Compounds > obidoxime chloride
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obidoxime chloride and Organophosphorus Poisoning

obidoxime chloride has been researched along with Organophosphorus Poisoning in 69 studies

Research

Studies (69)

TimeframeStudies, this research(%)All Research%
pre-199019 (27.54)18.7374
1990's11 (15.94)18.2507
2000's19 (27.54)29.6817
2010's16 (23.19)24.3611
2020's4 (5.80)2.80

Authors

AuthorsStudies
Thiermann, H; Worek, F1
Horn, G; John, H; Kranawetvogl, T; Rauen, U; Weigel, C; Wille, T; Worek, F1
Amend, N; John, H; Koller, M; Kranawetvogl, T; Langgartner, J; Mögele-Schmid, C; Pflügler, C; Siegert, M; Thiermann, H; Wille, T; Worek, F1
Appu, AP; Arun, P; Braga, MF; Figueiredo, TH; Flagg, T; Krishnan, JKS; Moffett, JR; Namboodiri, AM; Puthillathu, N1
Antonijevic, B; Antonijevic, E; Djukic-Cosic, D; Kosvancova, A; Kotur-Stevuljevic, J; Kuca, K; Musilek, K; Spasojevic-Kalimanovska, V1
Bird, M; Green, AC; Kassa, J; Tattersall, JEH; Timperley, CM; Williams, RL1
Gorecki, L; Jun, D; Korabecny, J; Kuca, K; Kucera, T; Malinak, D; Musilek, K; Soukup, O1
Cohen, Y; Eisenkraft, A; Kadar, T; Kassirer, M; Milk, N; Rosman, Y; Shiyovich, A; Shrot, S; Tauber, M1
Appu, AP; Arun, P; Baskota, S; Braga, MFM; Dagata, J; Farkas, N; Figueiredo, TH; Frey, WH; Krishnan, JKS; Moffett, JR; Namboodiri, AMA; Olsen, CH; Vijayakumar, N1
Babin, MC; Jett, DA; Platoff, GE; Snider, TH; Yeung, DT1
Abouzaid, M; Bond, GR; El Guindi, M; El Seddawy, A; Gamaluddin, H; Pièche, S; Sakr, M; Sonicki, Z; Youssef, A1
Jung, YS; Karasova, J; Kassa, J; Kuca, K; Musilek, K1
Bajgar, J; Karasova, J; Kassa, J; Kuca, K; Musilek, K1
Abdalla, MS; Badawy, SM; El-Naggar, Ael-R; El-Sebaey, AS1
Bajgar, J; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Tesarova, S1
Aurbek, N; Eyer, F; Eyer, P; Thiermann, H; Worek, F1
Bajgar, J; Caisberger, F; Karasova, JZ; Kassa, J; Misik, J; Pavlikova, R1
Eyer, F; Eyer, P; Felgenhauer, N; Thiermann, H; Worek, F; Zilker, T1
Eyer, F; Eyer, P; Felgenhauer, N; Pfab, R; Thiermann, H; Worek, F; Zilker, T1
Fusek, J; Jun, D; Kuca, K; Kumar, UK; Soukup, O; Tobin, G1
Esparza-Ceseña, MJ; Prieto-Miranda, SE1
Largu, E; Lionte, C; Petriş, O; Sorodoc, L1
Sanaei-Zadeh, H1
Antonijević, B; Bokonjić, D; Stojiljković, MP; Vucinić, S1
Jung, YS; Karasova, JZ; Kassa, J; Kuca, K; Musilek, K; Tesarova, S1
Kassa, J; Krejèová, G1
Kassa, J; Krejcová, G1
Abdi, M; Abdollahi, M; Pajoumand, A; Rezaie, A; Shadnia, S1
Eyer, P; Szinicz, L; Thiermann, H; Worek, F; Zilker, T1
Graham, P; Moran, JL; Peter, JV1
Bartosová, L; Kuca, K; Kunesová, G1
Gralewicz, S1
Antonijevic, B; Stojiljkovic, MP1
Jun, D; Kassa, J; Kuca, K1
Karasova, J; Kassa, J; Kuca, K; Musilek, K1
Humlicek, V; Kassa, J1
Klehr, HU; Lewalter, T; Lüderitz, B; Nickenig, G; Rabe, C; Schrickel, JW1
Inns, RH; Leadbeater, L1
Dierkes-Tizek, U; Glaser, U; Hettwer, H; Oldiges, H1
Hopff, WH; Riggio, G; Waser, PG1
Hapke, HJ1
Gajewski, D; Grudzińska, E1
Lüllmann, H; Schmaus, H; Staemmler, C; Ziegler, A1
Kleine, A; Szinicz, L; Worek, F1
Besser, R; Gutmann, L; Weilemann, LS1
Kirchner, T; Szinicz, L; Worek, F1
Kassa, J1
Bajgar, J; Kassa, J1
Bäcker, M; Eyer, P; Klimmek, R; Mast, U; Szinicz, L; Thiermann, H; Worek, F1
Eyer, P; Felgenhauer, N; Hibler, A; Pfab, R; Thiermann, H; Worek, F; Zilker, T1
Fjaerli, HO; Jacobsen, D; Kowalczyk, M; Meidel, N; Rolfsjord, LB; Stromme, JH1
Brüner, H; Gandawidjaja, L; Hettwer, H; Oldiges, H1
Gidyńska, T; Grudzińska, E; Rump, S1
Edery, H; Simon, GA; Tirosh, MS1
Bajgar, J; Hrdina, V; Jakl, A; Patocka, J1
Clement, JG1
Busker, RW; de Lange, J; Melchers, BP; van Helden, HP1
Asthana, SN; Batra, BS; Chowdhri, BL; Das Gupta, S; Ghosh, AK1
Hänninen, O; Kaliste-Korhonen, E; Ryhänen, R; Ylitalo, P1
Lund, C; Monteagudo, FS1
Jepsen, K; Lüllmann, H; Mohr, K; Pfeffer, J1
Nishimura, M; Suyama, Y; Yamanaka, S1
Clement, JG; Shiloff, JD1
Clement, JG; Gennings, C; Shiloff, JD1
Kontek, M; Paradowski, S1
Hopmann, G; Wanke, H1
Benschop, HP; Berends, F; De Jong, LP; Kepner, LA; Kientz, CE; Meeter, E; Van den Berg, GR; Van Hooidonk, C; Visser, RP1
Cashman, JR; Kalisiak, J; Ralph, EC; Zhang, J1
Baati, R; Calas, AG; Coisne, C; Courageux, C; Da Silva, O; Dehouck, MP; Dias, J; Gastellier, AJ; Gosselet, F; Hanak, AS; Jean, L; Landry, C; Nachon, F; Probst, N; Renard, PY; Trancart, M; Warnault, P1

Reviews

4 review(s) available for obidoxime chloride and Organophosphorus Poisoning

ArticleYear
Oxime therapy and outcomes in human organophosphate poisoning: an evaluation using meta-analytic techniques.
    Critical care medicine, 2006, Volume: 34, Issue:2

    Topics: Adult; Cholinesterase Reactivators; Clinical Trials as Topic; Female; Humans; Insecticides; Male; Mortality; Obidoxime Chloride; Organophosphate Poisoning; Pralidoxime Compounds; Respiration, Artificial; Treatment Outcome

2006
[Possible consequences of acetylcholinesterase inhibition in organophosphate poisoning. Discussion continued].
    Medycyna pracy, 2006, Volume: 57, Issue:3

    Topics: Acetylcholinesterase; Central Nervous System Diseases; Cognition; Cognition Disorders; Humans; Insecticides; Obidoxime Chloride; Organophosphate Poisoning

2006
Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.
    Clinical medicine & research, 2007, Volume: 5, Issue:1

    Topics: Acetylcholinesterase; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Humans; Insecticides; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pralidoxime Compounds; Sarin; Trimedoxime

2007
[Prevention, diagnosis and treatment of poisoning with pesticides, derivatives of organophosphorus compounds and carbamates].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1974, Feb-25, Volume: 29, Issue:8

    Topics: Acetylcholinesterase; Anti-Bacterial Agents; Anticonvulsants; Autonomic Nervous System; Carbamates; Central Nervous System; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Humans; Muscles; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Pesticides; Poisoning; Time Factors

1974

Trials

2 trial(s) available for obidoxime chloride and Organophosphorus Poisoning

ArticleYear
A clinical decision aid for triage of children younger than 5 years and with organophosphate or carbamate insecticide exposure in developing countries.
    Annals of emergency medicine, 2008, Volume: 52, Issue:6

    Topics: Atropine; Carbamates; Child, Preschool; Cholinesterase Reactivators; Decision Making; Developing Countries; Egypt; Environmental Exposure; Female; Humans; Infant; Insecticides; Male; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Poison Control Centers; Poisoning; Prospective Studies; Triage

2008
Benefits of magnesium sulfate in the management of acute human poisoning by organophosphorus insecticides.
    Human & experimental toxicology, 2004, Volume: 23, Issue:12

    Topics: Adolescent; Adult; Aged; Atropine; Cholinesterase Reactivators; Drug Therapy, Combination; Female; Humans; Insecticides; Magnesium Sulfate; Male; Middle Aged; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Pralidoxime Compounds; Single-Blind Method

2004

Other Studies

63 other study(ies) available for obidoxime chloride and Organophosphorus Poisoning

ArticleYear
Pro: Oximes should be used routinely in organophosphate poisoning.
    British journal of clinical pharmacology, 2022, Volume: 88, Issue:12

    Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Obidoxime Chloride; Organophosphate Poisoning; Oximes

2022
Human HepaRG liver spheroids: cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitro.
    Chemico-biological interactions, 2023, Jan-05, Volume: 369

    Topics: Acetylcholinesterase; Antidotes; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Cholinesterase Reactivators; Humans; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pyridinium Compounds

2023
A case report of cholinesterase inhibitor poisoning: cholinesterase activities and analytical methods for diagnosis and clinical decision making.
    Archives of toxicology, 2020, Volume: 94, Issue:6

    Topics: Acetylcholinesterase; Aged, 80 and over; Antidotes; Atropine; Biomarkers; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Clinical Decision-Making; Clinical Enzyme Tests; Diagnosis, Differential; GPI-Linked Proteins; Humans; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Predictive Value of Tests; Suicide, Attempted; Treatment Outcome

2020
Brief isoflurane administration as a post-exposure treatment for organophosphate poisoning.
    Neurotoxicology, 2017, Volume: 63

    Topics: Amygdala; Anesthetics, Inhalation; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Follow-Up Studies; Hippocampus; Isoflurane; Male; Obidoxime Chloride; Organophosphate Poisoning; Paraoxon; Rats; Rats, Sprague-Dawley; Time Factors

2017
Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain.
    Archives of toxicology, 2018, Volume: 92, Issue:2

    Topics: Animals; Aryldialkylphosphatase; Biomarkers; Brain; Cholinesterase Inhibitors; Dichlorvos; Male; Malondialdehyde; Obidoxime Chloride; Organophosphate Poisoning; Oxidative Stress; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Superoxide Dismutase; Trimedoxime

2018
Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice.
    Toxicology, 2018, 09-01, Volume: 408

    Topics: Animals; Atropine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Time Factors

2018
Oxime K203: a drug candidate for the treatment of tabun intoxication.
    Archives of toxicology, 2019, Volume: 93, Issue:3

    Topics: Acetylcholinesterase; Antidotes; Molecular Docking Simulation; Nerve Agents; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Trimedoxime

2019
Early brain magnetic resonance imaging can predict short and long-term outcomes after organophosphate poisoning in a rat model.
    Neurotoxicology, 2015, Volume: 48

    Topics: Animals; Aspartic Acid; Atropine; Behavior, Animal; Brain; Brain Edema; Choline; Cholinesterase Reactivators; Cognition; Creatine; Disease Models, Animal; Drug Therapy, Combination; Early Diagnosis; Magnetic Resonance Imaging; Male; Maze Learning; Midazolam; Neuroprotective Agents; Obidoxime Chloride; Organophosphate Poisoning; Paraoxon; Predictive Value of Tests; Proton Magnetic Resonance Spectroscopy; Rats, Sprague-Dawley; Scopolamine; Time Factors; Weight Loss

2015
Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning.
    Neurotoxicology, 2016, Volume: 53

    Topics: Acetylcholinesterase; Administration, Intranasal; Animals; Biological Availability; Brain; Central Nervous System Diseases; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Male; Obidoxime Chloride; Organophosphate Poisoning; Pralidoxime Compounds; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Tritium

2016
Toxicity and median effective doses of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig.
    The Journal of toxicological sciences, 2016, Volume: 41, Issue:4

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Dose-Response Relationship, Drug; Guinea Pigs; Lethal Dose 50; Male; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphorus Compounds; Oximes; Pesticides; Pralidoxime Compounds; Pyridinium Compounds; Time Factors

2016
A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
    Drug and chemical toxicology, 2008, Volume: 31, Issue:3

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterase Inhibitors; Diaphragm; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Trimedoxime

2008
An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice.
    Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:1

    Topics: Animals; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Cholinesterases; Diaphragm; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Rats; Rats, Wistar; Treatment Outcome

2009
Clinical findings and cholinesterase levels in children of organophosphates and carbamates poisoning.
    European journal of pediatrics, 2009, Volume: 168, Issue:8

    Topics: Adolescent; Atropine; Biomarkers; Carbamates; Child; Child, Preschool; Cholinesterase Reactivators; Cholinesterases; Early Diagnosis; Egypt; Female; Humans; Infant; Insecticides; Male; Obidoxime Chloride; Organophosphate Poisoning; Poisoning; Predictive Value of Tests; Respiration, Artificial; Retrospective Studies

2009
Evaluation of the neuroprotective efficacy of newly developed oximes (K206, K269) and currently available oximes (obidoxime, HI-6) in cyclosarin-poisoned rats.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 104, Issue:3

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Muscarinic Antagonists; Neuroprotective Agents; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar

2009
Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.
    Toxicology, 2009, May-17, Volume: 259, Issue:3

    Topics: Acetylcholinesterase; Biomarkers; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Kinetics; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pesticides; Pralidoxime Compounds; Pyridinium Compounds

2009
The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice.
    Journal of applied toxicology : JAT, 2010, Volume: 30, Issue:2

    Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar

2010
Monitoring of neuromuscular transmission in organophosphate pesticide-poisoned patients.
    Toxicology letters, 2009, Dec-15, Volume: 191, Issue:2-3

    Topics: Acetylcholinesterase; Adult; Cholinesterase Reactivators; Electric Stimulation; Erythrocytes; Humans; Monitoring, Physiologic; Muscle, Skeletal; Neuromuscular Junction; Obidoxime Chloride; Organophosphate Poisoning; Pesticides; Synaptic Transmission

2009
Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds.
    Toxicology letters, 2010, Sep-01, Volume: 197, Issue:3

    Topics: Adult; Aged; Cholinesterase Reactivators; Female; Humans; Male; Middle Aged; Obidoxime Chloride; Organophosphate Poisoning; Young Adult

2010
Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder.
    Toxicology mechanisms and methods, 2010, Volume: 20, Issue:7

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Heart Atria; Heart Rate; Male; Molecular Structure; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Rats; Urinary Bladder

2010
The efficacy of obidoxime 72 hours after intoxication by organophosphates.
    The American journal of emergency medicine, 2011, Volume: 29, Issue:2

    Topics: Adult; Atropine; Cholinesterase Reactivators; Humans; Male; Mexico; Obidoxime Chloride; Organophosphate Poisoning; Poisoning; Suicide, Attempted; Time Factors

2011
Benefits of butyrylcholinesterase reactivability testing in organophosphate poisoning.
    Human & experimental toxicology, 2011, Volume: 30, Issue:11

    Topics: Adult; Butyrylcholinesterase; Cholinesterase Reactivators; Female; Humans; Male; Middle Aged; Neurotoxicity Syndromes; Obidoxime Chloride; Organophosphate Poisoning; Reagent Kits, Diagnostic; Young Adult

2011
Atropine dosage in patients with severe organophosphate pesticide poisoning.
    The American journal of emergency medicine, 2012, Volume: 30, Issue:4

    Topics: Atropine; Humans; Male; Obidoxime Chloride; Organophosphate Poisoning

2012
[Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos].
    Vojnosanitetski pregled, 2011, Volume: 68, Issue:12

    Topics: Animals; Antidotes; Cholinesterase Reactivators; Dichlorvos; Drug Therapy, Combination; Male; Memantine; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Soman

2011
A comparison of neuroprotective efficacy of the oxime K203 and its fluorinated analogue (KR-22836) with obidoxime in Tabun-poisoned rats.
    Basic & clinical pharmacology & toxicology, 2010, Volume: 107, Issue:5

    Topics: Acute Disease; Animals; Autonomic Nervous System; Behavior, Animal; Chemical Warfare Agents; Hyperkinesis; Male; Molecular Structure; Muscle Tonus; Neuroprotective Agents; Neurotoxicity Syndromes; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Treatment Outcome

2010
Neuroprotective effects of currently used antidotes in tabun-poisoned rats.
    Pharmacology & toxicology, 2003, Volume: 92, Issue:6

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Motor Activity; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Wistar

2003
Anticholinergic drugs--functional antidotes for the treatment of tabun intoxication.
    Acta medica (Hradec Kralove), 2004, Volume: 47, Issue:1

    Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinergic Antagonists; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Rats; Rats, Wistar

2004
Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning.
    Chemico-biological interactions, 2005, Dec-15, Volume: 157-158

    Topics: Acetylcholinesterase; Erythrocytes; Female; Humans; Male; Middle Aged; Muscle, Skeletal; Neuromuscular Junction; Neurons; Obidoxime Chloride; Organophosphate Poisoning; Synaptic Transmission

2005
Effectivity of new acetylcholinesterase reactivators in treatment of cyclosarin poisoning in mice and rats.
    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2005, Volume: 149, Issue:2

    Topics: Animals; Cholinesterase Reactivators; Female; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats

2005
A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats.
    Journal of enzyme inhibition and medicinal chemistry, 2007, Volume: 22, Issue:3

    Topics: Animals; Antidotes; Brain; Butanes; Cholinesterase Reactivators; Drug Evaluation, Preclinical; Male; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Structure-Activity Relationship

2007
An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
    Toxicology, 2008, Jan-20, Volume: 243, Issue:3

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Injections, Intramuscular; Lethal Dose 50; Male; Mice; Molecular Structure; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Species Specificity; Toxicity Tests, Acute; Trimedoxime

2008
A comparison of the potency of newly developed oximes (K074, K075) and currently available oximes (obidoxime, trimedoxime, HI-6) to counteract acute toxic effects of tabun and cyclosarin in mice.
    Drug and chemical toxicology, 2008, Volume: 31, Issue:1

    Topics: Animals; Antidotes; Atropine; Butanes; Cholinesterase Inhibitors; Cholinesterase Reactivators; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Lethal Dose 50; Male; Mice; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Organophosphorus Compounds; Oximes; Poisoning; Pyridinium Compounds; Trimedoxime

2008
Recovery from ultra-high dose organophosphate poisoning after "in-the-field" antidote treatment: potential lessons for civil defense.
    The Journal of emergency medicine, 2009, Volume: 37, Issue:3

    Topics: Adult; Atropine; Cholinesterase Reactivators; Emergency Medical Services; Gastric Lavage; Hemoperfusion; Humans; Intensive Care Units; Male; Middle Aged; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Polyneuropathies

2009
The efficacy of bispyridinium derivatives in the treatment of organophosphonate poisoning in the guinea-pig.
    The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:7

    Topics: Animals; Atropine; Diazepam; Female; Guinea Pigs; Obidoxime Chloride; Organophosphate Poisoning; Pyridinium Compounds; Pyridostigmine Bromide; Soman

1983
[The effect of organophosphates on heart ATPase in the rat].
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:6

    Topics: Adenosine Triphosphatases; Animals; Antidotes; Atropine; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Electrophysiology; Female; Isoflurophate; Kinetics; Myocardium; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Parathion; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase

1984
Sarin poisoning in guinea pigs compared to reactivation of acetylcholinesterase in vitro as a basis for therapy.
    Acta pharmacologica et toxicologica, 1984, Volume: 55, Issue:1

    Topics: Acetylcholinesterase; Animals; Cholinesterase Reactivators; Female; Guinea Pigs; In Vitro Techniques; Lethal Dose 50; Male; Obidoxime Chloride; Organophosphate Poisoning; Sarin; Species Specificity

1984
[Treatment of intoxications with organophosphates (author's transl)].
    DTW. Deutsche tierarztliche Wochenschrift, 1980, Volume: 87, Issue:7

    Topics: Animal Diseases; Animals; Atropine; Diazepam; Drug Therapy, Combination; Insecticides; Obidoxime Chloride; Organophosphate Poisoning; Pralidoxime Compounds

1980
[Effects of trimethadione on the therapeutic efficiency of atropine and obidoxime in mice poisoned with various phosphoorganic compounds].
    Medycyna pracy, 1981, Volume: 32, Issue:5

    Topics: Animals; Atropine; Blood-Brain Barrier; Drug Synergism; Female; Lethal Dose 50; Mice; Mice, Inbred BALB C; Obidoxime Chloride; Organophosphate Poisoning; Oxazoles; Oximes; Trimethadione

1981
Comparison of atropine and dexetimide in treatment of intoxications by selected organophosphates.
    Acta pharmacologica et toxicologica, 1982, Volume: 50, Issue:3

    Topics: Animals; Atropine; Dexetimide; Diet; Guinea Pigs; Insecticides; Isoflurophate; Lethal Dose 50; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Paraoxon; Piperidines

1982
Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning.
    Human & experimental toxicology, 1995, Volume: 14, Issue:8

    Topics: Animals; Atropine; Blood Pressure; Cholinesterase Inhibitors; Cholinesterase Reactivators; Female; Guinea Pigs; Heart Rate; Hemodynamics; Injections, Intravenous; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Pyridostigmine Bromide; Respiration

1995
Efficacy of obidoxime in human organophosphorus poisoning: determination by neuromuscular transmission studies.
    Muscle & nerve, 1995, Volume: 18, Issue:1

    Topics: Action Potentials; Aged; Female; Humans; Male; Middle Aged; Muscles; Neuromuscular Junction; Obidoxime Chloride; Organophosphate Poisoning; Synaptic Transmission; Thumb

1995
Treatment of tabun poisoned guinea-pigs with atropine, HLö 7 or HI 6: effect on respiratory and circulatory function.
    Archives of toxicology, 1994, Volume: 68, Issue:4

    Topics: Animals; Atropine; Blood Circulation; Cholinesterase Reactivators; Female; Guinea Pigs; Lethal Dose 50; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridines; Pyridinium Compounds; Respiration

1994
A comparison of two oximes (HI-6 and obidoxime) for 2-dimethylaminoethyl-(dimethylamido)-phosphonofluoridate poisoning.
    Pharmacology & toxicology, 1995, Volume: 77, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidotes; Brain; Cholinesterases; Corticosterone; Diaphragm; Liver; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Rats; Rats, Wistar; Tyrosine Transaminase

1995
Therapeutic efficacy of obidoxime or HI-6 with atropine against intoxication with some nerve agents in mice.
    Acta medica (Hradec Kralove), 1996, Volume: 39, Issue:1

    Topics: Animals; Antidotes; Chemical Warfare Agents; Cholinesterase Reactivators; Female; Gas Poisoning; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pyridinium Compounds; Sarin; Soman

1996
Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning.
    Human & experimental toxicology, 1997, Volume: 16, Issue:8

    Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Reactivators; Erythrocyte Membrane; Humans; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Poisoning; Pralidoxime Compounds

1997
Factors influencing the efficacy of obidoxime in organophosphate pesticides poisoning.
    Przeglad lekarski, 1997, Volume: 54, Issue:10

    Topics: Adult; Atropine; Cholinesterase Reactivators; Cholinesterases; Drug Administration Schedule; Female; Humans; Insecticides; Male; Middle Aged; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphates; Parathion; Poisoning; Premedication

1997
Severe organophosphate (demeton-S-methyl) poisoning in a two-year-old child.
    Veterinary and human toxicology, 1998, Volume: 40, Issue:4

    Topics: Antidotes; Atropine; Child, Preschool; Cholinesterase Reactivators; Humans; Insecticides; Male; Muscarinic Antagonists; Obidoxime Chloride; Organophosphate Poisoning; Organothiophosphates; Poisoning

1998
[Possible combinations of antidotal therapy in rats following intoxication with phosphoric acid esters (author's transl)].
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:10

    Topics: Actihaemyl; Animals; Antidotes; Atropine; Drug Therapy, Combination; Female; Obidoxime Chloride; Organophosphate Poisoning; Rats

1977
Therapeutic value of anticonvulsant drugs in poisonings with an organophosphate.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 238, Issue:2

    Topics: Animals; Anticonvulsants; Atropine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Isoflurophate; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Rats

1979
Administration of obidoxime tablets to man. Plasma levels and side reactions.
    Archives of toxicology, 1976, Sep-15, Volume: 36, Issue:1

    Topics: Administration, Oral; Adult; Antidotes; Humans; Kinetics; Male; Obidoxime Chloride; Organophosphate Poisoning; Oximes

1976
Antidotal therapy and changes of acetylcholinesterase activity following isopropyl methylphosphonofluoridate intoxication in mice.
    Acta biologica et medica Germanica, 1975, Volume: 34, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Brain; Dose-Response Relationship, Drug; Drug Synergism; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Sarin; Trimedoxime

1975
Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice.
    Archives of toxicology, 1992, Volume: 66, Issue:2

    Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Reactivators; In Vitro Techniques; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Nervous System Diseases; Obidoxime Chloride; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Pralidoxime Compounds; Pyridinium Compounds

1992
Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation.
    Archives of toxicology, 1991, Volume: 65, Issue:7

    Topics: Animals; Antidotes; Blood-Brain Barrier; Cholinesterase Reactivators; Diaphragm; In Vitro Techniques; Male; Neuromuscular Junction; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Respiratory Insufficiency; Synaptic Transmission

1991
Actions and interactions of cholinolytics and cholinesterase reactivators in the treatment of acute organophosphorus toxicity.
    Drug and chemical toxicology, 1991, Volume: 14, Issue:3

    Topics: Acute Disease; Animals; Benactyzine; Cholinesterase Reactivators; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Parasympatholytics; Poisoning; Pralidoxime Compounds

1991
Cold exposure decreases the effectiveness of atropine-oxime treatment in organophosphate intoxication in rats and mice.
    General pharmacology, 1989, Volume: 20, Issue:6

    Topics: Animals; Antidotes; Atropine; Carboxylic Ester Hydrolases; Cholinesterase Reactivators; Cold Temperature; Enzyme Reactivators; Isoflurophate; Lethal Dose 50; Mice; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Rats; Rats, Inbred F344

1989
Therapeutic Protocol No. 1. Early management of organophosphate poisoning.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1986, Jan-04, Volume: 69, Issue:1

    Topics: Adult; Atropine; Child; Humans; Ipecac; Obidoxime Chloride; Organophosphate Poisoning

1986
Allosteric stabilization of 3H-N-methylscopolamine binding in guinea-pig myocardium by an antidote against organophosphate intoxication.
    Pharmacology & toxicology, 1988, Volume: 63, Issue:3

    Topics: Allosteric Regulation; Animals; Antidotes; Binding, Competitive; Female; Guinea Pigs; Heart; In Vitro Techniques; Isoindoles; Male; Myocardium; N-Methylscopolamine; Obidoxime Chloride; Organophosphate Poisoning; Parasympatholytics; Phthalimides; Receptors, Muscarinic; Scopolamine Derivatives; Trimedoxime

1988
[Efficacy of several oximes on organophosphorus poisoning].
    Nihon eiseigaku zasshi. Japanese journal of hygiene, 1988, Volume: 43, Issue:3

    Topics: Animals; Cholinesterase Reactivators; Male; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Rats; Rats, Inbred Strains

1988
Comparison of serum concentrations of the acetylcholinesterase oxime reactivators HI-6, obidoxime, and PAM to efficacy against sarin (isopropyl methylphosphonofluoridate) poisoning in rats.
    Toxicology and applied pharmacology, 1987, Jun-30, Volume: 89, Issue:2

    Topics: Acetylcholinesterase; Animals; Male; Obidoxime Chloride; Organophosphate Poisoning; Oximes; Pralidoxime Compounds; Pyridinium Compounds; Rats; Rats, Inbred Strains; Sarin

1987
Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning of mice.
    Archives of toxicology, 1987, Volume: 61, Issue:1

    Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Cholinesterase Reactivators; Drug Therapy, Combination; Male; Mice; Obidoxime Chloride; Organophosphate Poisoning; Organophosphates; Oximes; Pyridinium Compounds; Soman

1987
[Maximum dose atropin treatment in severe organophosphate poisoning (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1974, Oct-18, Volume: 99, Issue:42

    Topics: Atropine; Cholinesterases; Gastric Lavage; Heart Arrest; Humans; Male; Middle Aged; Obidoxime Chloride; Organophosphate Poisoning; Poisoning; Pralidoxime Compounds; Reflex, Pupillary; Respiratory Paralysis; Unconsciousness

1974
Antidotes or organophosphate poisoning. 2. Thiadiazole-5-carboxaldoximes.
    Journal of medicinal chemistry, 1979, Volume: 22, Issue:11

    Topics: Acetylcholinesterase; Animals; Antidotes; Body Temperature; Cattle; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Enzyme Reactivators; Female; Goats; Guinea Pigs; Half-Life; In Vitro Techniques; Lethal Dose 50; Male; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Rabbits; Rats; Rats, Inbred Strains; Sarin; Solubility; Structure-Activity Relationship

1979
Amidine-oximes: reactivators for organophosphate exposure.
    Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9

    Topics: Acetylcholinesterase; Amidines; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterases; Enzyme Reactivators; Female; Humans; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Permeability; Recombinant Proteins; Sarin; Soman; Structure-Activity Relationship

2011
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.
    Journal of medicinal chemistry, 2022, 03-24, Volume: 65, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidotes; Cholinesterase Inhibitors; Mice; Organophosphate Poisoning; Organophosphorus Compounds; Oximes; Sugars

2022