octadecenedioic-acid and Melanosis

Melasma is a common pigmentation disorder having considerable effect on patients' emotional and psychological well-being.. Assessment of efficacy and tolerability of a new face care product for the targeted spot treatment of darker pigmented areas in subjects with melasma and evaluation of effects on patients' quality of life.. Twenty subjects with melasma were enrolled in this study. Data of 19 participants were available for analysis. Melasma severity was evaluated at baseline, after 4 weeks, and after 8 weeks by using the Melasma Area and Severity Index (MASI). Furthermore, chromametry and digital image analysis of videomicroscopic photographs were performed, and quality of life was measured using the Melasma Quality of Life Scale.. The application of the product resulted in a significant lightening of melasma in comparison with baseline and to untreated control areas. The MASI score dropped by more than 40% after 8 weeks. Measurement of skin color by chromametry revealed lightening of pigmented areas and a significant decrease in contrast between melasma and normal-pigmented surrounding skin. These results were confirmed by digital image analysis. Tolerability of the product was rated to be excellent, and patients experienced a significant gain in quality of life.. The data demonstrate that the new face care product is effective and highly skin tolerable and clearly improves quality of life of patients with melasma.

Topics: Adult; Analysis of Variance; Colorimetry; Dermatologic Agents; Dicarboxylic Acids; Drug Combinations; Facial Dermatoses; Female; Humans; Image Processing, Computer-Assisted; Male; Melanosis; Microscopy, Video; Middle Aged; Oleic Acids; Quality of Life; Severity of Illness Index; Skin; Statistics, Nonparametric; Sunscreening Agents; Tocopherols