ofloxacin has been researched along with Hematologic Malignancies in 6 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An open-label randomised clinical trial was designed to compare the efficacy and tolerance of levofloxacin and ciprofloxacin plus phenethicillin for the prevention of bacterial infections in patients with high-risk neutropenia, and to monitor the emergence of antimicrobial resistance." | 5.12 | Levofloxacin vs. ciprofloxacin plus phenethicillin for the prevention of bacterial infections in patients with haematological malignancies. ( Huijgens, PC; Janssen, JJ; Leidekker, ME; Simoons-Smit, AM; Timmers, GJ; Vandenbroucke-Grauls, CM, 2007) |
| "Febrile neutropenia is an expected complication during treatment of aggressive hematological malignancies and hematopoietic cell transplantation." | 2.73 | The clinical impact of antibacterial prophylaxis and cycling antibiotics for febrile neutropenia in a hematological malignancy and transplantation unit. ( Craig, M; Cumpston, AD; Devetten, MP; Ericson, SG; Hobbs, GR; Sarwari, AR, 2007) |
| " Pharmacokinetic parameters of levofloxacin, including the maximum serum concentration (C(max)), time to C(max) (T(max)), area under the concentration-time curve (AUC), volume of distribution at steady state (V(ss)/F) and clearance (CL/F) were not statistically different at first dose and during neutropenia." | 2.71 | Pharmacokinetics and effects on bowel and throat microflora of oral levofloxacin as antibacterial prophylaxis in neutropenic patients with haematological malignancies. ( Dijstelbloem, Y; Huijgens, PC; Simoons-Smit, AM; Timmers, GJ; Touw, DJ; van Winkelhoff, AJ; Vandenbroucke-Grauls, CM, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellesso, M | 1 |
| Costa, SF | 1 |
| Pracchia, LF | 1 |
| Santos Dias, LC | 1 |
| Chamone, D | 1 |
| Dorlhiac-Llacer, PE | 1 |
| Zeuli, JD | 1 |
| Wilson, JW | 1 |
| Estes, LL | 1 |
| Timmers, GJ | 2 |
| Dijstelbloem, Y | 1 |
| Simoons-Smit, AM | 2 |
| van Winkelhoff, AJ | 1 |
| Touw, DJ | 1 |
| Vandenbroucke-Grauls, CM | 2 |
| Huijgens, PC | 2 |
| Di Bonaventura, G | 1 |
| Picciani, C | 1 |
| Spedicato, I | 1 |
| Piccolomini, R | 1 |
| Leidekker, ME | 1 |
| Janssen, JJ | 1 |
| Craig, M | 1 |
| Cumpston, AD | 1 |
| Hobbs, GR | 1 |
| Devetten, MP | 1 |
| Sarwari, AR | 1 |
| Ericson, SG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Trial of Tamoxifen Combined With Amphotericin B and Fluconazole for Cryptococcal Meningitis[NCT03112031] | Phase 2 | 50 participants (Actual) | Interventional | 2017-10-10 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for ofloxacin and Hematologic Malignancies
| Article | Year |
|---|---|
Pharmacokinetics and effects on bowel and throat microflora of oral levofloxacin as antibacterial prophylaxis in neutropenic patients with haematological malignancies.
Topics: Administration, Oral; Adult; Aged; Anti-Infective Agents; Digestive System; Drug Resistance, Bacteri | 2004 |
Levofloxacin vs. ciprofloxacin plus phenethicillin for the prevention of bacterial infections in patients with haematological malignancies.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Antibiotic Prophylaxis; Ciprofloxacin; Cross Infecti | 2007 |
The clinical impact of antibacterial prophylaxis and cycling antibiotics for febrile neutropenia in a hematological malignancy and transplantation unit.
Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacteremia; Drug Administration Schedule; Drug Resist | 2007 |
3 other studies available for ofloxacin and Hematologic Malignancies
| Article | Year |
|---|---|
Outpatient treatment with intravenous antimicrobial therapy and oral levofloxacin in patients with febrile neutropenia and hematological malignancies.
Topics: Adult; Anti-Bacterial Agents; Cefepime; Cephalosporins; Fever; Hematologic Neoplasms; Home Infusion | 2011 |
Effect of combined fluoroquinolone and azole use on QT prolongation in hematology patients.
Topics: Adult; Aged; Antifungal Agents; Drug Administration Schedule; Drug Therapy, Combination; Electrocard | 2013 |
E-test method for detecting antibiotic synergy against Pseudomonas aeruginosa from neutropenic patients: a cost-effective approach.
Topics: Anemia; Anti-Bacterial Agents; Cefotaxime; Ceftriaxone; Cost-Benefit Analysis; Drug Synergism; Drug | 2004 |