o-(6)-methylguanine has been researched along with Malignant Melanoma in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eich, M; Kaina, B; Nikolova, T; Roos, WP | 1 |
| Benharroch, D; Brkic, G; Galron, D; Gefen, N; Gopas, J; Ozer, J; Priel, E | 1 |
| Dianov, GL; Digweed, M; Eich, M; Kaina, B; Roos, WP | 1 |
| Kyrtopoulos, SA | 1 |
| Cooper, DP; Crowther, D; Lee, SM; Margison, GP; O'Connor, PJ; Thatcher, N | 1 |
| Ganesan, TS; Harris, AL; Kyrtopoulos, SA; Mitchell, K; Philip, PA; Salisbury, A; Souliotis, VL; Tates, AD; van Delft, JH | 1 |
| Arance, A; Lee, SM; Margison, GP; Middleton, MR; Thatcher, N; Wood, M | 1 |
| Dempke, W; Nehls, P; Osieka, R; Schmidt, CG; Soll, D; Wandl, U | 1 |
1 review(s) available for o-(6)-methylguanine and Malignant Melanoma
| Article | Year |
|---|---|
Variability in DNA repair and individual susceptibility to genotoxins.
Topics: Animals; Antineoplastic Agents, Alkylating; DNA; DNA Repair; Environmental Exposure; Genetic Predisposition to Disease; Guanine; Hodgkin Disease; Humans; Melanoma; Methyltransferases; Mutagens; O(6)-Methylguanine-DNA Methyltransferase | 1995 |
1 trial(s) available for o-(6)-methylguanine and Malignant Melanoma
| Article | Year |
|---|---|
O6-methylguanine formation, repair protein depletion and clinical outcome with a 4 hr schedule of temozolomide in the treatment of advanced melanoma: results of a phase II study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Dacarbazine; Drug Administration Schedule; Female; Guanine; Humans; Male; Melanoma; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2000 |
6 other study(ies) available for o-(6)-methylguanine and Malignant Melanoma
| Article | Year |
|---|---|
Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.
Topics: Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Checkpoint Kinase 1; Dacarbazine; DNA Breaks, Double-Stranded; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Glioblastoma; Guanine; Humans; Melanoma; Methylnitronitrosoguanidine; Phosphorylation; Protein Kinases; Signal Transduction; Temozolomide; Tumor Suppressor Proteins | 2013 |
Acquired resistance to 6-thioguanine in melanoma cells involves the repair enzyme O6-methylguanine-DNA methyltransferase (MGMT).
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; DNA Methylation; Dose-Response Relationship, Drug; Guanine; Humans; Melanoma; O(6)-Methylguanine-DNA Methyltransferase; Thioguanine | 2010 |
Nijmegen breakage syndrome protein (NBN) causes resistance to methylating anticancer drugs such as temozolomide.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Caspase 7; Cell Cycle Proteins; Cell Line, Transformed; Cell Line, Tumor; Dacarbazine; DNA Methylation; Drug Resistance, Neoplasm; Fibroblasts; Guanine; Homozygote; Humans; Melanoma; Methylnitronitrosoguanidine; Mutagens; Mutation; Necrosis; Nijmegen Breakage Syndrome; Nuclear Proteins; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Temozolomide; Uveal Neoplasms | 2010 |
Relationships between the formation of O6-methyldeoxyguanosine by 1-p-carboxyl-3,3-dimethylphenyltriazene in DNA and O6-alkylguanine-DNA alkyltransferase in human peripheral leukocytes.
Topics: Adult; Aged; Antineoplastic Agents; Deoxyguanosine; DNA Nucleotidyltransferases; DNA, Neoplasm; Female; Guanine; Humans; Leukocytes; Lymphocytes; Male; Melanoma; Middle Aged; Triazenes | 1994 |
Methyl DNA adducts, DNA repair, and hypoxanthine-guanine phosphoribosyl transferase mutations in peripheral white blood cells from patients with malignant melanoma treated with dacarbazine and hydroxyurea.
Topics: Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; DNA Adducts; DNA Repair; Female; Guanine; Humans; Hydroxyurea; Hypoxanthine Phosphoribosyltransferase; Leukocytes; Male; Melanoma; Middle Aged; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 1996 |
Increased cytotoxicity of 1-(2-chloroethyl)-1-nitroso-3(4-methyl)-cyclohexylurea by pretreatment with O6-methylguanine in resistant but not in sensitive human melanoma cells.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Division; Colony-Forming Units Assay; Cross-Linking Reagents; Drug Resistance; Drug Synergism; Guanine; Humans; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Nitrosourea Compounds; Semustine; Transplantation, Heterologous; Tumor Stem Cell Assay | 1987 |