoroquinolones and appears to occur most frequently in elderly patients with type 2 diabetes mellitus who are receiving therapy with oral hypoglycemics." | 5.32 | Fatal hypoglycemia associated with levofloxacin. ( Dougherty, R; Friedrich, LV, 2004) |
| "Although hypoglycemia is known to be associated with levofloxacin, patients are continually being hospitalized because of this adverse event." | 3.78 | Severe hypoglycemia associated with levofloxacin in Type 2 diabetic patients receiving polytherapy: two case reports. ( Micheli, L; Nencini, C; Sbrilli, M, 2012) |
| "A malnourished 58-year-old man with diabetes developed hypoglycemia after receiving levofloxacin in conjunction with glipizide." | 3.75 | Hypoglycemia associated with the use of levofloxacin. ( Garber, SM; Miller, SM; Pound, MW, 2009) |
| " Renal-dose levofloxacin was utilized as part of an antimicrobial regimen to treat post-operative peritonitis." | 3.74 | Levofloxacin-associated hypoglycaemia complicated by pontine myelinolysis and quadriplegia. ( Gregory, J; Huesmann, G; Jakoby, MG; Vallurupalli, S, 2008) |
| "To compare rates of hypoglycemia and hyperglycemia among elderly hospitalized patients with normal blood glucose concentrations at baseline who were receiving either gatifloxacin or levofloxacin, and to determine if appropriateness of their doses, according to their package inserts, was associated with hypoglycemia or hyperglycemia." | 3.74 | Effects of gatifloxacin and levofloxacin on rates of hypoglycemia and hyperglycemia among elderly hospitalized patients. ( Graves, J; Lodise, T; Lomaestro, B; Miller, C; Mohr, JF; Smith, RP, 2007) |
| "To assess the prevalence of dysglycemia (hypoglycemia or hyperglycemia) associated with oral levofloxacin and gatifloxacin therapy in an outpatient setting, and to determine the characteristics of patients who developed dysglycemia while receiving either fluoroquinolone." | 3.74 | Prevalence of and risk factors for dysglycemia in patients receiving gatifloxacin and levofloxacin in an outpatient setting. ( LaPlante, KL; Mersfelder, TL; Quilliam, BJ; Ward, KE, 2008) |
| " Hypoglycemia because of use of levofloxacin is a rarely reported complication." | 3.74 | Fatal hypoglycemia with levofloxacin use in an elderly patient in the post-operative period. ( Abraham, J; Jacob, JJ; Kapoor, R; Singh, M, 2008) |
| " We describe an elderly, non-diabetic patient with steroid-induced hyperglycemia prescribed glyburide who later developed severe hypoglycemia resulting in anoxic brain injury soon after initiating therapy with levofloxacin." | 3.73 | Hypoglycemia-induced anoxic brain injury possibly associated with levofloxacin. ( Adra, M; Keir, C; Lawrence, KR, 2006) |
| " In the first, case patients were persons treated in the hospital for hypoglycemia after outpatient treatment with a macrolide, a second-generation cephalosporin, or a respiratory fluoroquinolone (gatifloxacin, levofloxacin, moxifloxacin, or ciprofloxacin)." | 3.73 | Outpatient gatifloxacin therapy and dysglycemia in older adults. ( Dresser, L; Juurlink, DN; Kopp, A; Low, DE; Mamdani, MM; Park-Wyllie, LY; Shah, BR; Stukel, TA; Stumpo, C, 2006) |
| " Diphenhydramine (1 mg/kg) antagonized the hyperglycemia induced by 300 mg/kg of levofloxacin." | 3.73 | Effect of levofloxacin on serum glucose concentration in rats. ( Ishiwata, Y; Itoga, Y; Yasuhara, M, 2006) |
| "In moxifloxacin-treated rats, an increase in the EDHF response was observed, which was largely attributed to SK(Ca)-activation." | 1.39 | The effect of levofloxacin and moxifloxacin on cardiovascular functions of rats with streptozotocin-induced diabetes. ( Absi, M; Ghareeb, H; Khalil, A; Ruegg, UT, 2013) |
| " The incidence of adverse reactions was 1." | 1.34 | Post-marketing surveillance of the safety of levofloxacin in Japan. ( Kawai, H; Komiya, M; Matsumoto, T; Nakayasu, T; Shimada, J; Yamaguchi, H; Yokoyama, H, 2007) |
| "Although uncommon, hypoglycemia has been reported with all the fluoroquinolones and appears to occur most frequently in elderly patients with type 2 diabetes mellitus who are receiving therapy with oral hypoglycemics." | 1.32 | Fatal hypoglycemia associated with levofloxacin. ( Dougherty, R; Friedrich, LV, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 20 (83.33) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fusco, S | 1 |
| Reitano, F | 1 |
| Gambadoro, N | 1 |
| Previti, M | 1 |
| Russo, G | 1 |
| Basile, G | 1 |
| Cucinotta, D | 1 |
| Vallurupalli, S | 1 |
| Huesmann, G | 1 |
| Gregory, J | 1 |
| Jakoby, MG | 1 |
| Kelesidis, T | 1 |
| Canseco, E | 1 |
| Garber, SM | 1 |
| Pound, MW | 1 |
| Miller, SM | 1 |
| Micheli, L | 1 |
| Sbrilli, M | 1 |
| Nencini, C | 1 |
| Absi, M | 1 |
| Ghareeb, H | 1 |
| Khalil, A | 1 |
| Ruegg, UT | 1 |
| Parra-Riffo, H | 1 |
| Lemus-Peñaloza, J | 1 |
| Friedrich, LV | 1 |
| Dougherty, R | 1 |
| Graumlich, JF | 1 |
| Habis, S | 1 |
| Avelino, RR | 1 |
| Salverson, SM | 1 |
| Gaddamanugu, M | 1 |
| Jamma, K | 1 |
| Aldag, JC | 1 |
| Mohr, JF | 2 |
| McKinnon, PS | 1 |
| Peymann, PJ | 1 |
| Kenton, I | 1 |
| Septimus, E | 1 |
| Okhuysen, PC | 1 |
| Lawrence, KR | 1 |
| Adra, M | 1 |
| Keir, C | 1 |
| Tailor, SA | 1 |
| Simor, AE | 1 |
| Cornish, W | 1 |
| Phillips, EJ | 1 |
| Knowles, S | 1 |
| Rachlis, A | 1 |
| Park-Wyllie, LY | 1 |
| Juurlink, DN | 1 |
| Kopp, A | 1 |
| Shah, BR | 1 |
| Stukel, TA | 1 |
| Stumpo, C | 1 |
| Dresser, L | 1 |
| Low, DE | 1 |
| Mamdani, MM | 1 |
| Wang, S | 1 |
| Rizvi, AA | 1 |
| Kanbay, M | 1 |
| Aydogan, T | 1 |
| Bozalan, R | 1 |
| Isik, A | 1 |
| Uz, B | 1 |
| Kaya, A | 1 |
| Akcay, A | 1 |
| Ishiwata, Y | 1 |
| Itoga, Y | 1 |
| Yasuhara, M | 1 |
| Yamaguchi, H | 1 |
| Kawai, H | 1 |
| Matsumoto, T | 1 |
| Yokoyama, H | 1 |
| Nakayasu, T | 1 |
| Komiya, M | 1 |
| Shimada, J | 1 |
| Catero, M | 1 |
| Lodise, T | 1 |
| Graves, J | 1 |
| Miller, C | 1 |
| Lomaestro, B | 1 |
| Smith, RP | 1 |
| LaPlante, KL | 1 |
| Mersfelder, TL | 1 |
| Ward, KE | 1 |
| Quilliam, BJ | 1 |
| Singh, M | 1 |
| Jacob, JJ | 2 |
| Kapoor, R | 1 |
| Abraham, J | 1 |
| Gibert, AE | 1 |
| Porta, FS | 1 |
| Singh, N | 1 |
2 reviews available for ofloxacin and Hypoglycemia
| Article | Year |
|---|---|
Severe levofloxacin-induced hypoglycaemia: a case report and literature review.
Topics: Aged; Anti-Bacterial Agents; Catheter-Related Infections; Drug Therapy, Combination; Enterococcus; G | 2012 |
Dysglycemia and fluoroquinolones: are you putting patients at risk?
Topics: Adolescent; Adult; Aza Compounds; Bacterial Infections; Blood Glucose; Ciprofloxacin; Dose-Response | 2007 |
22 other studies available for ofloxacin and Hypoglycemia
| Article | Year |
|---|---|
Severe hypoglycemia associated with levofloxacin in a healthy older woman.
Topics: Administration, Oral; Aged, 80 and over; Anti-Bacterial Agents; Blood Glucose; Female; Humans; Hypog | 2013 |
Levofloxacin-associated hypoglycaemia complicated by pontine myelinolysis and quadriplegia.
Topics: Anti-Bacterial Agents; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Hypoglycemia; Kidne | 2008 |
Levofloxacin-induced hypoglycemia: a rare but life-threatening side effect of a widely used antibiotic.
Topics: Aged; Anti-Bacterial Agents; Female; Humans; Hypoglycemia; Levofloxacin; Ofloxacin | 2009 |
Hypoglycemia associated with the use of levofloxacin.
Topics: Anti-Bacterial Agents; Community-Acquired Infections; Diabetes Mellitus, Type 2; Drug Interactions; | 2009 |
Levofloxacin and glycaemic disorders. Diabetic patients: beware.
Topics: Canada; Diabetes Mellitus; Humans; Hyperglycemia; Hypoglycemia; Levofloxacin; Ofloxacin | 2008 |
Severe hypoglycemia associated with levofloxacin in Type 2 diabetic patients receiving polytherapy: two case reports.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Blood Glucose; Diabetes Mellitus, Type 2; Drug Interaction | 2012 |
The effect of levofloxacin and moxifloxacin on cardiovascular functions of rats with streptozotocin-induced diabetes.
Topics: Animals; Anti-Bacterial Agents; Aza Compounds; Biological Factors; Blood Glucose; Bradycardia; Cardi | 2013 |
Fatal hypoglycemia associated with levofloxacin.
Topics: Aged; Fatal Outcome; Humans; Hypoglycemia; Levofloxacin; Male; Ofloxacin | 2004 |
Hypoglycemia in inpatients after gatifloxacin or levofloxacin therapy: nested case-control study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Blood Glucose; Case-Control Studies; Female; | 2005 |
A retrospective, comparative evaluation of dysglycemias in hospitalized patients receiving gatifloxacin, levofloxacin, ciprofloxacin, or ceftriaxone.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Blood Glucose; Ceftriaxone; Ciprofloxacin; Fe | 2005 |
Hypoglycemia-induced anoxic brain injury possibly associated with levofloxacin.
Topics: Aged; Anti-Bacterial Agents; Blood Glucose; Glasgow Coma Scale; Humans; Hypoglycemia; Hypoxia, Brain | 2006 |
Glucose homeostasis abnormalities and gatifloxacin.
Topics: Aza Compounds; Fluoroquinolones; Gatifloxacin; Glucose; Homeostasis; Humans; Hyperglycemia; Hypoglyc | 2006 |
Outpatient gatifloxacin therapy and dysglycemia in older adults.
Topics: Aged; Aged, 80 and over; Ambulatory Care; Anti-Bacterial Agents; Case-Control Studies; Cephalosporin | 2006 |
Levofloxacin-induced hypoglycemia in a nondiabetic patient.
Topics: Aged; Anti-Bacterial Agents; Coronary Artery Bypass; Female; Glucagon; Glucose; Humans; Hypoglycemia | 2006 |
A Rare but serious side effect of Levofloxacin: hypoglycemia in a geriatric patient.
Topics: Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemia; Levofloxacin; Middle Aged; Ofloxacin; Pneum | 2006 |
Effect of levofloxacin on serum glucose concentration in rats.
Topics: Adrenal Medulla; Animals; Anti-Bacterial Agents; Blood Glucose; Diphenhydramine; Dose-Response Relat | 2006 |
Post-marketing surveillance of the safety of levofloxacin in Japan.
Topics: Achilles Tendon; Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Chemical and | 2007 |
Effects of gatifloxacin and levofloxacin on rates of hypoglycemia and hyperglycemia among elderly hospitalized patients.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Cohort Studies; Dose-Response Relationship, Drug; Fe | 2007 |
Prevalence of and risk factors for dysglycemia in patients receiving gatifloxacin and levofloxacin in an outpatient setting.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Azithromycin; Creatinin | 2008 |
Fatal hypoglycemia with levofloxacin use in an elderly patient in the post-operative period.
Topics: Acute Kidney Injury; Aged; Anti-Bacterial Agents; Drug Therapy, Combination; Duodenal Ulcer; Fatal O | 2008 |
Hypoglycemia and levofloxacin: a case report.
Topics: Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemia; Levofloxacin; Ofloxacin; | 2008 |
Levofloxacin and hypoglycemia.
Topics: Clinical Competence; Fluoroquinolones; Gatifloxacin; Health Services Research; Hospitals, University | 2008 |