ofloxacin has been researched along with Chondromalacia in 5 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Chondromalacia: Softening and degeneration of the CARTILAGE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ofloxacin treatment did not change the total magnesium concentrations in tissues, as determined with ashed samples." | 5.31 | Synergistic effect of ofloxacin and magnesium deficiency on joint cartilage in immature rats. ( Lozo, E; Riecke, K; Schwabe, R; Stahlmann, R; Vormann, J, 2002) |
| " To test the hypothesis that quinolone-induced arthropathy is caused (or aggravated) by magnesium deficiency in cartilage, we induced magnesium deficiency by feeding juvenile rats a magnesium-deficient diet for 9 days and treated the rats with single oral doses of ofloxacin (0, 100, 300, 600, or 1,200 mg/kg of body weight) during this period." | 3.69 | Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone-induced arthropathy. ( Förster, C; Günther, T; Merker, HJ; Shakibaei, M; Stahlmann, R; Vormann, J, 1995) |
| "Ofloxacin treatment did not change the total magnesium concentrations in tissues, as determined with ashed samples." | 1.31 | Synergistic effect of ofloxacin and magnesium deficiency on joint cartilage in immature rats. ( Lozo, E; Riecke, K; Schwabe, R; Stahlmann, R; Vormann, J, 2002) |
| " Juvenile (4- to 5-week-old) NZW were orally dosed with ofloxacin or pefloxacin (300 mg/kg of body weight for 1 day) or with pefloxacin (300 mg/kg for 7 days)." | 1.29 | Cytofluorometric analysis of chondrotoxicity of fluoroquinolone antimicrobial agents. ( Gaudin, C; Hayem, G; Kahn, MF; Levacher, M; Petit, PX; Pocidalo, JJ, 1994) |
| " Chondrocyte clusters producing glycosaminoglycans were observed 3 weeks after dosing and at later time points." | 1.29 | Quinolone-induced cartilage lesions are not reversible in rats. ( Förster, C; Kociok, K; Merker, HJ; Shakibaei, M; Stahlmann, R, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kappel, EM | 1 |
| Shakibaei, M | 3 |
| Bello, A | 1 |
| Stahlmann, R | 4 |
| Hayem, G | 1 |
| Petit, PX | 1 |
| Levacher, M | 1 |
| Gaudin, C | 1 |
| Kahn, MF | 1 |
| Pocidalo, JJ | 1 |
| Förster, C | 2 |
| Vormann, J | 2 |
| Günther, T | 1 |
| Merker, HJ | 2 |
| Kociok, K | 1 |
| Lozo, E | 1 |
| Riecke, K | 1 |
| Schwabe, R | 1 |
5 other studies available for ofloxacin and Chondromalacia
| Article | Year |
|---|---|
Effects of the Des-F(6)-quinolone garenoxacin (BMS-284756), in comparison to those of ciprofloxacin and ofloxacin, on joint cartilage in immature rats.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Cartilage Diseases; Cartilage, Articular; Cipr | 2002 |
Cytofluorometric analysis of chondrotoxicity of fluoroquinolone antimicrobial agents.
Topics: Animals; Anti-Infective Agents; Cartilage Diseases; Cartilage, Articular; Flow Cytometry; Fluorescen | 1994 |
Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone-induced arthropathy.
Topics: Animals; Anti-Infective Agents; Bone and Bones; Cartilage Diseases; Cartilage, Articular; Diet; Fema | 1995 |
Quinolone-induced cartilage lesions are not reversible in rats.
Topics: Animals; Anti-Infective Agents; Cartilage; Cartilage Diseases; Female; Male; Ofloxacin; Rats; Time F | 1996 |
Synergistic effect of ofloxacin and magnesium deficiency on joint cartilage in immature rats.
Topics: Animals; Anti-Infective Agents; Cartilage; Cartilage Diseases; Joints; Magnesium; Magnesium Deficien | 2002 |