Page last updated: 2024-11-01

ofloxacin and Gram-Negative Bacterial Infections

ofloxacin has been researched along with Gram-Negative Bacterial Infections in 70 studies

Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

Gram-Negative Bacterial Infections: Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.

Research Excerpts

ExcerptRelevanceReference
"Compare two dosage strengths of levofloxacin in the treatment of acute bacterial sinusitis."9.12A trial of high-dose, short-course levofloxacin for the treatment of acute bacterial sinusitis. ( Anon, J; Kahn, J; Khashab, M; Paglia, M; Poole, M; Xiang, J, 2006)
"A randomized, double-blind, double-dummy, three-arm parallel design, multicentre study was conducted among adult patients with acute exacerbation of chronic bronchitis (AECB) in order to compare the efficacy and safety of two different doses of levofloxacin with cefuroxime axetil."9.09Levofloxacin versus cefuroxime axetil in the treatment of acute exacerbation of chronic bronchitis: results of a randomized, double-blind study. ( Dolmann, A; Fiss, E; Maesen, FP; Shah, PM; Vetter, N; Wesch, R, 1999)
"An open, randomized, multinational, multicentre study was conducted to compare the efficacy, safety and tolerability of levofloxacin 500 mg twice daily with imipenem/cilastatin 1 g iv three-times daily in the treatment of hospitalized adult patients with clinically suspected bacteraemia/ sepsis."9.09Levofloxacin in the empirical treatment of patients with suspected bacteraemia/sepsis: comparison with imipenem/cilastatin in an open, randomized trial. ( Geddes, A; Härkönen, M; Jacobs, F; Nowotny, I; Schonwald, S; Thaler, M, 1999)
"Thirty cirrhotic patients with spontaneous bacterial peritonitis were assigned to receive either intravenous (1 g/12 h) cefotaxime for 7 days (n=17) or intravenous (200 mg/12 h) ofloxacin for 2 days followed by oral (200 mg/12 h) ofloxacin for 5 days (n=13)."7.72Comparison of cefotaxime and ofloxacin in treatment of spontaneous bacterial peritonitis. ( Aslan, SL; Buyraç, Z; Colakoğlu, O; Sözmen, B; Taşkiran, B; Unsal, B, 2004)
"Compare two dosage strengths of levofloxacin in the treatment of acute bacterial sinusitis."5.12A trial of high-dose, short-course levofloxacin for the treatment of acute bacterial sinusitis. ( Anon, J; Kahn, J; Khashab, M; Paglia, M; Poole, M; Xiang, J, 2006)
"A randomized, double-blind, double-dummy, three-arm parallel design, multicentre study was conducted among adult patients with acute exacerbation of chronic bronchitis (AECB) in order to compare the efficacy and safety of two different doses of levofloxacin with cefuroxime axetil."5.09Levofloxacin versus cefuroxime axetil in the treatment of acute exacerbation of chronic bronchitis: results of a randomized, double-blind study. ( Dolmann, A; Fiss, E; Maesen, FP; Shah, PM; Vetter, N; Wesch, R, 1999)
"An open, randomized, multinational, multicentre study was conducted to compare the efficacy, safety and tolerability of levofloxacin 500 mg twice daily with imipenem/cilastatin 1 g iv three-times daily in the treatment of hospitalized adult patients with clinically suspected bacteraemia/ sepsis."5.09Levofloxacin in the empirical treatment of patients with suspected bacteraemia/sepsis: comparison with imipenem/cilastatin in an open, randomized trial. ( Geddes, A; Härkönen, M; Jacobs, F; Nowotny, I; Schonwald, S; Thaler, M, 1999)
"A total of 125 ambulatory women (85 premenopausal and 40 postmenopausal) who experienced 174 acute urinary tract infections with mainly gram-negative bacteria (99%) was randomized to receive a single dose, 2-tablet treatment with either ofloxacin (400 mg."5.07Single dose quinolone treatment in acute uncomplicated urinary tract infection in women. ( Pfau, A; Sacks, TG, 1993)
" radiobacter bacteremia treated with levofloxacin."3.74[A rare cause of catheter-related bacteremia: Rhizobium radiobacter]. ( Görümlü, G; Işikgoz Taşbakan, M; Karabulut, B; Pullukçu, H; Sanli, UA; Sipahi, OR; Tünger, A, 2008)
"A 48-year-old man presented with a corneal ulcer in his right eye and was treated with ofloxacin and fortified bacitracin ophthalmic solution."3.72Chryseobacterium meningosepticum keratitis. ( Bloom, AH; Davis, RG; Donnenfeld, ED; Perry, HD, 2003)
"Thirty cirrhotic patients with spontaneous bacterial peritonitis were assigned to receive either intravenous (1 g/12 h) cefotaxime for 7 days (n=17) or intravenous (200 mg/12 h) ofloxacin for 2 days followed by oral (200 mg/12 h) ofloxacin for 5 days (n=13)."3.72Comparison of cefotaxime and ofloxacin in treatment of spontaneous bacterial peritonitis. ( Aslan, SL; Buyraç, Z; Colakoğlu, O; Sözmen, B; Taşkiran, B; Unsal, B, 2004)
" In the UK chloramphenicol is commonly recommended as the drug of first choice for the treatment of superficial bacterial eye infections."3.69Fluoroquinolones for the eye. ( , 1994)
"Febrile neutropenia is an expected complication during treatment of aggressive hematological malignancies and hematopoietic cell transplantation."2.73The clinical impact of antibacterial prophylaxis and cycling antibiotics for febrile neutropenia in a hematological malignancy and transplantation unit. ( Craig, M; Cumpston, AD; Devetten, MP; Ericson, SG; Hobbs, GR; Sarwari, AR, 2007)
"Both cancer centers differed in prophylactic antibiotic policies."2.69Bacteremia and fungemia in pediatric versus adult cancer patients after chemotherapy: comparison of etiology, risk factors and outcome. ( Foltinova, A; Kaiserova, E; Kiskova, M; Kovacicova, G; Krchnakova, A; Krcmery, V; Krupova, I; Kunova, A; Trupl, J; West, D, 1998)
" three times daily with dosage adjustment according to renal function and body weight (group 2)."2.67Empiric treatment of serious infections in patients with cancer: randomised comparison of two combinations. ( Maiche, AG; Teerenhovi, L, 1991)
" In particular, the deeper knowledge of kinetic-dynamic characteristics has allowed to highlight that high dosage approach in short term therapy might reveal as extremely interesting in a setting of critical patients."2.45[PK/PD profile and post-marketing surveillance of levofloxacin]. ( Pea, F, 2009)
"Levofloxacin is a fluoroquinolone antibiotic and is the optical S-(-) isomer of the racemic drug substance ofloxacin."2.40The clinical pharmacokinetics of levofloxacin. ( Chow, AT; Fish, DN, 1997)
"A case of septic arthritis in a 70-year-old man with chronic obstructive pulmonary disease (COPD) initially presenting with right knee pain, swelling and redness is reported."1.39[Septic monarthritis caused by Sphingomonas paucimobilis]. ( Burk, M; Dischereit, G; Lange, U; Storck-Müller, K, 2013)
"Gatifloxacin showed lower resistance levels than moxifloxacin."1.38[In vitro antibiotic susceptibility to fluoroquinolones]. ( Galvis, V; Rey, JJ; Tello, A; Villareal, D; Wong, CA, 2012)
"Septic pulmonary embolism (SPE) is an uncommon, but life-threatening event that is usually associated with extrapulmonary infections."1.37Tsukamurella tyrosinosolvens and Rhizobium radiobacter sepsis presenting with septic pulmonary emboli. ( Calista, F; Fadda, G; Fiori, B; Mignogna, S; Romano, L; Sali, M; Spanu, T; Zappacosta, B, 2011)
"Paronychia is a well-known, but difficult to treat cutaneous toxicity associated with epidermal growth factor receptor (EGFR) inhibitor therapy."1.36Microbiological analysis of epidermal growth factor receptor inhibitor therapy-associated paronychia. ( Eames, T; Grabein, B; Kroth, J; Wollenberg, A, 2010)
"Emerging evidence suggests that current fluoroquinolone dosing strategies may be inadequate to treat bloodstream infections caused by organisms classified as sensitive."1.35Effect of differences in MIC values on clinical outcomes in patients with bloodstream infections caused by gram-negative organisms treated with levofloxacin. ( Defife, R; Feinglass, JM; Postelnick, MJ; Scarsi, KK; Scheetz, MH, 2009)
" Efforts should be directed at modifying hospital policies for dosing of levofloxacin and DTCCs to prevent coadministration."1.33Coadministration of oral levofloxacin with agents that impair its absorption: potential impact on emergence of resistance. ( Barton, TD; Fishman, NO; Lautenbach, E; Quain, RD; Weiner, MG, 2005)
" pneumoniae, MPC results were below susceptible breakpoints and within clinically achievable and sustainable drug concentrations for >24 hours of the dosing interval against."1.33Comparison of the minimum inhibitory, mutant prevention and minimum bactericidal concentrations of ciprofloxacin, levofloxacin and garenoxacin against enteric Gram-negative urinary tract infection pathogens. ( Blondeau, JM; Hansen, GT, 2005)
"Levofloxacin resistance was detected in 2 of 2,834 isolates (0."1.32Susceptibilities to levofloxacin in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children: results from 2000-2001 and 2001-2002 TRUST studies in the United States. ( Critchley, IA; Evangelista, AT; Jones, ME; Karlowsky, JA; Noel, GJ; Sahm, DF; Thornsberry, C, 2003)
"Ofloxacin is a quinolone administered to patients with severe infections."1.32Single-dose pharmacokinetics of ofloxacin during continuous venovenous hemofiltration in critical care patients. ( El Menyawi, I; Fuhrmann, V; Mittermayer, C; Ratheiser, K; Schenk, P; Thalhammer, F, 2003)
"Ciprofloxacin was the most potent study drug against the family of Enterobacteriaceae and Pseudomonas spp."1.30Antibacterial activity of moxifloxacin (Bay 12-8039) against aerobic clinical isolates, and provisional criteria for disk susceptibility tests. ( Barry, AL; Brown, SD; Fuchs, PC, 1999)

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's20 (28.57)18.2507
2000's37 (52.86)29.6817
2010's13 (18.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dischereit, G1
Burk, M1
Storck-Müller, K1
Lange, U1
Ullah, O1
Khan, A1
Ambreen, A1
Ahmad, I1
Akhtar, T1
Gandapor, AJ1
Khan, AM1
Tanaseanu, C1
Bergallo, C1
Teglia, O1
Jasovich, A1
Oliva, ME1
Dukart, G1
Dartois, N1
Cooper, CA1
Gandjini, H1
Mallick, R1
Işikgoz Taşbakan, M1
Görümlü, G1
Pullukçu, H1
Sanli, UA1
Sipahi, OR1
Karabulut, B1
Tünger, A1
Green, O1
Murray, P1
Gea-Banacloche, JC1
Defife, R1
Scheetz, MH1
Feinglass, JM1
Postelnick, MJ1
Scarsi, KK1
Passerini de Rossi, B1
García, C1
Calenda, M1
Vay, C1
Franco, M1
Gupta, A1
Swaroop, C1
Agarwala, S1
Pandey, RM1
Bakhshi, S1
Eames, T1
Grabein, B1
Kroth, J1
Wollenberg, A1
Kelesidis, T1
Dien Bard, J1
Humphries, R1
Ward, K1
Lewinski, MA1
Uslan, DZ1
Pea, F1
Thabet, L1
Memmi, M1
Turki, A1
Messadi, AA1
Romano, L1
Spanu, T1
Calista, F1
Zappacosta, B1
Mignogna, S1
Sali, M1
Fiori, B1
Fadda, G1
Salman, S1
Young, M1
Van Sickels, JE1
Rafat, C1
Vimont, S1
Ancel, PY1
Xu-Dubois, YC1
Mesnard, L1
Ouali, N1
Denis, M1
Vandewalle, A1
Rondeau, E1
Hertig, A1
Lorenzo Garde, L1
Bolaños Rivero, M1
Turégano García, Á1
Martín Sánchez, AM1
Wong, CA1
Galvis, V1
Tello, A1
Villareal, D1
Rey, JJ1
Parra-Riffo, H1
Lemus-Peñaloza, J1
Gould, VC1
Okazaki, A1
Avison, MB1
Chung, HS1
Hong, SG1
Kim, YR1
Shin, KS1
Whang, DH1
Ahn, JY1
Park, YJ1
Uh, Y1
Chang, CL1
Shin, JH1
Lee, HS1
Lee, K1
Chong, Y1
Kherani, F1
Kherani, A1
Gehrs, KM1
Heilskov, TW1
Sutphin, JE1
Wagoner, MD1
Candel, FJ1
López, R1
Valdivia, A1
Núñez, MJ1
Roca-Arbonés, V1
Picazo de la Garza, JJ1
Karlowsky, JA1
Thornsberry, C1
Critchley, IA1
Jones, ME1
Evangelista, AT1
Noel, GJ1
Sahm, DF1
Ko, WC1
Chiang, SR1
Lee, HC1
Tang, HJ1
Wang, YY1
Chuang, YC1
Bloom, AH1
Perry, HD1
Donnenfeld, ED1
Davis, RG1
Fuhrmann, V1
Schenk, P1
Mittermayer, C1
El Menyawi, I1
Ratheiser, K1
Thalhammer, F1
Smith, MD1
Gradon, JD1
Chou, SY1
Tsai, CC1
Kau, SC1
Kau, HC1
Hsu, WM1
Taşkiran, B1
Colakoğlu, O1
Sözmen, B1
Unsal, B1
Aslan, SL1
Buyraç, Z1
Amoureux, MC1
Rajapakse, N1
Hegyi, E1
Le, D1
Grandics, P1
Szathmary, S1
Hoepelman, I1
Lanzafame, A1
Bonfiglio, G1
Santini, L1
Mattina, R1
McKnight, AJ1
Shaw, A1
Goldsmith, CE1
Clarke, L1
Millar, BC1
McCaughan, J1
Elborn, JS1
Reid, A1
Moore, JE1
Tash, K1
Quain, RD1
Barton, TD1
Fishman, NO1
Weiner, MG1
Lautenbach, E1
Hsueh, PR1
Chen, WH1
Luh, KT1
Hansen, GT1
Blondeau, JM2
Poole, M1
Anon, J1
Paglia, M1
Xiang, J1
Khashab, M1
Kahn, J1
Alvarez-Lerma, F1
Grau, S1
Alvarez-Beltrán, M1
Hassoun, A1
Eiland, E1
Legout, L1
Senneville, E1
Stern, R1
Yazdanpanah, Y1
Savage, C1
Roussel-Delvalez, M1
Rosele, B1
Migaud, H1
Mouton, Y1
Bassetti, M1
Righi, E1
Rosso, R1
Mannelli, S1
Di Biagio, A1
Fasce, R1
Pallavicini, FB1
Marchetti, F1
Viscoli, C1
Craig, M1
Cumpston, AD1
Hobbs, GR1
Devetten, MP1
Sarwari, AR1
Ericson, SG1
Noviello, S1
Ianniello, F1
Leone, S1
Esposito, S1
Chang, CY1
Lee, YT1
Liu, KS1
Wang, YL1
Tsao, SM1
Lerner, J1
Brumberger, V1
Preac-Mursic, V1
Savitskaia, KI1
Tsar'kova, LN1
Shanina, AG1
Nasonov, VN1
Solodilova, OE1
Rusanova, EV1
Beam, TR1
Belliveau, P1
Nightingale, CH1
Quintiliani, R1
Crowe, H1
Gousee, G1
Pfaller, MA1
Barry, AL2
Fuchs, PC2
Spivey, IM1
Pfau, A1
Sacks, TG1
Saenko, VF1
Viktorov, AP1
Golopykho, LI1
Nichitaĭlo, ME1
Gorshevikova, EV1
Karachalios, GN1
Nasiopoulou, DD1
Bourlinou, PK1
Reppa, A1
Fish, DN1
Chow, AT1
Krupova, I1
Kaiserova, E1
Foltinova, A1
Kovacicova, G1
Kiskova, M1
Krchnakova, A1
Kunova, A1
Trupl, J1
West, D1
Krcmery, V2
Krupova, Y1
Novotny, J1
Sabo, A1
Mateicka, F1
Iwata, M1
Tateda, K1
Matsumoto, T1
Furuya, N1
Mizuiri, S1
Yamaguchi, K1
Shah, PM1
Maesen, FP1
Dolmann, A1
Vetter, N1
Fiss, E1
Wesch, R1
Brown, SD1
Geddes, A1
Thaler, M1
Schonwald, S1
Härkönen, M1
Jacobs, F1
Nowotny, I1
Laskowski, R1
Bjarnason, J1
Stewart, C1
Cunha, BA1
Alexandrakis, G1
Alfonso, EC1
Miller, D1
Reid, G1
Habash, M1
Vachon, D1
Denstedt, J1
Riddell, J1
Beheshti, M1
Ledney, GD1
Elliott, TB1
Landauer, MR1
Vigneulle, RM1
Henderson, PL1
Harding, RA1
Tom, SP1
Soares-Weiser, K1
Paul, M1
Brezis, M1
Leibovici, L1
Gür, D1
Kocagöz, T1
Akalin, HE1
Maiche, AG1
Teerenhovi, L1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 3, Multicenter, Randomized, Double-Blind, Comparative Study Of The Efficacy And Safety Of Tigecycline Vs Levofloxacin To Treat Subjects Hospitalized With Community-Acquired Pneumonia[NCT00079885]Phase 3430 participants (Actual)Interventional2003-11-30Completed
A Phase 3, Multicenter, Randomized, Double-Blind, Comparative Study Of The Efficacy And Safety Of Intravenous Tigecycline Vs Intravenous Levofloxacin To Treat Subjects Hospitalized With Community-Acquired Pneumonia[NCT00081575]Phase 3434 participants (Actual)Interventional2004-01-31Completed
Contribution of Fast Molecular Bacterial Identification by Real-time PCR in Managing of Postoperative Acute Endophthalmitis[NCT02850653]150 participants (Anticipated)Interventional2007-11-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

10 reviews available for ofloxacin and Gram-Negative Bacterial Infections

ArticleYear
[PK/PD profile and post-marketing surveillance of levofloxacin].
    Le infezioni in medicina, 2009, Volume: 17 Suppl 5

    Topics: Animals; Anti-Bacterial Agents; Area Under Curve; Cohort Studies; Drug Resistance, Multiple, Bacteri

2009
Severe levofloxacin-induced hypoglycaemia: a case report and literature review.
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2012, Jul-17, Volume: 32, Issue:4

    Topics: Aged; Anti-Bacterial Agents; Catheter-Related Infections; Drug Therapy, Combination; Enterococcus; G

2012
[Endocarditis due to Stenotrophomonas maltophilia].
    Enfermedades infecciosas y microbiologia clinica, 2002, Volume: 20, Issue:9

    Topics: Aortic Valve Insufficiency; Disease Susceptibility; Drug Resistance, Multiple, Bacterial; Drug Thera

2002
Bacteremia due to Comamonas species possibly associated with exposure to tropical fish.
    Southern medical journal, 2003, Volume: 96, Issue:8

    Topics: Administration, Oral; Aged; Aged, 80 and over; Animals; Animals, Domestic; Anti-Infective Agents; Ba

2003
[New fluoroquinolones: levofloxacin, moxifloxacin and gatifloxacin].
    Nederlands tijdschrift voor geneeskunde, 2004, Oct-23, Volume: 148, Issue:43

    Topics: Anti-Bacterial Agents; Aza Compounds; Drug Resistance, Bacterial; Fluoroquinolones; Gatifloxacin; Gr

2004
Levofloxacin in the treatment of ventilator-associated pneumonia.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2006, Volume: 12 Suppl 3

    Topics: Anti-Infective Agents; Cross Infection; Gram-Negative Bacterial Infections; Humans; Levofloxacin; Of

2006
Quinolone therapy in intensive care unit settings.
    New horizons (Baltimore, Md.), 1993, Volume: 1, Issue:2

    Topics: Administration, Oral; Aged; Ciprofloxacin; Clinical Protocols; Clinical Trials as Topic; Cross Infec

1993
Oral ciprofloxacin, ofloxacin, and lomefloxacin as alternatives to intravenous antimicrobial therapy.
    Connecticut medicine, 1993, Volume: 57, Issue:8

    Topics: Administration, Oral; Anti-Bacterial Agents; Ciprofloxacin; Drug Costs; Drug Tolerance; Female; Fluo

1993
The clinical pharmacokinetics of levofloxacin.
    Clinical pharmacokinetics, 1997, Volume: 32, Issue:2

    Topics: Anti-Infective Agents; Clinical Trials, Phase III as Topic; Drug Interactions; Gram-Negative Bacteri

1997
Evidence based case report. Antibiotic treatment for spontaneous bacterial peritonitis.
    BMJ (Clinical research ed.), 2002, Jan-12, Volume: 324, Issue:7329

    Topics: Acute Disease; Anti-Bacterial Agents; Cefotaxime; Evidence-Based Medicine; Female; Gram-Negative Bac

2002

Trials

13 trials available for ofloxacin and Gram-Negative Bacterial Infections

ArticleYear
Integrated results of 2 phase 3 studies comparing tigecycline and levofloxacin in community-acquired pneumonia.
    Diagnostic microbiology and infectious disease, 2008, Volume: 61, Issue:3

    Topics: Adult; Aged; Anti-Bacterial Agents; Community-Acquired Infections; Female; Gram-Negative Bacterial I

2008
Integrated results of 2 phase 3 studies comparing tigecycline and levofloxacin in community-acquired pneumonia.
    Diagnostic microbiology and infectious disease, 2008, Volume: 61, Issue:3

    Topics: Adult; Aged; Anti-Bacterial Agents; Community-Acquired Infections; Female; Gram-Negative Bacterial I

2008
Integrated results of 2 phase 3 studies comparing tigecycline and levofloxacin in community-acquired pneumonia.
    Diagnostic microbiology and infectious disease, 2008, Volume: 61, Issue:3

    Topics: Adult; Aged; Anti-Bacterial Agents; Community-Acquired Infections; Female; Gram-Negative Bacterial I

2008
Integrated results of 2 phase 3 studies comparing tigecycline and levofloxacin in community-acquired pneumonia.
    Diagnostic microbiology and infectious disease, 2008, Volume: 61, Issue:3

    Topics: Adult; Aged; Anti-Bacterial Agents; Community-Acquired Infections; Female; Gram-Negative Bacterial I

2008
Randomized controlled trial comparing oral amoxicillin-clavulanate and ofloxacin with intravenous ceftriaxone and amikacin as outpatient therapy in pediatric low-risk febrile neutropenia.
    Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:9

    Topics: Administration, Oral; Adolescent; Ambulatory Care; Amikacin; Amoxicillin-Potassium Clavulanate Combi

2009
A trial of high-dose, short-course levofloxacin for the treatment of acute bacterial sinusitis.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2006, Volume: 134, Issue:1

    Topics: Acute Disease; Adult; Aged; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Double-Blind Me

2006
Efficacy of the combination of levofloxacin plus ceftazidime in the treatment of hospital-acquired pneumonia in the intensive care unit.
    International journal of antimicrobial agents, 2006, Volume: 28, Issue:6

    Topics: Aged; Anti-Bacterial Agents; Ceftazidime; Cross Infection; Drug Therapy, Combination; Female; Gram-N

2006
The clinical impact of antibacterial prophylaxis and cycling antibiotics for febrile neutropenia in a hematological malignancy and transplantation unit.
    Bone marrow transplantation, 2007, Volume: 39, Issue:8

    Topics: Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacteremia; Drug Administration Schedule; Drug Resist

2007
[Use of ofloxacin in the treatment of infections of the lower respiratory tract].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1994, Volume: 39, Issue:6

    Topics: Adolescent; Adult; Asthma; Bronchitis; Chronic Disease; Female; Gram-Negative Bacterial Infections;

1994
Single dose quinolone treatment in acute uncomplicated urinary tract infection in women.
    The Journal of urology, 1993, Volume: 149, Issue:3

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Ciprofloxacin; Female; Gram-Negative Bacterial Infect

1993
Treatment of acute biliary tract infections with ofloxacin: a randomized, controlled clinical trial.
    International journal of clinical pharmacology and therapeutics, 1996, Volume: 34, Issue:12

    Topics: Anti-Infective Agents; Bacteremia; Ceftriaxone; Cephalosporins; Cholangitis; Cholecystitis; Escheric

1996
Bacteremia and fungemia in pediatric versus adult cancer patients after chemotherapy: comparison of etiology, risk factors and outcome.
    Journal of chemotherapy (Florence, Italy), 1998, Volume: 10, Issue:3

    Topics: Adult; Analysis of Variance; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; A

1998
Levofloxacin versus cefuroxime axetil in the treatment of acute exacerbation of chronic bronchitis: results of a randomized, double-blind study.
    The Journal of antimicrobial chemotherapy, 1999, Volume: 43, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Bronchitis; Cefuroxime; Cephalosporins; Chron

1999
Levofloxacin in the empirical treatment of patients with suspected bacteraemia/sepsis: comparison with imipenem/cilastatin in an open, randomized trial.
    The Journal of antimicrobial chemotherapy, 1999, Volume: 44, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Bacteremia; Cilastatin; Cilastati

1999
Oral fluoroquinolone therapy results in drug adsorption on ureteral stents and prevention of biofilm formation.
    International journal of antimicrobial agents, 2001, Volume: 17, Issue:4

    Topics: Administration, Oral; Adsorption; Anti-Infective Agents; Anti-Infective Agents, Urinary; Biofilms; C

2001
Empiric treatment of serious infections in patients with cancer: randomised comparison of two combinations.
    Infection, 1991, Volume: 19 Suppl 6

    Topics: Administration, Oral; Cefotaxime; Drug Synergism; Drug Therapy, Combination; Gram-Negative Bacterial

1991

Other Studies

47 other studies available for ofloxacin and Gram-Negative Bacterial Infections

ArticleYear
[Septic monarthritis caused by Sphingomonas paucimobilis].
    Zeitschrift fur Rheumatologie, 2013, Volume: 72, Issue:8

    Topics: Aged; Anti-Bacterial Agents; Arthritis, Infectious; Diagnosis, Differential; Gram-Negative Bacterial

2013
Antibiotic Sensitivity pattern of Bacterial Isolates of Neonatal Septicemia in Peshawar, Pakistan.
    Archives of Iranian medicine, 2016, Volume: 19, Issue:12

    Topics: Anti-Bacterial Agents; Ciprofloxacin; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacteri

2016
[A rare cause of catheter-related bacteremia: Rhizobium radiobacter].
    Mikrobiyoloji bulteni, 2008, Volume: 42, Issue:2

    Topics: Adult; Agrobacterium tumefaciens; Anti-Bacterial Agents; Bacteremia; Bone Neoplasms; Catheterization

2008
Sepsis caused by Elizabethkingia miricola successfully treated with tigecycline and levofloxacin.
    Diagnostic microbiology and infectious disease, 2008, Volume: 62, Issue:4

    Topics: Anti-Bacterial Agents; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Levofloxa

2008
Effect of differences in MIC values on clinical outcomes in patients with bloodstream infections caused by gram-negative organisms treated with levofloxacin.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:3

    Topics: Adult; Aged; Anti-Bacterial Agents; Cohort Studies; Female; Gram-Negative Bacteria; Gram-Negative Ba

2009
Activity of levofloxacin and ciprofloxacin on biofilms and planktonic cells of Stenotrophomonas maltophilia isolates from patients with device-associated infections.
    International journal of antimicrobial agents, 2009, Volume: 34, Issue:3

    Topics: Anti-Infective Agents; Argentina; Biofilms; Ciprofloxacin; Cross Infection; Drug Resistance, Multipl

2009
Microbiological analysis of epidermal growth factor receptor inhibitor therapy-associated paronychia.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2010, Volume: 24, Issue:8

    Topics: Anti-Bacterial Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Age

2010
First report of treatment of Anaerobiospirillum succiniciproducens bloodstream infection with levofloxacin.
    Journal of clinical microbiology, 2010, Volume: 48, Issue:5

    Topics: Aged, 80 and over; Anaerobiospirillum; Anti-Bacterial Agents; Bacteremia; DNA, Bacterial; DNA, Ribos

2010
The impact of fluoroquinolones use on antibiotic resistance in an intensive care burn department.
    La Tunisie medicale, 2010, Volume: 88, Issue:5

    Topics: Acinetobacter; Anti-Infective Agents; Burn Units; Ceftazidime; Ciprofloxacin; Drug Resistance, Multi

2010
Tsukamurella tyrosinosolvens and Rhizobium radiobacter sepsis presenting with septic pulmonary emboli.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2011, Volume: 17, Issue:7

    Topics: Actinomycetales; Actinomycetales Infections; Aged; Agrobacterium tumefaciens; Anti-Bacterial Agents;

2011
Osteomyelitis after bilateral sagittal split osteotomy: case report and a review of the management.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2011, Volume: 111, Issue:4

    Topics: Adult; Anti-Bacterial Agents; beta-Lactams; Bone Plates; Bone Screws; Clindamycin; Drainage; Enterob

2011
Ofloxacin: new applications for the prevention of urinary tract infections in renal graft recipients.
    Transplant infectious disease : an official journal of the Transplantation Society, 2011, Volume: 13, Issue:4

    Topics: Acute Disease; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Drug Resistance, Bacterial; Dru

2011
[Intraperitoneal abscess for Eikenella corrodens].
    Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2011, Volume: 24, Issue:2

    Topics: Abdominal Abscess; Adenocarcinoma; Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacteri

2011
[In vitro antibiotic susceptibility to fluoroquinolones].
    Archivos de la Sociedad Espanola de Oftalmologia, 2012, Volume: 87, Issue:3

    Topics: Acanthamoeba Keratitis; Anti-Bacterial Agents; Aza Compounds; Body Fluids; Ciprofloxacin; Colombia;

2012
Coordinate hyperproduction of SmeZ and SmeJK efflux pumps extends drug resistance in Stenotrophomonas maltophilia.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:1

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Bacterial Toxins; Ciprofloxacin; Gene Expression; Genes,

2013
Antimicrobial susceptibility of stenotrophomonas maltophilia isolates from Korea, and the activity of antimicrobial combinations against the isolates.
    Journal of Korean medical science, 2013, Volume: 28, Issue:1

    Topics: Anti-Infective Agents; Gram-Negative Bacterial Infections; Hospitals, University; Humans; Levofloxac

2013
Xanthomonas maltophilia endophthalmitis following penetrating corneal injury.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2002, Volume: 37, Issue:5

    Topics: Amphotericin B; Cornea; Corneal Injuries; Drug Therapy, Combination; Endophthalmitis; Eye Infections

2002
Susceptibilities to levofloxacin in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children: results from 2000-2001 and 2001-2002 TRUST studies in the United States.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:6

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Azithromycin; Child; Child, Preschool; Drug Resistan

2003
In vitro and in vivo activities of fluoroquinolones against Aeromonas hydrophila.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:7

    Topics: Aeromonas hydrophila; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; Cefotaxi

2003
Chryseobacterium meningosepticum keratitis.
    American journal of ophthalmology, 2003, Volume: 136, Issue:2

    Topics: Bacitracin; Cornea; Corneal Ulcer; Drug Therapy, Combination; Eye Infections, Bacterial; Flavobacter

2003
Single-dose pharmacokinetics of ofloxacin during continuous venovenous hemofiltration in critical care patients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003, Volume: 42, Issue:2

    Topics: Acute Kidney Injury; Adult; Aged; Anti-Infective Agents; Chromatography, High Pressure Liquid; Criti

2003
Aeromonas hydrophila orbital cellulitis in a patient with myelodysplastic syndrome.
    Journal of the Chinese Medical Association : JCMA, 2004, Volume: 67, Issue:1

    Topics: Aeromonas hydrophila; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Cefuroxime; Cellulitis; Gr

2004
Comparison of cefotaxime and ofloxacin in treatment of spontaneous bacterial peritonitis.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2004, Volume: 15, Issue:1

    Topics: Adult; Aged; Analysis of Variance; Cefotaxime; Dose-Response Relationship, Drug; Drug Administration

2004
Endotoxin removal from whole blood by a novel adsorption resin: efficiency and hemocompatibility.
    The International journal of artificial organs, 2004, Volume: 27, Issue:6

    Topics: Adsorption; Anti-Infective Agents; Blood Coagulation Factors; Cell Count; Chromatography, Affinity;

2004
In vitro activity of levofloxacin against recent Gram-negative nosocomial pathogens.
    Chemotherapy, 2005, Volume: 51, Issue:1

    Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; beta-Lactams; Cross Infection; Gram-

2005
Comparison of in vitro susceptibilities to levofloxacin and ciprofloxacin with Pseudomonas aeruginosa and Stenotrophomonas maltophilia isolated from cystic fibrosis patients in Northern Ireland.
    British journal of biomedical science, 2005, Volume: 62, Issue:1

    Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Child; Ciprofloxacin; Cystic Fibrosis; Female;

2005
Rahnella aquatilis bacteremia from a suspected urinary source.
    Journal of clinical microbiology, 2005, Volume: 43, Issue:5

    Topics: Aged; Anti-Bacterial Agents; Gram-Negative Bacterial Infections; Humans; Infusions, Intravenous; Lev

2005
Coadministration of oral levofloxacin with agents that impair its absorption: potential impact on emergence of resistance.
    International journal of antimicrobial agents, 2005, Volume: 26, Issue:4

    Topics: Administration, Oral; Adsorption; Aged; Anti-Bacterial Agents; Case-Control Studies; Cations, Divale

2005
Relationships between antimicrobial use and antimicrobial resistance in Gram-negative bacteria causing nosocomial infections from 1991-2003 at a university hospital in Taiwan.
    International journal of antimicrobial agents, 2005, Volume: 26, Issue:6

    Topics: Aminoglycosides; Anti-Bacterial Agents; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Ca

2005
Comparison of the minimum inhibitory, mutant prevention and minimum bactericidal concentrations of ciprofloxacin, levofloxacin and garenoxacin against enteric Gram-negative urinary tract infection pathogens.
    Journal of chemotherapy (Florence, Italy), 2005, Volume: 17, Issue:5

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Fluoroquinolones; Gram-Negative Bacteri

2005
Effectiveness of flouroquinolone therapy for gram-negative infections within the intensive care unit setting.
    The American journal of medicine, 2006, Volume: 119, Issue:6

    Topics: Acinetobacter; Alabama; Ciprofloxacin; Drug Resistance, Bacterial; Enterobacter cloacae; Escherichia

2006
Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2006, Volume: 12, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bone Diseases, Infectious; Cefepime; Cephalos

2006
[In vitro activity of prulifloxacin, levofloxacin and ciprofloxacin against urinary pathogens].
    Le infezioni in medicina, 2006, Volume: 14, Issue:1

    Topics: Anti-Bacterial Agents; Ciprofloxacin; Dioxolanes; Drug Resistance, Multiple, Bacterial; Fluoroquinol

2006
Chromobacterium violaceum infection in Taiwan: a case report and literature review.
    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 2007, Volume: 40, Issue:3

    Topics: Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Chromobacterium; Female; Gram-Negative Bacteri

2007
Fluoroquinolones for the eye.
    Drug and therapeutics bulletin, 1994, Oct-20, Volume: 32, Issue:10

    Topics: Chloramphenicol; Ciprofloxacin; Eye Infections, Bacterial; Gram-Negative Bacterial Infections; Human

1994
Severe diarrhea associated with Arcobacter butzleri.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1994, Volume: 13, Issue:8

    Topics: Diarrhea; Doxycycline; Feces; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Hu

1994
Levofloxacin disk potency and tentative interpretive criteria for susceptibility tests.
    Journal of clinical microbiology, 1993, Volume: 31, Issue:7

    Topics: Evaluation Studies as Topic; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Gram-Positi

1993
Criteria for use of ofloxacin and lomefloxacin in adult inpatients and outpatients.
    Clinical pharmacy, 1993, Volume: 12, Issue:6

    Topics: Adult; Anti-Infective Agents; Fluoroquinolones; Gram-Negative Bacterial Infections; Humans; Infectio

1993
[A clinical evaluation of the efficacy of using Zanocin (ofloxacin) in surgery].
    Klinichna khirurhiia, 1995, Issue:9-10

    Topics: Adult; Anti-Infective Agents; Biliary Fistula; Cefazolin; Cephalosporins; Cholangitis; Drug Evaluati

1995
Aetiology, cost of antimicrobial therapy and outcome in neutropenic patients who developed bacteraemia during antimicrobial prophylaxis: a case-control study.
    International journal of antimicrobial agents, 1998, Volume: 10, Issue:4

    Topics: Amikacin; Amphotericin B; Antibiotic Prophylaxis; Bacteremia; Bacterial Infections; Case-Control Stu

1998
Primary Shewanella alga septicemia in a patient on hemodialysis.
    Journal of clinical microbiology, 1999, Volume: 37, Issue:6

    Topics: Anti-Bacterial Agents; Bacteremia; Cefazolin; Drug Therapy, Combination; Escherichia coli; Female; G

1999
Antibacterial activity of moxifloxacin (Bay 12-8039) against aerobic clinical isolates, and provisional criteria for disk susceptibility tests.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1999, Volume: 18, Issue:4

    Topics: Anti-Infective Agents; Aza Compounds; Bacteria, Aerobic; Ciprofloxacin; Fluoroquinolones; Gram-Negat

1999
Comparative in vitro activity of gatifloxacin, grepafloxacin, levofloxacin, moxifloxacin and trovafloxacin against 4151 Gram-negative and Gram-positive organisms.
    International journal of antimicrobial agents, 2000, Volume: 14, Issue:1

    Topics: Anti-Infective Agents; Aza Compounds; Drug Resistance, Microbial; Fluoroquinolones; Gatifloxacin; Gr

2000
Community-acquired pneumonia: reality revisited.
    The American journal of medicine, 2000, Apr-01, Volume: 108, Issue:5

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Community-Acquired Infections; Doxycycline; Gram-Negat

2000
Shifting trends in bacterial keratitis in south Florida and emerging resistance to fluoroquinolones.
    Ophthalmology, 2000, Volume: 107, Issue:8

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Ciprofloxacin; Cornea; Corneal Ulcer; Drug R

2000
Survival of irradiated mice treated with WR-151327, synthetic trehalose dicorynomycolate, or ofloxacin.
    Advances in space research : the official journal of the Committee on Space Research (COSPAR), 1994, Volume: 14, Issue:10

    Topics: Adjuvants, Immunologic; Animals; Anti-Infective Agents; Ceftriaxone; Cephalosporins; Cord Factors; F

1994
[In vitro activity of various antibiotic agents against gram-negative nosocomial bacteremia pathogens].
    Mikrobiyoloji bulteni, 1992, Volume: 26, Issue:3

    Topics: Amikacin; Anti-Bacterial Agents; Bacteremia; Ciprofloxacin; Cross Infection; Gram-Negative Bacteria;

1992