o-(6)-methylguanine has been researched along with Colorectal Neoplasms in 6 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Da Pieve, C; Moore, SA; Sahgal, N; Velasco-Garcia, MN | 1 |
| Chen, NZ; Chen, ZJ; Jin, C; Ye, LC; Zheng, CG | 1 |
| Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Kraus, A; Nagel, G; Seiwert, N | 1 |
| Badawi, AF; Cooper, DP; Hall, CN; Jackson, PE; O'Connor, PJ; Povey, AC | 1 |
| Aquilina, G; Bignami, M | 1 |
| Badawi, AF; Cooper, DP; Guppy, MJ; Hall, CN; Jackson, PE; Margison, GP; O'Connor, PJ; Povey, AC | 1 |
2 review(s) available for o-(6)-methylguanine and Colorectal Neoplasms
| Article | Year |
|---|---|
Clinicopathological significance and potential drug target of O6-methylguanine-DNA methyltransferase in colorectal cancer: a meta-analysis.
Topics: Colorectal Neoplasms; DNA Methylation; Gene Expression Regulation, Neoplastic; Guanine; Humans; Mutation; Neoplasm Staging; O(6)-Methylguanine-DNA Methyltransferase; Prognosis; Promoter Regions, Genetic | 2015 |
Genetic instability and methylation tolerance in colon cancer.
Topics: Cell Transformation, Neoplastic; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Damage; DNA Repair; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; O(6)-Methylguanine-DNA Methyltransferase; Phenotype | 1996 |
4 other study(ies) available for o-(6)-methylguanine and Colorectal Neoplasms
| Article | Year |
|---|---|
Development of a liquid chromatography/tandem mass spectrometry method to investigate the presence of biomarkers of DNA damage in urine related to red meat consumption and risk of colorectal cancer.
Topics: Animals; Chromatography, Liquid; Colorectal Neoplasms; Cross-Over Studies; Deoxyguanosine; Diet; Diet, Vegetarian; DNA Damage; Guanine; Humans; Limit of Detection; Meat; Tandem Mass Spectrometry | 2013 |
Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.
Topics: Animals; Antineoplastic Agents, Alkylating; Autophagy; Colorectal Neoplasms; Cysteine; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glutathione; Guanine; HCT116 Cells; Humans; Male; Mice, Inbred BALB C; Molecular Targeted Therapy; Temozolomide; Thioctic Acid; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2015 |
Frequency of Ki-ras mutations and DNA alkylation in colorectal tissue from individuals living in Manchester.
Topics: Base Sequence; Colon; Colorectal Neoplasms; DNA Damage; DNA Primers; England; Genes, ras; Guanine; Humans; Methylation; Molecular Sequence Data; Point Mutation; Proto-Oncogene Proteins p21(ras) | 1996 |
Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue: O(6)-methylguanine levels are associated with GSTT1 genotype and O(6)-alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype.
Topics: Adenosine Triphosphatases; Aged; Alkylation; Colorectal Neoplasms; Cross-Sectional Studies; Cytochrome P-450 CYP2D6; DNA Repair; DNA, Neoplasm; Female; Genetic Predisposition to Disease; Genotype; Glutathione Transferase; Guanine; Humans; Male; Middle Aged; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Proto-Oncogene Proteins p21(ras) | 2001 |