ofloxacin has been researched along with Corneal Ulcer in 43 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Corneal Ulcer: Loss of epithelial tissue from the surface of the cornea due to progressive erosion and necrosis of the tissue; usually caused by bacterial, fungal, or viral infection.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report six cases of corneal deposits after administration of topical ofloxacin in the treatment of bacterial keratitis." | 7.74 | Corneal deposits and topical ofloxacin--the effect of polypharmacy in the management of microbial keratitis. ( McElvanney, A; Mitra, A; Tsesmetzoglou, E, 2007) |
| "Ofloxacin and combined fortified tobramycin and cefazolin topical drops were comparable for treating cases of bacterial corneal ulcer." | 5.09 | Comparison of topical 0.3% ofloxacin with fortified tobramycin plus cefazolin in the treatment of bacterial keratitis. ( Ahuja, R; Panda, A; Sastry, SS, 1999) |
| "Corneal cross-linking (CXL) with riboflavin is being used more frequently for the treatment of therapy-resistant microbial keratitis, since increasing drug resistance and specific pathogens, e." | 3.80 | [Corneal cross-linking in microbial keratitis to prevent à chaud keratoplasty: a retrospective case series]. ( Ammermann, C; Cursiefen, C; Hermann, M, 2014) |
| "To compare the therapeutic effectiveness of a single intrastromal dose of gentamycin, tobramycin, ciprofloxacin and ofloxacin for the treatment of corneal ulcers due to Pseudomonas aeruginosa." | 3.75 | [Bacterial corneal ulcer treated with intrastromal antibiotic. Experimental model in vivo]. ( Naranjo-Tackman, R; Stangogiannis-Druya, C; Stangogiannis-Druya, E; Vanzzini, V; Villar-Kurí, J, 2009) |
| "To report six cases of corneal deposits after administration of topical ofloxacin in the treatment of bacterial keratitis." | 3.74 | Corneal deposits and topical ofloxacin--the effect of polypharmacy in the management of microbial keratitis. ( McElvanney, A; Mitra, A; Tsesmetzoglou, E, 2007) |
| "A 48-year-old man presented with a corneal ulcer in his right eye and was treated with ofloxacin and fortified bacitracin ophthalmic solution." | 3.72 | Chryseobacterium meningosepticum keratitis. ( Bloom, AH; Davis, RG; Donnenfeld, ED; Perry, HD, 2003) |
| "Ofloxacin is a potent broad-spectrum fluoroquinolone antibiotic commercially available as a topical ophthalmic preparation." | 2.68 | Ofloxacin monotherapy for the primary treatment of microbial keratitis: a double-masked, randomized, controlled trial with conventional dual therapy. The Ofloxacin Study Group. ( , 1997) |
| "Ofloxacin was found as effective, safe, and comfortable as tobramycin in patients with external ocular infection and may provide earlier symptom relief." | 2.67 | Ofloxacin vs tobramycin for the treatment of external ocular infection. Ofloxacin Study Group II. ( Gwon, A, 1992) |
| "Levofloxacin 1." | 1.36 | Topical levofloxacin 1.5% overcomes in vitro resistance in rabbit keratitis models. ( Gordon, YJ; Kowalski, RP; Mah, FS; Romanowski, EG; Shanks, RM, 2010) |
| "Although Pseudomonas infections in post-RK eyes have been reported, late-onset Pseudomonas keratitis in a patient with four radial incisions and no history of contact lens wear is contrary to previous reports." | 1.30 | Delayed-onset Pseudomonas keratitis after radial keratotomy. ( Procope, JA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (23.26) | 18.2507 |
| 2000's | 25 (58.14) | 29.6817 |
| 2010's | 8 (18.60) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tran, T | 1 |
| Samarawickrama, C | 1 |
| Petsoglou, C | 1 |
| Watson, S | 1 |
| Ammermann, C | 1 |
| Cursiefen, C | 1 |
| Hermann, M | 1 |
| Fernandes, M | 1 |
| Vira, D | 1 |
| Medikonda, R | 1 |
| Kumar, N | 1 |
| Rosenberg, J | 1 |
| Eisen, L | 1 |
| Kim, J | 1 |
| Konstantopoulos, A | 2 |
| Kuo, J | 1 |
| Anderson, D | 1 |
| Hossain, P | 2 |
| Bashir, G | 1 |
| Hussain, W | 1 |
| Rizvi, A | 1 |
| Stangogiannis-Druya, E | 1 |
| Stangogiannis-Druya, C | 1 |
| Naranjo-Tackman, R | 1 |
| Vanzzini, V | 1 |
| Villar-Kurí, J | 1 |
| Tam, PM | 1 |
| Young, AL | 1 |
| Cheng, L | 1 |
| Congdon, N | 1 |
| Lam, PT | 1 |
| Kowalski, RP | 3 |
| Romanowski, EG | 2 |
| Mah, FS | 2 |
| Shanks, RM | 1 |
| Gordon, YJ | 3 |
| Yadegarfar, G | 1 |
| Fievez, M | 1 |
| Anderson, DF | 1 |
| Fukumoto, A | 1 |
| Sotozono, C | 1 |
| Hieda, O | 1 |
| Kinoshita, S | 1 |
| Hafezi, F | 1 |
| Claerhout, I | 1 |
| Kestelyn, P | 1 |
| Meire, F | 1 |
| Remon, JP | 1 |
| Decaestecker, T | 1 |
| Van Bocxlaer, J | 1 |
| Solomon, R | 2 |
| Donnenfeld, ED | 3 |
| Perry, HD | 3 |
| Biser, S | 1 |
| Bloom, AH | 1 |
| Davis, RG | 1 |
| Dhaliwal, DK | 1 |
| Karenchak, LM | 1 |
| Ritterband, DC | 1 |
| Maĭchuk, IuF | 1 |
| Lee, EJ | 1 |
| Truong, TN | 1 |
| Mendoza, MN | 1 |
| Fleiszig, SM | 1 |
| Barequet, IS | 1 |
| Denton, P | 1 |
| Osterhout, GJ | 1 |
| Tuli, S | 1 |
| O'Brien, TP | 2 |
| Lang, J | 1 |
| Rah, MJ | 1 |
| Araki-Sasaki, K | 1 |
| Nishi, I | 1 |
| Yonemura, N | 1 |
| Takatsuka, H | 1 |
| Mutoh, K | 1 |
| Matsumoto, K | 1 |
| Asari, S | 1 |
| Tanihara, H | 1 |
| Caballero, AR | 1 |
| Marquart, ME | 1 |
| O'Callaghan, RJ | 1 |
| Thibodeaux, BA | 1 |
| Johnston, KH | 1 |
| Dajcs, JJ | 1 |
| Mitra, A | 1 |
| Tsesmetzoglou, E | 1 |
| McElvanney, A | 1 |
| Yilmaz, S | 1 |
| Saklamaz, A | 1 |
| Maden, A | 1 |
| Rubinfeld, RS | 1 |
| Ehrenhaus, M | 1 |
| Wittpenn, JR | 1 |
| Solomon, KD | 1 |
| Manche, EE | 1 |
| Moshirfar, M | 1 |
| Matzkin, DC | 1 |
| Mozayeni, RM | 1 |
| Maloney, RK | 1 |
| Constantinou, M | 1 |
| Daniell, M | 2 |
| Snibson, GR | 1 |
| Vu, HT | 1 |
| Taylor, HR | 1 |
| Kocatürk, T | 1 |
| Pineda, R | 1 |
| Green, LK | 1 |
| Azar, DT | 1 |
| Maguire, MG | 1 |
| Fink, NE | 1 |
| Alfonso, E | 1 |
| McDonnell, P | 1 |
| Shiao, S | 1 |
| Isobe, Y | 1 |
| Hatano, H | 1 |
| Ohno, S | 1 |
| Baker, RS | 1 |
| Flowers, CW | 1 |
| Casey, R | 1 |
| Fong, DS | 1 |
| Wilson, MR | 1 |
| Shiota, H | 1 |
| Nitta, K | 1 |
| Naito, T | 1 |
| Mimura, Y | 1 |
| Maruyama, T | 1 |
| Procope, JA | 1 |
| Yang, J | 1 |
| Baltatzis, S | 1 |
| Foster, CS | 1 |
| Goldstein, MH | 1 |
| Panda, A | 1 |
| Ahuja, R | 1 |
| Sastry, SS | 1 |
| Alexandrakis, G | 1 |
| Alfonso, EC | 1 |
| Miller, D | 1 |
| Rao, SN | 1 |
| Fong, Y | 1 |
| Kampmeier, J | 1 |
| LaBree, LD | 1 |
| Tanzer, DJ | 1 |
| McDonnell, PJ | 2 |
| Mallari, PL | 1 |
| McCarty, DJ | 1 |
| Taylor, H | 1 |
| Akamizu, T | 1 |
| Kaneko, H | 1 |
| Noguchi, N | 1 |
| Kashii, S | 1 |
| Nakao, K | 1 |
| Prajna, NV | 1 |
| George, C | 1 |
| Selvaraj, S | 1 |
| Lu, KL | 1 |
| Srinivasan, M | 1 |
| Hutchinson, K | 1 |
| Apel, A | 1 |
| Gwon, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Swiss PACK-CXL (Photoactivated Chromophore for Infectious Keratitis Cross-linking) Multicenter Trial for the Treatment of Infectious Keratitis[NCT02717871] | Phase 3 | 35 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| Contribution of Fast Molecular Bacterial Identification by Real-time PCR in Managing of Postoperative Acute Endophthalmitis[NCT02850653] | 150 participants (Anticipated) | Interventional | 2007-11-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 trials available for ofloxacin and Corneal Ulcer
| Article | Year |
|---|---|
Clinical efficacy of moxifloxacin in the treatment of bacterial keratitis: a randomized clinical trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Aza Compounds; Bacteria; Cefazoli | 2007 |
Efficacy of ofloxacin vs cefazolin and tobramycin in the therapy for bacterial keratitis. Report from the Bacterial Keratitis Study Research Group.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Cefazolin; Cephalospor | 1995 |
Clinical evaluation of carbocyclic oxetanocin G eyedrops in the treatment of herpes simplex corneal ulcers.
Topics: Administration, Topical; Anti-Infective Agents; Antiviral Agents; Corneal Ulcer; Eye Infections, Vir | 1996 |
Ofloxacin monotherapy for the primary treatment of microbial keratitis: a double-masked, randomized, controlled trial with conventional dual therapy. The Ofloxacin Study Group.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Cefuroxime; Cephalosporins; Cornea; Corneal | 1997 |
Comparison of topical 0.3% ofloxacin with fortified tobramycin plus cefazolin in the treatment of bacterial keratitis.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Cefazolin; Cephalosporins; Co | 1999 |
Bacteriologic and clinical efficacy of ofloxacin 0.3% versus ciprofloxacin 0.3% ophthalmic solutions in the treatment of patients with culture-positive bacterial keratitis.
Topics: Adult; Anti-Infective Agents; Bacteria; Ciprofloxacin; Corneal Ulcer; Double-Blind Method; Drug Admi | 2001 |
Ofloxacin vs tobramycin for the treatment of external ocular infection. Ofloxacin Study Group II.
Topics: Blepharitis; Colony Count, Microbial; Conjunctiva; Conjunctivitis, Bacterial; Corneal Ulcer; Double- | 1992 |
36 other studies available for ofloxacin and Corneal Ulcer
| Article | Year |
|---|---|
Recent cluster of childhood microbial keratitis due to orthokeratology.
Topics: Acanthamoeba Keratitis; Adolescent; Anti-Bacterial Agents; Biguanides; Cephalothin; Child; Chlorhexi | 2014 |
[Corneal cross-linking in microbial keratitis to prevent à chaud keratoplasty: a retrospective case series].
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Bacterial Infections; Biological Dressings; C | 2014 |
Extensively and pan-drug resistant Pseudomonas aeruginosa keratitis: clinical features, risk factors, and outcome.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Colistin; Corneal Ulcer; Drug Resistance, Multiple, Bacterial; | 2016 |
Moxifloxacin for bacterial keratitis.
Topics: Anti-Infective Agents; Aza Compounds; Bacteria; Cefazolin; Cornea; Corneal Ulcer; Drug Therapy, Comb | 2008 |
Assessment of the use of anterior segment optical coherence tomography in microbial keratitis.
Topics: Adult; Aged; Anterior Eye Segment; Anti-Bacterial Agents; Cefuroxime; Contact Lenses; Corneal Ulcer; | 2008 |
Bipolaris hawaiiensis keratomycosis and endophthalmitis.
Topics: Agriculture; Anti-Bacterial Agents; Antifungal Agents; Ascomycota; Cornea; Corneal Injuries; Corneal | 2009 |
[Bacterial corneal ulcer treated with intrastromal antibiotic. Experimental model in vivo].
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Cornea; | 2009 |
Tsukamurella: an unrecognized mimic of atypical mycobacterial keratitis? The first case report.
Topics: Actinomycetales; Actinomycetales Infections; Aged, 80 and over; Amikacin; Anti-Bacterial Agents; Cor | 2010 |
Topical levofloxacin 1.5% overcomes in vitro resistance in rabbit keratitis models.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Cefazolin; Ciprofloxacin; Colony Count, Mic | 2010 |
In vivo quantification of bacterial keratitis with optical coherence tomography.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Cefuroxime; Cornea; Corneal Ulcer; Drug Monit | 2011 |
Infectious keratitis caused by fluoroquinolone-resistant Corynebacterium.
Topics: Corneal Ulcer; Corynebacterium; Corynebacterium Infections; Drug Resistance, Bacterial; Eye Infectio | 2011 |
Significant visual increase following infectious keratitis after collagen cross-linking.
Topics: Anti-Bacterial Agents; Collagen; Corneal Stroma; Corneal Topography; Corneal Ulcer; Cross-Linking Re | 2012 |
Corneal deposits after the topical use of ofloxacin in two children with vernal keratoconjunctivitis.
Topics: Administration, Topical; Anti-Infective Agents; Child; Child, Preschool; Conjunctivitis, Allergic; C | 2003 |
Bilateral methicillin-resistant staphylococcus aureus keratitis in a medical resident following an uneventful bilateral photorefractive keratectomy.
Topics: Adult; Cornea; Corneal Ulcer; Drug Therapy, Combination; Eye Infections, Bacterial; Eyelids; Female; | 2003 |
Chryseobacterium meningosepticum keratitis.
Topics: Bacitracin; Cornea; Corneal Ulcer; Drug Therapy, Combination; Eye Infections, Bacterial; Flavobacter | 2003 |
Gatifloxacin and moxifloxacin: an in vitro susceptibility comparison to levofloxacin, ciprofloxacin, and ofloxacin using bacterial keratitis isolates.
Topics: Anti-Infective Agents; Aza Compounds; Bacteria; Ciprofloxacin; Corneal Ulcer; Drug Resistance, Bacte | 2003 |
[Levofloxacin (Tavanic) in the treatment of corneal ulcers].
Topics: Administration, Oral; Anti-Infective Agents; Corneal Ulcer; Drug Administration Schedule; Drug Thera | 2003 |
A comparison of invasive and cytotoxic Pseudomonas aeruginosa strain-induced corneal disease responses to therapeutics.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Cornea; Corneal Ulcer; Disease Models, Anim | 2003 |
Treatment of experimental bacterial keratitis with topical trovafloxacin.
Topics: Administration, Topical; Animals; Anti-Infective Agents; Biological Availability; Ciprofloxacin; Col | 2004 |
Adverse corneal events associated with corneal reshaping: a case series.
Topics: Adult; Anti-Bacterial Agents; Child; Contact Lenses; Corneal Ulcer; Eye Infections, Bacterial; Femal | 2004 |
Characteristics of Pseudomonas corneal infection related to orthokeratology.
Topics: Administration, Topical; Adolescent; Anti-Bacterial Agents; Cefmenoxime; Cefozopran; Cephalosporins; | 2005 |
Effectiveness of fluoroquinolones against Mycobacterium abscessus in vivo.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Aza Compounds; Ciprofloxacin; Colony Count, | 2006 |
Corneal deposits and topical ofloxacin--the effect of polypharmacy in the management of microbial keratitis.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Corne | 2007 |
Pseudomonas keratitis.
Topics: Adolescent; Anti-Bacterial Agents; Cornea; Corneal Ulcer; Drug Therapy, Combination; Eye Infections, | 2006 |
Methicillin-resistant Staphylococcus aureus infectious keratitis following refractive surgery.
Topics: Adult; Corneal Ulcer; Drug Therapy, Combination; Eye Infections, Bacterial; Female; Health Personnel | 2007 |
Post-LASIK epithelial dendritic defect associated with Alternaria.
Topics: Alternaria; Amphotericin B; Antifungal Agents; Combined Modality Therapy; Corneal Ulcer; Debridement | 2007 |
Comparative study on topical and oral administration of ofloxacin for Pseudomonas corneal ulcer in rabbits.
Topics: Administration, Oral; Administration, Topical; Animals; Cornea; Corneal Ulcer; Eye Infections, Bacte | 1995 |
Efficacy of ofloxacin vs cefazolin and tobramycin in the therapy for bacterial keratitis.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Cefazolin; Cephalosporins; Clinical Trials as Topic; C | 1996 |
Delayed-onset Pseudomonas keratitis after radial keratotomy.
Topics: Administration, Oral; Anti-Bacterial Agents; Anti-Infective Agents; Astigmatism; Cornea; Corneal Ulc | 1997 |
Peripheral ulcerative keratitis after Salmonella gastroenteritis.
Topics: Aged; Cornea; Corneal Neovascularization; Corneal Ulcer; Cyclopentolate; Drug Therapy, Combination; | 1998 |
Emerging fluoroquinolone resistance in bacterial keratitis: a 5-year review.
Topics: Anti-Infective Agents; Ciprofloxacin; Corneal Ulcer; Drug Resistance, Microbial; Eye Infections, Bac | 1999 |
Emerging fluoroquinolone resistance in bacterial keratitis: a 5-year review.
Topics: Anti-Infective Agents; Ciprofloxacin; Corneal Ulcer; Drug Resistance, Microbial; Eye Infections, Bac | 1999 |
Emerging fluoroquinolone resistance in bacterial keratitis: a 5-year review.
Topics: Anti-Infective Agents; Ciprofloxacin; Corneal Ulcer; Drug Resistance, Microbial; Eye Infections, Bac | 1999 |
Emerging fluoroquinolone resistance in bacterial keratitis: a 5-year review.
Topics: Anti-Infective Agents; Ciprofloxacin; Corneal Ulcer; Drug Resistance, Microbial; Eye Infections, Bac | 1999 |
Shifting trends in bacterial keratitis in south Florida and emerging resistance to fluoroquinolones.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Ciprofloxacin; Cornea; Corneal Ulcer; Drug R | 2000 |
The effectiveness of a topical antibiotic irrigating solution in a model of staphylococcal keratitis after lamellar keratectomy.
Topics: Administration, Topical; Animals; Anti-Infective Agents; Colony Count, Microbial; Corneal Stroma; Co | 2000 |
Increased incidence of corneal perforation after topical fluoroquinolone treatment for microbial keratitis.
Topics: Anti-Infective Agents; Bacteria; Cornea; Corneal Diseases; Corneal Ulcer; Eye Infections, Bacterial; | 2001 |
Moisture chamber for management of corneal ulcer due to Graves' ophthalmopathy.
Topics: Corneal Ulcer; Female; Graves Disease; Humans; Humidity; Methylprednisolone; Middle Aged; Ofloxacin; | 2000 |
Infectious keratitis in orthokeratology.
Topics: Acanthamoeba Keratitis; Adult; Antiprotozoal Agents; Astigmatism; Benzamidines; Chloramphenicol; Con | 2002 |