ofloxacin has been researched along with Central Nervous System Diseases in 6 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Central Nervous System Diseases: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Although very useful agents, the fluoroquinolones as a class are associated with a number of adverse events, some with considerable clinical significance." | 2.46 | Safety profile of the fluoroquinolones: focus on levofloxacin. ( Liu, HH, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, HH | 1 |
| Zubkov, MN | 1 |
| Iakovlev, VP | 1 |
| Svetukhin, AM | 1 |
| Blatun, LA | 1 |
| Ukhin, SA | 1 |
| Guven, EO | 1 |
| Balbay, D | 1 |
| Kilciler, M | 1 |
| Stahlmann, R | 1 |
| Kohler, RB | 1 |
| Arkins, N | 1 |
| Tack, KJ | 1 |
3 reviews available for ofloxacin and Central Nervous System Diseases
| Article | Year |
|---|---|
Safety profile of the fluoroquinolones: focus on levofloxacin.
Topics: Adult; Aged, 80 and over; Anti-Bacterial Agents; Cardiovascular Diseases; Central Nervous System Dis | 2010 |
[Efficacy and safety of levofloxacin in low respiratory tract infection].
Topics: Anti-Bacterial Agents; Central Nervous System Diseases; Clinical Trials as Topic; Dermatitis, Atopic | 2004 |
[Modern fluoroquinolones (ciprofoxacin, levofloxacin) and the treatment of skin and soft tissue infections].
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Central Nervous System Diseases; Ciprofloxacin; Gastro | 2004 |
3 other studies available for ofloxacin and Central Nervous System Diseases
| Article | Year |
|---|---|
Unexpected, severe central nerve system toxicity of ofloxacine: report of two cases.
Topics: Aged; Anti-Infective Agents, Urinary; Central Nervous System Diseases; Female; Humans; Male; Middle | 2007 |
Clinical toxicological aspects of fluoroquinolones.
Topics: Anti-Infective Agents; Bacterial Infections; Cardiovascular Diseases; Central Nervous System Disease | 2002 |
Accidental overdose of intravenous ofloxacin with benign outcome.
Topics: Adult; Central Nervous System Diseases; Drug Overdose; Female; Humans; Injections, Intravenous; Oflo | 1991 |