o-demethyltramadol has been researched along with Ache in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Court, MH; Greene, SA; Grubb, TL; Joo, H; Kukanich, B; Mealey, KL; Perez Jimenez, TE | 1 |
| Brosen, K; Damkier, P; Larsen, F; Noehr-Jensen, L; Sindrup, SH; Zwisler, ST | 1 |
| Akgül, O; Aypar, U; Dogrul, A; Kozak, O; Kurt, E; Sahin, A; Seyrek, M; Sizlan, A; Yanarates, O; Yildirim, V | 1 |
| Leppert, W; Mikolajczak, P | 1 |
| Balzarini, P; Baratelli, E; Bianchi, M; Broggini, M; Ferrario, P; Panerai, AE; Sacerdote, P | 1 |
| Abolin, C; Hewitt, MC; Koch, P; Shao, L; Varney, M | 1 |
| Bakale, R; Bhongle, N; Currie, M; Fang, K; Grover, P; Hewitt, M; Jerussi, TP; Koch, P; Malcolm, S; Ribe, S; Senanayake, C; Shao, L; Wu, F | 1 |
| Fu, W; Huang, H; Li, W; Liu, J; Wang, W; Wang, Y; Xu, X; Zhu, C | 1 |
3 trial(s) available for o-demethyltramadol and Ache
| Article | Year |
|---|---|
Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the
Topics: Administration, Oral; Analgesics, Opioid; Animals; Cross-Over Studies; Dogs; Drug Interactions; Female; Fluconazole; Male; Pain; Random Allocation; Tramadol | 2019 |
Escitalopram is a weak inhibitor of the CYP2D6-catalyzed O-demethylation of (+)-tramadol but does not reduce the hypoalgesic effect in experimental pain.
Topics: Adult; Analgesics, Opioid; Biotransformation; Citalopram; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dealkylation; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Pain; Pain Measurement; Reflex, Pupillary; Selective Serotonin Reuptake Inhibitors; Tramadol; Young Adult | 2009 |
Effects of tramadol on synovial fluid concentrations of substance P and interleukin-6 in patients with knee osteoarthritis: comparison with paracetamol.
Topics: Acetaminophen; Administration, Oral; Aged; Double-Blind Method; Female; Humans; Interleukin-6; Male; Middle Aged; Osteoarthritis, Knee; Pain; Pain Measurement; Prospective Studies; Substance P; Synovial Fluid; Time Factors; Tramadol | 2003 |
5 other study(ies) available for o-demethyltramadol and Ache
| Article | Year |
|---|---|
Spinal 5-HT7 receptors play an important role in the antinociceptive and antihyperalgesic effects of tramadol and its metabolite, O-Desmethyltramadol, via activation of descending serotonergic pathways.
Topics: Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred BALB C; Neural Pathways; Pain; Pain Measurement; Pain, Postoperative; Reaction Time; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spinal Cord; Tramadol | 2010 |
Analgesic effects and assays of controlled-release tramadol and o-desmethyltramadol in cancer patients with pain.
Topics: Aged; Aged, 80 and over; Analgesia; Analgesics, Opioid; Codeine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Middle Aged; Neoplasms; Pain; Pain Measurement; Tramadol | 2011 |
Derivatives of tramadol for increased duration of effect.
Topics: Analgesics, Opioid; Animals; Binding Sites; Codeine; Models, Chemical; Morphine; Pain; Rats; Time Factors; Tramadol | 2006 |
In vitro and in vivo evaluation of O-alkyl derivatives of tramadol.
Topics: Analgesics, Opioid; Animals; Humans; Microsomes, Liver; Molecular Structure; Pain; Protein Binding; Rats; Structure-Activity Relationship; Tramadol | 2008 |
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic.
Topics: Analgesics; Animals; Female; Ligands; Mice; Models, Molecular; Pain; Piperidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2020 |