octopamine has been researched along with Hepatic Encephalopathy in 39 studies
Octopamine: An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.
octopamine : A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a group of 30 patients with and without hepatic encephalopathy octopamine values were determined and EEG recorded." | 7.66 | Hepatic encephalopathy EEG and octopamine. ( Bucci, L; Chiaverelli, R, 1980) |
| "It has been recently proposed that hepatic encephalopathy could be due to the accumulation of octopamine acting as a false neurotransmitter, and the increase of ammonia might reflect this accumulation." | 7.65 | Octopamine and ammonia plasma levels in hepatic encephalopathy. ( Angelico, M; Attili, AF; Cangiano, C; Capocaccia, L; Cascino, A; Rossi Fanelli, F, 1977) |
| "Octopamine data were obtained either by direct extraction with 40% isoamyl alcohol in toluene according to Molinoff et al." | 5.26 | Influence of phenylethanolamine on octopamine plasma determination in hepatic encephalopathy. ( Calcaterra, V; Cangiano, C; Capocaccia, L; Cardelli, P; Cascino, A; Rossi Fanelli, F, 1979) |
| " Plasma concentrations of amino acids, octopamine, and ammonia were assayed in order to document the metabolic change of hepatic encephalopathy." | 3.67 | Visual evoked potential: a diagnostic tool for the assessment of hepatic encephalopathy. ( Gollini, G; Messori, E; Penne, A; Pinelli, G; Ventura, E; Zani, G; Zeneroli, ML, 1984) |
| "In fourteen subjects with various stages of hepatic encephalopathy (HE), Visual Evoked Potential (VEP) recording and blood ammonia (NH3), octopamine (OCT) and phenylethanolamine (PEA) determinations were performed before and during a four-day treatment with branched chain amino acid (BCAA) i." | 3.67 | Visual evoked potential recordings in hepatic encephalopathy and their variations during branched chain amino-acid treatment. ( Bernardi, L; Bombardieri, G; Ferri, R; Gigli, GL; Grassi, C; Milani, A, 1985) |
| "In a group of 30 patients with and without hepatic encephalopathy octopamine values were determined and EEG recorded." | 3.66 | Hepatic encephalopathy EEG and octopamine. ( Bucci, L; Chiaverelli, R, 1980) |
| "Hepatic encephalopathy (HE) is currently felt to be secondary to a disturbance in the metabolism of cerebral catecholamines with a decline in dopamine and noradrenaline and a rise in the false neurotransmitter octopamine." | 3.66 | Changes in brain catecholamine levels in human cirrhotic hepatic encephalopathy. ( Cadilhac, J; Cuilleret, G; Michel, H; Pomier-Layrargues, G; Pons, F, 1980) |
| "It has been recently proposed that hepatic encephalopathy could be due to the accumulation of octopamine acting as a false neurotransmitter, and the increase of ammonia might reflect this accumulation." | 3.65 | Octopamine and ammonia plasma levels in hepatic encephalopathy. ( Angelico, M; Attili, AF; Cangiano, C; Capocaccia, L; Cascino, A; Rossi Fanelli, F, 1977) |
| " The potential development of hepatic encephalopathy was evaluated by serial determinations of serum ammonia and the biogenic amine, octopamine, which correlated well with the patient's clinical state." | 3.65 | Serum polyamine and octopamine changes following partial hepatectomy and portacaval shunt. ( Garnica, AD; Monson, RC; Rodgers, BM; Talbert, JL, 1977) |
| "To evaluate the role of tyramine in hepatic disorders, we used a radioimmunoassay to study plasma concentration of tyramine in eight healthy subjects, 20 hospitalized patients without liver disease, and 13 cirrhotic patients of whom seven had hepatic encephalopathy." | 3.65 | Hypertyraminemia in cirrhotic patients. ( Bowen, PA; Faraj, BA; Isaacs, JW; Rudman, D, 1976) |
| "When octopamine was added at the same concentrations as in serum of HE patients, the blood platelets from five controls showed a decrease in dopamine uptake proportional to the concentration of octopamine added." | 1.26 | Dopamine uptake by platelets in hepatic encephalopathy; evidence for a possible depletion of brain dopamine. ( Camardella, G; Floridi, A; Morelli, A; Narducci, F; Nenci, GG; Pelli, MA, 1977) |
| "Octopamine data were obtained either by direct extraction with 40% isoamyl alcohol in toluene according to Molinoff et al." | 1.26 | Influence of phenylethanolamine on octopamine plasma determination in hepatic encephalopathy. ( Calcaterra, V; Cangiano, C; Capocaccia, L; Cardelli, P; Cascino, A; Rossi Fanelli, F, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (94.87) | 18.7374 |
| 1990's | 2 (5.13) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bozzi, A | 1 |
| Cardelli-Cangiano, P | 2 |
| Strom, R | 2 |
| Riggio, O | 1 |
| Rossi Fanelli, F | 3 |
| Cangiano, C | 5 |
| Gentile, S | 1 |
| Capocaccia, L | 5 |
| Denis, J | 1 |
| Delorme, ML | 3 |
| Boschat, M | 3 |
| Nordlinger, B | 1 |
| Opolon, P | 3 |
| Baraldi, M | 2 |
| Zeneroli, ML | 3 |
| Ricci, P | 1 |
| Caselgrandi, E | 1 |
| Ventura, E | 3 |
| Pinelli, G | 1 |
| Gollini, G | 1 |
| Penne, A | 1 |
| Messori, E | 1 |
| Zani, G | 1 |
| Loda, M | 1 |
| Clowes, GH | 1 |
| Nespoli, A | 2 |
| Bigatello, L | 1 |
| Birkett, DH | 1 |
| Menzoian, JO | 1 |
| Bucci, L | 1 |
| Chiaverelli, R | 1 |
| Cuilleret, G | 1 |
| Pomier-Layrargues, G | 1 |
| Pons, F | 1 |
| Cadilhac, J | 1 |
| Michel, H | 1 |
| Bevilacqua, G | 1 |
| Staudacher, C | 1 |
| Rossi, N | 1 |
| Salerno, F | 1 |
| Castelli, MR | 1 |
| Hörtnagl, H | 1 |
| Lochs, H | 1 |
| Kleinberger, G | 1 |
| Hackl, JM | 1 |
| Hammerle, AF | 1 |
| Binder, H | 1 |
| Wewalka, F | 1 |
| Farber, MO | 1 |
| Rossi-Fanelli, F | 2 |
| Cascino, A | 4 |
| Cockerill, EM | 1 |
| Manfredi, F | 1 |
| Prill, A | 1 |
| Holm, E | 1 |
| Striebel, JP | 1 |
| Münzenmaier, R | 1 |
| Kattermann, R | 1 |
| Bloch, P | 1 |
| Rapin, JR | 2 |
| Granger, A | 2 |
| Manghani, KK | 1 |
| Lunzer, MR | 1 |
| Billing, BH | 1 |
| Sherlock, S | 1 |
| Schönborn, H | 1 |
| Schölmerich, P | 1 |
| Attili, AF | 1 |
| Angelico, M | 2 |
| Trewby, PN | 1 |
| Chase, RA | 1 |
| Davis, M | 1 |
| Williams, R | 1 |
| Morelli, A | 2 |
| Frintzilas, M | 1 |
| Zimmon, DS | 1 |
| Teitelbaum, H | 1 |
| Hevia, JE | 1 |
| Monson, RC | 1 |
| Rodgers, BM | 1 |
| Garnica, AD | 1 |
| Talbert, JL | 1 |
| Narducci, F | 1 |
| Camardella, G | 1 |
| Pelli, MA | 1 |
| Floridi, A | 1 |
| Nenci, GG | 1 |
| Zieve, L | 1 |
| Olsen, RL | 1 |
| Calcaterra, V | 1 |
| Cardelli, P | 1 |
| Chamuleau, RA | 1 |
| Schoemaker, LP | 1 |
| Smit, EM | 1 |
| Attili, A | 1 |
| Crifó, C | 1 |
| Faraj, BA | 1 |
| Bowen, PA | 1 |
| Isaacs, JW | 1 |
| Rudman, D | 1 |
| Huguet, C | 1 |
| Sausse, A | 1 |
| Fischer, JE | 5 |
| Rosen, HM | 1 |
| Ebeid, AM | 1 |
| James, JH | 5 |
| Keane, JM | 1 |
| Soeters, PB | 1 |
| Vezzelli, C | 1 |
| Tofanetti, O | 1 |
| Germini, M | 1 |
| Casciarri, I | 1 |
| Yonekura, T | 1 |
| Kamata, S | 1 |
| Wasa, M | 1 |
| Okada, A | 1 |
| Kawata, S | 1 |
| Tarui, S | 1 |
| Bombardieri, G | 1 |
| Gigli, GL | 1 |
| Bernardi, L | 1 |
| Ferri, R | 1 |
| Grassi, C | 1 |
| Milani, A | 1 |
| Hilgier, W | 1 |
| Zitting, A | 1 |
| Albrecht, J | 1 |
| Lam, KC | 1 |
| Tall, AR | 1 |
| Goldstein, GB | 1 |
| Mistilis, SP | 1 |
| Dodsworth, JM | 1 |
| Cummings, MC | 1 |
| Fischer, JF | 1 |
| Baldessarini, R | 1 |
| Keane, J | 1 |
| Shuman, L | 1 |
| Dodsworth, J | 1 |
| Funovics, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intravenous Branched-chain Amino Acids for Overt Hepatic Encephalopathy in Patients With Acute on Chronic Liver Failure - A Multi-centric Double-blind Randomized Controlled Trial[NCT05700695] | Phase 1 | 246 participants (Anticipated) | Interventional | 2023-01-17 | Recruiting | ||
| Efficacy of Lactulose Plus Intravenous Branched Chain Amino Acids Versus Lactulose Alone in Patients of Acute on Chronic Liver Failure With Overt Hepatic Encephalopathy: A Prospective Randomized Clinical Trial[NCT04238416] | Phase 1 | 70 participants (Actual) | Interventional | 2019-11-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for octopamine and Hepatic Encephalopathy
| Article | Year |
|---|---|
[Hepatic coma and insufficiency].
Topics: Ammonia; Brain; Electrocardiography; Fatty Acids; Hepatic Encephalopathy; Hepatitis; Humans; Liver; | 1977 |
38 other studies available for octopamine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Biochemical monitoring of encephalopathy in liver failure.
Topics: Acute Kidney Injury; Amino Acids; Hepatic Encephalopathy; Humans; Liver; Octopamine; Toxins, Biologi | 1980 |
Simultaneous radioenzymatic determination of phenylethylamine, phenylethanolamine, tyramine and octopamine in plasma of patients with hepatic encephalopathy.
Topics: Ethanolamines; Hepatic Encephalopathy; Humans; Neurotransmitter Agents; Octopamine; Phenethylamines; | 1981 |
Respective roles of ammonia, amino acids, and medium-sized molecules in the pathogenesis of experimentally induced acute hepatic encephalopathy.
Topics: Amino Acids; Ammonia; Animals; Brain; Cerebral Cortex; Dopamine; Hepatic Encephalopathy; Ischemia; L | 1983 |
Down regulation of striatal dopamine receptors in experimental hepatic encephalopathy.
Topics: Amino Acids; Animals; Catecholamines; Corpus Striatum; Hepatic Encephalopathy; Male; Octopamine; Rat | 1983 |
Visual evoked potential: a diagnostic tool for the assessment of hepatic encephalopathy.
Topics: Adult; Amino Acids, Essential; Ammonia; Electroencephalography; Evoked Potentials, Visual; Female; H | 1984 |
Encephalopathy, oxygen consumption, visceral amino acid clearance, and mortality in cirrhotic surgical patients.
Topics: Adult; Aged; Amino Acids; Amino Acids, Branched-Chain; Ammonia; Female; Hemodynamics; Hepatic Enceph | 1984 |
Hepatic encephalopathy EEG and octopamine.
Topics: Adult; Electroencephalography; Female; Hepatic Encephalopathy; Humans; Male; Middle Aged; Octopamine | 1980 |
Changes in brain catecholamine levels in human cirrhotic hepatic encephalopathy.
Topics: Brain; Dopamine; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Norepinephrine; Octopamine | 1980 |
Pathogenesis of hepatic encephalopathy and hyperdynamic syndrome in cirrhosis. Role of false neurotransmitters.
Topics: Adolescent; Adult; Aged; Amino Acids; Cardiac Output; Female; Hemodynamics; Hepatic Encephalopathy; | 1981 |
Plasma catecholamines in hepatic coma and liver cirrhosis: role of octopamine.
Topics: Adolescent; Adult; Aged; Blood Pressure; Child; Epinephrine; Female; Hepatic Encephalopathy; Hepatit | 1981 |
Plasma levels of false neurotransmitters across the brain in portal-systemic encephalopathy.
Topics: 2-Hydroxyphenethylamine; Amino Acids; Amino Acids, Branched-Chain; Ammonia; Brain Chemistry; Glutami | 1982 |
[Porto-systemic encephalopathy].
Topics: Biogenic Amines; Hepatic Encephalopathy; Humans; Hypertension, Portal; Liver Circulation; Neurotrans | 1976 |
[Pathogenesis of hepatic encephalopathy (author's transl)].
Topics: Alkalosis; Amino Acids; Ammonia; Anemia; Animals; Brain; Brain Edema; Carbon Dioxide; Catecholamines | 1977 |
Reversible modifications of neurotransmitters of the brain in experimental acute hepatic coma.
Topics: Acrylic Resins; Acrylonitrile; Acute Disease; Amino Acids; Ammonia; Animals; Brain; Cellulose; Coppe | 1978 |
Urinary and serum octopamine in patients with portal-systemic encephalopathy.
Topics: Adolescent; Adult; Aged; Circadian Rhythm; Female; Hepatic Encephalopathy; Humans; Liver Diseases; M | 1975 |
[Principles of infusion therapy with amino acids].
Topics: Amino Acids; Energy Intake; Glucose; Hepatic Encephalopathy; Humans; Kidney Diseases; Liver Diseases | 1979 |
Octopamine and ammonia plasma levels in hepatic encephalopathy.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Octopamine | 1977 |
The role of the false neurotransmitter octopamine in the hypotension of fulminant hepatic failure.
Topics: Cardiac Output; Heart; Hepatic Encephalopathy; Humans; Hypotension; Norepinephrine; Octopamine; Pres | 1977 |
Platelet uptake of octopamine and norepinephrine in hepatic encephalopathy.
Topics: Amines; Blood Platelets; Depression, Chemical; Hepatic Encephalopathy; Humans; Models, Biological; N | 1977 |
Serum polyamine and octopamine changes following partial hepatectomy and portacaval shunt.
Topics: Ammonia; Child, Preschool; Hepatectomy; Hepatic Duct, Common; Hepatic Encephalopathy; Humans; Liver; | 1977 |
Dopamine uptake by platelets in hepatic encephalopathy; evidence for a possible depletion of brain dopamine.
Topics: Adult; Aged; Blood Platelets; Brain; Dopamine; Female; Hepatic Encephalopathy; Humans; Male; Middle | 1977 |
Can hepatic coma be caused by a reduction of brain noradrenaline or dopamine?
Topics: Animals; Brain Chemistry; Dopamine; Hepatic Encephalopathy; Male; Norepinephrine; Octopamine; Pargyl | 1977 |
Influence of phenylethanolamine on octopamine plasma determination in hepatic encephalopathy.
Topics: 2-Hydroxyphenethylamine; Hepatic Encephalopathy; Humans; Octopamine; Phenethylamines | 1979 |
In vitro adsorption of possible aetiological factors of hepatic encephalopathy.
Topics: Absorption; Amino Acids; Ammonium Chloride; Artificial Organs; Bile Acids and Salts; Charcoal; Fatty | 1979 |
Octopamine plasma levels and hepatic encephalopathy: a re-appraisal of the problem.
Topics: Adult; Hepatic Encephalopathy; Humans; Kinetics; Liver Cirrhosis; Methyltransferases; Octopamine | 1976 |
Hypertyraminemia in cirrhotic patients.
Topics: Adult; Aged; Ammonia; Blood Pressure; Brain; Dietary Proteins; Hepatic Encephalopathy; Humans; Liver | 1976 |
Hepatic failure coma (HFC) treated by polyacrylonitrile membrane (PAN) hemodialysis (HD).
Topics: Acrylic Resins; Adolescent; Adult; Aged; Animals; Cerebral Cortex; Dopamine; Female; Hepatic Encepha | 1976 |
The effect of normalization of plasma amino acids on hepatic encephalopathy in man.
Topics: Adult; Aged; Albumins; Amino Acids; Ammonia; Body Weight; Electroencephalography; Female; Glucose; H | 1976 |
The effect of normalization of plasma amino acids on hepatic encephalopathy in man.
Topics: Adult; Aged; Albumins; Amino Acids; Ammonia; Body Weight; Electroencephalography; Female; Glucose; H | 1976 |
The effect of normalization of plasma amino acids on hepatic encephalopathy in man.
Topics: Adult; Aged; Albumins; Amino Acids; Ammonia; Body Weight; Electroencephalography; Female; Glucose; H | 1976 |
The effect of normalization of plasma amino acids on hepatic encephalopathy in man.
Topics: Adult; Aged; Albumins; Amino Acids; Ammonia; Body Weight; Electroencephalography; Female; Glucose; H | 1976 |
Alterations of GABA-A and dopamine D-2 brain receptors in dogs with portal-systemic encephalopathy.
Topics: Animals; Brain; Diazepam; Dimethylnitrosamine; Disease Models, Animal; Dogs; Dopamine; Glutamate Dec | 1991 |
Simultaneous analysis of plasma phenethylamine, phenylethanolamine, tyramine and octopamine in patients with hepatic encephalopathy.
Topics: 2-Hydroxyphenethylamine; Chromatography, High Pressure Liquid; Hepatic Encephalopathy; Humans; Liver | 1991 |
Visual evoked potential recordings in hepatic encephalopathy and their variations during branched chain amino-acid treatment.
Topics: Adult; Aged; Amino Acids, Branched-Chain; Ammonia; Ethanolamines; Evoked Potentials, Visual; Female; | 1985 |
The brain octopamine and phenylethanolamine content in rats in thioacetamide-induced hepatogenic encephalopathy.
Topics: 2-Hydroxyphenethylamine; Acetamides; Animals; Brain; Female; Hepatic Encephalopathy; Octopamine; Phe | 1985 |
Treatment of hepatic coma and hepatorenal syndrome. Mechanism of action of L-dopa and aramine.
Topics: Adult; Brain Chemistry; Carbon Isotopes; Cardiac Output; Dihydroxyphenylalanine; Female; Hepatic Enc | 1972 |
Role of a false neurotransmitter, octopamine, in the pathogenesis of hepatic and renal encephalopathy.
Topics: Blood Urea Nitrogen; Coma; Glomerular Filtration Rate; Hepatic Encephalopathy; Humans; Kidney Diseas | 1973 |
Depletion of brain norepinephrine in acute hepatic coma.
Topics: Acute Disease; Animals; Brain; Female; Hepatic Artery; Hepatic Encephalopathy; Ligation; Myocardium; | 1974 |
Changes in brain amines following portal flow diversion and acute hepatic coma: effects of levodopa (L-dopa) and intestinal sterilization.
Topics: Animals; Brain; Dihydroxyphenylalanine; Hepatic Encephalopathy; Intestines; Kanamycin; Octopamine; P | 1972 |
False neurotransmitters and hepatic coma.
Topics: Amines; Animals; Brain; Dihydroxyphenylalanine; Female; Hepatic Encephalopathy; Humans; Intestinal M | 1974 |
An alternative mechanism for beneficial effects of intestinal sterilization in hepatic encephalopathy.
Topics: Animals; Brain Chemistry; Female; Hepatic Encephalopathy; Kanamycin; Norepinephrine; Octopamine; Phe | 1974 |