octanoic acid has been researched along with Coma in 4 studies
octanoic acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #1764
octanoic acid : A straight-chain saturated fatty acid that is heptane in which one of the hydrogens of a terminal methyl group has been replaced by a carboxy group. Octanoic acid is also known as caprylic acid.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dose-response curves for the incidence of coma after intraperitoneal injections of various doses of valproic acid (VP) and octanoic acid (OA) showed that, mole for mole, valproic acid was less toxic than octanoic acid." | 7.67 | Valproic acid induction of coma in rats: synergism with NH4+ and pentobarbital. ( Lyftogt, C; Zieve, L, 1989) |
| "Dose-response curves for the incidence of coma after intraperitoneal injections of various doses of valproic acid (VP) and octanoic acid (OA) showed that, mole for mole, valproic acid was less toxic than octanoic acid." | 3.67 | Valproic acid induction of coma in rats: synergism with NH4+ and pentobarbital. ( Lyftogt, C; Zieve, L, 1989) |
| "The coma-inducing effect of phenol was studied in normal 300 +/- 50 gm Sprague-Dawley rats." | 3.66 | Encephalopathic effect of phenol in rats. ( Brunner, G; Lyftogt, C; Windus-Podehl, G; Zieve, L, 1983) |
| "05) with increasing MCT dosage through 9 mL of NE and 6 mL of emulsified MCT." | 1.29 | Utilization of medium-chain triglycerides by neonatal pigs: effects of emulsification and dose delivered. ( Lin, X; Odle, J; Wieland, TM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Windus-Podehl, G | 1 |
| Lyftogt, C | 2 |
| Zieve, L | 2 |
| Brunner, G | 1 |
| Wieland, TM | 1 |
| Lin, X | 1 |
| Odle, J | 1 |
| McCandless, DW | 1 |
4 other studies available for octanoic acid and Coma
| Article | Year |
|---|---|
Encephalopathic effect of phenol in rats.
Topics: Animals; Brain; Caprylates; Coma; Disulfides; Dose-Response Relationship, Drug; Drug Synergism; Male | 1983 |
Utilization of medium-chain triglycerides by neonatal pigs: effects of emulsification and dose delivered.
Topics: Animals; Animals, Newborn; Caprylates; Coma; Decanoates; Digestion; Dose-Response Relationship, Drug | 1993 |
Valproic acid induction of coma in rats: synergism with NH4+ and pentobarbital.
Topics: Ammonium Chloride; Animals; Anticonvulsants; Caprylates; Coma; Dose-Response Relationship, Drug; Dru | 1989 |
Octanoic acid-induced coma and reticular formation energy metabolism.
Topics: Adenosine Triphosphate; Animals; Caprylates; Coma; Energy Metabolism; Female; Glucose; Glycogen; Inf | 1985 |