ofloxacin has been researched along with Experimental Pneumococcal Meningitis in 9 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ofloxacin diffusion into cerebrospinal fluid (CSF) was evaluated in nine patients with bacterial meningitis." | 7.67 | Diffusion of ofloxacin into the cerebrospinal fluid in patients with bacterial meningitis. ( Bru, JP; Croize, J; Fourtillan, JB; Guyot, A; Leduc, D; Lefèbvre, MA; Micoud, M; Stahl, JP, 1986) |
| "Ofloxacin diffusion into cerebrospinal fluid (CSF) was evaluated in nine patients with bacterial meningitis." | 3.67 | Diffusion of ofloxacin into the cerebrospinal fluid in patients with bacterial meningitis. ( Bru, JP; Croize, J; Fourtillan, JB; Guyot, A; Leduc, D; Lefèbvre, MA; Micoud, M; Stahl, JP, 1986) |
| " The elimination half-life in plasma and CSF was calculated using non-linear regression analysis." | 1.31 | Cerebrospinal fluid penetration and pharmacokinetics of levofloxacin in an experimental rabbit meningitis model. ( Dash, AK; Destache, CJ; Larsen, C; Owens, H; Pakiz, CB, 2001) |
| "We have assessed levofloxacin penetration in cerebrospinal fluid (CSF) and the liquor-to-plasma ratio (C(L)/C(P)) at 2 hours after dosing in 5 patients with spontaneous acute bacterial meningitis." | 1.31 | Cerebrospinal fluid penetration of levofloxacin in patients with spontaneous acute bacterial meningitis. ( Baraldo, M; Furlanut, M; Giobbia, M; Pea, F; Scotton, PG; Vaglia, A, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ciccotelli, W | 1 |
| Poutanen, S | 1 |
| Morris, S | 1 |
| Alqahtani, M | 1 |
| Cox, P | 1 |
| Low, D | 1 |
| Pillai, D | 1 |
| Opavsky, M | 1 |
| Kühn, F | 3 |
| Cottagnoud, M | 3 |
| Acosta, F | 2 |
| Flatz, L | 3 |
| Entenza, J | 3 |
| Cottagnoud, P | 3 |
| Stucki, A | 2 |
| Wortmann, GW | 1 |
| Bennett, SP | 1 |
| Klugman, KP | 1 |
| Destache, CJ | 1 |
| Pakiz, CB | 1 |
| Larsen, C | 1 |
| Owens, H | 1 |
| Dash, AK | 1 |
| Scotton, PG | 1 |
| Pea, F | 1 |
| Giobbia, M | 1 |
| Baraldo, M | 1 |
| Vaglia, A | 1 |
| Furlanut, M | 1 |
| Stahl, JP | 1 |
| Croize, J | 1 |
| Lefèbvre, MA | 1 |
| Bru, JP | 1 |
| Guyot, A | 1 |
| Leduc, D | 1 |
| Fourtillan, JB | 1 |
| Micoud, M | 1 |
9 other studies available for ofloxacin and Experimental Pneumococcal Meningitis
| Article | Year |
|---|---|
A new twist on an old problem: a case of pediatric meningitis caused by multidrug-resistant Streptococcus pneumoniae serotype 19A.
Topics: Anti-Bacterial Agents; Cefuroxime; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; | 2008 |
Cefotaxime acts synergistically with levofloxacin in experimental meningitis due to penicillin-resistant pneumococci and prevents selection of levofloxacin-resistant mutants in vitro.
Topics: Animals; Anti-Infective Agents; Cefotaxime; Cephalosporins; DNA, Bacterial; Drug Resistance, Bacteri | 2003 |
Meropenem prevents levofloxacin-induced resistance in penicillin-resistant pneumococci and acts synergistically with levofloxacin in experimental meningitis.
Topics: Animals; Disease Models, Animal; DNA, Bacterial; Dose-Response Relationship, Drug; Drug Resistance, | 2003 |
Ceftriaxone acts synergistically with levofloxacin in experimental meningitis and reduces levofloxacin-induced resistance in penicillin-resistant pneumococci.
Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Cephalosporins; DNA Topoisomerase IV; DNA, Bacterial; D | 2004 |
Fatal meningitis due to levofloxacin-resistant Streptococcus pneumoniae.
Topics: Anti-Infective Agents; Drug Resistance, Microbial; Fatal Outcome; Humans; Levofloxacin; Male; Mening | 1999 |
Levofloxacin-resistant pneumococcus.
Topics: Anti-Infective Agents; Drug Resistance, Microbial; Humans; Levofloxacin; Meningitis, Pneumococcal; M | 2000 |
Cerebrospinal fluid penetration and pharmacokinetics of levofloxacin in an experimental rabbit meningitis model.
Topics: Animals; Anti-Infective Agents; Area Under Curve; Disease Models, Animal; Levofloxacin; Meningitis, | 2001 |
Cerebrospinal fluid penetration of levofloxacin in patients with spontaneous acute bacterial meningitis.
Topics: Acute Disease; Adult; Aged; Anti-Infective Agents; Female; Humans; Levofloxacin; Male; Meningitis, E | 2001 |
Diffusion of ofloxacin into the cerebrospinal fluid in patients with bacterial meningitis.
Topics: Adult; Anti-Infective Agents; Bacterial Infections; Female; Humans; Male; Meningitis; Meningitis, Me | 1986 |