ofloxacin has been researched along with Extensively Drug-Resistant Tuberculosis in 36 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Extensively Drug-Resistant Tuberculosis: Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.
| Excerpt | Relevance | Reference |
|---|---|---|
| "tuberculosis were obtained from the Novosibirsk Research Institute of Tuberculosis, Russia." | 1.40 | Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia. ( Alkhovik, OI; Cherednichenko, AG; Dymova, MA; Filipenko, ML; Khrapov, EA; Petrenko, TI, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (11.11) | 29.6817 |
| 2010's | 29 (80.56) | 24.3611 |
| 2020's | 3 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Khanna, A | 1 |
| Raj, VS | 1 |
| Tarai, B | 1 |
| Sood, R | 1 |
| Pareek, PK | 1 |
| Upadhyay, DJ | 1 |
| Sharma, P | 1 |
| Rattan, A | 1 |
| Saini, KS | 1 |
| Singh, H | 1 |
| Dixit, PP | 2 |
| Thore, SN | 1 |
| Rahman, SMM | 1 |
| Nasrin, R | 1 |
| Rahman, A | 1 |
| Ahmed, S | 1 |
| Khatun, R | 1 |
| Uddin, MKM | 1 |
| Rahman, MM | 1 |
| Banu, S | 1 |
| Jia, QJ | 1 |
| Zeng, MC | 1 |
| Xie, L | 1 |
| Cheng, QL | 1 |
| Huang, YY | 1 |
| Li, QC | 1 |
| Wu, YF | 1 |
| Ai, LY | 1 |
| Lu, M | 1 |
| Fang, ZJ | 1 |
| Sy, KTL | 1 |
| Leavitt, SV | 1 |
| de Vos, M | 1 |
| Dolby, T | 1 |
| Bor, J | 1 |
| Horsburgh, CR | 1 |
| Warren, RM | 2 |
| Streicher, EM | 1 |
| Jenkins, HE | 1 |
| Jacobson, KR | 1 |
| Kuo, CY | 1 |
| Wang, WH | 1 |
| Huang, CH | 1 |
| Chen, YH | 1 |
| Lu, PL | 1 |
| Ennassiri, W | 1 |
| Jaouhari, S | 1 |
| Cherki, W | 1 |
| Charof, R | 1 |
| Filali-Maltouf, A | 1 |
| Lahlou, O | 1 |
| Alene, KA | 1 |
| Yi, H | 1 |
| Viney, K | 1 |
| McBryde, ES | 1 |
| Yang, K | 1 |
| Bai, L | 1 |
| Gray, DJ | 1 |
| Clements, ACA | 1 |
| Xu, Z | 1 |
| Oudghiri, A | 1 |
| Karimi, H | 1 |
| Chetioui, F | 1 |
| Zakham, F | 1 |
| Bourkadi, JE | 1 |
| Elmessaoudi, MD | 1 |
| Laglaoui, A | 1 |
| Chaoui, I | 1 |
| El Mzibri, M | 1 |
| Sharma, AK | 1 |
| Gupta, N | 1 |
| Kala, DK | 1 |
| Patni, T | 1 |
| Dixit, R | 1 |
| Verma, S | 1 |
| Chandran, A | 1 |
| Chernyaeva, E | 1 |
| Fedorova, E | 1 |
| Zhemkova, G | 1 |
| Korneev, Y | 1 |
| Kozlov, A | 1 |
| Ahmed, I | 1 |
| Jabeen, K | 1 |
| Inayat, R | 1 |
| Hasan, R | 2 |
| Tukvadze, N | 1 |
| Bablishvili, N | 1 |
| Apsindzelashvili, R | 1 |
| Blumberg, HM | 1 |
| Kempker, RR | 1 |
| Huang, ZK | 2 |
| Luo, Q | 2 |
| Xiong, GL | 2 |
| Li, WT | 1 |
| Xu, XM | 1 |
| Li, JM | 2 |
| Dymova, MA | 1 |
| Cherednichenko, AG | 1 |
| Alkhovik, OI | 1 |
| Khrapov, EA | 1 |
| Petrenko, TI | 1 |
| Filipenko, ML | 1 |
| Lee, YS | 1 |
| Kang, MR | 1 |
| Jung, H | 1 |
| Choi, SB | 1 |
| Jo, KW | 1 |
| Shim, TS | 1 |
| Chen, Y | 1 |
| Zhao, B | 1 |
| Liu, HC | 1 |
| Sun, Q | 1 |
| Zhao, XQ | 1 |
| Liu, ZG | 1 |
| Wan, KL | 1 |
| Zhao, LL | 1 |
| Qing, C | 1 |
| Deng, YT | 1 |
| Pang, Y | 1 |
| Dong, H | 1 |
| Tan, Y | 1 |
| Deng, Y | 1 |
| Cai, X | 1 |
| Jing, H | 1 |
| Xia, H | 1 |
| Li, Q | 1 |
| Ou, X | 1 |
| Su, B | 1 |
| Li, X | 1 |
| Zhang, Z | 1 |
| Li, J | 1 |
| Zhang, J | 1 |
| Huan, S | 1 |
| Zhao, Y | 1 |
| Singhal, P | 1 |
| Dixit, P | 1 |
| Singh, P | 1 |
| Jaiswal, I | 1 |
| Singh, M | 1 |
| Jain, A | 2 |
| Disratthakit, A | 1 |
| Prammananan, T | 1 |
| Tribuddharat, C | 1 |
| Thaipisuttikul, I | 1 |
| Doi, N | 1 |
| Leechawengwongs, M | 1 |
| Chaiprasert, A | 1 |
| Kumar, R | 1 |
| Garg, R | 1 |
| Kant, S | 1 |
| Verma, SK | 1 |
| Kushwaha, RA | 1 |
| Kumar, S | 1 |
| Javaid, A | 1 |
| Zafar, A | 1 |
| Chaudry, MA | 1 |
| Qayyum, S | 1 |
| Qadeer, E | 1 |
| Shaheen, Z | 1 |
| Agha, N | 1 |
| Rizvi, N | 1 |
| Afridi, MZ | 1 |
| Chima, MK | 1 |
| Khan, AR | 1 |
| Ghafoor, A | 1 |
| Khan, S | 1 |
| Awan, SR | 1 |
| Akhtar, S | 1 |
| Choudry, K | 1 |
| Iqbal, ZH | 1 |
| Ansarie, M | 1 |
| Ahmad, N | 1 |
| Cox, HS | 2 |
| Sibilia, K | 1 |
| Feuerriegel, S | 2 |
| Kalon, S | 1 |
| Polonsky, J | 1 |
| Khamraev, AK | 1 |
| Rüsch-Gerdes, S | 2 |
| Mills, C | 1 |
| Niemann, S | 2 |
| Zarkua, N | 1 |
| Karimovich, HA | 1 |
| Braker, K | 1 |
| Ramachandran, R | 1 |
| Nalini, S | 1 |
| Chandrasekar, V | 1 |
| Dave, PV | 1 |
| Sanghvi, AS | 1 |
| Wares, F | 1 |
| Paramasivan, CN | 1 |
| Narayanan, PR | 1 |
| Sahu, S | 1 |
| Parmar, M | 1 |
| Chadha, S | 1 |
| Dewan, P | 1 |
| Chauhan, LS | 1 |
| Tabarsi, P | 1 |
| Chitsaz, E | 1 |
| Baghaei, P | 1 |
| Shamaei, M | 1 |
| Farnia, P | 1 |
| Marjani, M | 1 |
| Kazempour, M | 1 |
| Amiri, M | 1 |
| Mansouri, D | 1 |
| Masjedi, MR | 1 |
| Velayati, AA | 1 |
| Caminero, JA | 2 |
| Sotgiu, G | 1 |
| Zumla, A | 1 |
| Migliori, GB | 1 |
| Chang, KC | 1 |
| Leung, CC | 1 |
| Tam, CM | 1 |
| Yew, WW | 1 |
| Moodley, P | 1 |
| Shah, NS | 1 |
| Tayob, N | 1 |
| Connolly, C | 1 |
| Zetola, N | 1 |
| Gandhi, N | 1 |
| Friedland, G | 1 |
| Sturm, AW | 1 |
| Lee, J | 1 |
| Lee, CH | 1 |
| Kim, DK | 1 |
| Yoon, HI | 1 |
| Kim, JY | 1 |
| Lee, SM | 1 |
| Yang, SC | 1 |
| Lee, JH | 1 |
| Yoo, CG | 1 |
| Lee, CT | 1 |
| Chung, HS | 1 |
| Kim, YW | 1 |
| Han, SK | 1 |
| Yim, JJ | 1 |
| Ramos, E | 1 |
| Fissette, K | 1 |
| de Rijk, P | 1 |
| Palomino, JC | 1 |
| Martin, A | 1 |
| Barnard, M | 1 |
| Warren, R | 1 |
| Gey Van Pittius, N | 1 |
| van Helden, P | 1 |
| Bosman, M | 1 |
| Streicher, E | 1 |
| Coetzee, G | 1 |
| O'Brien, R | 1 |
| Jin, J | 1 |
| Shen, Y | 1 |
| Fan, X | 1 |
| Diao, N | 1 |
| Wang, F | 1 |
| Wang, S | 1 |
| Weng, X | 1 |
| Zhang, W | 1 |
| Porwal, C | 1 |
| Kaushik, A | 1 |
| Makkar, N | 1 |
| Banavaliker, JN | 1 |
| Hanif, M | 1 |
| Singla, R | 1 |
| Bhatnagar, AK | 1 |
| Behera, D | 1 |
| Pande, JN | 1 |
| Singh, UB | 1 |
| Mlambo, CK | 1 |
| Poswa, X | 1 |
| Victor, TC | 1 |
| Duse, AG | 1 |
| Marais, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacometrics to Advance Novel Regimens for Drug-resistant Tuberculosis[NCT03827811] | 625 participants (Anticipated) | Observational | 2020-01-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ofloxacin and Extensively Drug-Resistant Tuberculosis
| Article | Year |
|---|---|
Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis.
Topics: Amikacin; Antitubercular Agents; Capreomycin; Drug Resistance, Multiple; Ethambutol; Extensively Dru | 2010 |
35 other studies available for ofloxacin and Extensively Drug-Resistant Tuberculosis
| Article | Year |
|---|---|
Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
Topics: Amikacin; Antitubercular Agents; Bacterial Proteins; Capreomycin; DNA Gyrase; DNA Mutational Analysi | 2010 |
Hybrid triazoles: Design and synthesis as potential dual inhibitor of growth and efflux inhibition in tuberculosis.
Topics: Antitubercular Agents; Cells, Cultured; Chemistry Techniques, Synthetic; Drug Design; Drug Evaluatio | 2016 |
Performance of GenoType MTBDRsl assay for detection of second-line drugs and ethambutol resistance directly from sputum specimens of MDR-TB patients in Bangladesh.
Topics: Adult; Aged; Aged, 80 and over; Antitubercular Agents; Bangladesh; DNA, Bacterial; Ethambutol; Exten | 2021 |
Molecular Detection of Ofloxacin and Kanamycin Resistance in Patients with MDR and Non-MDR TB from Suburban Districts in Hangzhou, China, 2019-2020.
Topics: Antitubercular Agents; China; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant Tuber | 2022 |
Spatial heterogeneity of extensively drug resistant-tuberculosis in Western Cape Province, South Africa.
Topics: Amikacin; Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Fluoroquinolones; Humans; | 2022 |
Resistance to first- and second-line antituberculosis drugs in Southern Taiwan: Implications for empirical treatment.
Topics: Aminosalicylic Acid; Antitubercular Agents; Ethambutol; Extensively Drug-Resistant Tuberculosis; Flu | 2018 |
Extensively drug-resistant tuberculosis (XDR-TB) in Morocco.
Topics: Adolescent; Adult; Aged; Amikacin; Extensively Drug-Resistant Tuberculosis; Female; Genotype; Humans | 2017 |
Treatment outcomes of patients with multidrug-resistant and extensively drug resistant tuberculosis in Hunan Province, China.
Topics: Adult; Antitubercular Agents; China; Cohort Studies; Extensively Drug-Resistant Tuberculosis; Female | 2017 |
Molecular characterization of mutations associated with resistance to second-line tuberculosis drug among multidrug-resistant tuberculosis patients from high prevalence tuberculosis city in Morocco.
Topics: Amikacin; Antitubercular Agents; Base Sequence; Capreomycin; DNA Mutational Analysis; Drug Resistanc | 2018 |
A study on pattern of resistance to second line anti tubercular drugs among multi drug resistant tuberculosis patients.
Topics: Aminoglycosides; Antitubercular Agents; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resis | 2018 |
Characterization of multiple and extensively drug resistant Mycobacterium tuberculosis isolates with different ofloxacin-resistance levels.
Topics: Amino Acid Substitution; Antitubercular Agents; DNA Gyrase; Dose-Response Relationship, Drug; Drug R | 2013 |
Susceptibility testing of extensively drug-resistant and pre-extensively drug-resistant Mycobacterium tuberculosis against levofloxacin, linezolid, and amoxicillin-clavulanate.
Topics: Acetamides; Amoxicillin-Potassium Clavulanate Combination; Antitubercular Agents; Extensively Drug-R | 2013 |
Performance of the MTBDRsl assay in Georgia.
Topics: Antitubercular Agents; Capreomycin; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant | 2014 |
Evaluation of indirect drug susceptibility testing using the MODS assay for the detection of XDR-TB in China.
Topics: Antitubercular Agents; Bacteriological Techniques; China; DNA Mutational Analysis; DNA, Bacterial; D | 2014 |
Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia.
Topics: Adult; Amikacin; Antitubercular Agents; Capreomycin; Cross-Sectional Studies; Drug Resistance, Multi | 2014 |
Performance of REBA MTB-XDR to detect extensively drug-resistant tuberculosis in an intermediate-burden country.
Topics: Adult; Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant Tuber | 2015 |
Prevalence of mutations conferring resistance among multi- and extensively drug-resistant Mycobacterium tuberculosis isolates in China.
Topics: Antitubercular Agents; Bacterial Proteins; Catalase; China; DNA-Directed RNA Polymerases; DNA, Bacte | 2016 |
Evaluation of the direct nitrate reductase assay for rapid detection of extensively drug-resistant tuberculosis.
Topics: Adult; Capreomycin; China; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant Tubercul | 2016 |
Rapid diagnosis of MDR and XDR tuberculosis with the MeltPro TB assay in China.
Topics: Amikacin; China; Extensively Drug-Resistant Tuberculosis; Humans; Kanamycin; Microbial Sensitivity T | 2016 |
A study on pre-XDR & XDR tuberculosis & their prevalent genotypes in clinical isolates of Mycobacterium tuberculosis in north India.
Topics: Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant Tuberculosis; Genotype; Humans; Ind | 2016 |
Role of gyrB Mutations in Pre-extensively and Extensively Drug-Resistant Tuberculosis in Thai Clinical Isolates.
Topics: Aminopyridines; Antitubercular Agents; Ciprofloxacin; DNA Gyrase; Drug Resistance, Bacterial; Extens | 2016 |
High correlation of clinical criteria in the diagnosis of drug-resistant TB and prevalence of ofloxacin resistance.
Topics: Adult; Antitubercular Agents; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant Tuber | 2016 |
Pattern of first- and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan.
Topics: Adolescent; Adult; Antitubercular Agents; Cross-Sectional Studies; Extensively Drug-Resistant Tuberc | 2017 |
Emergence of extensive drug resistance during treatment for multidrug-resistant tuberculosis.
Topics: Analysis of Variance; Antitubercular Agents; Cross Infection; Extensively Drug-Resistant Tuberculosi | 2008 |
Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment.
Topics: Amikacin; Antitubercular Agents; Bacterial Proteins; Capreomycin; DNA Gyrase; Extensively Drug-Resis | 2009 |
Surveillance of drug-resistant tuberculosis in the state of Gujarat, India.
Topics: Antitubercular Agents; Bacteriological Techniques; Colony Count, Microbial; Drug Resistance, Multipl | 2009 |
Impact of extensively drug-resistant tuberculosis on treatment outcome of multidrug-resistant tuberculosis patients with standardized regimen: report from Iran.
Topics: Adult; Amikacin; Anti-Bacterial Agents; Clinical Protocols; Cycloserine; Drug Resistance, Multiple, | 2010 |
Streptomycin susceptibility and MDR-TB: can we refine the definition of XDR-TB?
Topics: Antitubercular Agents; Extensively Drug-Resistant Tuberculosis; Humans; Microbial Sensitivity Tests; | 2011 |
Spread of extensively drug-resistant tuberculosis in KwaZulu-Natal province, South Africa.
Topics: Antitubercular Agents; Cross-Sectional Studies; Ethambutol; Extensively Drug-Resistant Tuberculosis; | 2011 |
Retrospective comparison of levofloxacin and moxifloxacin on multidrug-resistant tuberculosis treatment outcomes.
Topics: Adult; Antitubercular Agents; Aza Compounds; Case-Control Studies; Chi-Square Distribution; Drug Res | 2011 |
Integrated detection of multi- and extensively drug-resistant tuberculosis using the nitrate reductase assay.
Topics: Antitubercular Agents; Colorimetry; DNA Mutational Analysis; Drug Resistance, Multiple, Bacterial; E | 2012 |
Genotype MTBDRsl line probe assay shortens time to diagnosis of extensively drug-resistant tuberculosis in a high-throughput diagnostic laboratory.
Topics: Amikacin; Antitubercular Agents; Drug Resistance, Multiple, Bacterial; Ethambutol; Extensively Drug- | 2012 |
Underestimation of the resistance of Mycobacterium tuberculosis to second-line drugs by the new GenoType MTBDRsl test.
Topics: Antitubercular Agents; China; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Ethambutol; Exte | 2013 |
Incidence and risk factors for extensively drug-resistant tuberculosis in Delhi region.
Topics: Adult; Amikacin; Antitubercular Agents; Capreomycin; Ethionamide; Extensively Drug-Resistant Tubercu | 2013 |
Genotypic diversity of extensively drug-resistant tuberculosis (XDR-TB) in South Africa.
Topics: Antitubercular Agents; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resist | 2008 |