oc000459 has been researched along with Rhinitis--Allergic--Perennial* in 2 studies
1 review(s) available for oc000459 and Rhinitis--Allergic--Perennial
| Article | Year |
|---|---|
Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.
Topics: Acetates; Animals; Asthma; Aza Compounds; Carbazoles; Clinical Trials as Topic; Humans; Indoleacetic Acids; Pyrazoles; Pyrimidines; Pyrroles; Receptors, Immunologic; Receptors, Prostaglandin; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sulfonamides; Th2 Cells; Thiazoles | 2012 |
1 other study(ies) available for oc000459 and Rhinitis--Allergic--Perennial
| Article | Year |
|---|---|
Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis.
The synthesis of a series of tricyclic antagonists for the prostaglandin D(2) receptor DP2 (CRTH2) is disclosed. The activities of the compounds were evaluated in a human DP2 binding assay and a human whole blood eosinophil shape change assay. Potential metabolic liabilities of the compounds were addressed through in vitro CYP studies. The lead compound was demonstrated to have efficacy in a mouse model of allergic rhinitis following oral dosing. Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Cytochrome P-450 Enzyme System; Disease Models, Animal; Female; Heterocyclic Compounds, 3-Ring; Humans; Mice; Receptors, Immunologic; Receptors, Prostaglandin; Rhinitis, Allergic, Perennial | 2009 |