o-(6)-methylguanine has been researched along with Cell Transformation, Neoplastic in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (29.41) | 18.7374 |
| 1990's | 8 (47.06) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bastek, H; Benda, N; Collins, LB; Damme, K; Dietrich, DR; Ellinger-Ziegelbauer, H; Frötschl, R; Klaus, V; Lutter, D; Stemmer, K; Swenberg, JA | 1 |
| Burns, JA; Dreij, K; Ezerskyte, M; Malvezzi, S; Margison, GP; Olsson, M; Paredes, JA; Scicchitano, DA | 1 |
| Pegg, AE | 1 |
| Singer, B | 1 |
| Bassendine, M; Collier, J; Foster, H; Griffiths, I; Guo, K; Major, G; Ross, D | 1 |
| Bassendine, MF; Burt, AD; Collier, JD; Guo, K; Major, GN | 1 |
| Bishop, RE; Dolan, ME; Dunn, LL; Moschel, RC; Pauly, GT | 1 |
| Aquilina, G; Bignami, M | 1 |
| Collier, JD; Major, GN | 1 |
| Allay, E; Gerson, SL; Veigl, M | 1 |
| Boley, SE; Maher, VM; McCormick, JJ; McManus, TP | 1 |
| Fukushima, S | 1 |
| Beattie, C; Guzman, RC; Hamdan, MA; Mascharack, P; Nandi, S; Yang, J | 1 |
| Kamiya, H; Miura, K; Nishimura, S; Ohtomo, N; Ohtsuka, E | 1 |
| D'Ambrosio, SM; Gibson-D'Ambrosio, R; Lowder, E; Samuel, M; Wani, AA; Wani, G | 1 |
| Day, RS; DiPaolo, JA; Doniger, J | 1 |
| Boucheron, JA; Dyroff, MC; Richardson, FC; Swenberg, JA | 1 |
2 review(s) available for o-(6)-methylguanine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Genetic instability and methylation tolerance in colon cancer.
Topics: Cell Transformation, Neoplastic; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; DNA Damage; DNA Repair; Guanine; Humans; Methylation; Methyltransferases; Microsatellite Repeats; O(6)-Methylguanine-DNA Methyltransferase; Phenotype | 1996 |
Repair of DNA lesion O6-methylguanine in hepatocellular carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; DNA Repair; Guanine; Humans; Liver Cirrhosis; Liver Neoplasms; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase | 1998 |
15 other study(ies) available for o-(6)-methylguanine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Time-matched analysis of DNA adduct formation and early gene expression as predictive tool for renal carcinogenesis in methylazoxymethanol acetate treated Eker rats.
Topics: Animals; Cell Proliferation; Cell Transformation, Neoplastic; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Guanine; Kidney; Male; Methylazoxymethanol Acetate; Rats, Mutant Strains; Time Factors | 2017 |
Topics: Amino Acid Substitution; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Repair; G1 Phase Cell Cycle Checkpoints; Guanine; Humans; Mutagenesis; Mutation, Missense; S Phase Cell Cycle Checkpoints; Transcription, Genetic; Tumor Suppressor Protein p53 | 2018 |
Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Guanine; Humans; Liver; Methylation; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Pyrimidines; Structure-Activity Relationship | 1984 |
Alkylation of the O6 of guanine is only one of many chemical events that may initiate carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Ethylnitrosourea; Guanine; Methylnitrosourea; Neoplasms, Experimental | 1984 |
Defective repair of O6-methylguanine-DNA in primary Sjögren's syndrome patients predisposed to lymphoma.
Topics: Aged; Autoimmune Diseases; Cell Transformation, Neoplastic; DNA Repair; Female; Guanine; Humans; Lymphocytes; Lymphoma; Methyltransferases; Middle Aged; O(6)-Methylguanine-DNA Methyltransferase; Sjogren's Syndrome | 1995 |
Deficient repair of DNA lesion O6-methylguanine in cirrhosis.
Topics: Biopsy; Carcinoma, Hepatocellular; Causality; Cell Division; Cell Transformation, Neoplastic; DNA Repair; Evaluation Studies as Topic; Guanine; Humans; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Lymphocytes; Mutagenesis; Risk Factors | 1993 |
The role of O6-alkylguanine-DNA alkyltransferase in protecting Rat4 cells against the mutagenic effects of O6-substituted guanine residues incorporated in codon 12 of the H-ras gene.
Topics: Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; Codon; DNA Damage; DNA Repair; Genes, ras; Guanine; Methyltransferases; Molecular Sequence Data; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Transfection | 1993 |
Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; Codon; DNA Adducts; DNA Damage; DNA Methylation; Genes, ras; Guanine; Humans; Lac Operon; Lymphoma; Methylnitrosourea; Mice; Mice, Transgenic; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Organ Specificity; Point Mutation; Spleen; Thymus Gland; Thymus Neoplasms; Transgenes | 1999 |
Malignant transformation of human fibroblast cell strain MSU-1.1 by N-methyl-N-nitrosourea: evidence of elimination of p53 by homologous recombination.
Topics: Alleles; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Codon; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Gene Deletion; Genes, p53; Guanine; Homozygote; Humans; Loss of Heterozygosity; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Transcriptional Activation | 2000 |
Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis.
Topics: Animals; Butylhydroxybutylnitrosamine; Cacodylic Acid; Carcinogens; Cell Division; Cell Transformation, Neoplastic; DNA Mutational Analysis; Female; Guanine; Humans; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Mice, Knockout; Mice, Transgenic; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Single-Stranded Conformational; RNA, Messenger; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms | 2001 |
Depletion of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine in three-dimensional collagen cultures of normal human breast epithelial cells.
Topics: Animals; Base Sequence; Breast; Cell Transformation, Neoplastic; Cells, Cultured; Collagen; Culture Media; Epithelial Cells; Epithelium; Female; Guanine; Humans; Menopause; Methyltransferases; Mice; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1992 |
Transforming activity of a synthetic c-Ha-ras gene containing O6-methylguanine in codon 12.
Topics: 3T3 Cells; Adenine; Amino Acid Sequence; Animals; Base Sequence; Cell Transformation, Neoplastic; Codon; Genes, ras; Genes, Synthetic; Genetic Vectors; Guanine; Humans; Mice; Molecular Sequence Data; Mutagenesis, Insertional; Mutation; Oligonucleotides; Transfection | 1991 |
Absence of DNA damage-mediated induction of human methyltransferase specific for precarcinogenic O6-methylguanine.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA Repair; Female; Fetus; Guanine; Humans; Kidney; Liver; Methylnitronitrosoguanidine; Methyltransferases; Pregnancy; Rats | 1989 |
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; DNA; Dose-Response Relationship, Drug; Female; Guanine; Mesocricetus; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Pregnancy | 1985 |
Relationships between DNA adduct formation and carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; DNA Replication; Environmental Exposure; Guanine; Humans; Liver; Neoplasms; Organ Specificity; Rats; Rats, Inbred F344; Risk | 1985 |