ofloxacin has been researched along with Abnormalities, Autosome in 8 studies
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.
ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levofloxacin n-oxide is an impurity isolated from levofloxacin." | 1.38 | In silico and in vitro genotoxicity evaluation of levofloxacin n-oxide, an impurity in levofloxacin. ( Guo, M; Li, J; Li, T; Wang, W; Zhang, X; Zhu, Q, 2012) |
| "OFX did not induce any significant chromosomal aberrations in human lymphocytes." | 1.36 | A comparative analysis of chromosomal aberrations in cultured human lymphocytes due to fluoroquinolone drugs at different expression periods. ( Anupama, M; Murthy, PB; Seiler, JP, 2010) |
| " Animals were killed on Days 2, 3, 4, 5 or 8 (the dosing day was designated as Day 1), and the incidence of micronucleus in the epidermis was determined." | 1.31 | In vivo photochemical micronucleus induction due to certain quinolone antimicrobial agents in the skin of hairless mice. ( Furuhama, K; Itoh, S; Katoh, M, 2002) |
| "The failure of OFLX to induce chromosome aberrations was seen even in the presence of exogenous metabolic activation using a 5% rat liver post-mitochondrial supernatant mixture." | 1.31 | Cytological and cytogenetic effects of the fluoroquinolone ofloxacin on human periodontal ligament fibroblasts. ( Someya, T; Tamura, Y; Tsutsui, T, 2000) |
| "Ofloxacin did not cause any point mutations, nor did it induce any in vivo or in vitro chromosome mutation in the systems tested." | 1.27 | [No indications for the mutagenicity of ofloxacin]. ( Bruch, K; Mayer, D, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anupama, M | 1 |
| Seiler, JP | 1 |
| Murthy, PB | 1 |
| Zhu, Q | 1 |
| Li, T | 1 |
| Li, J | 1 |
| Guo, M | 1 |
| Wang, W | 1 |
| Zhang, X | 1 |
| Itoh, S | 2 |
| Katoh, M | 1 |
| Furuhama, K | 1 |
| Takahashi, N | 1 |
| Shiragiku, T | 1 |
| Itoh, T | 1 |
| Kaneko, E | 1 |
| Shibahara, T | 1 |
| Kanbe, T | 1 |
| Yamashita, S | 1 |
| Someya, T | 1 |
| Tamura, Y | 1 |
| Tsutsui, T | 1 |
| Shimada, H | 1 |
| Hattori, C | 1 |
| Tada, S | 1 |
| Matsuura, Y | 1 |
| Mitelman, F | 1 |
| Kolnig, AM | 1 |
| Strömbeck, B | 1 |
| Norrby, R | 1 |
| Kromann-Andersen, B | 1 |
| Sommer, P | 1 |
| Wadstein, J | 1 |
| Mayer, D | 1 |
| Bruch, K | 1 |
1 trial available for ofloxacin and Abnormalities, Autosome
| Article | Year |
|---|---|
No cytogenetic effects of quinolone treatment in humans.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Chromosome Aberrations; Ciprofloxacin; Female | 1988 |
7 other studies available for ofloxacin and Abnormalities, Autosome
| Article | Year |
|---|---|
A comparative analysis of chromosomal aberrations in cultured human lymphocytes due to fluoroquinolone drugs at different expression periods.
Topics: Anti-Infective Agents; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Ciprofloxacin; DNA Repli | 2010 |
In silico and in vitro genotoxicity evaluation of levofloxacin n-oxide, an impurity in levofloxacin.
Topics: Animals; Cell Line, Tumor; Chi-Square Distribution; Chromosome Aberrations; Computer Simulation; Cri | 2012 |
In vivo photochemical micronucleus induction due to certain quinolone antimicrobial agents in the skin of hairless mice.
Topics: Animals; Anti-Infective Agents; Chromosome Aberrations; Dose-Response Relationship, Drug; Fluoroquin | 2002 |
In vitro clastogenicity of optical isomers of nadifloxacin.
Topics: Animals; Anti-Infective Agents; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Fluoroqui | 1994 |
Cytological and cytogenetic effects of the fluoroquinolone ofloxacin on human periodontal ligament fibroblasts.
Topics: Alkaline Phosphatase; Anti-Infective Agents; Cell Division; Cell Survival; Chromosome Aberrations; C | 2000 |
Mutagenicity of the new quinolone antibacterial agent levofloxacin.
Topics: Animals; Anti-Infective Agents; Body Weight; Cell Line; Cell Survival; CHO Cells; Chromosome Aberrat | 1992 |
[No indications for the mutagenicity of ofloxacin].
Topics: Animals; Anti-Infective Agents; Cell Line; Chromosome Aberrations; Cricetinae; DNA Repair; Female; H | 1986 |