ofloxacin has been researched along with Aging in 10 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levofloxacin was recently (May 2008) approved by the U." | 6.75 | Pharmacometrics-based dose selection of levofloxacin as a treatment for postexposure inhalational anthrax in children. ( Chien, S; Li, F; Nandy, P; Noel, GJ; Tornoe, CW, 2010) |
| "Leprosy affects skin and peripheral nerves, and acute inflammatory type 1 reactions (reversal reaction) can cause neurologic impairment and disabilities." | 5.34 | Mycobacterium leprae DNA associated with type 1 reactions in single lesion paucibacillary leprosy treated with single dose rifampin, ofloxacin, and minocycline. ( Costa, MB; Gillis, TP; Gomes, MK; Krahenbuhl, JL; Martelli, CM; Narahashi, K; Pereira, GA; Rebello, PF; Sousa, AL; Stefani, MM, 2007) |
| "In this study, 20 men suffering from acute nongonococcal epididymitis were treated with ofloxacin 200mg bid given orally for 2 weeks." | 3.67 | Acute nongonococcal epididymitis. Aetiological and therapeutic aspects. ( Garbe, C; Schiefer, HG; Weidner, W, 1987) |
| "Levofloxacin was recently (May 2008) approved by the U." | 2.75 | Pharmacometrics-based dose selection of levofloxacin as a treatment for postexposure inhalational anthrax in children. ( Chien, S; Li, F; Nandy, P; Noel, GJ; Tornoe, CW, 2010) |
| " The apparent differences in the calculated pharmacokinetic parameters for levofloxacin between the age groups (young versus elderly) and between the gender groups (males versus females) could be explained by differences in renal function among the subjects." | 2.68 | Absence of age and gender effects on the pharmacokinetics of a single 500-milligram oral dose of levofloxacin in healthy subjects. ( Chien, SC; Chow, AT; Natarajan, J; Nayak, RK; Rogge, MC; Williams, RR; Wong, FA, 1997) |
| "Levofloxacin has a tolerability profile similar to that of other oral fluoroquinolones, with gastrointestinal and central nervous system effects reported most commonly." | 2.39 | Levofloxacin. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy. ( Bryson, HM; Davis, R, 1994) |
| "Leprosy affects skin and peripheral nerves, and acute inflammatory type 1 reactions (reversal reaction) can cause neurologic impairment and disabilities." | 1.34 | Mycobacterium leprae DNA associated with type 1 reactions in single lesion paucibacillary leprosy treated with single dose rifampin, ofloxacin, and minocycline. ( Costa, MB; Gillis, TP; Gomes, MK; Krahenbuhl, JL; Martelli, CM; Narahashi, K; Pereira, GA; Rebello, PF; Sousa, AL; Stefani, MM, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, FT | 1 |
| Ding, Y | 1 |
| Shah, Z | 1 |
| Xing, D | 1 |
| Gao, Y | 1 |
| Liu, DM | 1 |
| Ding, MX | 1 |
| Koyanagi, T | 1 |
| Yamaura, Y | 1 |
| Yano, K | 1 |
| Kim, S | 1 |
| Yamazaki, H | 1 |
| Li, F | 1 |
| Nandy, P | 1 |
| Chien, S | 1 |
| Noel, GJ | 1 |
| Tornoe, CW | 1 |
| Sousa, AL | 1 |
| Stefani, MM | 1 |
| Pereira, GA | 1 |
| Costa, MB | 1 |
| Rebello, PF | 1 |
| Gomes, MK | 1 |
| Narahashi, K | 1 |
| Gillis, TP | 1 |
| Krahenbuhl, JL | 1 |
| Martelli, CM | 1 |
| Davis, R | 1 |
| Bryson, HM | 1 |
| Iakovlev, VP | 1 |
| Chien, SC | 1 |
| Chow, AT | 1 |
| Natarajan, J | 1 |
| Williams, RR | 1 |
| Wong, FA | 1 |
| Rogge, MC | 1 |
| Nayak, RK | 1 |
| Shakibaei, M | 1 |
| Pfister, K | 1 |
| Schwabe, R | 1 |
| Vormann, J | 1 |
| Stahlmann, R | 1 |
| Takagi, K | 1 |
| Hasegawa, T | 1 |
| Yamaki, K | 1 |
| Suzuki, K | 1 |
| Nabeshima, T | 1 |
| Weidner, W | 1 |
| Schiefer, HG | 1 |
| Garbe, C | 1 |
2 reviews available for ofloxacin and Aging
| Article | Year |
|---|---|
Levofloxacin. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy.
Topics: Administration, Oral; Aging; Bacteria; Bacterial Infections; Biological Availability; Drug Interacti | 1994 |
[Pharmacokinetic properties of ofloxacin (review of the literature].
Topics: Aging; Anti-Infective Agents; Body Fluids; Drug Interactions; Humans; Intestinal Absorption; Metabol | 1996 |
2 trials available for ofloxacin and Aging
| Article | Year |
|---|---|
Pharmacometrics-based dose selection of levofloxacin as a treatment for postexposure inhalational anthrax in children.
Topics: Adolescent; Aging; Anthrax; Anti-Bacterial Agents; Area Under Curve; Biological Availability; Body W | 2010 |
Absence of age and gender effects on the pharmacokinetics of a single 500-milligram oral dose of levofloxacin in healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anti-Infective Agents; Fema | 1997 |
6 other studies available for ofloxacin and Aging
| Article | Year |
|---|---|
TNF/TNFR₁ pathway and endoplasmic reticulum stress are involved in ofloxacin-induced apoptosis of juvenile canine chondrocytes.
Topics: Aging; Animals; Anti-Bacterial Agents; Apoptosis; Caspase 12; Cells, Cultured; Chondrocytes; Dogs; D | 2014 |
Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs.
Topics: Acetaminophen; Age Factors; Aging; Albumins; Animals; Antipyrine; Blood Proteins; Diazepam; Diphenhy | 2014 |
Mycobacterium leprae DNA associated with type 1 reactions in single lesion paucibacillary leprosy treated with single dose rifampin, ofloxacin, and minocycline.
Topics: Adolescent; Adult; Aging; Cohort Studies; DNA, Bacterial; Erythema Nodosum; Female; Humans; Leprosy; | 2007 |
Ultrastructure of Achilles tendons of rats treated with ofloxacin and fed a normal or magnesium-deficient diet.
Topics: Achilles Tendon; Aging; Animals; Anti-Infective Agents; Diet; Magnesium Deficiency; Ofloxacin; Rats; | 2000 |
Secretion of ofloxacin into saliva in patients with respiratory tract infection.
Topics: Administration, Oral; Aged; Aging; Female; Humans; Male; Middle Aged; Ofloxacin; Respiratory Tract I | 1992 |
Acute nongonococcal epididymitis. Aetiological and therapeutic aspects.
Topics: Acute Disease; Adolescent; Adult; Aging; Anti-Infective Agents; Epididymitis; Humans; Male; Middle A | 1987 |