o-demethyltramadol has been researched along with Acute Post-operative Pain in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, L; Cai, XJ; Jiang, B; Lv, XQ; Wang, GX; Xu, J; Xu, YY; Zhang, XC | 1 |
| Benitez, ME; KuKanich, B; McMurphy, R; Roush, JK | 1 |
| Brockmöller, J; Musshoff, F; Stamer, UM; Steffens, M; Stüber, F; Tzvetkov, MV | 1 |
| Bressolle, F; Capdevila, X; Dadure, C; Khier, S; Ouaki, J; Rochette, A | 1 |
| Akgül, O; Aypar, U; Dogrul, A; Kozak, O; Kurt, E; Sahin, A; Seyrek, M; Sizlan, A; Yanarates, O; Yildirim, V | 1 |
| Ilett, KF; Paech, MJ; Page-Sharp, M; Salman, S; Sy, SK | 1 |
| Madea, B; Musshoff, F; Stamer, UM; Stuber, F | 1 |
| Hoeft, A; Kobilay, M; Madea, B; Musshoff, F; Stamer, UM; Stuber, F | 1 |
| Gan, SH; Ismail, R | 1 |
2 trial(s) available for o-demethyltramadol and Acute Post-operative Pain
| Article | Year |
|---|---|
Pharmacokinetics of hydrocodone and tramadol administered for control of postoperative pain in dogs following tibial plateau leveling osteotomy.
Topics: Acetaminophen; Analgesics, Opioid; Animals; Area Under Curve; Dogs; Half-Life; Hydrocodone; Hydromorphone; Osteotomy; Pain, Postoperative; Tramadol | 2015 |
Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Genotype; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Pain Measurement; Pain, Postoperative; Phenotype; Polymorphism, Single Nucleotide; Stereoisomerism; Tandem Mass Spectrometry; Tramadol; Treatment Outcome | 2007 |
7 other study(ies) available for o-demethyltramadol and Acute Post-operative Pain
| Article | Year |
|---|---|
Effect of the cytochrome P450 2D6*10 genotype on the pharmacokinetics of tramadol in post-operative patients.
Topics: Adult; Aged; Analgesics, Opioid; Area Under Curve; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Female; Gastrointestinal Tract; Genotype; Half-Life; Humans; Male; Mass Spectrometry; Middle Aged; Pain, Postoperative; Polymorphism, Genetic; Tramadol | 2014 |
Loss-of-function polymorphisms in the organic cation transporter OCT1 are associated with reduced postoperative tramadol consumption.
Topics: Adult; Aged; Analgesics, Opioid; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Male; Middle Aged; Organic Cation Transporter 1; Pain, Postoperative; Pharmacogenetics; Polymorphism, Single Nucleotide; Postoperative Nausea and Vomiting; Principal Component Analysis; Regression Analysis; Time Factors; Tramadol | 2016 |
Population pharmacokinetics of the two enantiomers of tramadol and O-demethyl tramadol after surgery in children.
Topics: Analgesics, Opioid; Body Weight; Child; Child, Preschool; Drug Administration Schedule; Gastroesophageal Reflux; Humans; Infant; Models, Chemical; Pain Measurement; Pain, Postoperative; Postoperative Care; Stereoisomerism; Tramadol | 2009 |
Spinal 5-HT7 receptors play an important role in the antinociceptive and antihyperalgesic effects of tramadol and its metabolite, O-Desmethyltramadol, via activation of descending serotonergic pathways.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred BALB C; Neural Pathways; Pain; Pain Measurement; Pain, Postoperative; Reaction Time; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spinal Cord; Tramadol | 2010 |
Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk.
Topics: Adult; Analgesics, Opioid; Cesarean Section; Cytochrome P-450 CYP2D6; Drug Administration Schedule; Female; Humans; Milk, Human; Models, Biological; Nonlinear Dynamics; Pain, Postoperative; Polymorphism, Genetic; Predictive Value of Tests; Tissue Distribution; Tramadol | 2011 |
Enantiomeric determination of tramadol and O-desmethyltramadol by liquid chromatography- mass spectrometry and application to postoperative patients receiving tramadol.
Topics: Analgesics, Opioid; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Drug Monitoring; Humans; Isomerism; Mass Spectrometry; Pain, Postoperative; Postoperative Period; Reproducibility of Results; Tramadol | 2006 |
Validation of a high-performance liquid chromatography method for tramadol and o-desmethyltramadol in human plasma using solid-phase extraction.
Topics: Analgesics, Opioid; Chromatography, High Pressure Liquid; Humans; Pain, Postoperative; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tramadol | 2001 |