ofloxacin has been researched along with Brucellosis in 15 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Brucellosis: Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this prospective randomized study, the efficacy and safety of the combination of ofloxacin plus rifampin were compared with the efficacy and safety of doxycycline plus rifampin, both combinations administered for a 6-week period in treatment of brucellosis." | 9.07 | Quinolones in treatment of human brucellosis: comparative trial of ofloxacin-rifampin versus doxycycline-rifampin. ( Akalin, HE; Akova, M; Gür, D; Hayran, M; Unal, S; Uzun, O, 1993) |
| "Traditional regimens for the treatment of brucellosis are associated with significant relapse rates." | 6.77 | Comparison of doxycycline-streptomycin, doxycycline-rifampin, and ofloxacin-rifampin in the treatment of brucellosis: a randomized clinical trial. ( Gachkar, L; Hajilooi, M; Hashemi, SH; Janbakhsh, A; Keramat, F; Mahjub, H; Majzoobi, MM; Mamani, M, 2012) |
| " In this prospective randomized study, the efficacy and safety of the combination of ofloxacin plus rifampin were compared with the efficacy and safety of doxycycline plus rifampin, both combinations administered for a 6-week period in treatment of brucellosis." | 5.07 | Quinolones in treatment of human brucellosis: comparative trial of ofloxacin-rifampin versus doxycycline-rifampin. ( Akalin, HE; Akova, M; Gür, D; Hayran, M; Unal, S; Uzun, O, 1993) |
| "The efficacy of levofloxacin and dirithromycin, alone and in combination with rifampicin in the treatment of experimental brucellosis was investigated." | 3.72 | Efficacy of oral levofloxacin and dirithromycin alone and in combination with rifampicin in the treatment of experimental murine Brucella abortus infection. ( Arda, B; Gökengin, D; Gürel, O; Tunçel, M; Yaimazhan, T, 2004) |
| "Traditional regimens for the treatment of brucellosis are associated with significant relapse rates." | 2.77 | Comparison of doxycycline-streptomycin, doxycycline-rifampin, and ofloxacin-rifampin in the treatment of brucellosis: a randomized clinical trial. ( Gachkar, L; Hajilooi, M; Hashemi, SH; Janbakhsh, A; Keramat, F; Mahjub, H; Majzoobi, MM; Mamani, M, 2012) |
| "Brucellosis was diagnosed using standard clinical and microbiological findings." | 2.71 | Comparison of three different combination therapies in the treatment of human brucellosis. ( But, AD; Ersoy, Y; Sonmez, E; Tevfik, MR, 2005) |
| "Brucellosis is the most common zoonotic infection in the world." | 2.48 | Antibiotics for treating human brucellosis. ( Mehrani, M; Mortaz-Hejri, S; Sadeghipour, P; Yousefi-Nooraie, R, 2012) |
| "Cryoglobulinemia has been described in infectious diseases, but in only three patients with brucellosis." | 1.33 | Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis. ( Hermida Lazcano, I; Sáez Méndez, L; Solera Santos, J, 2005) |
| "The principal treatment of brucellosis of the spine is conservative, namely, immobilization and antimicrobial therapy." | 1.29 | Brucellosis of the spine. ( Akalin, E; Berker, M; Ozcan, OE; Ozgen, T; Tekkök, IH, 1993) |
| "Ofloxacin was the most active of the test antimicrobial agents." | 1.28 | Comparative in vitro activities of ofloxacin, difloxacin, ciprofloxacin, and other selected antimicrobial agents against Brucella melitensis. ( Dizon, M; Khan, MY; Kiel, FW, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Karabay, O | 2 |
| Okan, HD | 1 |
| Simsek, A | 1 |
| Guclu, E | 1 |
| Hashemi, SH | 1 |
| Gachkar, L | 1 |
| Keramat, F | 1 |
| Mamani, M | 1 |
| Hajilooi, M | 1 |
| Janbakhsh, A | 1 |
| Majzoobi, MM | 1 |
| Mahjub, H | 1 |
| Yousefi-Nooraie, R | 1 |
| Mortaz-Hejri, S | 1 |
| Mehrani, M | 1 |
| Sadeghipour, P | 1 |
| Arda, B | 1 |
| Tunçel, M | 1 |
| Yaimazhan, T | 1 |
| Gökengin, D | 1 |
| Gürel, O | 1 |
| Sencan, I | 1 |
| Kayas, D | 1 |
| Sahin, I | 1 |
| Hermida Lazcano, I | 1 |
| Sáez Méndez, L | 1 |
| Solera Santos, J | 1 |
| Ersoy, Y | 1 |
| Sonmez, E | 1 |
| Tevfik, MR | 1 |
| But, AD | 1 |
| Akova, M | 1 |
| Uzun, O | 1 |
| Akalin, HE | 1 |
| Hayran, M | 1 |
| Unal, S | 1 |
| Gür, D | 1 |
| Tekkök, IH | 1 |
| Berker, M | 1 |
| Ozcan, OE | 1 |
| Ozgen, T | 1 |
| Akalin, E | 1 |
| Tatlişen, A | 1 |
| Carpinlioğlu, M | 1 |
| Sümerkan, B | 1 |
| Gülmez, I | 1 |
| Karacagil, M | 1 |
| Ying, W | 1 |
| Nguyen, MQ | 1 |
| Jahre, JA | 1 |
| Taşova, Y | 1 |
| Saltoğlu, N | 1 |
| Sahin, G | 1 |
| Aksu, HS | 1 |
| Shasha, B | 1 |
| Lang, R | 1 |
| Rubinstein, E | 1 |
| Khuri-Bulos, N | 1 |
| Shaker, K | 1 |
| Khan, MY | 1 |
| Dizon, M | 1 |
| Kiel, FW | 1 |
1 review available for ofloxacin and Brucellosis
| Article | Year |
|---|---|
Antibiotics for treating human brucellosis.
Topics: Anti-Bacterial Agents; Brucellosis; Ciprofloxacin; Doxycycline; Humans; Ofloxacin; Randomized Contro | 2012 |
4 trials available for ofloxacin and Brucellosis
| Article | Year |
|---|---|
Comparison of doxycycline-streptomycin, doxycycline-rifampin, and ofloxacin-rifampin in the treatment of brucellosis: a randomized clinical trial.
Topics: Adult; Anti-Bacterial Agents; Brucella melitensis; Brucellosis; Doxycycline; Drug Therapy, Combinati | 2012 |
Ofloxacin plus rifampicin versus doxycycline plus rifampicin in the treatment of brucellosis: a randomized clinical trial [ISRCTN11871179].
Topics: Adolescent; Adult; Brucellosis; Diarrhea; Doxycycline; Drug Costs; Drug Therapy, Combination; Female | 2004 |
Comparison of three different combination therapies in the treatment of human brucellosis.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Brucella; Brucellosis; Doxycycline; Drug Therapy, Co | 2005 |
Quinolones in treatment of human brucellosis: comparative trial of ofloxacin-rifampin versus doxycycline-rifampin.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Brucella melitensis; Brucellosis; Doxycycline; Femal | 1993 |
10 other studies available for ofloxacin and Brucellosis
| Article | Year |
|---|---|
Use of Rifabutin as an Alternative Agent for Human Brucellosis: A Case Report.
Topics: Adult; Antibiotics, Antitubercular; Brucellosis; Ceftriaxone; Drug Therapy, Combination; Female; Hum | 2018 |
Efficacy of oral levofloxacin and dirithromycin alone and in combination with rifampicin in the treatment of experimental murine Brucella abortus infection.
Topics: Animals; Anti-Bacterial Agents; Brucella abortus; Brucellosis; Drug Therapy, Combination; Erythromyc | 2004 |
Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis.
Topics: Anti-Bacterial Agents; Ascitic Fluid; Brucella melitensis; Brucellosis; Cryoglobulinemia; Doxycyclin | 2005 |
Brucellosis of the spine.
Topics: Adolescent; Adult; Aged; Brucella melitensis; Brucellosis; Combined Modality Therapy; Diagnosis, Dif | 1993 |
[Evaluation of 18 epididymo-orchitis cases].
Topics: Adolescent; Adult; Bacteriuria; Brucellosis; Doxycycline; Drug Therapy, Combination; Epididymitis; E | 1993 |
Brucella canis endocarditis: case report.
Topics: Brucella; Brucellosis; Doxycycline; Drug Therapy, Combination; Endocarditis, Bacterial; Female; Huma | 1999 |
Osteoarthricular involvement of brucellosis in Turkey.
Topics: Adolescent; Adult; Age Distribution; Aged; Brucella; Brucellosis; Doxycycline; Female; Humans; Joint | 1999 |
Therapy of experimental murine brucellosis with streptomycin, co-trimoxazole, ciprofloxacin, ofloxacin, pefloxacin, doxycycline, and rifampin.
Topics: Administration, Oral; Animals; Brucellosis; Ciprofloxacin; Doxycycline; Injections, Intraperitoneal; | 1992 |
Relapse of brucellosis following ofloxacin therapy.
Topics: Adolescent; Adult; Brucellosis; Female; Humans; Male; Ofloxacin; Prospective Studies; Recurrence | 1991 |
Comparative in vitro activities of ofloxacin, difloxacin, ciprofloxacin, and other selected antimicrobial agents against Brucella melitensis.
Topics: Anti-Infective Agents; Brucella; Brucellosis; Ciprofloxacin; Fluoroquinolones; Humans; Microbial Sen | 1989 |