o-(6)-methylguanine has been researched along with Glioma in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arpagaus, B; Brambilla, D; Casalini, T; Grandjean, J; Leroux, JC; Luciani, P; Martin, E; Papachristodoulou, A; Roth, P; Signorell, RD; Steiniger, F; Thamm, J; Weller, M; Werner, B; Xiao, J | 1 |
| Boldorini, R; Buosi, R; Gaudino, E; Mancuso, G; Mercalli, F; Mezzapelle, R; Miglio, U; Paganotti, A; Rena, O; Veggiani, C | 1 |
| Luedtke, NW; Marsoner, T; Schmidt, OP; Triemer, T | 1 |
| Ancheta, K; Chtchetinin, J; Cloughesy, T; Lai, A; Nghiemphu, PL; Remington, M | 1 |
| Christmann, M; Kaina, B; Knizhnik, AV; Nikolova, T; Quiros, S; Roos, WP; Tomaszowski, KH | 1 |
| Batista, LF; Kaina, B; Menck, CF; Naumann, SC; Roos, WP; Weller, M; Wick, W | 1 |
| Kohda, K; Koyama, K; Mineura, K; Terashima, I; Watanabe, K | 1 |
| Ikenaga, M; Izumi, I; Kohda, K; Kowada, M; Mineura, K; Watanabe, K | 1 |
| Chen, ZP; Garcia, Y; Langleben, A; Malapetsa, A; Mohr, G; Panasci, LC; Tampieri, D; Yarosh, D | 1 |
| Day, RS | 1 |
| Fushimi, S; Ishino, Y; Kowada, M; Mineura, K; Sasajima, H; Sasaki, J | 1 |
| Aida, T; Berger, MS; Bodell, WJ; Rosenblum, ML | 1 |
1 trial(s) available for o-(6)-methylguanine and Glioma
| Article | Year |
|---|---|
Frequency of O⁶-methylguanine-DNA methyltransferase promoter methylation in cytological samples from small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Biopsy, Fine-Needle; Dacarbazine; DNA Methylation; Glioma; Guanine; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Small Cell Lung Carcinoma; Temozolomide | 2015 |
11 other study(ies) available for o-(6)-methylguanine and Glioma
| Article | Year |
|---|---|
Preparation of PEGylated liposomes incorporating lipophilic lomeguatrib derivatives for the sensitization of chemo-resistant gliomas.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Glioma; Guanine; Humans; Liposomes; Mice; Polyethylene Glycols; Purines | 2018 |
DNA-Targeted Inhibition of MGMT.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Dacarbazine; DNA; DNA Modification Methylases; DNA Repair Enzymes; Glioma; Guanine; Humans; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2017 |
The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity.
Topics: Antineoplastic Agents, Alkylating; Blotting, Western; Cell Nucleus; Cell Proliferation; Cell Survival; Cycloheximide; Dacarbazine; Drug Resistance, Neoplasm; Enzyme Stability; Gene Expression Regulation, Neoplastic; Glioma; Green Fluorescent Proteins; Guanine; Humans; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Genetic; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2009 |
Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Autophagy; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Survival; Cellular Senescence; Dacarbazine; DNA Damage; DNA Mismatch Repair; DNA Modification Methylases; DNA-Binding Proteins; Glioma; Guanine; Homologous Recombination; Humans; Protein Serine-Threonine Kinases; Temozolomide; Tumor Suppressor Proteins | 2013 |
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Brain Neoplasms; Caspases; Cell Cycle; Cell Proliferation; Dacarbazine; DNA Breaks, Double-Stranded; DNA Damage; Fas Ligand Protein; Fas-Associated Death Domain Protein; Flow Cytometry; Glioma; Guanine; Humans; Methylnitronitrosoguanidine; O(6)-Methylguanine-DNA Methyltransferase; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Temozolomide; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2007 |
Potentiation of the cytotoxicity of chloroethylnitrosourea by O6-arylmethylguanines.
Topics: Alkylation; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Drug Synergism; Glioma; Guanine; HeLa Cells; Humans; Methyltransferases; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Phenols; Prohibitins; Rats; Tumor Cells, Cultured | 1995 |
Potential of O6-methylguanine or O6-benzylguanine in the enhancement of chloroethylnitrosourea cytotoxicity on brain tumours.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Basal Ganglia; Brain Neoplasms; Cell Count; Cell Division; Culture Techniques; DNA Repair; DNA, Neoplasm; Drug Synergism; Glioma; Guanine; Male; Nimustine; Rats; Rats, Wistar | 1994 |
Relationship between O6-methylguanine-DNA methyltransferase levels and clinical response induced by chloroethylnitrosourea therapy in glioma patients.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Brain Neoplasms; DNA Modification Methylases; Drug Resistance, Neoplasm; Female; Glioma; Guanine; Humans; Male; Middle Aged; Nitroso Compounds; Tumor Cells, Cultured | 1999 |
Incision at O6-methylguanine:thymine mispairs in DNA by extracts of human cells.
Topics: Base Composition; Base Sequence; Binding, Competitive; Colonic Neoplasms; Deoxyribonuclease I; DNA; DNA Repair; Glioma; Guanine; Humans; Kinetics; Methylnitronitrosoguanidine; Methyltransferases; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Thymine; Tumor Cells, Cultured | 1992 |
[Circumvention of ACNU-resistance in rat glioma cells by pretreatment with O6-methylguanine].
Topics: Animals; Brain Neoplasms; Cell Survival; Drug Resistance; Drug Synergism; Enzyme Induction; Glioma; Guanine; Methyltransferases; Nimustine; O(6)-Methylguanine-DNA Methyltransferase; Rats; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Increased repair of O6-alkylguanine DNA adducts in glioma-derived human cells resistant to the cytotoxic and cytogenetic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Alkylation; Carmustine; Cell Line; Cell Survival; DNA; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Glioma; Guanine; Humans; Methylnitrosourea; Methyltransferases; Nitroso Compounds; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange; Tritium | 1986 |