ofloxacin has been researched along with Drug-Induced Stevens Johnson Syndrome in 13 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Generalized tonic-clonic seizures are a rare complication of levofloxacin therapy." | 3.73 | Generalized seizure and toxic epidermal necrolysis following levofloxacin exposure. ( Christie, MJ; Sikaneta, TG; Tam, PY; Ting, RH; Wong, K, 2005) |
| "To report a fatal case of toxic epidermal necrolysis in a man who was treated with oral ofloxacin for epididymitis." | 3.71 | Ofloxacin: a probable cause of toxic epidermal necrolysis. ( Melde, SL, 2001) |
| "The series is part of an ongoing randomised controlled trial assessing rechallenge dosing following TB-associated cutaneous ADR." | 2.77 | Multiple drug hypersensitivity reactions to anti-tuberculosis drugs: five cases in HIV-infected patients. ( Dheda, K; Lehloenya, RJ; Todd, G; Wallace, J, 2012) |
| "Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), also known as Lyell's syndrome, are rare and life-threatening conditions, for which etiopathogenesis, as well as pharmacotherapy, is yet unclear." | 1.48 | A Rare Case Report of Toxic Epidermal Necrolysis Due to Ofloxacin. ( Chavda, BC; Mehta, HH; Nimbark, VN; Purohit, BM; Vaghela, JJ, 2018) |
| "Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN) are mild-to-life-threatening adverse reactions that have been described after exposure to fluoroquinolones." | 1.31 | Levofloxacin-induced toxic epidermal necrolysis in an elderly patient. ( Ackerman, BH; Cawley, MJ; Digwood-Lettieri, S; Guilday, RJ; Haith, LR; Patton, ML; Reilly, KJ, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Shaw, B | 1 |
| Madden, M | 1 |
| Crespo, A | 1 |
| Madruga, M | 1 |
| Carlan, SJ | 1 |
| Vaghela, JJ | 1 |
| Nimbark, VN | 1 |
| Chavda, BC | 1 |
| Mehta, HH | 1 |
| Purohit, BM | 1 |
| Parmar, NV | 1 |
| Kuruvila, S | 1 |
| Ganguly, S | 1 |
| Krishna, CV | 1 |
| Davila, G | 1 |
| Ruiz-Hornillos, J | 1 |
| Rojas, P | 1 |
| De Castro, F | 1 |
| Zubeldia, JM | 1 |
| Hafiji, J | 1 |
| Orpin, S | 1 |
| Roberts, C | 1 |
| Heagerty, A | 1 |
| Lewis, H | 1 |
| Yoon, SY | 1 |
| Bae, YJ | 1 |
| Cho, YS | 1 |
| Moon, HB | 1 |
| Kim, TB | 1 |
| Teo, WL | 1 |
| Pang, SM | 1 |
| Lehloenya, RJ | 1 |
| Wallace, J | 1 |
| Todd, G | 1 |
| Dheda, K | 1 |
| Christie, MJ | 1 |
| Wong, K | 1 |
| Ting, RH | 1 |
| Tam, PY | 1 |
| Sikaneta, TG | 1 |
| Islam, AF | 1 |
| Rahman, MS | 1 |
| Melde, SL | 1 |
| Digwood-Lettieri, S | 1 |
| Reilly, KJ | 1 |
| Haith, LR | 1 |
| Patton, ML | 1 |
| Guilday, RJ | 1 |
| Cawley, MJ | 1 |
| Ackerman, BH | 1 |
1 review available for ofloxacin and Drug-Induced Stevens Johnson Syndrome
| Article | Year |
|---|---|
Levofloxacin revisited.
Topics: Animals; Anti-Infective Agents; Bacterial Infections; Gastrointestinal Diseases; Humans; Levofloxaci | 2011 |
1 trial available for ofloxacin and Drug-Induced Stevens Johnson Syndrome
| Article | Year |
|---|---|
Multiple drug hypersensitivity reactions to anti-tuberculosis drugs: five cases in HIV-infected patients.
Topics: Adult; Antitubercular Agents; Coinfection; Drug Eruptions; Drug Hypersensitivity; Edema; Eosinophili | 2012 |
11 other studies available for ofloxacin and Drug-Induced Stevens Johnson Syndrome
| Article | Year |
|---|---|
A Rare Case of Severe Stevens-Johnson Syndrome Triggered by Topical Ofloxacin.
Topics: Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Exanthema; Female; Humans; Ofloxacin; Stevens | 2023 |
A Rare Case Report of Toxic Epidermal Necrolysis Due to Ofloxacin.
Topics: Anti-Bacterial Agents; Fatal Outcome; Humans; Male; Middle Aged; Ofloxacin; Stevens-Johnson Syndrome | 2018 |
Ofloxacin eyedrops-induced toxic epidermal necrolysis treated with intravenous immunoglobulin.
Topics: Administration, Topical; Anti-Bacterial Agents; Hordeolum; Humans; Immunoglobulins, Intravenous; Imm | 2014 |
Toxic epidermal necrolysis induced by levofloxacin.
Topics: Fatal Outcome; Female; Humans; Levofloxacin; Middle Aged; Ofloxacin; Pyelonephritis; Stevens-Johnson | 2009 |
Radiotherapy: a protective role for toxic epidermal necrolysis?
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Humans; Lung Neoplasms; Male; | 2010 |
Toxic epidermal necrolysis induced by ofloxacin.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Bandages; Combined Moda | 2010 |
Levofloxacin-induced toxic epidermal necrolysis treated with intravenous immunoglobulin.
Topics: Anti-Bacterial Agents; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Levofloxacin; Oflo | 2010 |
Generalized seizure and toxic epidermal necrolysis following levofloxacin exposure.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Female; Humans; Levofloxacin; Ofloxacin; Se | 2005 |
Levofloxacin-induced fatal toxic epidermal necrolysis.
Topics: Administration, Oral; Adolescent; Anti-Bacterial Agents; Fatal Outcome; Humans; Levofloxacin; Male; | 2005 |
Ofloxacin: a probable cause of toxic epidermal necrolysis.
Topics: Aged; Anti-Infective Agents; Epididymitis; Fatal Outcome; Humans; Male; Ofloxacin; Stevens-Johnson S | 2001 |
Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.
Topics: Aged; Anti-Infective Agents; Community-Acquired Infections; Female; Fluid Therapy; Humans; Levofloxa | 2002 |