octanoic acid has been researched along with Parkinson Disease in 7 studies
octanoic acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #1764
octanoic acid : A straight-chain saturated fatty acid that is heptane in which one of the hydrogens of a terminal methyl group has been replaced by a carboxy group. Octanoic acid is also known as caprylic acid.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rotenone is used to generate Parkinson's disease (PD)-like symptoms in experimental animals." | 1.72 | Amelioration of rotenone-induced alterations in energy/redox system, stress response and cytoskeleton proteins by octanoic acid in zebrafish: A proteomic study. ( Alturfan, AA; Büyükkayhan, D; Cansız, D; Emekli-Alturfan, E; Sürmen, MG; Sürmen, S; Ünal, İ; Üstündağ, ÜV, 2022) |
| "Rotenone is a neurotoxin that is used to induce experimental PD model." | 1.62 | Quantitative phosphoproteomics to resolve the cellular responses to octanoic acid in rotenone exposed zebrafish. ( Alturfan, AA; Cansız, D; Emekli-Alturfan, E; Sürmen, MG; Sürmen, S; Ünal, İ; Üstündağ, ÜV, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 3 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Sürmen, MG | 2 |
| Sürmen, S | 2 |
| Cansız, D | 3 |
| Ünal, İ | 3 |
| Üstündağ, ÜV | 3 |
| Alturfan, AA | 3 |
| Emekli-Alturfan, E | 3 |
| Büyükkayhan, D | 1 |
| Altinoz, MA | 1 |
| Elmacı, İ | 1 |
| Joniec-Maciejak, I | 1 |
| Wawer, A | 1 |
| Turzyńska, D | 1 |
| Sobolewska, A | 1 |
| Maciejak, P | 1 |
| Szyndler, J | 1 |
| Mirowska-Guzel, D | 1 |
| Płaźnik, A | 1 |
| Epprecht, L | 1 |
| Schreglmann, SR | 1 |
| Goetze, O | 2 |
| Woitalla, D | 2 |
| Baumann, CR | 1 |
| Waldvogel, D | 1 |
| Müller, T | 1 |
| Erdmann, C | 1 |
| Unger, MM | 1 |
| Möller, JC | 1 |
| Mankel, K | 1 |
| Schmittinger, K | 1 |
| Eggert, KM | 1 |
| Stamelou, M | 1 |
| Stiasny-Kolster, K | 1 |
| Bohne, K | 1 |
| Bodden, M | 1 |
| Mayer, G | 1 |
| Oertel, WH | 1 |
| Tebbe, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Orthostatic Dysregulation and Associated Gastrointestinal Dysfunction in Parkinson's Disease - Evolution A Monocentric Study to Investigate the Development of Symptoms of Autonomic Dysregulation in Parkinson's Disease[NCT01518751] | 27 participants (Actual) | Observational | 2011-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for octanoic acid and Parkinson Disease
| Article | Year |
|---|---|
Unchanged gastric emptying and visceral perception in early Parkinson's disease after a high caloric test meal.
Topics: Adult; Aged; Appetite; Benserazide; Breath Tests; Caprylates; Dopamine Agents; Drug Combinations; Ga | 2015 |
Entacapone improves absorption of a coadministered salt in patients with Parkinson's disease.
Topics: Adult; Aged; Antiparkinson Agents; Breath Tests; Caprylates; Carbidopa; Carbon Isotopes; Catechol O- | 2008 |
Patients with idiopathic rapid-eye-movement sleep behavior disorder show normal gastric motility assessed by the 13C-octanoate breath test.
Topics: Adult; Aged; Breath Tests; Caprylates; Carbon Isotopes; Enteric Nervous System; Female; Gastric Empt | 2011 |
4 other studies available for octanoic acid and Parkinson Disease
| Article | Year |
|---|---|
Quantitative phosphoproteomics to resolve the cellular responses to octanoic acid in rotenone exposed zebrafish.
Topics: Animals; Caprylates; Parkinson Disease; Rotenone; Zebrafish | 2021 |
Amelioration of rotenone-induced alterations in energy/redox system, stress response and cytoskeleton proteins by octanoic acid in zebrafish: A proteomic study.
Topics: Animals; Caprylates; Chromatography, Liquid; Cytoskeletal Proteins; Cytoskeleton; Oxidation-Reductio | 2022 |
Caprylic acid ameliorates rotenone induced inflammation and oxidative stress in the gut-brain axis in Zebrafish.
Topics: Animals; Brain; Brain-Gut Axis; Caprylates; Disease Models, Animal; Gastrointestinal Tract; Glutathi | 2021 |
Octanoic acid prevents reduction of striatal dopamine in the MPTP mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Caprylates; C | 2018 |