ofloxacin has been researched along with HIV Infections in 20 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The series is part of an ongoing randomised controlled trial assessing rechallenge dosing following TB-associated cutaneous ADR." | 2.77 | Multiple drug hypersensitivity reactions to anti-tuberculosis drugs: five cases in HIV-infected patients. ( Dheda, K; Lehloenya, RJ; Todd, G; Wallace, J, 2012) |
| " This trial is based on the hypothesis that current anti-mycobacterial treatment schedules for TBM are not potent enough and that outcomes will be improved by increasing the CSF penetrating power of this regimen by optimising dosage and using additional drugs with better CSF penetration." | 2.76 | Intensified treatment with high dose rifampicin and levofloxacin compared to standard treatment for adult patients with tuberculous meningitis (TBM-IT): protocol for a randomized controlled trial. ( Bang, ND; Caws, M; Chau, TT; Day, J; Dung, NH; Farrar, J; Heemskerk, D; Merson, L; Olliaro, P; Pouplin, T; Wolbers, M; Yen, NT, 2011) |
| " For levofloxacin, plasma samples were obtained at steady state during a 24-h dosing interval." | 2.70 | Pharmacokinetic evaluation of oral levofloxacin in human immunodeficiency virus-infected subjects receiving concomitant antiretroviral therapy. ( Cadeo, B; Carosi, G; Fiocchi, C; Marchetti, F; Regazzi, MB; Signorini, L; Viale, P; Villani, A; Villani, P, 2001) |
| "Levofloxacin disposition was characterized by rapid oral absorption, with peak concentrations occurring approximately 1." | 2.69 | Pharmacokinetics and safety of high-dose and extended-interval regimens of levofloxacin in human immunodeficiency virus-infected patients. ( Baird, B; Chow, AT; Fowler, CL; Masur, H; Natarajan, J; Piscitelli, SC; Spooner, K; Walker, RE; Williams, RR, 1999) |
| "Levofloxacin was rapidly absorbed (time to maximum plasma concentration, approximately 1." | 2.68 | Pharmacokinetics and safety of oral levofloxacin in human immunodeficiency virus-infected individuals receiving concomitant zidovudine. ( Chien, SC; Chow, AT; Hendrix, CW; Rogge, MC; Williams, RR, 1997) |
| "Levofloxacin was well- tolerated in this group of asymptomatic HIV-infected males: there were no statistically significant differences in adverse effects in the two groups (P = 0." | 2.67 | Pharmacokinetics and safety of levofloxacin in patients with human immunodeficiency virus infection. ( Bartlett, JA; Chow, AT; Flor, SC; Gallis, HA; Goodwin, SD; Wong, FA, 1994) |
| "Ofloxacin has been advocated by the WHO in case of MDR-TB, when susceptibility to test results are not available before starting the new treatment, in the continuation period (18 months) and if resistance is proven to at least isoniazid and rifampicin." | 1.32 | Ofloxacin in multidrug resistant tuberculosis. ( Gawde, AS; Morye, VK; Walwaikar, PP, 2003) |
| "HIV infection due to intravenous drug abuse had been diagnosed in 1986." | 1.28 | [Reversible space-occupying lesions of the kidney in HIV infection]. ( Bogner, JR; Middeke, M; Zoller, WG, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 8 (40.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pietersen, E | 1 |
| Anderson, K | 1 |
| Cox, H | 2 |
| Dheda, K | 2 |
| Bian, A | 1 |
| Shepherd, BE | 1 |
| Sterling, TR | 1 |
| Warren, RM | 1 |
| van der Heijden, YF | 1 |
| Van der Walt, M | 1 |
| Lancaster, J | 1 |
| Odendaal, R | 1 |
| Davis, JG | 1 |
| Shean, K | 1 |
| Farley, J | 1 |
| Seddon, JA | 2 |
| Hesseling, AC | 2 |
| Finlayson, H | 1 |
| Fielding, K | 1 |
| Hughes, J | 1 |
| Godfrey-Faussett, P | 1 |
| Schaaf, HS | 2 |
| Rautenbach, C | 1 |
| Le Falher, G | 1 |
| Makinson, A | 1 |
| Eden, A | 1 |
| Lesnik, A | 1 |
| Le Moing, V | 1 |
| Reynes, J | 1 |
| Heemskerk, D | 1 |
| Day, J | 1 |
| Chau, TT | 1 |
| Dung, NH | 1 |
| Yen, NT | 1 |
| Bang, ND | 1 |
| Merson, L | 1 |
| Olliaro, P | 1 |
| Pouplin, T | 1 |
| Caws, M | 1 |
| Wolbers, M | 1 |
| Farrar, J | 1 |
| Lehloenya, RJ | 1 |
| Wallace, J | 1 |
| Todd, G | 1 |
| Moretti, F | 1 |
| Quiros-Roldan, E | 1 |
| Casari, S | 1 |
| Viale, P | 2 |
| Chiodera, A | 1 |
| Carosi, G | 2 |
| Candel, FJ | 2 |
| López, R | 1 |
| Valdivia, A | 2 |
| Núñez, MJ | 2 |
| Roca-Arbonés, V | 2 |
| Picazo de la Garza, JJ | 1 |
| Walwaikar, PP | 1 |
| Morye, VK | 1 |
| Gawde, AS | 1 |
| Arroyo, C | 1 |
| Téllez, MJ | 1 |
| Picazo, JJ | 1 |
| Biswas, SK | 1 |
| Guettrot-Imbert, G | 1 |
| Letranchant, L | 1 |
| Gallot, D | 1 |
| Romaszko, C | 1 |
| Laurichesse, H | 1 |
| Goodwin, SD | 1 |
| Gallis, HA | 1 |
| Chow, AT | 3 |
| Wong, FA | 1 |
| Flor, SC | 1 |
| Bartlett, JA | 1 |
| Bruguera, M | 1 |
| Chien, SC | 1 |
| Rogge, MC | 1 |
| Williams, RR | 2 |
| Hendrix, CW | 1 |
| Piscitelli, SC | 1 |
| Spooner, K | 1 |
| Baird, B | 1 |
| Fowler, CL | 1 |
| Natarajan, J | 1 |
| Masur, H | 1 |
| Walker, RE | 1 |
| Villani, P | 1 |
| Signorini, L | 1 |
| Cadeo, B | 1 |
| Marchetti, F | 1 |
| Villani, A | 1 |
| Fiocchi, C | 1 |
| Regazzi, MB | 1 |
| Richter, E | 1 |
| Wessling, J | 1 |
| Lügering, N | 1 |
| Domschke, W | 1 |
| Rüsch-Gerdes, S | 1 |
| Bogner, JR | 1 |
| Zoller, WG | 1 |
| Middeke, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Leveraging mHealth to Enable and Adapt Community Health Worker Strategies to Improve TB/HIV Patient Outcomes in South Africa (LEAP-TB-SA) Trial[NCT04298905] | 200 participants (Anticipated) | Interventional | 2022-03-10 | Recruiting | |||
| A Double-Blind Study to Evaluate the Safety and Pharmacokinetics of L-Ofloxacin (RWJ 25213) in Subjects With HIV Infection[NCT00002249] | Phase 1 | 0 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ofloxacin and HIV Infections
| Article | Year |
|---|---|
[Endocarditis due to Stenotrophomonas maltophilia].
Topics: Aortic Valve Insufficiency; Disease Susceptibility; Drug Resistance, Multiple, Bacterial; Drug Thera | 2002 |
[Treatment of chronic hepatitis C: still many problems pending].
Topics: Adrenal Cortex Hormones; Aged; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antiv | 1997 |
6 trials available for ofloxacin and HIV Infections
| Article | Year |
|---|---|
Intensified treatment with high dose rifampicin and levofloxacin compared to standard treatment for adult patients with tuberculous meningitis (TBM-IT): protocol for a randomized controlled trial.
Topics: Adult; Antitubercular Agents; Disability Evaluation; Double-Blind Method; Drug Therapy, Combination; | 2011 |
Multiple drug hypersensitivity reactions to anti-tuberculosis drugs: five cases in HIV-infected patients.
Topics: Adult; Antitubercular Agents; Coinfection; Drug Eruptions; Drug Hypersensitivity; Edema; Eosinophili | 2012 |
Pharmacokinetics and safety of levofloxacin in patients with human immunodeficiency virus infection.
Topics: Absorption; Adolescent; Adult; Chromatography, High Pressure Liquid; Double-Blind Method; Half-Life; | 1994 |
Pharmacokinetics and safety of oral levofloxacin in human immunodeficiency virus-infected individuals receiving concomitant zidovudine.
Topics: Adult; Anti-HIV Agents; Anti-Infective Agents; Double-Blind Method; Drug Interactions; HIV Infection | 1997 |
Pharmacokinetics and safety of high-dose and extended-interval regimens of levofloxacin in human immunodeficiency virus-infected patients.
Topics: Administration, Oral; Adult; Anti-Infective Agents; Area Under Curve; CD4 Lymphocyte Count; Dose-Res | 1999 |
Pharmacokinetic evaluation of oral levofloxacin in human immunodeficiency virus-infected subjects receiving concomitant antiretroviral therapy.
Topics: Administration, Oral; Alkynes; Anti-HIV Agents; Anti-Infective Agents; Benzoxazines; Cohort Studies; | 2001 |
12 other studies available for ofloxacin and HIV Infections
| Article | Year |
|---|---|
Variation in missed doses and reasons for discontinuation of anti-tuberculosis drugs during hospital treatment for drug-resistant tuberculosis in South Africa.
Topics: Adult; Amikacin; Aminosalicylic Acid; Antitubercular Agents; Ethionamide; Female; HIV Infections; Ho | 2023 |
Serious treatment related adverse drug reactions amongst anti-retroviral naïve MDR-TB patients.
Topics: Adult; Antitubercular Agents; Coinfection; Cycloserine; Drug Resistance, Multiple, Bacterial; Female | 2013 |
Preventive therapy for child contacts of multidrug-resistant tuberculosis: a prospective cohort study.
Topics: Antitubercular Agents; Child, Preschool; Ethambutol; Female; HIV Infections; Humans; Infant; Infant, | 2013 |
Trends in childhood drug-resistant tuberculosis in South Africa: a window into the wider epidemic?
Topics: Age Factors; Antitubercular Agents; Bacterial Proteins; Child; Child, Preschool; Drug Resistance, Mu | 2014 |
[Two cases of pulmonary gangrene in HIV-infected patients: favorable outcome without surgery].
Topics: Acetamides; Adult; Alcoholism; Amoxicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Gangre | 2011 |
Rhodococcus equi: pulmonary cavitation lesion in patient infected with HIV cured by levofloxacin and rifampicin.
Topics: Actinomycetales Infections; Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Ant | 2002 |
Ofloxacin in multidrug resistant tuberculosis.
Topics: Anti-Infective Agents; Comorbidity; HIV Infections; Humans; Ofloxacin; Tuberculosis, Multidrug-Resis | 2003 |
A rare cause of pericarditis.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; HIV Infections; HIV-1; Humans; | 2003 |
Chemotherapy of leprosy.
Topics: Anti-Bacterial Agents; Clofazimine; Dapsone; Dose-Response Relationship, Drug; Drug Combinations; Dr | 2004 |
[Multiorgan failure due to gonococcal peritonitis in an HIV-HCV co-infected female patient].
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Ascites; Bacteremia; Carcinoma, Hepatocellular | 2004 |
Mycobacterium avium subsp. paratuberculosis infection in a patient with HIV, Germany.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antitubercular Agents; Ciproflo | 2002 |
[Reversible space-occupying lesions of the kidney in HIV infection].
Topics: Abscess; Adult; Cefuroxime; Female; HIV Infections; Humans; Nephritis; Ofloxacin; Opportunistic Infe | 1990 |