ofloxacin has been researched along with Dermatitis, Contact, Phototoxic in 12 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a second study, two dosage regimens of sitafloxacin were compared with placebo in Oriental subjects." | 2.71 | A randomized controlled trial (volunteer study) of sitafloxacin, enoxacin, levofloxacin and sparfloxacin phototoxicity. ( Dawe, RS; Ferguson, J; Ibbotson, SH; Sanderson, JB; Thomson, EM, 2003) |
| "Levofloxacin has a low photosensitizing potential when administered to healthy subjects." | 2.69 | Photoreaction potential of orally administered levofloxacin in healthy subjects. ( Boccumini, LE; Campbell, TA; Fowler, CL; Kaidbey, KH; Puertolas, LF, 2000) |
| " Although very useful agents, the fluoroquinolones as a class are associated with a number of adverse events, some with considerable clinical significance." | 2.46 | Safety profile of the fluoroquinolones: focus on levofloxacin. ( Liu, HH, 2010) |
| "Levofloxacin was found to be very safe with a low rate of hepatic abnormalities (1/650,000)." | 2.41 | Comparison of side effects of levofloxacin versus other fluoroquinolones. ( Carbon, C, 2001) |
| "Levofloxacin has a very low phototoxicity-inducing potential confirmed by pre-clinical animal studies and the results of post-marketing surveillance (PMS)." | 2.41 | Latest industry information on the safety profile of levofloxacin in Japan. ( Yagawa, K, 2001) |
| "In vitro, phototoxicity for cultured cells of PZFX, which is active principle of PZFX mesilate, was studied, and stability for long-wavelength ultraviolet (UVA) was examined." | 1.31 | [Phototoxicity studies of pazufloxacin mesilate, a novel parenteral quinolone antimicrobial agent--in vitro and in vivo studies]. ( Hayakawa, H; Kawamura, Y; Miyazaki, M; Nagasawa, M; Nakamura, S; Nojima, Y, 2002) |
| "To elucidate the mechanism of phototoxicity induced as a side effect by some of the new quinolone antibiotics, we studied sparfloxacin (SPFX), lomefloxacin, enoxacin, ofloxacin, and ciprofloxacin." | 1.30 | Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents. ( Arakane, K; Hirobe, M; Mashiko, S; Nagano, T; Ryu, A; Umezawa, N, 1997) |
| "Lomefloxacin was the strongest sensitizer, followed by fleroxacin and ciprofloxacin." | 1.30 | In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation. ( Gomi, H; Hatanaka, K; Kawada, A; Matsuo, I, 1999) |
| "(S)-10-[(S)-(8-Amino-6-azaspiro[3,4]octan-6-yl)]-9-fluoro-2, 3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxyli c acid hemihydrate (CAS 151390-79-3, DV-7751a) a new quinolone antibacterial agent, was examined for LD50 value, phototoxicity and convulsion inducing potential in laboratory animals." | 1.29 | LD50 value, phototoxicity and convulsion induction test of the new quinolone antibacterial agent (S)-10-[(S)-(8-amino-6-azaspiro[3,4]octan-6-yl)]-9-fluoro-2, 3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxyl ic acid hemihydrate in la ( Akahane, K; Kato, M; Nomura, M; Shimoda, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dawson, GA | 1 |
| Brown, SI | 1 |
| Tellefsen, L | 1 |
| Liu, HH | 1 |
| Nagasawa, M | 1 |
| Nakamura, S | 1 |
| Miyazaki, M | 1 |
| Nojima, Y | 1 |
| Hayakawa, H | 1 |
| Kawamura, Y | 1 |
| Dawe, RS | 1 |
| Ibbotson, SH | 1 |
| Sanderson, JB | 1 |
| Thomson, EM | 1 |
| Ferguson, J | 1 |
| Fujita, H | 1 |
| Matsuo, I | 2 |
| Shimoda, K | 1 |
| Akahane, K | 1 |
| Nomura, M | 1 |
| Kato, M | 1 |
| Mäkinen, M | 1 |
| Forbes, PD | 1 |
| Stenbäck, F | 1 |
| Umezawa, N | 1 |
| Arakane, K | 1 |
| Ryu, A | 1 |
| Mashiko, S | 1 |
| Hirobe, M | 1 |
| Nagano, T | 1 |
| Kawada, A | 1 |
| Hatanaka, K | 1 |
| Gomi, H | 1 |
| Boccumini, LE | 1 |
| Fowler, CL | 1 |
| Campbell, TA | 1 |
| Puertolas, LF | 1 |
| Kaidbey, KH | 1 |
| Carbon, C | 1 |
| Yagawa, K | 1 |
3 reviews available for ofloxacin and Dermatitis, Contact, Phototoxic
| Article | Year |
|---|---|
Safety profile of the fluoroquinolones: focus on levofloxacin.
Topics: Adult; Aged, 80 and over; Anti-Bacterial Agents; Cardiovascular Diseases; Central Nervous System Dis | 2010 |
Comparison of side effects of levofloxacin versus other fluoroquinolones.
Topics: Anti-Infective Agents; Cardiovascular System; Dermatitis, Phototoxic; Digestive System; Hepatocytes; | 2001 |
Latest industry information on the safety profile of levofloxacin in Japan.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Infective Agents; Central Nervous System; Chemical and | 2001 |
2 trials available for ofloxacin and Dermatitis, Contact, Phototoxic
| Article | Year |
|---|---|
A randomized controlled trial (volunteer study) of sitafloxacin, enoxacin, levofloxacin and sparfloxacin phototoxicity.
Topics: Adult; Anti-Bacterial Agents; Asian People; China; Dermatitis, Phototoxic; Dose-Response Relationshi | 2003 |
Photoreaction potential of orally administered levofloxacin in healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Anti-Infective Agents; Dermatitis, Phototoxic; Double-Blind | 2000 |
7 other studies available for ofloxacin and Dermatitis, Contact, Phototoxic
| Article | Year |
|---|---|
A drug-related phototoxic reaction and its possible relationship to a radiation-induced skin reaction.
Topics: Dermatitis, Phototoxic; Drug Eruptions; Humans; Male; Middle Aged; Ofloxacin; Photosensitivity Disor | 2009 |
[Phototoxicity studies of pazufloxacin mesilate, a novel parenteral quinolone antimicrobial agent--in vitro and in vivo studies].
Topics: Animals; Anti-Infective Agents; Cells, Cultured; Ciprofloxacin; Dermatitis, Phototoxic; Enoxacin; Fe | 2002 |
In vitro phototoxic activities of new quinolone antibacterial agents: lipid peroxidative potentials.
Topics: Absorption; Anti-Infective Agents; Azides; Ciprofloxacin; Dermatitis, Phototoxic; Enoxacin; Fluoroqu | 1994 |
LD50 value, phototoxicity and convulsion induction test of the new quinolone antibacterial agent (S)-10-[(S)-(8-amino-6-azaspiro[3,4]octan-6-yl)]-9-fluoro-2, 3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxyl ic acid hemihydrate in la
Topics: Administration, Oral; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Behav | 1996 |
Quinolone antibacterials: a new class of photochemical carcinogens.
Topics: Animals; Anti-Infective Agents; Carcinoma, Squamous Cell; Ciprofloxacin; Dermatitis, Phototoxic; Fle | 1997 |
Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents.
Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Dermatitis, Phototoxic; DNA; DNA Damage; Enoxacin; Fl | 1997 |
In vitro phototoxicity of new quinolones: production of active oxygen species and photosensitized lipid peroxidation.
Topics: Anti-Infective Agents; Ciprofloxacin; Dermatitis, Phototoxic; DNA Damage; Fleroxacin; Fluoroquinolon | 1999 |