ofloxacin has been researched along with Drug Hypersensitivity in 25 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Drug Hypersensitivity: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To better understand how T cells interact with quinolones, we analysed six patients with delayed hypersensitivity reactions to ciprofloxacin (CPFX), norfloxacin (NRFX) or moxifloxacin (MXFX)." | 3.73 | T cell-mediated hypersensitivity to quinolones: mechanisms and cross-reactivity. ( Depta, JP; Pichler, WJ; Schmid, DA, 2006) |
| "The series is part of an ongoing randomised controlled trial assessing rechallenge dosing following TB-associated cutaneous ADR." | 2.77 | Multiple drug hypersensitivity reactions to anti-tuberculosis drugs: five cases in HIV-infected patients. ( Dheda, K; Lehloenya, RJ; Todd, G; Wallace, J, 2012) |
| " Although very useful agents, the fluoroquinolones as a class are associated with a number of adverse events, some with considerable clinical significance." | 2.46 | Safety profile of the fluoroquinolones: focus on levofloxacin. ( Liu, HH, 2010) |
| " C3H/HeOuJ mice were dosed by oral gavage with diclofenac (DF), APAP, AMAP, OFLX, MET, or CMZ." | 1.37 | Oral exposure to drugs with immune-adjuvant potential induces hypersensitivity responses to the reporter antigen TNP-OVA. ( Bleumink, R; Boon, L; Fiechter, D; Hassing, I; Kwast, LM; Ludwig, IS; Pieters, RH, 2011) |
| "Levofloxacin was discontinued, and supportive care was provided." | 1.31 | Anaphylactoid reaction to levofloxacin. ( Cappelletty, DM; Smythe, MA, 2000) |
| "Ciprofloxacin (CPFX) is a widely used fluoroquinolone antibiotic, inducing cutaneous adverse drug reactions in about 1 to 2% of the treated patients." | 1.30 | Cutaneous adverse reaction to ciprofloxacin: demonstration of specific lymphocyte proliferation and cross-reactivity to ofloxacin in vitro. ( Gleichmann, E; Hunzelmann, N; Rönnau, AC; Ruzicka, T; Sachs, B; Schuppe, HC; von Schmiedeberg, S, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.00) | 18.7374 |
| 1990's | 5 (20.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 9 (36.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ouni, B | 1 |
| Fathallah, N | 1 |
| Slim, R | 1 |
| Brahim, A | 1 |
| Ben Salem, C | 1 |
| Kwast, L | 1 |
| Fiechter, D | 2 |
| Kruijssen, L | 1 |
| Bleumink, R | 2 |
| Ludwig, I | 1 |
| Bol-Schoenmakers, M | 1 |
| Smit, J | 1 |
| Pieters, R | 1 |
| Gisbert, JP | 1 |
| Pérez-Aisa, A | 1 |
| Castro-Fernández, M | 1 |
| Barrio, J | 1 |
| Rodrigo, L | 1 |
| Cosme, A | 1 |
| Gisbert, JL | 1 |
| Marcos, S | 1 |
| Moreno-Otero, R | 1 |
| Liu, HH | 1 |
| Konno, T | 1 |
| Motoori, S | 1 |
| Iwamoto, N | 1 |
| Miyazawa, T | 1 |
| Saito, S | 1 |
| Kitagawa, N | 1 |
| Saisho, H | 1 |
| Furuse, J | 1 |
| Itabashi, M | 1 |
| Lobera, T | 1 |
| Audícana, MT | 1 |
| Alarcón, E | 1 |
| Longo, N | 1 |
| Navarro, B | 1 |
| Muñoz, D | 1 |
| Kwast, LM | 1 |
| Hassing, I | 1 |
| Boon, L | 1 |
| Ludwig, IS | 1 |
| Pieters, RH | 1 |
| Lehloenya, RJ | 1 |
| Wallace, J | 1 |
| Todd, G | 1 |
| Dheda, K | 1 |
| Fukushima, K | 1 |
| Nakatsubo, M | 1 |
| Noda, M | 1 |
| Uenami, T | 1 |
| Hayama, Y | 1 |
| Tsuruta, N | 1 |
| Oniki, S | 1 |
| Saito, Y | 1 |
| Niju, T | 1 |
| Ikeda, T | 1 |
| Nettis, E | 1 |
| Giordano, D | 1 |
| Pierluigi, T | 1 |
| Ferrannini, A | 1 |
| Tursi, A | 1 |
| González-Mancebo, E | 1 |
| Fernández-Rivas, M | 1 |
| Wall, GC | 1 |
| Peters, L | 1 |
| Leaders, CB | 1 |
| Wille, JA | 1 |
| Schmid, DA | 1 |
| Depta, JP | 1 |
| Pichler, WJ | 1 |
| Komericki, P | 1 |
| Arbab, E | 1 |
| Grims, R | 1 |
| Kränke, B | 1 |
| Aberer, W | 1 |
| Isik, SR | 1 |
| Karakaya, G | 1 |
| Erkin, G | 1 |
| Kalyoncu, AF | 1 |
| Lecordier, J | 1 |
| Lahet, JJ | 1 |
| Courderot-Masuyer, C | 1 |
| Beaudoin, E | 1 |
| Chaillot, B | 1 |
| Rönnau, AC | 1 |
| Sachs, B | 1 |
| von Schmiedeberg, S | 1 |
| Hunzelmann, N | 1 |
| Ruzicka, T | 1 |
| Gleichmann, E | 1 |
| Schuppe, HC | 1 |
| Kaplanski, G | 1 |
| Granel, B | 1 |
| Vaz, T | 1 |
| Durand, JM | 1 |
| Desai, C | 1 |
| Desai, KJ | 1 |
| Shah, UH | 1 |
| Smythe, MA | 1 |
| Cappelletty, DM | 1 |
| Hofer, T | 1 |
| Becker, EW | 2 |
| Weigand, K | 1 |
| Berg, PA | 2 |
| Kulessa, W | 1 |
| Huminer, D | 1 |
| Cohen, JD | 1 |
| Majadla, R | 1 |
| Dux, S | 1 |
| Jüngst, G | 2 |
| Mohr, R | 2 |
1 review available for ofloxacin and Drug Hypersensitivity
| Article | Year |
|---|---|
Safety profile of the fluoroquinolones: focus on levofloxacin.
Topics: Adult; Aged, 80 and over; Anti-Bacterial Agents; Cardiovascular Diseases; Central Nervous System Dis | 2010 |
3 trials available for ofloxacin and Drug Hypersensitivity
| Article | Year |
|---|---|
Multiple drug hypersensitivity reactions to anti-tuberculosis drugs: five cases in HIV-infected patients.
Topics: Adult; Antitubercular Agents; Coinfection; Drug Eruptions; Drug Hypersensitivity; Edema; Eosinophili | 2012 |
Overview of postmarketing experience with ofloxacin in Germany.
Topics: Clinical Trials as Topic; Colitis; Drug Hypersensitivity; Drug Interactions; Female; Germany, West; | 1988 |
Side effects of ofloxacin in clinical trials and in postmarketing surveillance.
Topics: Anti-Infective Agents; Clinical Trials as Topic; Drug Hypersensitivity; Evaluation Studies as Topic; | 1987 |
21 other studies available for ofloxacin and Drug Hypersensitivity
| Article | Year |
|---|---|
Anaphylactic shock secondary to oral ofloxacin administration with cross-reactivity to levofloxacin and ciprofloxacin.
Topics: Administration, Oral; Adolescent; Anaphylaxis; Ciprofloxacin; Cross Reactions; Drug Hypersensitivity | 2018 |
Oral exposure to immunostimulating drugs results in early changes in innate immune parameters in the spleen.
Topics: Acetaminophen; Adaptive Immunity; Administration, Oral; Animals; Carbamazepine; Cells, Cultured; Dic | 2016 |
Helicobacter pylori first-line treatment and rescue option containing levofloxacin in patients allergic to penicillin.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Ulcer Agents; Clarithromycin; Drug Administration | 2010 |
[A case of mucosa-associated lymphoid tissue lymphoma with penicillin allergy successfully treated with levofloxacin, minomycin and rabeprazole].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Biopsy; Drug Hypersensitivity; Female; Helicobacter Infecti | 2010 |
Allergy to quinolones: low cross-reactivity to levofloxacin.
Topics: Adult; Aged, 80 and over; Basophils; Cross Reactions; Drug Hypersensitivity; Female; Flow Cytometry; | 2010 |
Oral exposure to drugs with immune-adjuvant potential induces hypersensitivity responses to the reporter antigen TNP-OVA.
Topics: Acetaminophen; Acetanilides; Adjuvants, Immunologic; Administration, Oral; Animals; Antibody Formati | 2011 |
Anaphylaxis due to intravenous levofloxacin with tolerance to garenoxacin.
Topics: Adult; Anaphylaxis; Anti-Bacterial Agents; Cross Reactions; Drug Hypersensitivity; Fluoroquinolones; | 2012 |
Erythema multiforme-like rash in a patient sensitive to ofloxacin.
Topics: Adrenal Cortex Hormones; Adult; Conjunctivitis, Bacterial; Drug Hypersensitivity; Drug Therapy, Comb | 2002 |
Immediate hypersensitivity to levofloxacin diagnosed through skin prick test.
Topics: Adult; Anti-Infective Agents; Delayed-Action Preparations; Drug Hypersensitivity; Humans; Levofloxac | 2004 |
Pharmacist-managed service providing penicillin allergy skin tests.
Topics: Academic Medical Centers; Anti-Bacterial Agents; Drug Hypersensitivity; Education, Pharmacy, Continu | 2004 |
T cell-mediated hypersensitivity to quinolones: mechanisms and cross-reactivity.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antigen-Presenting Cells; Aza Compounds; Cell | 2006 |
Tryptase as severity marker in drug provocation tests.
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Diclofenac; Drug Hypersensitivity; Female; Humans; Lidoca | 2006 |
Multidrug-induced erythema multiforme.
Topics: Adult; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Azithromycin; Ceftriaxone; Ci | 2007 |
Determination of acid base balance and oil water partition coefficient of an atopy patch test of levofloxacin.
Topics: Acid-Base Equilibrium; Anti-Bacterial Agents; Drug Hypersensitivity; Humans; Levofloxacin; Ofloxacin | 2008 |
Cutaneous adverse reaction to ciprofloxacin: demonstration of specific lymphocyte proliferation and cross-reactivity to ofloxacin in vitro.
Topics: Aged; Anti-Infective Agents; Ciprofloxacin; Cross Reactions; Drug Eruptions; Drug Hypersensitivity; | 1997 |
Jarisch-Herxheimer reaction complicating the treatment of chronic Q fever endocarditis: elevated TNFalpha and IL-6 serum levels.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Chronic Disease; Coxiella burnetii; Doxycycline; Drug | 1998 |
Ofloxacin induced hypersensitivity reaction.
Topics: Aged; Anti-Infective Agents; Drug Hypersensitivity; Femoral Neck Fractures; Follow-Up Studies; Hip P | 1999 |
Anaphylactoid reaction to levofloxacin.
Topics: Anaphylaxis; Anti-Infective Agents; Drug Hypersensitivity; Female; Humans; Levofloxacin; Middle Aged | 2000 |
Demonstration of sensitized lymphocytes to trimethoprim/sulfamethoxazole and ofloxacin in a patient with cholestatic hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Hypersensitivity; Female; Humans; O | 1992 |
[Recurrent agranulocytosis after taking calcium dobesilate].
Topics: Agranulocytosis; Calcium Dobesilate; Cefotaxime; Drug Hypersensitivity; Female; Humans; Lymphocyte A | 1992 |
Hypersensitivity vasculitis due to ofloxacin.
Topics: Aged; Drug Hypersensitivity; Hospitalization; Humans; Male; Ofloxacin; Vasculitis | 1989 |