ofloxacin has been researched along with Agranulocytosis in 9 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy and safety of oral ofloxacin were compared with those of vancomycin/polymyxin for prophylaxis of bacterial infections in granulocytopenic patients undergoing chemotherapy for hematologic malignancy." | 5.06 | Ofloxacin versus vancomycin/polymyxin for prevention of infections in granulocytopenic patients. ( Bruckner, DA; Champlin, RE; Gale, RP; Ho, WG; Winston, DJ, 1990) |
| "We evaluated the efficacy and toxicity of piperacillin-ofloxacin as an empiric treatment of fever in patients with neutropenia." | 3.68 | [Empirical treatment of febrile episodes in granulocytopenic patients with a combination of piperacillin and ofloxacin. Preliminary study]. ( Brisseau, JM; Feve, B; Grolleau, JY; Raffi, F; Reynaud, AE; Tiab, M, 1990) |
| "Ciprofloxacin was therefore superior to the other two fluoroquinolones in preventing infections due to Gram-negative bacteria in this population of neutropenic patients." | 2.67 | Comparison of ciprofloxacin, ofloxacin and pefloxacin for the prevention of the bacterial infection in neutropenic patients with haematological malignancies. ( Accorsi, P; Betti, S; D'Antonio, D; Dell'Isola, M; Favalli, C; Fioritoni, G; Iacone, A; Parruti, G; Piccolomini, R; Quaglietta, AM, 1994) |
| "Ofloxacin was superior to co-trimoxazole in preventing infection in this population of neutropenic patients." | 2.67 | Ofloxacin versus co-trimoxazole for prevention of infection in neutropenic patients following cytotoxic chemotherapy. ( Chan, TK; Chau, PY; Lam, WK; Liang, RH; So, SY; Todd, D; Yung, RW, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| D'Antonio, D | 1 |
| Piccolomini, R | 1 |
| Iacone, A | 1 |
| Fioritoni, G | 1 |
| Parruti, G | 1 |
| Betti, S | 1 |
| Quaglietta, AM | 1 |
| Accorsi, P | 1 |
| Dell'Isola, M | 1 |
| Favalli, C | 1 |
| Kulessa, W | 1 |
| Becker, EW | 1 |
| Berg, PA | 1 |
| Tsutani, H | 1 |
| Imamura, S | 1 |
| Ueda, T | 1 |
| Yoshida, H | 1 |
| Iwasaki, H | 1 |
| Fukushima, T | 1 |
| Yoshimura, T | 1 |
| Toyooka, S | 1 |
| Nakamura, T | 1 |
| Winston, DJ | 1 |
| Ho, WG | 1 |
| Bruckner, DA | 1 |
| Gale, RP | 1 |
| Champlin, RE | 1 |
| Liang, RH | 1 |
| Yung, RW | 1 |
| Chan, TK | 1 |
| Chau, PY | 1 |
| Lam, WK | 1 |
| So, SY | 1 |
| Todd, D | 1 |
| Raffi, F | 1 |
| Feve, B | 1 |
| Tiab, M | 1 |
| Brisseau, JM | 1 |
| Reynaud, AE | 1 |
| Grolleau, JY | 1 |
| Bartoloni, A | 1 |
| Fanci, R | 1 |
| Orsi, A | 1 |
| Aquilini, D | 1 |
| Bosi, A | 1 |
| Rossi Ferrini, P | 1 |
| Paradisi, F | 1 |
| Hartlapp, JH | 1 |
| Guerra, L | 1 |
| Erani, E | 1 |
| Xerri, L | 1 |
6 trials available for ofloxacin and Agranulocytosis
| Article | Year |
|---|---|
Comparison of ciprofloxacin, ofloxacin and pefloxacin for the prevention of the bacterial infection in neutropenic patients with haematological malignancies.
Topics: Adult; Aged; Agranulocytosis; Anti-Infective Agents; Bacteremia; Bacterial Infections; Ciprofloxacin | 1994 |
Prophylactic use of ofloxacin in granulocytopenic patients with hematological malignancies during post-remission chemotherapy.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Antineoplastic Agents; Bacterial Infections; Female; Human | 1992 |
Ofloxacin versus vancomycin/polymyxin for prevention of infections in granulocytopenic patients.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Bacteria; Bacterial Infections; Digestive System; Drug The | 1990 |
Ofloxacin versus co-trimoxazole for prevention of infection in neutropenic patients following cytotoxic chemotherapy.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Antineoplastic Agents; Bacterial Infections; Child; Female | 1990 |
The influence of ofloxacin versus trimethoprim-sulfamethoxazole on the aerobic flora in granulocytopenic subjects.
Topics: Adult; Aged; Agranulocytosis; Bacteria, Aerobic; Drug Combinations; Female; Humans; Intestines; Leuk | 1989 |
Antimicrobial prophylaxis in immunocompromised patients.
Topics: Adult; Agranulocytosis; Anti-Infective Agents; Antineoplastic Agents; Bacterial Infections; Clinical | 1987 |
3 other studies available for ofloxacin and Agranulocytosis
| Article | Year |
|---|---|
[Recurrent agranulocytosis after taking calcium dobesilate].
Topics: Agranulocytosis; Calcium Dobesilate; Cefotaxime; Drug Hypersensitivity; Female; Humans; Lymphocyte A | 1992 |
[Empirical treatment of febrile episodes in granulocytopenic patients with a combination of piperacillin and ofloxacin. Preliminary study].
Topics: Adult; Aged; Aged, 80 and over; Agranulocytosis; Bacterial Infections; Drug Therapy, Combination; Fe | 1990 |
Ofloxacin: therapeutic activity in experimental infections.
Topics: Administration, Oral; Agranulocytosis; Animals; Anti-Infective Agents; Female; Male; Mice; Ofloxacin | 1986 |