ocotillol and Liver-Neoplasms

Aiming at seeking an effective anti-hepatocarcinoma drug with low toxicity, a total of 24 amino acid derivatives (20 new along with 4 known derivatives) of two active ocotillol-type sapogenins (pyxinol and ocotillol) were synthesized. Both in vitro and in vivo anti-hepatocarcinoma effects of derivatives were evaluated. At first, the HepG2 human cancer cell was employed to evaluate the anti-cancer activity. Most of the derivatives showed obvious enhanced activity compared with pyxinol or ocotillol. Among them, compound

Topics: Amino Acids; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Ginsenosides; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Structure-Activity Relationship; Xenograft Model Antitumor Assays