Compounds > ofloxacin
Page last updated: 2024-11-01

ofloxacin and Dermatitis Medicamentosa

ofloxacin has been researched along with Dermatitis Medicamentosa in 26 studies

Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

Research Excerpts

ExcerptRelevanceReference
"To report a patient with lung cancer and idiopathic myelofibrosis with myeloid metaplasia who developed purpura and acute renal failure while receiving levofloxacin, and review the existing literature on quinolone nephrotoxicity."7.71Nephrotoxicity and purpura associated with levofloxacin. ( De Simone, C; Famularo, G, 2002)
"To report a patient with lung cancer and idiopathic myelofibrosis with myeloid metaplasia who developed purpura and acute renal failure while receiving levofloxacin, and review the existing literature on quinolone nephrotoxicity."3.71Nephrotoxicity and purpura associated with levofloxacin. ( De Simone, C; Famularo, G, 2002)
" The patient, who was asthmatic and who was being treated with ofloxacin for bronchitis and pharyngitis, developed intense erythemas followed by subcorneal pustulation associated with fever and a neutrophil leukocytosis."3.68Toxic pustuloderma induced by ofloxacin. ( Inou, Y; Karashima, T; Kato, K; Sasai, Y; Tsuda, S, 1993)
"The series is part of an ongoing randomised controlled trial assessing rechallenge dosing following TB-associated cutaneous ADR."2.77Multiple drug hypersensitivity reactions to anti-tuberculosis drugs: five cases in HIV-infected patients. ( Dheda, K; Lehloenya, RJ; Todd, G; Wallace, J, 2012)
" In all, 130 adverse reactions have been recorded in 116 patients (5."2.66Safety profile of ofloxacin: the Italian data base. ( Fostini, R; Granata, F; Koverech, A; Picari, M; Recchia, G; Toniolo, D, 1986)
" Drug eruption due to a drug combination appears to be very rare."1.33Multiple fixed drug eruption due to drug combination. ( Hara, H; Yokoyama, A, 2005)
"The case of a patient with infectious mononucleosis who was treated with levofloxacin and developed a rash similar to the ampicillin rash is reviewed."1.31Quinolone drug rash in a patient with infectious mononucleosis. ( Paily, R, 2000)
"Ciprofloxacin (CPFX) is a widely used fluoroquinolone antibiotic, inducing cutaneous adverse drug reactions in about 1 to 2% of the treated patients."1.30Cutaneous adverse reaction to ciprofloxacin: demonstration of specific lymphocyte proliferation and cross-reactivity to ofloxacin in vitro. ( Gleichmann, E; Hunzelmann, N; Rönnau, AC; Ruzicka, T; Sachs, B; Schuppe, HC; von Schmiedeberg, S, 1997)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19904 (15.38)18.7374
1990's7 (26.92)18.2507
2000's7 (26.92)29.6817
2010's8 (30.77)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Goyal, T1
Varshney, A1
Sharma, V1
Zawar, V1
Dawson, GA1
Brown, SI1
Tellefsen, L1
Hager, JL1
Mir, MR1
Hsu, S1
Esparza, EM1
Takeshita, J1
George, E1
Ben Fredj, N1
Aouam, K1
Chaabane, A1
Braham, D1
Boughattas, NA1
Belghith, I1
Badri, T1
Zaiem, A1
Benmously, R1
Mokhtar, I1
Lehloenya, RJ1
Wallace, J1
Todd, G1
Dheda, K1
Ponce Guevara, LV1
Yges, EL1
Gracia Bara, MT1
González Ruiz, AM1
Rodilla, EM1
Llamas-Velasco, M1
Godoy, A1
Sánchez-Pérez, J1
García-Diez, A1
Fraga, J1
Pulitzer, MP1
Nolan, KA1
Oshman, RG1
Phelps, RG1
Famularo, G1
De Simone, C1
Corral de la Calle, M1
Martín Díaz, MA1
Flores, CR1
Vidaurrazaga, C1
Yokoyama, A1
Hara, H1
Kawada, A2
Hiruma, M2
Morimoto, K1
Ishibashi, A2
Banba, H2
Tsuda, S1
Kato, K1
Karashima, T1
Inou, Y1
Sasai, Y1
Noguchi, H1
Banba, K1
Marshall, J1
Drouet, M1
Nicolie, B1
Mauffret, N1
Kuriyama, T1
Nakagawa, K1
Saiki, Y1
Yamamoto, E1
Rönnau, AC1
Sachs, B1
von Schmiedeberg, S1
Hunzelmann, N1
Ruzicka, T1
Gleichmann, E1
Schuppe, HC1
Paily, R1
Wood, ML1
Schlessinger, S1
Baran, R2
Brun, P1
Blomer, R1
Bruch, K1
Krauss, H1
Wacheck, W1
Koverech, A1
Picari, M1
Granata, F1
Fostini, R1
Toniolo, D1
Recchia, G1
Juhlin, L1

Trials

2 trials available for ofloxacin and Dermatitis Medicamentosa

ArticleYear
Multiple drug hypersensitivity reactions to anti-tuberculosis drugs: five cases in HIV-infected patients.
    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2012, Volume: 16, Issue:9

    Topics: Adult; Antitubercular Agents; Coinfection; Drug Eruptions; Drug Hypersensitivity; Edema; Eosinophili

2012
Safety profile of ofloxacin: the Italian data base.
    Infection, 1986, Volume: 14 Suppl 4

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Clinical Trials as Topic; Drug Eruptions; Female; Ga

1986

Other Studies

24 other studies available for ofloxacin and Dermatitis Medicamentosa

ArticleYear
A rare case of facial annular bullous erythema nodosum leprosum reaction in a young boy.
    International journal of dermatology, 2016, Volume: 55, Issue:6

    Topics: Adolescent; Anti-Infective Agents, Urinary; Drug Eruptions; Erythema Nodosum; Humans; Leprosy, Lepro

2016
A drug-related phototoxic reaction and its possible relationship to a radiation-induced skin reaction.
    The oncologist, 2009, Volume: 14, Issue:3

    Topics: Dermatitis, Phototoxic; Drug Eruptions; Humans; Male; Middle Aged; Ofloxacin; Photosensitivity Disor

2009
Fluoroquinolone-induced generalized fixed drug eruption.
    Dermatology online journal, 2009, Dec-15, Volume: 15, Issue:12

    Topics: Anti-Infective Agents; Ciprofloxacin; Drug Eruptions; Female; Fluoroquinolones; Humans; Middle Aged;

2009
Lymphomatoid hypersensitivity reaction to levofloxacin during autologous stem cell transplantation: a potential diagnostic pitfall in patients treated for lymphoma or leukemia.
    Journal of cutaneous pathology, 2011, Volume: 38, Issue:1

    Topics: Anti-Bacterial Agents; Biomarkers, Tumor; Diagnosis, Differential; Drug Eruptions; Female; Hematopoi

2011
Fixed drug eruption: levofloxacin, another culprit drug.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:5

    Topics: Aged; Anti-Infective Agents; Drug Eruptions; Female; Humans; Levofloxacin; Ofloxacin; Skin; Skin Tes

2012
[Scrofuloderma with hypersensitivity to rifampicin and pyrazinamide, treated with a combination therapy including ofloxacin].
    Presse medicale (Paris, France : 1983), 2012, Volume: 41, Issue:4

    Topics: Adult; Antibiotics, Antitubercular; Diagnosis, Differential; Drug Eruptions; Drug Therapy, Combinati

2012
Fixed drug eruption due to amoxicillin and quinolones.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2013, Volume: 110, Issue:1

    Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Drug Eruptions; Humans; Male; Ofloxacin

2013
Acute generalized exanthematous pustulosis with histopathologic findings of lymphomatoid drug reaction.
    The American Journal of dermatopathology, 2013, Volume: 35, Issue:6

    Topics: Acute Generalized Exanthematous Pustulosis; Aged; Anti-Bacterial Agents; Biomarkers; Biopsy; Clindam

2013
CD30+ lymphomatoid drug reactions.
    The American Journal of dermatopathology, 2013, Volume: 35, Issue:3

    Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Amines; Amlodipine; Anti-Bacterial Agents; Ant

2013
Nephrotoxicity and purpura associated with levofloxacin.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:9

    Topics: Acute Kidney Injury; Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Diuretics; Drug Eruption

2002
Acute localized exanthematous pustulosis secondary to levofloxacin.
    The British journal of dermatology, 2005, Volume: 152, Issue:5

    Topics: Acute Disease; Aged; Anti-Bacterial Agents; Drug Eruptions; Exanthema; Humans; Levofloxacin; Male; O

2005
Multiple fixed drug eruption due to drug combination.
    Contact dermatitis, 2005, Volume: 52, Issue:6

    Topics: Acetaminophen; Aged; Aged, 80 and over; Anti-Bacterial Agents; Caffeine; Diagnosis, Differential; Dr

2005
Fixed drug eruption induced by ciprofloxacin followed by ofloxacin.
    Contact dermatitis, 1994, Volume: 31, Issue:3

    Topics: Adult; Ciprofloxacin; Drug Eruptions; Humans; Male; Ofloxacin

1994
Toxic pustuloderma induced by ofloxacin.
    Acta dermato-venereologica, 1993, Volume: 73, Issue:5

    Topics: Bronchitis; Drug Eruptions; Female; Humans; Middle Aged; Ofloxacin; Pharyngitis; Skin; Skin Diseases

1993
Fixed drug eruption induced by ofloxacin.
    Contact dermatitis, 1996, Volume: 34, Issue:6

    Topics: Anti-Infective Agents; Blister; Ciprofloxacin; Drug Eruptions; Erythema; Female; Foot Dermatoses; Ha

1996
[Unusual clinical form of amoxicillin allergy].
    Allergie et immunologie, 1996, Volume: 28, Issue:9

    Topics: Amoxicillin; Clarithromycin; Drug Eruptions; Drug Therapy, Combination; Edema; Female; Humans; Methy

1996
Sparfloxacin and levofloxacin.
    The Medical letter on drugs and therapeutics, 1997, Apr-25, Volume: 39, Issue:999

    Topics: Administration, Oral; Anti-Infective Agents; Bronchitis; Chronic Disease; Clinical Trials as Topic;

1997
[A case of severe odontogenic infection with allergic skin reaction for beta-lactam antibiotics].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 1997, Volume: 71, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Cellulitis; Cephalosporins; Clindamycin; Drug Eruptions; Drug Therapy,

1997
Cutaneous adverse reaction to ciprofloxacin: demonstration of specific lymphocyte proliferation and cross-reactivity to ofloxacin in vitro.
    Acta dermato-venereologica, 1997, Volume: 77, Issue:4

    Topics: Aged; Anti-Infective Agents; Ciprofloxacin; Cross Reactions; Drug Eruptions; Drug Hypersensitivity;

1997
Quinolone drug rash in a patient with infectious mononucleosis.
    The Journal of dermatology, 2000, Volume: 27, Issue:6

    Topics: Administration, Oral; Adult; Anti-Infective Agents; Drug Eruptions; Female; Follow-Up Studies; Human

2000
Levaquin induced acute tubulointerstitial nephritis--two case reports.
    Journal of the Mississippi State Medical Association, 2002, Volume: 43, Issue:4

    Topics: Adult; Anti-Infective Agents; Drug Eruptions; Drug Therapy, Combination; Female; Humans; Levofloxaci

2002
Photoonycholysis induced by the fluoroquinolones pefloxacine and ofloxacine. Report on 2 cases.
    Dermatologica, 1986, Volume: 173, Issue:4

    Topics: Aged; Aged, 80 and over; Drug Eruptions; Humans; Male; Mycosis Fungoides; Nail Diseases; Norfloxacin

1986
Safety of ofloxacin--adverse drug reactions reported during phase-II studies in Europe and in Japan.
    Infection, 1986, Volume: 14 Suppl 4

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Drug Eruptions; Drug Evaluation; Europe; Female; Gas

1986
Drug-induced photo-onycholysis. Three subtypes identified in a study of 15 cases.
    Journal of the American Academy of Dermatology, 1987, Volume: 17, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Child; Doxycycline; Drug Eruptions; Female; H

1987