ofloxacin has been researched along with Deficiency, Magnesium in 6 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recently, we showed that magnesium deficiency induces lesions in knee joint cartilage from 5-week-old rats that are very similar to ofloxacin-induced cartilage defects." | 7.69 | Integrins on joint cartilage chondrocytes and alterations by ofloxacin or magnesium deficiency in immature rats. ( Förster, C; Günther, T; Kociok, K; Merker, HJ; Shakibaei, M; Stahlmann, R; Vormann, J, 1996) |
| "Ofloxacin treatment did not change the total magnesium concentrations in tissues, as determined with ashed samples." | 5.31 | Synergistic effect of ofloxacin and magnesium deficiency on joint cartilage in immature rats. ( Lozo, E; Riecke, K; Schwabe, R; Stahlmann, R; Vormann, J, 2002) |
| " To test the hypothesis that quinolone-induced arthropathy is caused (or aggravated) by magnesium deficiency in cartilage, we induced magnesium deficiency by feeding juvenile rats a magnesium-deficient diet for 9 days and treated the rats with single oral doses of ofloxacin (0, 100, 300, 600, or 1,200 mg/kg of body weight) during this period." | 3.69 | Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone-induced arthropathy. ( Förster, C; Günther, T; Merker, HJ; Shakibaei, M; Stahlmann, R; Vormann, J, 1995) |
| "Recently, we showed that magnesium deficiency induces lesions in knee joint cartilage from 5-week-old rats that are very similar to ofloxacin-induced cartilage defects." | 3.69 | Integrins on joint cartilage chondrocytes and alterations by ofloxacin or magnesium deficiency in immature rats. ( Förster, C; Günther, T; Kociok, K; Merker, HJ; Shakibaei, M; Stahlmann, R; Vormann, J, 1996) |
| "Ofloxacin treatment did not change the total magnesium concentrations in tissues, as determined with ashed samples." | 1.31 | Synergistic effect of ofloxacin and magnesium deficiency on joint cartilage in immature rats. ( Lozo, E; Riecke, K; Schwabe, R; Stahlmann, R; Vormann, J, 2002) |
| "5 and 6 h after dosing and the drug was still detectable in plasma 48 h after dosing (0." | 1.30 | Quinolone-induced arthropathy: exposure of magnesium-deficient aged rats or immature rats, mineral concentrations in target tissues and pharmacokinetics. ( Förster, C; Günther, T; Lozo, E; Merker, HJ; Schwabe, R; Stahlmann, R; Vormann, J; Zippel, U, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stahlmann, R | 6 |
| Förster, C | 4 |
| Shakibaei, M | 4 |
| Vormann, J | 6 |
| Günther, T | 3 |
| Merker, HJ | 3 |
| Kociok, K | 1 |
| Schwabe, R | 3 |
| Lozo, E | 2 |
| Zippel, U | 1 |
| Rücker, M | 1 |
| Baumann-Wilschke, I | 1 |
| Pfister, K | 1 |
| Riecke, K | 1 |
6 other studies available for ofloxacin and Deficiency, Magnesium
| Article | Year |
|---|---|
Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone-induced arthropathy.
Topics: Animals; Anti-Infective Agents; Bone and Bones; Cartilage Diseases; Cartilage, Articular; Diet; Fema | 1995 |
Integrins on joint cartilage chondrocytes and alterations by ofloxacin or magnesium deficiency in immature rats.
Topics: Animals; Anti-Infective Agents; Calcium; Cartilage, Articular; Immunohistochemistry; Integrins; Magn | 1996 |
Quinolone-induced arthropathy: exposure of magnesium-deficient aged rats or immature rats, mineral concentrations in target tissues and pharmacokinetics.
Topics: Age Factors; Animals; Anti-Infective Agents; Calcium; Cartilage; Ciprofloxacin; Contraindications; F | 1997 |
Effects of fluoroquinolones and magnesium deficiency in murine limb bud cultures.
Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Dose-Response Relationship, Drug; Embryo, Mammalian; | 1998 |
Ultrastructure of Achilles tendons of rats treated with ofloxacin and fed a normal or magnesium-deficient diet.
Topics: Achilles Tendon; Aging; Animals; Anti-Infective Agents; Diet; Magnesium Deficiency; Ofloxacin; Rats; | 2000 |
Synergistic effect of ofloxacin and magnesium deficiency on joint cartilage in immature rats.
Topics: Animals; Anti-Infective Agents; Cartilage; Cartilage Diseases; Joints; Magnesium; Magnesium Deficien | 2002 |