ofloxacin has been researched along with Chromosome-Defective Micronuclei in 3 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Animals were killed on Days 2, 3, 4, 5 or 8 (the dosing day was designated as Day 1), and the incidence of micronucleus in the epidermis was determined." | 1.31 | In vivo photochemical micronucleus induction due to certain quinolone antimicrobial agents in the skin of hairless mice. ( Furuhama, K; Itoh, S; Katoh, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Şekeroğlu, V | 1 |
| Aksoy, M | 1 |
| Atlı Şekeroğlu, Z | 1 |
| Vasquez, MI | 1 |
| Garcia-Käufer, M | 1 |
| Hapeshi, E | 1 |
| Menz, J | 1 |
| Kostarelos, K | 1 |
| Fatta-Kassinos, D | 1 |
| Kümmerer, K | 1 |
| Itoh, S | 1 |
| Katoh, M | 1 |
| Furuhama, K | 1 |
3 other studies available for ofloxacin and Chromosome-Defective Micronuclei
| Article | Year |
|---|---|
Cytogenetic alterations in human lymphocyte cultures following exposure to ofloxacin.
Topics: Anti-Bacterial Agents; Cell Proliferation; Cells, Cultured; DNA Damage; Dose-Response Relationship, | 2017 |
Chronic ecotoxic effects to Pseudomonas putida and Vibrio fischeri, and cytostatic and genotoxic effects to the hepatoma cell line (HepG2) of ofloxacin photo(cata)lytically treated solutions.
Topics: Aliivibrio fischeri; Cell Proliferation; Chromatography, Liquid; Ecotoxicology; Hep G2 Cells; Humans | 2013 |
In vivo photochemical micronucleus induction due to certain quinolone antimicrobial agents in the skin of hairless mice.
Topics: Animals; Anti-Infective Agents; Chromosome Aberrations; Dose-Response Relationship, Drug; Fluoroquin | 2002 |