o-(6)-methylguanine has been researched along with Neoplasms in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (42.11) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goodfellow, E; Jean-Claude, B; Senhaji Mouhri, Z | 1 |
| Margison, G | 1 |
| Kaina, B; Roos, WP | 1 |
| Lauffenburger, DA; Noonan, EM; Samson, LD; Shah, D; Yaffe, MB | 1 |
| Margison, GP; Povey, AC; Santibáñez Koref, MF | 1 |
| Christmann, M; Kaina, B | 1 |
| Clatterbuck, BE; Day, RS; Mattern, MR; Meyer, SA; Scudiero, DA; Ziolkowski, CH | 1 |
| Day, RS; Yagi, T; Yarosh, DB | 1 |
| Pegg, AE | 1 |
| Day, RS; Foote, RS; Mitra, S; Yarosh, DB | 1 |
| Bignami, M; Karran, P | 1 |
| Battershill, J; Fielder, RJ; Mulholland, C | 1 |
| Anderson, LM; Chhabra, SK; Georgiadis, P; Kyrtopoulos, SA; Pletsa, V; Souliotis, VL; Valavanis, C | 1 |
| Erickson, LC | 1 |
| Essigmann, JM; Singer, B | 1 |
| Cao, EH; Carlson, C; Grist, E; Holehan, AM; Merry, BJ; Woodhead, AD | 1 |
| Margison, GP; O'Connor, PJ; Saffhill, R | 1 |
| Babich, MA; Day, RS; Hurst-Calderone, S; Yarosh, DB | 1 |
| Boucheron, JA; Dyroff, MC; Richardson, FC; Swenberg, JA | 1 |
8 review(s) available for o-(6)-methylguanine and Neoplasms
| Article | Year |
|---|---|
DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Death; DNA; DNA Adducts; DNA Damage; DNA Repair; Guanine; Humans; Inhibitor of Apoptosis Proteins; Neoplasms; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; Radiation, Ionizing; Signal Transduction; Survivin | 2013 |
Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine.
Topics: Alkylating Agents; Animals; DNA; DNA Adducts; DNA Damage; DNA Methylation; Guanine; Humans; Neoplasms; Point Mutation; Recombination, Genetic | 2002 |
DNA repair in resistance to alkylating anticancer drugs.
Topics: Alkyl and Aryl Transferases; Antineoplastic Agents, Alkylating; DNA Repair; Drug Resistance, Neoplasm; Guanine; Neoplasms | 2002 |
DNA damage tolerance, mismatch repair and genome instability.
Topics: Animals; Bacterial Proteins; Base Sequence; CHO Cells; Colonic Neoplasms; Cricetinae; DNA Damage; DNA Repair; DNA, Satellite; Escherichia coli; Female; Fungal Proteins; Genome; Guanine; Humans; Male; Mammals; Methylation; Methyltransferases; Molecular Sequence Data; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Saccharomyces cerevisiae; Sister Chromatid Exchange | 1994 |
DNA adducts and the mechanism of carcinogenesis and cytotoxicity of methylating agents of environmental and clinical significance.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carcinogens, Environmental; Dimethylnitrosamine; DNA Adducts; DNA Damage; DNA Methylation; Erythrocebus patas; Ethanol; Female; Guanine; Humans; Leukocytes; Liver; Mice; Mice, Transgenic; Neoplasms; Nitroso Compounds; Procarbazine | 1997 |
The role of O-6 methylguanine DNA methyltransferase (MGMT) in drug resistance and strategies for its inhibition.
Topics: Animals; DNA Repair; Drug Resistance; Ethylnitrosourea; Guanine; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Rats; Streptozocin | 1991 |
Site-specific mutagenesis: retrospective and prospective.
Topics: Animals; DNA; DNA Damage; Guanine; Humans; Mutagenesis; Neoplasms; Thymine | 1991 |
Mechanisms of carcinogenesis induced by alkylating agents.
Topics: Alkylating Agents; Alkylation; Animals; Cells, Cultured; Cricetinae; Deoxyribonucleotides; DNA; DNA Repair; Escherichia coli; Guanine; Mice; Mutagens; Mutation; Neoplasms; Oncogenes; Rats | 1985 |
11 other study(ies) available for o-(6)-methylguanine and Neoplasms
| Article | Year |
|---|---|
A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; BRCA1 Protein; BRCA2 Protein; Cell Line, Tumor; Cricetulus; Dacarbazine; DNA Repair; DNA, Neoplasm; Guanine; Humans; Mutation; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Temozolomide | 2017 |
O(6)-methylguanine in DNA: bad penny?
Topics: Antineoplastic Agents; DNA; DNA Damage; DNA Mismatch Repair; DNA Replication; Guanine; Humans; Models, Biological; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase | 2010 |
O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.
Topics: Antineoplastic Agents; Apoptosis; Base Pair Mismatch; Cell Cycle; Cell Death; Cell Line; DNA; DNA Damage; DNA Repair; DNA Replication; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Guanine; Humans; Neoplasms; S Phase; Signal Transduction | 2012 |
Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas.
Topics: Alkylating Agents; Cell Line; Cell Survival; DNA Repair; Female; Guanine; Humans; Kinetics; Neoplasms; Nitrosourea Compounds; Structure-Activity Relationship; Ultraviolet Rays | 1984 |
Comparison of repair of O6-methylguanine produced by N-methyl-N'-nitro-N-nitrosoguanidine in mouse and human cells.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; DNA Repair; Embryo, Mammalian; Female; Guanine; Humans; Kinetics; Methylation; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Neoplasms; Neoplasms, Experimental; Species Specificity | 1984 |
Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Guanine; Humans; Liver; Methylation; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidines; Structure-Activity Relationship | 1984 |
Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains.
Topics: DNA Repair; DNA, Neoplasm; Female; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Phenotype | 1983 |
Symposium on the significance of low level exposures to DNA adduct inducing chemicals, Department of Health, London, UK, May 1996.
Topics: Adenomatous Polyposis Coli; Animals; Biomarkers; Carcinogens; DNA Adducts; DNA Damage; Environmental Monitoring; Enzyme-Linked Immunosorbent Assay; Epidemiologic Methods; Epidemiological Monitoring; Guanine; Humans; Isotope Labeling; Models, Biological; Neoplasms; Phosphorus Radioisotopes; Risk Factors | 1997 |
Levels of O6-methylguanine acceptor protein in tissues of rats and their relationship to carcinogenicity and aging.
Topics: Aging; Animals; Brain; Carrier Proteins; DNA Repair; Female; Guanine; Kidney; Liver; Male; Neoplasms; Organ Specificity; Rats; Rats, Inbred Strains; Spleen | 1985 |
Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base.
Topics: Cell Survival; DNA Repair; Ethylnitrosourea; Fibroblasts; Guanine; Humans; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Substrate Specificity | 1986 |
Relationships between DNA adduct formation and carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; DNA Replication; Environmental Exposure; Guanine; Humans; Liver; Neoplasms; Organ Specificity; Rats; Rats, Inbred F344; Risk | 1985 |